메뉴 건너뛰기




Volumn 139, Issue 3, 2019, Pages 208-219

Short-chain fatty acids and gut microbiota in multiple sclerosis

Author keywords

experimental autoimmune encephalomyelitis; gut microbiota; multiple sclerosis; short chain fatty acids

Indexed keywords

SHORT CHAIN FATTY ACID; VOLATILE FATTY ACID;

EID: 85058056874     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/ane.13045     Document Type: Review
Times cited : (84)

References (75)
  • 1
    • 85020415209 scopus 로고    scopus 로고
    • The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement
    • Hedstrom AK, Katsoulis M, Hossjer O, et al. The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement. Eur J Epidemiol. 2017;32(10):909-919.
    • (2017) Eur J Epidemiol , vol.32 , Issue.10 , pp. 909-919
    • Hedstrom, A.K.1    Katsoulis, M.2    Hossjer, O.3
  • 2
    • 85029620990 scopus 로고    scopus 로고
    • Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop
    • Amato MP, Derfuss T, Hemmer B, et al. Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop. Multiple Sclerosis J. 2018;24(5):590-603.
    • (2018) Multiple Sclerosis J , vol.24 , Issue.5 , pp. 590-603
    • Amato, M.P.1    Derfuss, T.2    Hemmer, B.3
  • 3
    • 84866034486 scopus 로고    scopus 로고
    • High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women
    • Hedstrom AK, Olsson T, Alfredsson L. High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler. 2012;18(9):1334-1336.
    • (2012) Mult Scler , vol.18 , Issue.9 , pp. 1334-1336
    • Hedstrom, A.K.1    Olsson, T.2    Alfredsson, L.3
  • 4
    • 84883415327 scopus 로고    scopus 로고
    • Childhood body mass index and multiple sclerosis risk: a long-term cohort study
    • Munger KL, Bentzen J, Laursen B, et al. Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Mult Scl. 2013;19(10):1323-1329.
    • (2013) Mult Scl , vol.19 , Issue.10 , pp. 1323-1329
    • Munger, K.L.1    Bentzen, J.2    Laursen, B.3
  • 5
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S, Hellenthal G, Pirinen M, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011;476(7359):214-219.
    • (2011) Nature , vol.476 , Issue.7359 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3
  • 6
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • Beecham AH, Patsopoulos NA, Xifara DK, et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013;45(11):1353-1360.
    • (2013) Nat Genet , vol.45 , Issue.11 , pp. 1353-1360
    • Beecham, A.H.1    Patsopoulos, N.A.2    Xifara, D.K.3
  • 7
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372:1502-1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 8
    • 85016062284 scopus 로고    scopus 로고
    • Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases
    • Chen B, Sun L, Zhang X. Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases. J Autoimmun. 2017;83:31-42.
    • (2017) J Autoimmun , vol.83 , pp. 31-42
    • Chen, B.1    Sun, L.2    Zhang, X.3
  • 9
    • 84908323732 scopus 로고    scopus 로고
    • Digesting the emerging role for the gut microbiome in central nervous system demyelination
    • Joscelyn J, Kasper LH. Digesting the emerging role for the gut microbiome in central nervous system demyelination. Mult Scler. 2014;20(12):1553-1559.
    • (2014) Mult Scler , vol.20 , Issue.12 , pp. 1553-1559
    • Joscelyn, J.1    Kasper, L.H.2
  • 10
    • 85014692997 scopus 로고    scopus 로고
    • Influence of the gut microbiome on autoimmunity in the central nervous system
    • Colpitts SL, Kasper LH. Influence of the gut microbiome on autoimmunity in the central nervous system. J Immunol. 2017;198(2):596-604.
    • (2017) J Immunol , vol.198 , Issue.2 , pp. 596-604
    • Colpitts, S.L.1    Kasper, L.H.2
  • 11
    • 85016449053 scopus 로고    scopus 로고
    • The gut microbiome and microbial translocation in multiple sclerosis
    • Mirza A, Mao-Draayer Y. The gut microbiome and microbial translocation in multiple sclerosis. Clin Immunol. 2017;183:213-224.
