-
1
-
-
34548133584
-
Multiple sclerosis: A complicated picture of autoimmunity
-
H. F. McFarland, R. Martin, Multiple sclerosis: A complicated picture of autoimmunity. Nat. Immunol. 8, 913-919 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 913-919
-
-
McFarland, H.F.1
Martin, R.2
-
2
-
-
67349216357
-
Autoimmune T cell responses in the central nervous system
-
J. Goverman, Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol. 9, 393-407 (2009).
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 393-407
-
-
Goverman, J.1
-
4
-
-
34548299105
-
Risk alleles for multiple sclerosis identified by a genomewide study
-
D. A. Hafler, A. Compston, S. Sawcer, E. S. Lander, M. J. Daly, P. L. De Jager, P. I. De Bakker, S. B. Gabriel, D. B. Mirel, A. J. Ivinson, M. A. Pericak-Vance, S. G. Gregory, J. D. Rioux, J. L. McCauley, J. L. Haines, L. F. Barcellos, B. Cree, J. R. Oksenberg, S. L. Hauser; International Multiple Sclerosis Genetics Consortium, Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 357, 851-862 (2007).
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 851-862
-
-
International Multiple Sclerosis Genetics Consortium1
Hafler, D.A.2
Compston, A.3
Sawcer, S.4
Lander, E.S.5
Daly, M.J.6
De Jager, P.L.7
De Bakker, P.I.8
Gabriel, S.B.9
Mirel, D.B.10
Ivinson, A.J.11
Pericak-Vance, M.A.12
Gregory, S.G.13
Rioux, J.D.14
McCauley, J.L.15
Haines, J.L.16
Barcellos, L.F.17
Cree, B.18
Oksenberg, J.R.19
Hauser, S.L.20
more..
-
5
-
-
80051684615
-
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
-
S. Sawcer, G. Hellenthal, M. Pirinen, C. C. Spencer, N. A. Patsopoulos, L. Moutsianas, A. Dilthey, Z. Su, C. Freeman, S. E. Hunt, S. Edkins, E. Gray, D. R. Booth, S. C. Potter, A. Goris, G. Band, A. B. Oturai, A. Strange, J. Saarela, C. Bellenguez, B. Fontaine, M. Gillman, B. Hemmer, R. Gwilliam, F. Zipp, A. Jayakumar, R. Martin, S. Leslie, S. Hawkins, E. Giannoulatou, S. D'alfonso, H. Blackburn, F. Martinelli Boneschi, J. Liddle, H. F. Harbo, M. L. Perez, A. Spurkland, M. J. Waller, M. P. Mycko, M. Ricketts, M. Comabella, N. Hammond, I. Kockum, O. T. McCann, M. Ban, P. Whittaker, A. Kemppinen, P. Weston, C. Hawkins, S. Widaa, J. Zajicek, S. Dronov, N. Robertson, S. J. Bumpstead, L. F. Barcellos, R. Ravindrarajah, R. Abraham, L. Alfredsson, K. Ardlie, C. Aubin, A. Baker, K. Baker, S. E. Baranzini, L. Bergamaschi, R. Bergamaschi, A. Bernstein, A. Berthele, M. Boggild, J. P. Bradfield, D. Brassat, S. A. Broadley, D. Buck, H. Butzkueven, R. Capra, W. M. Carroll, P. Cavalla, E. G. Celius, S. Cepok, R. Chiavacci, F. Clerget-Darpoux, K. Clysters, G. Comi, M. Cossburn, I. Cournu-Rebeix, M. B. Cox, W. Cozen, B. A. Cree, A. H. Cross, D. Cusi, M. J. Daly, E. Davis, P. I. De Bakker, M. Debouverie, M. B. D'hooghe, K. Dixon, R. Dobosi, B. Dubois, D. Ellinghaus, I. Elovaara, F. Esposito, C. Fontenille, S. Foote, A. Franke, D. Galimberti, A. Ghezzi, J. Glessner, R. Gomez, O. Gout, C. Graham, S. F. Grant, F. R. Guerini, H. Hakonarson, P. Hall, A. Hamsten, H. P. Hartung, R. N. Heard, S. Heath, J. Hobart, M. Hoshi, C. Infante-Duarte, G. Ingram, W. Ingram, T. Islam, M. Jagodic, M. Kabesch, A. G. Kermode, T. J. Kilpatrick, C. Kim, N. Klopp, K. Koivisto, M. Larsson, M. Lathrop, J. S. Lechner-Scott, M. A. Leone, V. Leppä, U. Liljedahl, I. L. Bomfim, R. R. Lincoln, J. Link, J. Liu, A. R. Lorentzen, S. Lupoli, F. Macciardi, T. Mack, M. Marriott, V. Martinelli, D. Mason, J. L. McCauley, F. Mentch, I. L. Mero, T. Mihalova, X. Montalban, J. Mottershead, K. M. Myhr, P. Naldi, W. Ollier, A. Page, A. Palotie, J. Pelletier, L. Piccio, T. Pickersgill, F. Piehl, S. Pobywajlo, H. L. Quach, P. P. Ramsay, M. Reunanen, R. Reynolds, J. D. Rioux, M. Rodegher, S. Roesner, J. P. Rubio, I. M. Rückert, M. Salvetti, E. Salvi, A. Santaniello, C. A. Schaefer, S. Schreiber, C. Schulze, R. J. Scott, F. Sellebjerg, K. W. Selmaj, D. Sexton, L. Shen, B. Simms-Acuna, S. Skidmore, P. M. Sleiman, C. Smestad, P. S. Sørensen, H. B. Søndergaard, J. Stankovich, R. C. Strange, A. M. Sulonen, E. Sundqvist, A. C. Syvänen, F. Taddeo, B. Taylor, J. M. Blackwell, P. Tienari, E. Bramon, A. Tourbah, M. A. Brown, E. Tronczynska, J. P. Casas, N. Tubridy, A. Corvin, J. Vickery, J. Jankowski, P. Villoslada, H. S. Markus, K. Wang, C. G. Mathew, J. Wason, C. N. Palmer, H. E. Wichmann, R. Plomin, E. Willoughby, A. Rautanen, J. Winkelmann, M. Wittig, R. C. Trembath, J. Yaouanq, A. C. Viswanathan, H. Zhang, N. W. Wood, R. Zuvich, P. Deloukas, C. Langford, A. Duncanson, J. R. Oksenberg, M. A. Pericak-Vance, J. L. Haines, T. Olsson, J. Hillert, A. J. Ivinson, P. L. De Jager, L. Peltonen, G. J. Stewart, D. A. Hafler, S. L. Hauser, G. McVean, P. Donnelly, A. Compston; International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium, Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214-219 (2011).
-
(2011)
Nature
, vol.476
, pp. 214-219
-
-
International Multiple Sclerosis Genetics Consortium1
Wellcome Trust Case Control Consortium2
Sawcer, S.3
Hellenthal, G.4
Pirinen, M.5
Spencer, C.C.6
Patsopoulos, N.A.7
Moutsianas, L.8
Dilthey, A.9
Su, Z.10
Freeman, C.11
Hunt, S.E.12
Edkins, S.13
Gray, E.14
Booth, D.R.15
Potter, S.C.16
Goris, A.17
Band, G.18
Oturai, A.B.19
Strange, A.20
Saarela, J.21
Bellenguez, C.22
Fontaine, B.23
Gillman, M.24
Hemmer, B.25
Gwilliam, R.26
Zipp, F.27
Jayakumar, A.28
Martin, R.29
Leslie, S.30
Hawkins, S.31
Giannoulatou, E.32
D'alfonso, S.33
Blackburn, H.34
Martinelli Boneschi, F.35
Liddle, J.36
Harbo, H.F.37
Perez, M.L.38
Spurkland, A.39
Waller, M.J.40
Mycko, M.P.41
Ricketts, M.42
Comabella, M.43
Hammond, N.44
Kockum, I.45
McCann, O.T.46
Ban, M.47
Whittaker, P.48
Kemppinen, A.49
Weston, P.50
Hawkins, C.51
Widaa, S.52
Zajicek, J.53
Dronov, S.54
Robertson, N.55
Bumpstead, S.J.56
Barcellos, L.F.57
Ravindrarajah, R.58
Abraham, R.59
Alfredsson, L.60
Ardlie, K.61
Aubin, C.62
Baker, A.63
Baker, K.64
Baranzini, S.E.65
Bergamaschi, L.66
Bergamaschi, R.67
Bernstein, A.68
Berthele, A.69
Boggild, M.70
Bradfield, J.P.71
Brassat, D.72
Broadley, S.A.73
Buck, D.74
Butzkueven, H.75
Capra, R.76
Carroll, W.M.77
Cavalla, P.78
Celius, E.G.79
Cepok, S.80
Chiavacci, R.81
Clerget-Darpoux, F.82
Clysters, K.83
Comi, G.84
more..
-
6
-
-
84882449068
-
Genetic insights into common pathways and complex relationships among immune-mediated diseases
-
M. Parkes, A. Cortes, D. A. Van Heel, M. A. Brown, Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat. Rev. Genet. 14, 661-673 (2013).
