Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 40, 2017, Pages 10719-10724

  Berer, Kerstin ^a   Gerdes, Lisa Ann ^b   Cekanaviciute, Egle ^c   Jia, Xiaoming ^c   Xiao, Liang ^d   Xia, Zhongkui ^d   Liu, Chuan ^d   Klotz, Luisa ^e   Stauffer, Uta ^f   Baranzini, Sergio E ^c,g   Kümpfel, Tania ^b   Hohlfeld, Reinhard ^b,h   Krishnamoorthy, Gurumoorthy ^a,i   Wekerle, Hartmut ^a,h  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BGI SHENZHEN   (China)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^f MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF MUNICH   (Germany)

ⁱ MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Experimental autoimmune encephalomyelitis; Germ free mice; Gut microbiome; Multiple sclerosis; Twin study

Indexed keywords

AZATHIOPRINE; DNA; GAMMA INTERFERON; GLATIRAMER; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 5; MONOCLONAL ANTIBODY; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NATALIZUMAB; RNA 16S; T LYMPHOCYTE RECEPTOR;

ADULT; AKKERMANSIA; ALLERGIC ENCEPHALOMYELITIS; AMPLICON; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; BACTERIUM; CD4+ T LYMPHOCYTE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOKINE RELEASE; FECES MICROFLORA; FEMALE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IN VITRO STUDY; INTESTINE FLORA; MALE; METAGENOMICS; MICROBIAL COMMUNITY; MONOZYGOTIC TWINS; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RUMINOCOCCUS; SPLENIC T CELL; SUTTERELLA; TANNERELLA; TWIN STUDY; VIBRISSA; AGED; ANIMAL; BRAIN; DISEASE MODEL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; IMMUNOLOGY; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; REGULATORY T LYMPHOCYTE; TWINS; YOUNG ADULT;

ADULT; AGED; ANIMALS; BRAIN; COHORT STUDIES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; MALE; METAGENOMICS; MICE; MIDDLE AGED; MULTIPLE SCLEROSIS; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 85030262731     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1711233114     Document Type: Article

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