    • (2017) Clin Immunol , vol.183 , pp. 213-224
    • Mirza, A.1    Mao-Draayer, Y.2
  • 12
    • 85024919285 scopus 로고    scopus 로고
    • Gut-CNS-axis as possibility to modulate inflammatory disease activity-implications for multiple sclerosis
    • Fleck AK, Schuppan D, Wiendl H, Klotz L. Gut-CNS-axis as possibility to modulate inflammatory disease activity-implications for multiple sclerosis. Int J Mol Sci. 2017;18(7):1526.
    • (2017) Int J Mol Sci , vol.18 , Issue.7 , pp. 1526
    • Fleck, A.K.1    Schuppan, D.2    Wiendl, H.3    Klotz, L.4
  • 13
    • 85026859563 scopus 로고    scopus 로고
    • Gut microbiome in multiple sclerosis: The players involved and the roles they play
    • Shahi SK, Freedman SN, Mangalam AK. Gut microbiome in multiple sclerosis: The players involved and the roles they play. Gut Microbes. 2017;8(6):607-615.
    • (2017) Gut Microbes , vol.8 , Issue.6 , pp. 607-615
    • Shahi, S.K.1    Freedman, S.N.2    Mangalam, A.K.3
  • 14
    • 84995579364 scopus 로고    scopus 로고
    • The emerging role of the gut microbiome in adult patients with multiple sclerosis
    • Newland PK, Heitkemper M, Zhou Y. The emerging role of the gut microbiome in adult patients with multiple sclerosis. J Neurosci Nurs. 2016;48(6):358-364.
    • (2016) J Neurosci Nurs , vol.48 , Issue.6 , pp. 358-364
    • Newland, P.K.1    Heitkemper, M.2    Zhou, Y.3
  • 15
    • 84897935033 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmune neuroinflammation
    • Kleinewietfeld M, Hafler DA. Regulatory T cells in autoimmune neuroinflammation. Immunol Rev. 2014;259(1):231-244.
    • (2014) Immunol Rev , vol.259 , Issue.1 , pp. 231-244
    • Kleinewietfeld, M.1    Hafler, D.A.2
  • 16
    • 21944448962 scopus 로고    scopus 로고
    • Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis
    • Cepok S, Rosche B, Grummel V, et al. Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis. Brain. 2005;128(Pt 7):1667-1676.
    • (2005) Brain , vol.128 , pp. 1667-1676
    • Cepok, S.1    Rosche, B.2    Grummel, V.3
  • 17
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • Hauser SL, Waubant E, Arnold DL, et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med. 2008;358(7):676-688.
    • (2008) N Engl J Med , vol.358 , Issue.7 , pp. 676-688
    • Hauser, S.L.1    Waubant, E.2    Arnold, D.L.3
  • 18
    • 81555202418 scopus 로고    scopus 로고
    • Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial
    • Kappos L, Li D, Calabresi PA, et al. Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet. 2011;378(9805):1779-1787.
    • (2011) Lancet , vol.378 , Issue.9805 , pp. 1779-1787
    • Kappos, L.1    Li, D.2    Calabresi, P.A.3
  • 19
    • 43149122203 scopus 로고    scopus 로고
    • Rituximab in a patient with multiple sclerosis–effect on B cells, plasma cells and intrathecal IgG synthesis
    • Petereit HF, Moeller-Hartmann W, Reske D, Rubbert A. Rituximab in a patient with multiple sclerosis–effect on B cells, plasma cells and intrathecal IgG synthesis. Acta Neurol Scand. 2008;117(6):399-403.
    • (2008) Acta Neurol Scand , vol.117 , Issue.6 , pp. 399-403
    • Petereit, H.F.1    Moeller-Hartmann, W.2    Reske, D.3    Rubbert, A.4
  • 20
    • 33751085414 scopus 로고    scopus 로고
    • Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    • Cross AH, Stark JL, Lauber J, Ramsbottom MJ, Lyons JA. Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol. 2006;180(1–2):63-70.
    • (2006) J Neuroimmunol , vol.180 , Issue.1-2 , pp. 63-70
    • Cross, A.H.1    Stark, J.L.2    Lauber, J.3    Ramsbottom, M.J.4    Lyons, J.A.5
  • 21
    • 0025240576 scopus 로고
    • Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes
    • Lanzavecchia A. Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu Rev Immunol. 1990;8:773-793.
