The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Mizuno, Miho ^a   Noto, Daisuke ^a   Kaga, Naoko ^b   Chiba, Asako ^a   Miyake, Sachiko ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; SHORT CHAIN FATTY ACID; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENT; VOLATILE FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; CLINICAL ASSESSMENT; CLOSTRIDIA; COLLAGEN-INDUCED ARTHRITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; EXPERIMENTAL ALLERGIC ENCEPHALITIS; FLOW CYTOMETRY; HEREDITY; HIGH FIBER DIET; HISTOPATHOLOGY; IMMUNE RESPONSE; INNATE IMMUNITY; LAMINA PROPRIA; MASS FRAGMENTOGRAPHY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TH1 CELL; WEIGHT REDUCTION; ANIMAL; ARTHRITIS, EXPERIMENTAL; C57BL MOUSE; DBA MOUSE; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOLOGY; ORAL DRUG ADMINISTRATION; PRECLINICAL STUDY; REGULATORY T LYMPHOCYTE; TRANSGENIC MOUSE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; DRUG EVALUATION, PRECLINICAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FATTY ACIDS, VOLATILE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; T-LYMPHOCYTES, REGULATORY; TH1 CELLS;

EID: 85014049062     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0173032     Document Type: Article

References (46)

1. Belkaid Y, Hand TW. Role of the Microbiota in Immunity and Inflammation. Cell. 2014; 157:121-41. doi: 10.1016/j.cell.2014.03.011 PMID: 24679531
2. Yokote H, Miyake S, Croxford JL, Oki S, Mizusawa H, Yamamura T. NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol. 2008; 173: 1714-23. doi: 10. 2353/ajpath.2008.080622 PMID: 18974295
3. Berer K, Mues M, Koutrolos M, Rasbi Z Al, Boziki M, Johner C, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011; 479: 538-41. doi: 10.1038/ nature10554 PMID: 22031325
4. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2011; 108 Suppl: 4615-22.
5. Gaboriau-Routhiau V, Rakotobe S, Lécuyer E, Mulder I, Lan A, Bridonneau C, et al. The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses. Immunity. 2009; 31: 677-689. doi: 10.1016/j.immuni.2009.08.020 PMID: 19833089
6. Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, et al. Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. Cell. 2009; 139: 485-498. doi: 10.1016/j.cell.2009.09.033 PMID: 19836068
7. Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, Burroughs AR, Begum-Haque S, Dasgupta S, et al. Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression. J Immunol. 2010; 185: 4101-4108. doi: 10.4049/jimmunol. 1001443 PMID: 20817872
8. Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al. Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species. Science. 2011; 331: 337-341. doi: 10.1126/science. 1198469 PMID: 21205640
9. Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013; 500: 232-236. doi: 10. 1038/nature12331 PMID: 23842501
10. Miyake S, Kim S, Suda W, Oshima K, Nakamura M, Matsuoka T, et al. Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters. PLoS One. 2015; 10: e0137429. doi: 10.1371/journal.pone.0137429 PMID: 26367776
11. Furusawa Y, Obata Y, Fukuda S, Endo T a, Nakato G, Takahashi D, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013; 504: 446-450. doi: 10. 1038/nature12721 PMID: 24226770
12. Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, et al. The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis. Science. 2013; 341: 569-573. doi: 10.1126/science.1241165 PMID: 23828891
13. Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, DeRoos P, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 504: 451-455. doi: 10.1038/nature12726 PMID: 24226773
14. Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014; 20: 159-166. doi: 10.1038/nm.3444 PMID: 24390308
15. Haghikia A, Jörg S, Duscha A, Berg J, Manzel A, Waschbisch A, et al. Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine. Immunity. 2015; 43: 817-829. doi: 10.1016/j.immuni.2015.09.007 PMID: 26488817
16. Lefrançois L, Lycke N. Isolation of Mouse Small Intestinal Intraepithelial Lymphocytes, Peyer's Patch, and Lamina Propria Cells. In: Curr. Protoc. Immunol. Hoboken: John Wiley & Sons, Inc; 2001. pp. 3-19.
17. Park J, Goergen CJ, HogenEsch H, Kim CH. Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell-Mediated Ureteritis and Hydronephrosis. J Immunol. 2016; 196: 2388-2400. doi: 10. 4049/jimmunol.1502046 PMID: 26819206
18. Gurav A, Sivaprakasam S, Bhutia YD, Boettger T, Singh N, Ganapathy V. Slc5a8, a Na+ -coupled highaffinity transporter for short-chain fatty acids, is a conditional tumor suppressor in colon that protects against colitis and colon cancer under low-fiber dietary conditions. Biochem J. 2015; 469: 267-278. doi: 10.1042/BJ20150242 PMID: 25984582
19. Kouskoff V, Korganow A-S, Duchatelle V, Degott C, Benoist C, Mathis D. Organ-Specific Disease Provoked by Systemic Autoimmunity. Cell. 1996; 87: 811-822. PMID: 8945509
20. Korganow A-S, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, et al. From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins. Immunity. 1999; 10: 451-461. PMID: 10229188