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 661-673
-
-
Parkes, M.1
Cortes, A.2
Van Heel, D.A.3
Brown, M.A.4
-
7
-
-
84923326765
-
Genetic and epigenetic fine mapping of causal autoimmune disease variants
-
K. K. Farh, A. Marson, J. Zhu, M. Kleinewietfeld, W. J. Housley, S. Beik, N. Shoresh, H. Whitton, R. J. Ryan, A. A. Shishkin, M. Hatan, M. J. Carrasco-Alfonso, D. Mayer, C. J. Luckey, N. A. Patsopoulos, P. L. De Jager, V. K. Kuchroo, C. B. Epstein, M. J. Daly, D. A. Hafler, B. E. Bernstein, Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518, 337-343 (2015).
-
(2015)
Nature
, vol.518
, pp. 337-343
-
-
Farh, K.K.1
Marson, A.2
Zhu, J.3
Kleinewietfeld, M.4
Housley, W.J.5
Beik, S.6
Shoresh, N.7
Whitton, H.8
Ryan, R.J.9
Shishkin, A.A.10
Hatan, M.11
Carrasco-Alfonso, M.J.12
Mayer, D.13
Luckey, C.J.14
Patsopoulos, N.A.15
De Jager, P.L.16
Kuchroo, V.K.17
Epstein, C.B.18
Daly, M.J.19
Hafler, D.A.20
Bernstein, B.E.21
more..
-
8
-
-
34547907306
-
Observations on attempts to produce acute disseminated encephalomyelitis in monkeys
-
T. M. Rivers, D. H. Sprunt, G. P. Berry, Observations on attempts to produce acute disseminated encephalomyelitis in monkeys. J. Exp. Med. 58, 39-53 (1933).
-
(1933)
J. Exp. Med.
, vol.58
, pp. 39-53
-
-
Rivers, T.M.1
Sprunt, D.H.2
Berry, G.P.3
-
9
-
-
0025370870
-
T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis
-
K. Ota, M. Matsui, E. L. Milford, G. A. Mackin, H. L. Weiner, D. A. Hafler, T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis. Nature 346, 183-187 (1990).
-
(1990)
Nature
, vol.346
, pp. 183-187
-
-
Ota, K.1
Matsui, M.2
Milford, E.L.3
Mackin, G.A.4
Weiner, H.L.5
Hafler, D.A.6
-
10
-
-
0025966510
-
A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis
-
R. Martin, M. D. Howell, D. Jaraquemada, M. Flerlage, J. Richert, S. Brostoff, E. O. Long, H. F. McFarland, A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J. Exp. Med. 173, 19-24 (1991).
-
(1991)
J. Exp. Med.
, vol.173
, pp. 19-24
-
-
Martin, R.1
Howell, M.D.2
Jaraquemada, D.3
Flerlage, M.4
Richert, J.5
Brostoff, S.6
Long, E.O.7
McFarland, H.F.8
-
11
-
-
79960536431
-
Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis
-
K. Raddassi, S. C. Kent, J. Yang, K. Bourcier, E. M. Bradshaw, V. Seyfert-Margolis, G. T. Nepom, W. W. Kwok, D. A. Hafler, Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J. Immunol. 187, 1039-1046 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 1039-1046
-
-
Raddassi, K.1
Kent, S.C.2
Yang, J.3
Bourcier, K.4
Bradshaw, E.M.5
Seyfert-Margolis, V.6
Nepom, G.T.7
Kwok, W.W.8
Hafler, D.A.9
-
12
-
-
3142724732
-
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
-
E. Bettelli, B. Sullivan, S. J. Szabo, R. A. Sobel, L. H. Glimcher, V. K. Kuchroo, Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 200, 79-87 (2004).
-
(2004)
J. Exp. Med.
, vol.200
, pp. 79-87
-
-
Bettelli, E.1
Sullivan, B.2
Szabo, S.J.3
Sobel, R.A.4
Glimcher, L.H.5
Kuchroo, V.K.6
-
13
-
-
77958584113
-
Generation of pathogenic TH17 cells in the absence of TGF-b signalling
-
K. Ghoreschi, A. Laurence, X. P. Yang, C. M. Tato, M. J. McGeachy, J. E. Konkel, H. L. Ramos, L. Wei, T. S. Davidson, N. Bouladoux, J. R. Grainger, Q. Chen, Y. Kanno, W. T. Watford, H. W. Sun, G. Eberl, E. M. Shevach, Y. Belkaid, D. J. Cua, W. Chen, J. J. O'Shea, Generation of pathogenic TH17 cells in the absence of TGF-b signalling. Nature 467, 967-971 (2010).