    • (1990) Annu Rev Immunol , vol.8 , pp. 773-793
    • Lanzavecchia, A.1
  • 22
    • 0022455430 scopus 로고
    • Chronic relapsing experimental allergic encephalomyelitis. Inhibition of lymphocyte mitogenesis by disease-related serum factors
    • Symons JA, Suckling AJ, Bundick RV, Rumsby MG. Chronic relapsing experimental allergic encephalomyelitis. Inhibition of lymphocyte mitogenesis by disease-related serum factors. J Neuroimmunol. 1986;12(2):163-169.
    • (1986) J Neuroimmunol , vol.12 , Issue.2 , pp. 163-169
    • Symons, J.A.1    Suckling, A.J.2    Bundick, R.V.3    Rumsby, M.G.4
  • 23
    • 80053300497 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
    • Constantinescu CS, Farooqi N, O'Brien K, Gran B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol. 2011;164(4):1079-1106.
    • (2011) Br J Pharmacol , vol.164 , Issue.4 , pp. 1079-1106
    • Constantinescu, C.S.1    Farooqi, N.2    O'Brien, K.3    Gran, B.4
  • 24
    • 79952748674 scopus 로고    scopus 로고
    • Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
    • Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA. 2011;108(Suppl 1):4615-4622.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4615-4622
    • Lee, Y.K.1    Menezes, J.S.2    Umesaki, Y.3    Mazmanian, S.K.4
  • 25
    • 85005965070 scopus 로고    scopus 로고
    • The human intestinal microbiome in health and disease
    • Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med. 2016;375(24):2369-2379.
    • (2016) N Engl J Med , vol.375 , Issue.24 , pp. 2369-2379
    • Lynch, S.V.1    Pedersen, O.2
  • 26
    • 85074159611 scopus 로고    scopus 로고
    • Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases
    • Richards JL, Yap YA, McLeod KH, Mackay CR, Marino E. Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases. Clin Transl Immunol. 2016;5(5):e82.
    • (2016) Clin Transl Immunol , vol.5 , Issue.5
    • Richards, J.L.1    Yap, Y.A.2    McLeod, K.H.3    Mackay, C.R.4    Marino, E.5
  • 27
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011;479(7374):538-541.
    • (2011) Nature , vol.479 , Issue.7374 , pp. 538-541
    • Berer, K.1    Mues, M.2    Koutrolos, M.3
  • 28
    • 85030262731 scopus 로고    scopus 로고
    • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice
    • Berer K, Gerdes LA, Cekanaviciute E, et al. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci. 2017;114(40):10719–10724.
    • (2017) Proc Natl Acad Sci , vol.114 , Issue.40 , pp. 10719-10724
    • Berer, K.1    Gerdes, L.A.2    Cekanaviciute, E.3
  • 29
    • 85040823707 scopus 로고    scopus 로고
    • Gut reactions: How the blood-brain barrier connects the microbiome and the brain
    • Logsdon AF, Erickson MA, Rhea EM, Salameh TS, Banks WA. Gut reactions: How the blood-brain barrier connects the microbiome and the brain. Exp Biol Med. 2018;243(2):159-165.
    • (2018) Exp Biol Med , vol.243 , Issue.2 , pp. 159-165
    • Logsdon, A.F.1    Erickson, M.A.2    Rhea, E.M.3    Salameh, T.S.4    Banks, W.A.5
  • 30
    • 84961200851 scopus 로고    scopus 로고
    • Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
    • Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes. 2016;7(3):189-200.
    • (2016) Gut Microbes , vol.7 , Issue.3 , pp. 189-200
    • Morrison, D.J.1    Preston, T.2
  • 31
    • 0029882856 scopus 로고    scopus 로고
    • Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora
    • Miller TL, Wolin MJ. Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora. Appl Environ Microbiol. 1996;62(5):1589-1592.
    • (1996) Appl Environ Microbiol , vol.62 , Issue.5 , pp. 1589-1592
    • Miller, T.L.1    Wolin, M.J.2
  • 32
    • 84883139076 scopus 로고    scopus 로고
    • The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
    • den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud D-J, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54(9):2325-2340.
