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Volumn 4, Issue 4, 2015, Pages 687-705

Role of the polycystins in cell migration, polarity, and tissue morphogenesis

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN ADENOSINE TRIPHOSPHATASE; POLYCYSTIN; POLYCYSTIN 1; POLYCYSTIN 2;

EID: 85056746737     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells4040687     Document Type: Review
Times cited : (21)

References (102)
  • 1
    • 54849146500 scopus 로고    scopus 로고
    • Clinical practice. Autosomal dominant polycystic kidney disease
    • Grantham, J.J. Clinical practice. Autosomal dominant polycystic kidney disease. N. Engl. J. Med. 2008, 359, 1477–1485.
    • (2008) N. Engl. J. Med , vol.359 , pp. 1477-1485
    • Grantham, J.J.1
  • 2
    • 58149504281 scopus 로고    scopus 로고
    • Nephronophthisis: Disease mechanisms of a ciliopathy
    • Hildebrandt, F.; Attanasio, M.; Otto, E. Nephronophthisis: Disease mechanisms of a ciliopathy. J. Am. Soc. Nephrol. 2009, 20, 23–35.
    • (2009) J. Am. Soc. Nephrol , vol.20 , pp. 23-35
    • Hildebrandt, F.1    Attanasio, M.2    Otto, E.3
  • 4
    • 84922438982 scopus 로고    scopus 로고
    • Cilia and diseases
    • Brown, J.M.; Witman, G.B. Cilia and diseases. Bioscience 2014, 64, 1126–1137.
    • (2014) Bioscience , vol.64 , pp. 1126-1137
    • Brown, J.M.1    Witman, G.B.2
  • 6
    • 84899956827 scopus 로고    scopus 로고
    • Polycystin signaling is required for directed endothelial cell migration and lymphatic development
    • Outeda, P.; Huso, D.L.; Fisher, S.A.; Halushka, M.K.; Kim, H.; Qian, F.; Germino, G.G.; Watnick, T. Polycystin signaling is required for directed endothelial cell migration and lymphatic development. Cell Rep. 2014, 7, 634–644.
    • (2014) Cell Rep , vol.7 , pp. 634-644
    • Outeda, P.1    Huso, D.L.2    Fisher, S.A.3    Halushka, M.K.4    Kim, H.5    Qian, F.6    Germino, G.G.7    Watnick, T.8
  • 7
    • 84898815152 scopus 로고    scopus 로고
    • Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex
    • Yao, G.; Su, X.; Nguyen, V.; Roberts, K.; Li, X.; Takakura, A.; Plomann, M.; Zhou, J. Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex. Hum. Mol. Genet. 2014, 23, 2769–2779.
    • (2014) Hum. Mol. Genet , vol.23 , pp. 2769-2779
    • Yao, G.1    Su, X.2    Nguyen, V.3    Roberts, K.4    Li, X.5    Takakura, A.6    Plomann, M.7    Zhou, J.8
  • 8
    • 84964696012 scopus 로고    scopus 로고
    • Regulation of the microtubular cytoskeleton by polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration
    • Castelli, M.; de Pascalis, C.; Distefano, G.; Ducano, N.; Oldani, A.; Lanzetti, L.; Boletta, A. Regulation of the microtubular cytoskeleton by polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration. BMC Cell Biol. 2015, 16, 15, doi:10.1186/s12860-015-0059-3.
    • (2015) BMC Cell Biol , vol.16
    • Castelli, M.1    De Pascalis, C.2    Distefano, G.3    Ducano, N.4    Oldani, A.5    Lanzetti, L.6    Boletta, A.7
  • 9
    • 84942983407 scopus 로고    scopus 로고
    • A polycystin-centric view of cyst formation and disease: The polycystins revisited
    • Ong, A.C.; Harris, P.C. A polycystin-centric view of cyst formation and disease: The polycystins revisited. Kidney Int. 2015, 88, 699–710.