-
(2010)
Nature
, vol.467
, pp. 967-971
-
-
Ghoreschi, K.1
Laurence, A.2
Yang, X.P.3
Tato, C.M.4
McGeachy, M.J.5
Konkel, J.E.6
Ramos, H.L.7
Wei, L.8
Davidson, T.S.9
Bouladoux, N.10
Grainger, J.R.11
Chen, Q.12
Kanno, Y.13
Watford, W.T.14
Sun, H.W.15
Eberl, G.16
Shevach, E.M.17
Belkaid, Y.18
Cua, D.J.19
Chen, W.20
O'Shea, J.J.21
more..
-
14
-
-
79956152607
-
The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
-
M. El-Behi, B. Ciric, H. Dai, Y. Yan, M. Cullimore, F. Safavi, G. X. Zhang, B. N. Dittel, A. Rostami, The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol. 12, 568-575 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 568-575
-
-
El-Behi, M.1
Ciric, B.2
Dai, H.3
Yan, Y.4
Cullimore, M.5
Safavi, F.6
Zhang, G.X.7
Dittel, B.N.8
Rostami, A.9
-
15
-
-
79956116032
-
RORgt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
-
L. Codarri, G. Gyülveszi, V. Tosevski, L. Hesske, A. Fontana, L. Magnenat, T. Suter, B. Becher, RORgt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 12, 560-567 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 560-567
-
-
Codarri, L.1
Gyülveszi, G.2
Tosevski, V.3
Hesske, L.4
Fontana, A.5
Magnenat, L.6
Suter, T.7
Becher, B.8
-
16
-
-
84866532132
-
Induction and molecular signature of pathogenic TH17 cells
-
Y. Lee, A. Awasthi, N. Yosef, F. J. Quintana, S. Xiao, A. Peters, C. Wu, M. Kleinewietfeld, S. Kunder, D. A. Hafler, R. A. Sobel, A. Regev, V. K. Kuchroo, Induction and molecular signature of pathogenic TH17 cells. Nat. Immunol. 13, 991-999 (2012).
-
(2012)
Nat. Immunol.
, vol.13
, pp. 991-999
-
-
Lee, Y.1
Awasthi, A.2
Yosef, N.3
Quintana, F.J.4
Xiao, S.5
Peters, A.6
Wu, C.7
Kleinewietfeld, M.8
Kunder, S.9
Hafler, D.A.10
Sobel, R.A.11
Regev, A.12
Kuchroo, V.K.13
-
17
-
-
77449132554
-
Antigenspecific dependence of Tr1-cell therapy in preclinical models of islet transplant
-
N. Gagliani, T. Jofra, A. Stabilini, A. Valle, M. Atkinson, M. G. Roncarolo, M. Battaglia, Antigenspecific dependence of Tr1-cell therapy in preclinical models of islet transplant. Diabetes 59, 433-439 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 433-439
-
-
Gagliani, N.1
Jofra, T.2
Stabilini, A.3
Valle, A.4
Atkinson, M.5
Roncarolo, M.G.6
Battaglia, M.7
-
18
-
-
56249119186
-
Re-establishing immune tolerance in type 1 diabetes via regulatory T cells
-
S. Gregori, M. Battaglia, M. G. Roncarolo, Re-establishing immune tolerance in type 1 diabetes via regulatory T cells. Novartis Found. Symp. 292, 174-183 (2008).
-
(2008)
Novartis Found. Symp.
, vol.292
, pp. 174-183
-
-
Gregori, S.1
Battaglia, M.2
Roncarolo, M.G.3
-
19
-
-
33845302957
-
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
-
A. L. Astier, G. Meiffren, S. Freeman, D. A. Hafler, Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J. Clin. Invest. 116, 3252-3257 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 3252-3257
-
-
Astier, A.L.1
Meiffren, G.2
Freeman, S.3
Hafler, D.A.4
-
20
-
-
67650469829
-
Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
-
R. Geiger, T. Duhen, A. Lanzavecchia, F. Sallusto, Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells. J. Exp. Med. 206, 1525-1534 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1525-1534
-
-
Geiger, R.1
Duhen, T.2
Lanzavecchia, A.3
Sallusto, F.4
-
21
-
-
65249175159
-
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
-
A. Reboldi, C. Coisne, D. Baumjohann, F. Benvenuto, D. Bottinelli, S. Lira, A. Uccelli, A. Lanzavecchia, B. Engelhardt, F. Sallusto, C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat. Immunol. 10, 514-523 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 514-523
-
-
Reboldi, A.1
Coisne, C.2
Baumjohann, D.3
Benvenuto, F.4
Bottinelli, D.5
Lira, S.6
Uccelli, A.7
Lanzavecchia, A.8
Engelhardt, B.9
Sallusto, F.10
-
22
-
-
64849093508
-
Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response
-
A. Liston, R. E. Kohler, S. Townley, S. Haylock-Jacobs, I. Comerford, A. C. Caon, J. Webster, J. M. Harrison, J. Swann, I. Clark-Lewis, H. Korner, S. R. McColl, Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response. J. Immunol. 182, 3121-3130 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 3121-3130
-
-
Liston, A.1
Kohler, R.E.2
Townley, S.3
Haylock-Jacobs, S.4
Comerford, I.5
Caon, A.C.6
Webster, J.7
Harrison, J.M.8
Swann, J.9
Clark-Lewis, I.10
Korner, H.11
McColl, S.R.12
-
23
-
-
84875804013
-
The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis
-
K. Moriguchi, K. Miyamoto, N. Tanaka, O. Yoshie, S. Kusunoki, The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 257, 53-58 (2013).