    • (2013) J Lipid Res , vol.54 , Issue.9 , pp. 2325-2340
    • den Besten, G.1    van Eunen, K.2    Groen, A.K.3    Venema, K.4    Reijngoud, D.-J.5    Bakker, B.M.6
  • 33
    • 85046078410 scopus 로고    scopus 로고
    • Breaking down the gut microbiome composition in multiple sclerosis
    • Budhram A, Parvathy S, Kremenchutzky M, Silverman M. Breaking down the gut microbiome composition in multiple sclerosis. Mult Scler. 2017;23(5):628-636.
    • (2017) Mult Scler , vol.23 , Issue.5 , pp. 628-636
    • Budhram, A.1    Parvathy, S.2    Kremenchutzky, M.3    Silverman, M.4
  • 34
    • 84941695464 scopus 로고    scopus 로고
    • Role of intestinal microbiota in the development of multiple sclerosis
    • Castillo-Alvarez F, Marzo-Sola ME. Role of intestinal microbiota in the development of multiple sclerosis. Neurologia. 2017;32(3):175-184.
    • (2017) Neurologia , vol.32 , Issue.3 , pp. 175-184
    • Castillo-Alvarez, F.1    Marzo-Sola, M.E.2
  • 35
    • 84947447931 scopus 로고    scopus 로고
    • Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters
    • Miyake S, Kim S, Suda W, et al. Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters. PLoS ONE. 2015;10(9):e0137429.
    • (2015) PLoS ONE , vol.10 , Issue.9
    • Miyake, S.1    Kim, S.2    Suda, W.3
  • 36
    • 84976612100 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in multiple sclerosis
    • Jangi S, Gandhi R, Cox LM, et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016;7:12015.
    • (2016) Nat Commun , vol.7 , pp. 12015
    • Jangi, S.1    Gandhi, R.2    Cox, L.M.3
  • 38
    • 84921454304 scopus 로고    scopus 로고
    • Links between diet, gut microbiota composition and gut metabolism
    • Flint HJ, Duncan SH, Scott KP, Louis P. Links between diet, gut microbiota composition and gut metabolism. Proc Nutr Soc. 2015;74(1):13-22.
    • (2015) Proc Nutr Soc , vol.74 , Issue.1 , pp. 13-22
    • Flint, H.J.1    Duncan, S.H.2    Scott, K.P.3    Louis, P.4
  • 39
    • 85032972157 scopus 로고    scopus 로고
    • Fatty is not that bad: feeding short-chain fatty acids to restrain autoimmunity
    • Brevi A, Bellone M. Fatty is not that bad: feeding short-chain fatty acids to restrain autoimmunity. Cell Mol Immunol. 2017.
    • (2017) Cell Mol Immunol
    • Brevi, A.1    Bellone, M.2
  • 40
    • 0015788448 scopus 로고
    • Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
    • Oldendorf WH. Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids. Am J Physiol. 1973;224(6):1450-1453.
    • (1973) Am J Physiol , vol.224 , Issue.6 , pp. 1450-1453
    • Oldendorf, W.H.1
  • 41
    • 84911884131 scopus 로고    scopus 로고
    • The gut microbiota influences blood-brain barrier permeability in mice
    • Braniste V, Al-Asmakh M, Kowal C, et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014;6(263):263ra158.
    • (2014) Sci Transl Med , vol.6 , Issue.263 , pp. 263ra158
    • Braniste, V.1    Al-Asmakh, M.2    Kowal, C.3
  • 42
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013;504(7480):446-450.
    • (2013) Nature , vol.504 , Issue.7480 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3
  • 43
    • 85016122461 scopus 로고    scopus 로고
    • Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
    • Marino E, Richards JL, McLeod KH, et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol. 2017;18(5):552-562.
    • (2017) Nat Immunol , vol.18 , Issue.5 , pp. 552-562
    • Marino, E.1    Richards, J.L.2    McLeod, K.H.3
  • 44
    • 69149107165 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • w64
    • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264-269, w64.
    • (2009) Ann Intern Med , vol.151 , Issue.4 , pp. 264-226
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 45
    • 84944682179 scopus 로고    scopus 로고
    • Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine
    • Haghikia A, Jorg S, Duscha A, et al. Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine. Immunity. 2015;43(4):817-829.