    • (2015) Kidney Int , vol.88 , pp. 699-710
    • Ong, A.C.1    Harris, P.C.2
  • 10
    • 1242351972 scopus 로고    scopus 로고
    • Planar polarity from flies to vertebrates
    • Fanto, M.; McNeill, H. Planar polarity from flies to vertebrates. J. Cell Sci. 2004, 117, 527–533.
    • (2004) J. Cell Sci , vol.117 , pp. 527-533
    • Fanto, M.1    McNeill, H.2
  • 11
    • 79955565085 scopus 로고    scopus 로고
    • Principles of planar polarity in animal development
    • Goodrich, L.V.; Strutt, D. Principles of planar polarity in animal development. Development 2011, 138, 1877–1892.
    • (2011) Development , vol.138 , pp. 1877-1892
    • Goodrich, L.V.1    Strutt, D.2
  • 12
    • 69449085460 scopus 로고    scopus 로고
    • Line up and listen: Planar cell polarity regulation in the mammalian inner ear
    • Rida, P.C.; Chen, P. Line up and listen: Planar cell polarity regulation in the mammalian inner ear. Semin. Cell Dev. Biol. 2009, 20, 978–985.
    • (2009) Semin. Cell Dev. Biol , vol.20 , pp. 978-985
    • Rida, P.C.1    Chen, P.2
  • 13
    • 84879151685 scopus 로고    scopus 로고
    • Revisiting planar cell polarity in the inner ear
    • Ezan, J.; Montcouquiol, M. Revisiting planar cell polarity in the inner ear. Semin. Cell Dev. Biol. 2013, 24, 499–506.
    • (2013) Semin. Cell Dev. Biol , vol.24 , pp. 499-506
    • Ezan, J.1    Montcouquiol, M.2
  • 15
    • 84867241248 scopus 로고    scopus 로고
    • Convergent extension: Using collective cell migration and cell intercalation to shape embryos
    • Tada, M.; Heisenberg, C.P. Convergent extension: Using collective cell migration and cell intercalation to shape embryos. Development 2012, 139, 3897–3904.
    • (2012) Development , vol.139 , pp. 3897-3904
    • Tada, M.1    Heisenberg, C.P.2
  • 16
    • 1642282826 scopus 로고    scopus 로고
    • Patterned gene expression directs bipolar planar polarity in drosophila
    • Zallen, J.A.; Wieschaus, E. Patterned gene expression directs bipolar planar polarity in drosophila. Dev. Cell 2004, 6, 343–355.
    • (2004) Dev. Cell , vol.6 , pp. 343-355
    • Zallen, J.A.1    Wieschaus, E.2
  • 17
    • 84955375538 scopus 로고    scopus 로고
    • The involvement of PCP proteins in radial cell intercalations during xenopus embryonic development
    • Ossipova, O.; Chu, C.W.; Fillatre, J.; Brott, B.K.; Itoh, K.; Sokol, S.Y. The involvement of PCP proteins in radial cell intercalations during xenopus embryonic development. Dev. Biol. 2015, doi:10.1016/j.ydbio.2015.06.013.
    • (2015) Dev. Biol
    • Ossipova, O.1    Chu, C.W.2    Fillatre, J.3    Brott, B.K.4    Itoh, K.5    Sokol, S.Y.6
  • 18
    • 84940889508 scopus 로고    scopus 로고
    • Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development
    • Sokol, S.Y. Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development. Semin. Cell Dev. Biol. 2015, 42, 78–85.
    • (2015) Semin. Cell Dev. Biol , vol.42 , pp. 78-85
    • Sokol, S.Y.1
  • 19
    • 0034680788 scopus 로고    scopus 로고
    • A positive role for the PP2A catalytic subunit in Wnt signal transduction
    • Ratcliffe, M.J.; Itoh, K.; Sokol, S.Y. A positive role for the PP2A catalytic subunit in Wnt signal transduction. J. Biol. Chem. 2000, 275, 35680–35683.
