Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

The Lancet Diabetes and Endocrinology

Volumn 6, Issue 2, 2018, Pages 122-129

  Thomas, Nicholas J ^a   Jones, Samuel E ^a   Weedon, Michael N ^a   Shields, Beverley M ^a   Oram, Richard A ^a   Hattersley, Andrew T ^a  

^a UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BODY MASS; CAUCASIAN; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC KETOACIDOSIS; FEMALE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PRIORITY JOURNAL; SURVIVAL ANALYSIS; UNITED KINGDOM; BIOBANK; FACTUAL DATABASE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED; MORTALITY; PREVALENCE; STATISTICS AND NUMERICAL DATA; SURVIVAL RATE; TIME FACTOR;

ADULT; AGED; BIOLOGICAL SPECIMEN BANKS; CROSS-SECTIONAL STUDIES; DATABASES, FACTUAL; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; PREVALENCE; SURVIVAL RATE; TIME FACTORS; UNITED KINGDOM;

EID: 85035361972     PISSN: 22138587     EISSN: 22138595     Source Type: Journal    
DOI: 10.1016/S2213-8587(17)30362-5     Document Type: Article

References (28)

1. Maahs, DM, West, NA, Lawrence, JM, Mayer-Davis, EJ, Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am 39 (2010), 481–497.
2. Diaz-Valencia, PA, Bougneres, P, Valleron, AJ, Global epidemiology of type 1 diabetes in young adults and adults: a systematic review. BMC Public Health, 15, 2015, 255.
3. Scottish Diabetes Survey Monitoring Group. Scottish Diabetes Survey 2015. http://diabetesinscotland.org.uk/Publications/SDS2015.pdf, 2015 (accessed June 15, 2017).
4. Hope, SV, Wienand-Barnett, S, Shepherd, M, et al. Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis. Br J Gen Pract 66 (2016), E315–E322.
5. Farmer, A, Fox, R, Diagnosis, classification, and treatment of diabetes. BMJ, 342, 2011, d3319.
6. Diabetes, UK, Theresa May: “Type 1 doesn't change what you can do”. https://www.diabetes.org.uk/about_us/news/balance-interview-with-theresa-may, 2014 (accessed May 19, 2017).
7. Jones, AG, Hattersley, AT, The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabet Med 30 (2013), 803–817.
8. Sabbah, E, Savola, K, Ebeling, T, et al. Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes. Diabetes Care 23 (2000), 1326–1332.
9. Bingley, PJ, Clinical applications of diabetes antibody testing. J Clin Endocrinol Metab 95 (2010), 25–33.
10. Clayton, DG, Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet, 5, 2009, e1000540.
11. Husby, S, Koletzko, S, Korponay-Szabo, IR, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 54 (2012), 136–160.
12. Kaukinen, K, Partanen, J, Maki, M, Collin, P, HLA-DQ typing in the diagnosis of celiac disease. Am J Gastroenterol 97 (2002), 695–699.
13. Taurog, JD, Chhabra, A, Colbert, RA, Ankylosing spondylitis and axial spondyloarthritis. N Engl J Med, 375, 2016, 1303.
14. Barrett, JC, Clayton, DG, Concannon, P, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 41 (2009), 703–707.
15. Morris, AP, Voight, BF, Teslovich, TM, et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 44 (2012), 981–990.
16. Oram, RA, Patel, K, Hill, A, et al. A type 1 diabetes genetic risk score can aid discrimination between type 1 and type 2 diabetes in young adults. Diabetes Care 39 (2016), 337–344.
17. Winkler, C, Krumsiek, J, Buettner, F, et al. Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes. Diabetologia 57 (2014), 2521–2529.
18. Patel, KA, Oram, RA, Flanagan, SE, et al. Type 1 diabetes genetic risk score: a novel tool to discriminate monogenic and type 1 diabetes. Diabetes 65 (2016), 2094–2099.
19. Allen, NE, Sudlow, C, Peakman, T, Collins, R, UK Biobank data: come and get it. Sci Transl Med, 6, 2014, 224.
20. Tyrrell, J, Jones, SE, Beaumont, R, et al. Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. BMJ, 352, 2016, i582.
21. Barker, JM, Triolo, TM, Aly, TA, et al. Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screening. Diabetes 57 (2008), 3152–3155.
22. Eastwood, SV, Mathur, R, Atkinson, M, et al. Algorithms for the capture and adjudication of prevalent and incident diabetes in UK Biobank. PLoS One, 11, 2016, e0162388.
23. Wellcome Trust Case Control Consortium. Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 447 (2007), 661–678.
24. Tuomi, T, Santoro, N, Caprio, S, Cai, M, Weng, J, Groop, L, The many faces of diabetes: a disease with increasing heterogeneity. Lancet 383 (2014), 1084–1094.
25. Davey Smith, G, Davies, NM, Can genetic evidence help us understand why height and weight relate to social position?. BMJ, 352, 2016, i1224.
26. Mayer-Davis, EJ, Bell, RA, Dabelea, D, et al. The many faces of diabetes in American youth: type 1 and type 2 diabetes in five race and ethnic populations: the SEARCH for Diabetes in Youth Study. Diabetes Care 32:suppl 2 (2009), S99–S101.
27. Gillespie, KM, Bain, SC, Barnett, AH, et al. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet 364 (2004), 1699–1700.
28. Howson, JMM, Rosinger, S, Smyth, DJ, Boehm, BO, Todd, JA, Grp, A-ES, Genetic analysis of adult-onset autoimmune diabetes. Diabetes 60 (2011), 2645–2653.