    • (2015) Immunity , vol.43 , Issue.4 , pp. 817-829
    • Haghikia, A.1    Jorg, S.2    Duscha, A.3
  • 46
    • 85014049062 scopus 로고    scopus 로고
    • The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models
    • Mizuno M, Noto D, Kaga N, Chiba A, Miyake S. The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models. PLoS ONE. 2017;12(2):e0173032.
    • (2017) PLoS ONE , vol.12 , Issue.2
    • Mizuno, M.1    Noto, D.2    Kaga, N.3    Chiba, A.4    Miyake, S.5
  • 47
    • 85020190108 scopus 로고    scopus 로고
    • CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice
    • Chitrala KN, Guan H, Singh NP, et al. CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice. Eur J Immunol. 2017;47(7):1188-1199.
    • (2017) Eur J Immunol , vol.47 , Issue.7 , pp. 1188-1199
    • Chitrala, K.N.1    Guan, H.2    Singh, N.P.3
  • 48
    • 79959536193 scopus 로고    scopus 로고
    • CD44 reciprocally regulates the differentiation of encephalitogenic Th1/Th17 and Th2/regulatory T cells through epigenetic modulation involving DNA methylation of cytokine gene promoters, thereby controlling the development of experimental autoimmune encephalomyelitis
    • Guan H, Nagarkatti PS, Nagarkatti M. CD44 reciprocally regulates the differentiation of encephalitogenic Th1/Th17 and Th2/regulatory T cells through epigenetic modulation involving DNA methylation of cytokine gene promoters, thereby controlling the development of experimental autoimmune encephalomyelitis. J Immunol. 2011;186(12):6955-6964.
    • (2011) J Immunol , vol.186 , Issue.12 , pp. 6955-6964
    • Guan, H.1    Nagarkatti, P.S.2    Nagarkatti, M.3
  • 49
    • 68949094114 scopus 로고    scopus 로고
    • Role of CD44 in the Differentiation of Th1 and Th2 cells: CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin
    • Guan H, Nagarkatti PS, Nagarkatti M. Role of CD44 in the Differentiation of Th1 and Th2 cells: CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin. J Immunol. 2009;183(1):172-180.
    • (2009) J Immunol , vol.183 , Issue.1 , pp. 172-180
    • Guan, H.1    Nagarkatti, P.S.2    Nagarkatti, M.3
  • 50
    • 85030229360 scopus 로고    scopus 로고
    • Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models
    • Cekanaviciute E, Yoo BB, Runia TF, et al. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc Natl Acad Sci. 2017;114(40):10713-10718.
    • (2017) Proc Natl Acad Sci , vol.114 , Issue.40 , pp. 10713-10718
    • Cekanaviciute, E.1    Yoo, B.B.2    Runia, T.F.3
  • 51
    • 84976612100 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in multiple sclerosis
    • Jangi S, Gandhi R, Cox LM, et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016;7:12015.
    • (2016) Nat Commun , vol.7 , pp. 12015
    • Jangi, S.1    Gandhi, R.2    Cox, L.M.3
  • 52
    • 84930361344 scopus 로고    scopus 로고
    • Gut microbiota in multiple sclerosis: possible influence of immunomodulators
    • Cantarel BL, Waubant E, Chehoud C, et al. Gut microbiota in multiple sclerosis: possible influence of immunomodulators. J Investig Med. 2015;63(5):729-734.
    • (2015) J Investig Med , vol.63 , Issue.5 , pp. 729-734
    • Cantarel, B.L.1    Waubant, E.2    Chehoud, C.3
  • 53
    • 84881477044 scopus 로고    scopus 로고
    • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
    • Atarashi K, Tanoue T, Oshima K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013;500(7461):232-236.
    • (2013) Nature , vol.500 , Issue.7461 , pp. 232-236
    • Atarashi, K.1    Tanoue, T.2    Oshima, K.3
  • 54
    • 84976536578 scopus 로고    scopus 로고
    • Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
    • Chen J, Chia N, Kalari KR, et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. 2016;6:28484.
    • (2016) Sci Rep , vol.6 , pp. 28484
    • Chen, J.1    Chia, N.2    Kalari, K.R.3
  • 55
    • 84959084455 scopus 로고    scopus 로고
    • Gut microbiota composition and relapse risk in pediatric MS: A pilot study
    • Tremlett H, Fadrosh DW, Faruqi AA, et al. Gut microbiota composition and relapse risk in pediatric MS: A pilot study. J Neurol Sci. 2016;363:153-157.
    • (2016) J Neurol Sci , vol.363 , pp. 153-157
    • Tremlett, H.1    Fadrosh, D.W.2    Faruqi, A.A.3
  • 56
    • 84988462424 scopus 로고    scopus 로고
    • Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls
    • Tremlett H, Fadrosh DW, Faruqi AA, et al. Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls. BMC Neurol. 2016;16(1):182.
    • (2016) BMC Neurol , vol.16 , Issue.1 , pp. 182
    • Tremlett, H.1    Fadrosh, D.W.2    Faruqi, A.A.3
  • 57
    • 85027917252 scopus 로고    scopus 로고
    • Gut microbiota in early pediatric multiple sclerosis: a case-control study
    • Tremlett H, Fadrosh DW, Faruqi AA, et al. Gut microbiota in early pediatric multiple sclerosis: a case-control study. Eur J Neurol. 2016;23(8):1308-1321.
    • (2016) Eur J Neurol , vol.23 , Issue.8 , pp. 1308-1321
    • Tremlett, H.1    Fadrosh, D.W.2    Faruqi, A.A.3
  • 58
    • 85040361759 scopus 로고    scopus 로고
    • High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis
    • Cosorich I, Dalla-Costa G, Sorini C, et al. High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis. Sci Adv. 2017;3(7):e1700492.
    • (2017) Sci Adv , vol.3 , Issue.7
    • Cosorich, I.1    Dalla-Costa, G.2    Sorini, C.3
  • 59
    • 84999634064 scopus 로고    scopus 로고
    • Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis
    • Branton WG, Lu JQ, Surette MG, et al. Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis. Sci Rep. 2016;6:37344.
    • (2016) Sci Rep , vol.6 , pp. 37344
    • Branton, W.G.1    Lu, J.Q.2    Surette, M.G.3
  • 60
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • Macia L, Tan J, Vieira AT, et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun. 2015;6:6734.
    • (2015) Nat Commun , vol.6 , pp. 6734
    • Macia, L.1    Tan, J.2    Vieira, A.T.3
  • 61
    • 85029597674 scopus 로고    scopus 로고
    • Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine
    • Nakamura YK, Janowitz C, Metea C, et al. Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine. Sci Rep. 2017;7(1):11745.
    • (2017) Sci Rep , vol.7 , Issue.1 , pp. 11745
    • Nakamura, Y.K.1    Janowitz, C.2    Metea, C.3
  • 62
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard A, Belzer C, Geurts L, et al Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci. 2013;110(22):9066-9071.
    • (2013) Proc Natl Acad Sci , vol.110 , Issue.22 , pp. 9066-9071
    • Everard, A.1    Belzer, C.2    Geurts, L.3
  • 63
    • 84901686870 scopus 로고    scopus 로고
    • An atlas of genetic influences on human blood metabolites
    • Shin SY, Fauman EB, Petersen AK, et al. An atlas of genetic influences on human blood metabolites. Nat Genet. 2014;46(6):543-550.
    • (2014) Nat Genet , vol.46 , Issue.6 , pp. 543-550
    • Shin, S.Y.1    Fauman, E.B.2    Petersen, A.K.3
  • 64
    • 85035805907 scopus 로고    scopus 로고
    • Multiple sclerosis: A possible link between multiple sclerosis and gut microbiota
    • Hindson J. Multiple sclerosis: A possible link between multiple sclerosis and gut microbiota. Nat Rev Neurol. 2017;13(12):705-705.
    • (2017) Nat Rev Neurol , vol.13 , Issue.12 , pp. 705
    • Hindson, J.1
  • 65
    • 33845302957 scopus 로고    scopus 로고
    • Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
    • Astier AL, Meiffren G, Freeman S, Hafler DA. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest. 2006;116(12):3252-3257.
    • (2006) J Clin Invest , vol.116 , Issue.12 , pp. 3252-3257
    • Astier, A.L.1    Meiffren, G.2    Freeman, S.3    Hafler, D.A.4
  • 66
    • 84929630106 scopus 로고    scopus 로고
    • Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis
    • Cao Y, Goods BA, Raddassi K, et al. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Sci Transl Med. 2015;7(287):287ra74.
    • (2015) Sci Transl Med , vol.7 , Issue.287 , pp. 287ra74
    • Cao, Y.1    Goods, B.A.2    Raddassi, K.3
  • 67
    • 42249086506 scopus 로고    scopus 로고
    • IL-10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis
    • Martinez-Forero I, Garcia-Munoz R, Martinez-Pasamar S, et al. IL-10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis. Eur J Immunol. 2008;38(2):576-586.
    • (2008) Eur J Immunol , vol.38 , Issue.2 , pp. 576-586
    • Martinez-Forero, I.1    Garcia-Munoz, R.2    Martinez-Pasamar, S.3
  • 69
    • 84876414806 scopus 로고    scopus 로고
    • The gut microbiota–masters of host development and physiology
    • Sommer F, Backhed F. The gut microbiota–masters of host development and physiology. Nat Rev Microbiol. 2013;11(4):227-238.
    • (2013) Nat Rev Microbiol , vol.11 , Issue.4 , pp. 227-238
    • Sommer, F.1    Backhed, F.2
  • 70
    • 84920404296 scopus 로고    scopus 로고
    • How informative is the mouse for human gut microbiota research?
    • Nguyen T, Vieira-Silva S, Liston A, Raes J. How informative is the mouse for human gut microbiota research? Dis Model Mech. 2015;8(1):1-16.
    • (2015) Dis Model Mech , vol.8 , Issue.1 , pp. 1-16
    • Nguyen, T.1    Vieira-Silva, S.2    Liston, A.3    Raes, J.4
  • 71
    • 85007508333 scopus 로고    scopus 로고
    • Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches
    • e4
    • Sartor RB, Wu GD. Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches. Gastroenterology. 2017;152(2):327-339. e4.
    • (2017) Gastroenterology , vol.152 , Issue.2 , pp. 327-339
    • Sartor, R.B.1    Wu, G.D.2
  • 72
    • 78650873385 scopus 로고    scopus 로고
    • Changes of intestinal microflora in patients with rheumatoid arthritis during fasting or a mediterranean diet
    • Abendroth A, Michalsen A, Ludtke R, et al. Changes of intestinal microflora in patients with rheumatoid arthritis during fasting or a mediterranean diet. Forsch Komplementarmed. 2010;17(6):307-313.
    • (2010) Forsch Komplementarmed , vol.17 , Issue.6 , pp. 307-313
    • Abendroth, A.1    Michalsen, A.2    Ludtke, R.3
  • 73
    • 33644822609 scopus 로고    scopus 로고
    • Gut microflora associated characteristics in children with celiac disease
    • Tjellstrom B, Stenhammar L, Hogberg L, et al. Gut microflora associated characteristics in children with celiac disease. Am J Gastroenterol. 2005;100(12):2784-2788.
    • (2005) Am J Gastroenterol , vol.100 , Issue.12 , pp. 2784-2788
    • Tjellstrom, B.1    Stenhammar, L.2    Hogberg, L.3
  • 74
    • 80054722148 scopus 로고    scopus 로고
    • Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes
    • Brown CT, Davis-Richardson AG, Giongo A, et al. Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS ONE. 2011;6(10):e25792.
    • (2011) PLoS ONE , vol.6 , Issue.10
    • Brown, C.T.1    Davis-Richardson, A.G.2    Giongo, A.3
  • 75
    • 84923061194 scopus 로고    scopus 로고
    • Behcet's syndrome patients exhibit specific microbiome signature
    • Consolandi C, Turroni S, Emmi G, et al. Behcet's syndrome patients exhibit specific microbiome signature. Autoimmun Rev. 2015;14(4):269-276.
    • (2015) Autoimmun Rev , vol.14 , Issue.4 , pp. 269-276
    • Consolandi, C.1    Turroni, S.2    Emmi, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.