21. Matsumoto I. Arthritis Provoked by Linked T and B Cell Recognition of a Glycolytic Enzyme. Science. 1999; 286: 1732-1735. PMID: 10576739
22. Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM., Boackle SA, et al. Arthritis Critically Dependent on Innate Immune System Players. Immunity. 2002; 16: 157-168. PMID: 11869678
23. Lee DM. Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis. Science. 2002; 297: 1689-1692. doi: 10.1126/science.1073176 PMID: 12215644
24. Wipke BT, Allen PM. Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis. J Immunol. 2001; 167: 1601-1608. PMID: 11466382
25. Solomon S, Rajasekaran N, Jeisy-Walder E, Snapper SB, Illges H. A crucial role for macrophages in the pathology of K/B ? N serum-induced arthritis. Eur J Immunol. 2005; 35: 3064-3073. doi: 10.1002/ eji.200526167 PMID: 16180250
26. Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, et al. Critical Roles for Interleukin 1 and Tumor Necrosis Factor α in Antibody-induced Arthritis. J Exp Med. 2002; 196: 77-85. doi: 10.1084/jem. 20020439 PMID: 12093872
27. Sokol H, Seksik P, Furet JP, Firmesse O, Nion-Larmurier I, Beaugerie L, et al. Low counts of faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis. 2009; 15: 1183-1189. doi: 10.1002/ibd. 20903 PMID: 19235886
28. Kaieda S, Tomi C, Oki S, Yamamura T, Miyake S. Activation of invariant natural killer T cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis. Arthritis Rheum. 2007; 56: 1836-1845. doi: 10.1002/art.22714 PMID: 17530712
29. Boissier MC, Chiocchia G, Bessis N, Hajnal J, Garotta G, Nicoletti F, et al. Biphasic effect of interferongamma in murine collagen-induced arthritis. Eur J Immunol. 1995; 25:1184-90. doi: 10.1002/eji. 1830250508 PMID: 7774621
30. Bhattacharya P, Thiruppathi M, Elshabrawy HA, Alharshawi K, Kumar P, Prabhakar BS. GM-CSF: An immune modulatory cytokine that can suppress autoimmunity. Cytokine. 2015; 75: 261-271. doi: 10. 1016/j.cyto.2015.05.030 PMID: 26113402
31. Bhattacharya P, Budnick I, Singh M, Thiruppathi M, Alharshawi K, Elshabrawy H, et al. Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy. J Interferon Cytokine Res. 2015; 35: 585-99. doi: 10.1089/jir.2014.0149 PMID: 25803788
32. Haddad CS, Bhattacharya P, Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, et al. Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice. Autoimmunity. 2016; 49: 298-311. doi: 10.1080/08916934.2016.1183657 PMID: 27245356
33. Gathungu G, Kim M-O, Ferguson JP, Sharma Y, Zhang W, Ng SME, et al. Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease. Inflamm Bowel Dis. 2013; 19: 1671-80. doi: 10.1097/MIB.0b013e318281f506 PMID: 23749272
34. Rowin J, Thiruppathi M, Arhebamen E, Sheng J, Prabhakar BS, Meriggioli MN. Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: effects on regulatory T cells. Muscle Nerve. 2012; 46: 449-53. doi: 10.1002/mus.23488 PMID: 22907239
35. Ang Z, Er JZ, Tan NS, Lu J, Liou Y-C, Grosse J, et al. Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists. Sci Rep. 2016; 6: 34145. doi: 10.1038/srep34145 PMID: 27667443
36. Cook AD, Turner AL, Braine EL, Pobjoy J, Lenzo JC, Hamilton JA. Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis. Arthritis Rheum. 2011; 63: 2340-2351. doi: 10.1002/art. 30354 PMID: 21809323
37. Wang F, Liu J, Wong T, Shen K, Chen Z, Yu Y, et al. The inflammation induced by lipopolysaccharide can be mitigated by short chain fatty acid, butyrate, through up-regulation of IL-10 in septic shock. Scand J Immunol. 2016 Dec 10.
38. Rahman M, Kukita A, Kukita T, Shobuike T, Nakamura T, Kohashi O. Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. Blood. 2003; 101: 3451-3459. doi: 10.1182/blood-2002-08-2622 PMID: 12511413
39. Scher JU, Ubeda C, Equinda M, Khanin R, Buischi Y, Viale A, et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum. 2012; 64: 3083-3094. doi: 10.1002/art. 34539 PMID: 22576262
40. Fuggle NR, Smith TO, Kaul A, Sofat N. Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis. Front Immunol. 2016; 7: 1-10.
41. Chang M-C, Tsai Y-L, Chen Y-W, Chan C-P, Huang C-F, Lan W-C, et al. Butyrate induces reactive oxygen species production and affects cell cycle progression in human gingival fibroblasts. J Periodontal Res. 2013; 48: 66-73. doi: 10.1111/j.1600-0765.2012.01504.x PMID: 22834967
42. Farooq SM, Ashour HM. Type II Collagen Induces Peripheral Tolerance in BALB/c Mice via the Generation of CD8+ T Regulatory Cells. PLoS One. 2012; 7: 6-11.
43. Farooq SM, Ashour HM. Eye-mediated induction of specific immune tolerance to encephalitogenic antigens. CNS Neurosci Ther. 2013; 19: 503-510. doi: 10.1111/cns.12087 PMID: 23522052
44. Farooq SM, Ashour HM. In vitro-induced cell-mediated immune deviation to encephalitogenic antigens. Brain Behav Immun. Elsevier Inc.; 2014; 35: 64-69.
45. Farooq SM, Elkhatib WF, Ashour HM. The in vivo and in vitro induction of anterior chamber associated immune deviation to myelin antigens in C57BL/6 mice. Brain Behav Immun. Elsevier Inc.; 2014; 42: 118-122.
46. Farooq SM, Kumar A, Ashour HM. Eye-mediated immune tolerance to Type II collagen in arthritisprone strains of mice. J Cell Mol Med. 2014; 18: 2512-2518. doi: 10.1111/jcmm.12376 PMID: 25211510