-
(2013)
J. Neuroimmunol.
, vol.257
, pp. 53-58
-
-
Moriguchi, K.1
Miyamoto, K.2
Tanaka, N.3
Yoshie, O.4
Kusunoki, S.5
-
24
-
-
67651171182
-
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells
-
S. Trifari, C. D. Kaplan, E. H. Tran, N. K. Crellin, H. Spits, Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells. Nat. Immunol. 10, 864-871 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 864-871
-
-
Trifari, S.1
Kaplan, C.D.2
Tran, E.H.3
Crellin, N.K.4
Spits, H.5
-
25
-
-
77949511548
-
CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function
-
L. Rivino, P. Gruarin, B. Häringer, S. Steinfelder, L. Lozza, B. Steckel, A. Weick, E. Sugliano, D. Jarrossay, A. A. Kühl, C. Loddenkemper, S. Abrignani, F. Sallusto, A. Lanzavecchia, J. Geginat, CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function. J. Exp. Med. 207, 565-577 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 565-577
-
-
Rivino, L.1
Gruarin, P.2
Häringer, B.3
Steinfelder, S.4
Lozza, L.5
Steckel, B.6
Weick, A.7
Sugliano, E.8
Jarrossay, D.9
Kühl, A.A.10
Loddenkemper, C.11
Abrignani, S.12
Sallusto, F.13
Lanzavecchia, A.14
Geginat, J.15
-
26
-
-
0031726374
-
The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis
-
V. K. Tuohy, M. Yu, L. Yin, J. A. Kawczak, J. M. Johnson, P. M. Mathisen, B. Weinstock-Guttman, R. P. Kinkel, The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 164, 93-100 (1998).
-
(1998)
Immunol. Rev.
, vol.164
, pp. 93-100
-
-
Tuohy, V.K.1
Yu, M.2
Yin, L.3
Kawczak, J.A.4
Johnson, J.M.5
Mathisen, P.M.6
Weinstock-Guttman, B.7
Kinkel, R.P.8
-
27
-
-
16244417773
-
Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
-
E. J. McMahon, S. L. Bailey, C. V. Castenada, H. Waldner, S. D. Miller, Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 11, 335-339 (2005).
-
(2005)
Nat. Med.
, vol.11
, pp. 335-339
-
-
McMahon, E.J.1
Bailey, S.L.2
Castenada, C.V.3
Waldner, H.4
Miller, S.D.5
-
28
-
-
0029019568
-
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans
-
S. Markovic-Plese, H. Fukaura, J. Zhang, A. Al-Sabbagh, S. Southwood, A. Sette, V. K. Kuchroo, D. A. Hafler, T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J. Immunol. 155, 982-992 (1995).
-
(1995)
J. Immunol.
, vol.155
, pp. 982-992
-
-
Markovic-Plese, S.1
Fukaura, H.2
Zhang, J.3
Al-Sabbagh, A.4
Southwood, S.5
Sette, A.6
Kuchroo, V.K.7
Hafler, D.A.8
-
29
-
-
1542723658
-
Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis
-
B. Bielekova, M. H. Sung, N. Kadom, R. Simon, H. McFarland, R. Martin, Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis. J. Immunol. 172, 3893-3904 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 3893-3904
-
-
Bielekova, B.1
Sung, M.H.2
Kadom, N.3
Simon, R.4
McFarland, H.5
Martin, R.6
-
30
-
-
84860241847
-
Pathogen-induced human TH17 cells produce IFN-g or IL-10 and are regulated by IL-1b
-
C. E. Zielinski, F. Mele, D. Aschenbrenner, D. Jarrossay, F. Ronchi, M. Gattorno, S. Monticelli, A. Lanzavecchia, F. Sallusto, Pathogen-induced human TH17 cells produce IFN-g or IL-10 and are regulated by IL-1b. Nature 484, 514-518 (2012).
-
(2012)
Nature
, vol.484
, pp. 514-518
-
-
Zielinski, C.E.1
Mele, F.2
Aschenbrenner, D.3
Jarrossay, D.4
Ronchi, F.5
Gattorno, M.6
Monticelli, S.7
Lanzavecchia, A.8
Sallusto, F.9
-
31
-
-
72649089874
-
Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
-
V. Brucklacher-Waldert, K. Stuerner, M. Kolster, J. Wolthausen, E. Tolosa, Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 132, 3329-3341 (2009).
-
(2009)
Brain
, vol.132
, pp. 3329-3341
-
-
Brucklacher-Waldert, V.1
Stuerner, K.2
Kolster, M.3
Wolthausen, J.4
Tolosa, E.5
-
32
-
-
84863344656
-
Association between pathological and MRI findings in multiple sclerosis
-
M. Filippi, M. A. Rocca, F. Barkhof, W. Brück, J. T. Chen, G. Comi, G. De Luca, N. De Stefano, B. J. Erickson, N. Evangelou, F. Fazekas, J. J. Geurts, C. Lucchinetti, D. H. Miller, D. Pelletier, B. F. Popescu, H. Lassmann; Attendees of the Correlation between Pathological MRI findings in MS workshop, Association between pathological and MRI findings in multiple sclerosis. Lancet Neurol. 11, 349-360 (2012).
-
(2012)
Lancet Neurol.
, vol.11
, pp. 349-360
-
-
Attendees of the Correlation between Pathological MRI findings in MS workshop1
Filippi, M.2
Rocca, M.A.3
Barkhof, F.4
Brück, W.5
Chen, J.T.6
Comi, G.7
De Luca, G.8
De Stefano, N.9
Erickson, B.J.10
Evangelou, N.11
Fazekas, F.12
Geurts, J.J.13
Lucchinetti, C.14
Miller, D.H.15
Pelletier, D.16
Popescu, B.F.17
Lassmann, H.18
-
33
-
-
73249122274
-
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
-
J. D. Rioux, P. Goyette, T. J. Vyse, L. Hammarström, M. M. Fernando, T. Green, P. L. De Jager, S. Foisy, J. Wang, P. I. De Bakker, S. Leslie, G. McVean, L. Padyukov, L. Alfredsson, V. Annese, D. A. Hafler, Q. Pan-Hammarström, R. Matell, S. J. Sawcer, A. D. Compston, B. A. Cree, D. B. Mirel, M. J. Daly, T. W. Behrens, L. Klareskog, P. K. Gregersen, J. R. Oksenberg, S. L. Hauser; International MHC and Autoimmunity Genetics Network, Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc. Natl. Acad. Sci. U. S. A. 106, 18680-18685 (2009).
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 18680-18685
-
-
International MHC and Autoimmunity Genetics Network1
Rioux, J.D.2
Goyette, P.3
Vyse, T.J.4
Hammarström, L.5
Fernando, M.M.6
Green, T.7
De Jager, P.L.8
Foisy, S.9
Wang, J.10
De Bakker, P.I.11
Leslie, S.12
McVean, G.13
Padyukov, L.14
Alfredsson, L.15
Annese, V.16
Hafler, D.A.17
Pan-Hammarström, Q.18
Matell, R.19
Sawcer, S.J.20
Compston, A.D.21
Cree, B.A.22
Mirel, D.B.23
Daly, M.J.24
Behrens, T.W.25
Klareskog, L.26
Gregersen, P.K.27
Oksenberg, J.R.28
Hauser, S.L.29
more..
-
34
-
-
34547214205
-
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
-
M. G. Roncarolo, M. Battaglia, Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat. Rev. Immunol. 7, 585-598 (2007).
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 585-598
-
-
Roncarolo, M.G.1
Battaglia, M.2
-
35
-
-
79954620910
-
Th17 cells express interleukin-10 receptor and are controlled by Foxp3- and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
-
S. Huber, N. Gagliani, E. Esplugues, W. O'Connor Jr., F. J. Huber, A. Chaudhry, M. Kamanaka, Y. Kobayashi, C. J. Booth, A. Y. Rudensky, M. G. Roncarolo, M. Battaglia, R. A. Flavell, Th17 cells express interleukin-10 receptor and are controlled by Foxp3- and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 34, 554-565 (2011).
-
(2011)
Immunity
, vol.34
, pp. 554-565
-
-
Huber, S.1
Gagliani, N.2
Esplugues, E.3
O'Connor, W.4
Huber, F.J.5
Chaudhry, A.6
Kamanaka, M.7
Kobayashi, Y.8
Booth, C.J.9
Rudensky, A.Y.10
Roncarolo, M.G.11
Battaglia, M.12
Flavell, R.A.13
-
36
-
-
27344435774
-
Gene set enrichment analysis: A knowledgebased approach for interpreting genome-wide expression profiles
-
A. Subramanian, P. Tamayo, V. K. Mootha, S. Mukherjee, B. L. Ebert, M. A. Gillette, A. Paulovich, S. L. Pomeroy, T. R. Golub, E. S. Lander, J. P. Mesirov, Gene set enrichment analysis: A knowledgebased approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U. S. A. 102, 15545-15550 (2005).