    • (2000) J. Biol. Chem , vol.275 , pp. 35680-35683
    • Ratcliffe, M.J.1    Itoh, K.2    Sokol, S.Y.3
  • 20
    • 0036922915 scopus 로고    scopus 로고
    • Neural tube closure requires dishevelled-dependent convergent extension of the midline
    • Wallingford, J.B.; Harland, R.M. Neural tube closure requires dishevelled-dependent convergent extension of the midline. Development 2002, 129, 5815–5825.
    • (2002) Development , vol.129 , pp. 5815-5825
    • Wallingford, J.B.1    Harland, R.M.2
  • 21
    • 0036087024 scopus 로고    scopus 로고
    • Convergent extension: The molecular control of polarized cell movement during embryonic development
    • Wallingford, J.B.; Fraser, S.E.; Harland, R.M. Convergent extension: The molecular control of polarized cell movement during embryonic development. Dev. Cell 2002, 2, 695–706.
    • (2002) Dev. Cell , vol.2 , pp. 695-706
    • Wallingford, J.B.1    Fraser, S.E.2    Harland, R.M.3
  • 22
    • 0037032828 scopus 로고    scopus 로고
    • Shaping the vertebrate body plan by polarized embryonic cell movements
    • Keller, R. Shaping the vertebrate body plan by polarized embryonic cell movements. Science 2002, 298, 1950–1954.
    • (2002) Science , vol.298 , pp. 1950-1954
    • Keller, R.1
  • 23
    • 0027082578 scopus 로고
    • Cell motility driving mediolateral intercalation in explants of Xenopus laevis
    • Shih, J.; Keller, R. Cell motility driving mediolateral intercalation in explants of Xenopus laevis. Development 1992, 116, 901–914.
    • (1992) Development , vol.116 , pp. 901-914
    • Shih, J.1    Keller, R.2
  • 26
    • 84893638187 scopus 로고    scopus 로고
    • PCP and septins compartmentalize cortical actomyosin to direct collective cell movement
    • Shindo, A.; Wallingford, J.B. PCP and septins compartmentalize cortical actomyosin to direct collective cell movement. Science 2014, 343, 649–652.
    • (2014) Science , vol.343 , pp. 649-652
    • Shindo, A.1    Wallingford, J.B.2
  • 27
    • 0041677608 scopus 로고    scopus 로고
    • Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
    • Carreira-Barbosa, F.; Concha, M.L.; Takeuchi, M.; Ueno, N.; Wilson, S.W.; Tada, M. Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development 2003, 130, 4037–4046.
    • (2003) Development , vol.130 , pp. 4037-4046
    • Carreira-Barbosa, F.1    Concha, M.L.2    Takeuchi, M.3    Ueno, N.4    Wilson, S.W.5    Tada, M.6
  • 28
    • 20444396897 scopus 로고    scopus 로고
    • Combinatorial activity of flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway
    • Formstone, C.J.; Mason, I. Combinatorial activity of flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway. Dev. Biol. 2005, 282, 320–335.
    • (2005) Dev. Biol , vol.282 , pp. 320-335
    • Formstone, C.J.1    Mason, I.2
  • 30
    • 0034130385 scopus 로고    scopus 로고
    • Xwnt11 is a target of xenopus brachyury: Regulation of gastrulation movements via dishevelled, but not through the canonical wnt pathway
    • Tada, M.; Smith, J.C. Xwnt11 is a target of xenopus brachyury: Regulation of gastrulation movements via dishevelled, but not through the canonical wnt pathway. Development 2000, 127, 2227–2238.
    • (2000) Development , vol.127 , pp. 2227-2238
    • Tada, M.1    Smith, J.C.2
  • 31
    • 0036079896 scopus 로고    scopus 로고
    • The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in xenopus
    • Goto, T.; Keller, R. The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in xenopus. Dev. Biol. 2002, 247, 165–181.
    • (2002) Dev. Biol , vol.247 , pp. 165-181
    • Goto, T.1    Keller, R.2
  • 32
    • 84926379944 scopus 로고    scopus 로고
    • Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation
    • Andre, P.; Song, H.; Kim, W.; Kispert, A.; Yang, Y. Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development 2015, 142, 1516–1527.
    • (2015) Development , vol.142 , pp. 1516-1527
    • