β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults

Diabetic Medicine

Volumn 34, Issue 3, 2017, Pages 419-425

  Arif, S ^a,c   Gibson, V B ^a   Nguyen, V ^a   Bingley, P J ^b,c   Todd, J A ^c   Guy, C ^c,d   Dunger, D B ^c,d   Dayan, C M ^e   Powrie, J ^f   Lorenc, A ^f   Peakman, M ^a,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

^e CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^f GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE 65; HLA DRB1 ANTIGEN; INSULIN; INSULIN A1 21; INSULIN B1 20; INSULIN IA 752 775; INTERLEUKIN 10; PEPTIDE; PROINSULIN; UNCLASSIFIED DRUG; IL10 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ADOLESCENT; ADULT; ARTICLE; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HELPER CELL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; PHENOTYPE; PREVALENCE; AGING; AUTOIMMUNITY; BIOLOGICAL MODEL; BLOOD; CD4+ T LYMPHOCYTE; IMMUNOLOGY; INTERFERON GAMMA RELEASE ASSAY; METABOLISM; PRESCHOOL CHILD; SECRETION (PROCESS); SIBLING; YOUNG ADULT;

ADOLESCENT; ADULT; AGING; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-GAMMA RELEASE TESTS; INTERLEUKIN-10; MALE; MODELS, IMMUNOLOGICAL; SIBLINGS; YOUNG ADULT;

EID: 84973595170     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.13153     Document Type: Article

References (17)

1. Ziegler AGPM, Winkler C, Achenbach P, Akolkar B, Krischer JP, Bonifacio E. Accelerated progression from islet autoimmunity to diabetes is causing the escalated incidence of type 1 diabetes in young children. J Autoimmun 2011; 37: 3–7.
2. Hummel M, Realsen J, Messer LH, Klingensmith GJ, Chase HP. The increasing onset of type 1 diabetes in children. J Pediatr 2012; 161: 652–657.
3. Chmiel R, Giannopoulou EZ, Winkler C, Achenbach P, Ziegler AG, Bonifacio E. Progression from single to multiple islet autoantibodies oftens occurs after seroconversion:implications for early screening. Diabetologia 2014; 58: 411–413.
4. Achenbach P, Hummel M, Thümer L, Boerschmann H, Höfelmann D, Ziegler AG. Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children. Diebetologia 2013; 56: 1615–1622.
5. Roep BO, Peakman M. Antigen targets of type 1 diabetes autoimmunity. Cold Spring Harb Perspect Med 2012; 2: a007781.
6. Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 2009; 5: 219–226.
7. Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M et al. Blood and islet phenotypes indicate immunological heterogeneity in type 1diabetes. Diabetes 2014; 63: 3835–3845.
8. Long AE, Gillespie K, Rokni S, Bingley PJ, Williams AJ. Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis. Diabetes 2012; 61: 683–686.
9. Bonifacio E, Yu L, Williams AK, Eisenbarth GS, Bingley PJ, Marcovina SM et al. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. J Clin Endocrinol Metab 2010; 95: 3360–3367.
10. Greenbaum CJ, Beam CA, Boulware D, Gitelman SE, Gottlieb PA, Herold KC et al. Type 1 Diabetes TrialNet Study Group. Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data. Diabetes 2012; 61: 2066–2073.
11. Luczyński W, Stasiak-Barmuta A, Urban R, Urban M, Florys B, Hryszko M. Lower percentages of T regulatory cells in children with type 1 diabetes -preliminary report. Pediatr Endocrinol Diabetes Metab 2009; 15: 34–38.
12. Zahran AM, Elsayh KI, Metwalley KA. Regulatory T cells in children with recently diagnosed type 1 diabetes. Indian J Endocrinol Metab 2012; 16: 952–957.
13. + T-cells in type 1 diabetes. Diabetes 2005; 54: 1407–1414.
14. Howson JM, Rosinger S, Smyth DJ, Boehm BO; ADBW-END Study Group, Todd JA. Genetic analysis of adult-onset autoimmune diabetes. Diabetes 2011; 60: 2645–2653.
15. Howson JM, Cooper JD, Smyth DJ, Walker NM, Stevens H, She JX et al. Type 1 Diabetes Genetics Consortium. Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. Diabetes 2012; 61: 3012–3017.
16. Arif S, Tree T, Astill TP, Tremble JM, Bishop AJ, Dayan CM et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 2004; 113: 451–463.
17. Hawa MI, Kolb H, Schloot N, Beyan H, Paschou SA, Buzzetti R et al. Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7. Diabetes Care 2013; 36: 908–913.