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
37
-
-
84900303365
-
Transcriptomic meta-analysis of multiple sclerosis and its experimental models
-
B. B. Raddatz, F. Hansmann, I. Spitzbarth, A. Kalkuhl, U. Deschl, W. Baumgärtner, R. Ulrich, Transcriptomic meta-analysis of multiple sclerosis and its experimental models. PLOS One 9, e86643 (2014).
-
(2014)
PLOS One
, vol.9
, pp. e86643
-
-
Raddatz, B.B.1
Hansmann, F.2
Spitzbarth, I.3
Kalkuhl, A.4
Deschl, U.5
Baumgärtner, W.6
Ulrich, R.7
-
38
-
-
80051885764
-
Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types
-
G. Wei, B. J. Abraham, R. Yagi, R. Jothi, K. Cui, S. Sharma, L. Narlikar, D. L. Northrup, Q. Tang, W. E. Paul, J. Zhu, K. Zhao, Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 35, 299-311 (2011).
-
(2011)
Immunity
, vol.35
, pp. 299-311
-
-
Wei, G.1
Abraham, B.J.2
Yagi, R.3
Jothi, R.4
Cui, K.5
Sharma, S.6
Narlikar, L.7
Northrup, D.L.8
Tang, Q.9
Paul, W.E.10
Zhu, J.11
Zhao, K.12
-
39
-
-
84867581744
-
A validated regulatory network for Th17 cell specification
-
M. Ciofani, A. Madar, C. Galan, M. Sellars, K. Mace, F. Pauli, A. Agarwal, W. Huang, C. N. Parkurst, M. Muratet, K. M. Newberry, S. Meadows, A. Greenfield, Y. Yang, P. Jain, F. K. Kirigin, C. Birchmeier, E. F. Wagner, K. M. Murphy, R. M. Myers, R. Bonneau, D. R. Littman, A validated regulatory network for Th17 cell specification. Cell 151, 289-303 (2012).
-
(2012)
Cell
, vol.151
, pp. 289-303
-
-
Ciofani, M.1
Madar, A.2
Galan, C.3
Sellars, M.4
Mace, K.5
Pauli, F.6
Agarwal, A.7
Huang, W.8
Parkurst, C.N.9
Muratet, M.10
Newberry, K.M.11
Meadows, S.12
Greenfield, A.13
Yang, Y.14
Jain, P.15
Kirigin, F.K.16
Birchmeier, C.17
Wagner, E.F.18
Murphy, K.M.19
Myers, R.M.20
Bonneau, R.21
Littman, D.R.22
more..
-
40
-
-
84892536761
-
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
-
R. Ramesh, L. Kozhaya, K. McKevitt, I. M. Djuretic, T. J. Carlson, M. A. Quintero, J. L. McCauley, M. T. Abreu, D. Unutmaz, M. S. Sundrud, Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J. Exp. Med. 211, 89-104 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 89-104
-
-
Ramesh, R.1
Kozhaya, L.2
McKevitt, K.3
Djuretic, I.M.4
Carlson, T.J.5
Quintero, M.A.6
McCauley, J.L.7
Abreu, M.T.8
Unutmaz, D.9
Sundrud, M.S.10
-
41
-
-
77649184739
-
The regulation of IL-10 production by immune cells
-
M. Saraiva, A. O'Garra, The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 10, 170-181 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 170-181
-
-
Saraiva, M.1
O'Garra, A.2
-
42
-
-
84866871850
-
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity
-
L. Ottoboni, B. T. Keenan, P. Tamayo, M. Kuchroo, J. P. Mesirov, G. J. Buckle, S. J. Khoury, D. A. Hafler, H. L. Weiner, P. L. De Jager, An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Sci. Transl. Med. 4, 153ra131 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
, pp. 153ra131
-
-
Ottoboni, L.1
Keenan, B.T.2
Tamayo, P.3
Kuchroo, M.4
Mesirov, J.P.5
Buckle, G.J.6
Khoury, S.J.7
Hafler, D.A.8
Weiner, H.L.9
De Jager, P.L.10
-
43
-
-
84902193078
-
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells
-
D. M. Kofler, A. Marson, M. Dominguez-Villar, S. Xiao, V. K. Kuchroo, D. A. Hafler, Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J. Clin. Invest. 124, 2513-2522 (2014).
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 2513-2522
-
-
Kofler, D.M.1
Marson, A.2
Dominguez-Villar, M.3
Xiao, S.4
Kuchroo, V.K.5
Hafler, D.A.6
-
44
-
-
84355166761
-
Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation
-
A. Peters, L. A. Pitcher, J. M. Sullivan, M. Mitsdoerffer, S. E. Acton, B. Franz, K. Wucherpfennig, S. Turley, M. C. Carroll, R. A. Sobel, E. Bettelli, V. K. Kuchroo, Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity 35, 986-996 (2011).
-
(2011)
Immunity
, vol.35
, pp. 986-996
-
-
Peters, A.1
Pitcher, L.A.2
Sullivan, J.M.3
Mitsdoerffer, M.4
Acton, S.E.5
Franz, B.6
Wucherpfennig, K.7
Turley, S.8
Carroll, M.C.9
Sobel, R.A.10
Bettelli, E.11
Kuchroo, V.K.12
-
45
-
-
84891766847
-
Human T follicular helper (Tfh) cells and disease
-
C. S. Ma, E. K. Deenick, Human T follicular helper (Tfh) cells and disease. Immunol. Cell Biol. 92, 64-71 (2014).
-
(2014)
Immunol. Cell Biol.
, vol.92
, pp. 64-71
-
-
Ma, C.S.1
Deenick, E.K.2
-
46
-
-
84896883113
-
Chemokines and chemokine receptors in multiple sclerosis
-
W. Cheng, G. Chen, Chemokines and chemokine receptors in multiple sclerosis. Mediators Inflamm. 2014, 659206 (2014).
-
(2014)
Mediators Inflamm.
, vol.2014
, pp. 659206
-
-
Cheng, W.1
Chen, G.2
-
47
-
-
84927580933
-
STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation
-
W. Sheng, F. Yang, Y. Zhou, H. Yang, P. Y. Low, D. M. Kemeny, P. Tan, A. Moh, M. H. Kaplan, Y. Zhang, X. Y. Fu, STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation. Cell Res. 24, 1387-1402 (2014).
-
(2014)
Cell Res.
, vol.24
, pp. 1387-1402
-
-
Sheng, W.1
Yang, F.2
Zhou, Y.3
Yang, H.4
Low, P.Y.5
Kemeny, D.M.6
Tan, P.7
Moh, A.8
Kaplan, M.H.9
Zhang, Y.10
Fu, X.Y.11
-
48
-
-
84903783415
-
IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells
-
R. Noster, R. Riedel, M. F. Mashreghi, H. Radbruch, L. Harms, C. Haftmann, H. D. Chang, A. Radbruch, C. E. Zielinski, IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Sci. Transl. Med. 6, 241ra80 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 241ra80
-
-
Noster, R.1
Riedel, R.2
Mashreghi, M.F.3
Radbruch, H.4
Harms, L.5
Haftmann, C.6
Chang, H.D.7
Radbruch, A.8
Zielinski, C.E.9
-
49
-
-
33746729791
-
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
-
R. Gold, C. Linington, H. Lassmann, Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129, 1953-1971 (2006).
-
(2006)
Brain
, vol.129
, pp. 1953-1971
-
-
Gold, R.1
Linington, C.2
Lassmann, H.3
-
50
-
-
0037413240
-
A4 Integrins as therapeutic targets in autoimmune disease
-
U. H. Von Andrian, B. Engelhardt, a4 Integrins as therapeutic targets in autoimmune disease. N. Engl. J. Med. 348, 68-72 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 68-72
-
-
Von Andrian, U.H.1
Engelhardt, B.2
-
51
-
-
63449129385
-
Systematic method for determining an ideal housekeeping gene for real-time PCR analysis
-
V. P. Mane, M. A. Heuer, P. Hillyer, M. B. Navarro, R. L. Rabin, Systematic method for determining an ideal housekeeping gene for real-time PCR analysis. J. Biomol. Tech. 19, 342-347 (2008).
-
(2008)
J. Biomol. Tech.
, vol.19
, pp. 342-347
-
-
Mane, V.P.1
Heuer, M.A.2
Hillyer, P.3
Navarro, M.B.4
Rabin, R.L.5
-
52
-
-
33745259517
-
Cell-type specific gene expression profiles of leukocytes in human peripheral blood
-
C. Palmer, M. Diehn, A. A. Alizadeh, P. O. Brown, Cell-type specific gene expression profiles of leukocytes in human peripheral blood. BMC Genomics 7, 115 (2006).
-
(2006)
BMC Genomics
, vol.7
, pp. 115
-
-
Palmer, C.1
Diehn, M.2
Alizadeh, A.A.3
Brown, P.O.4
|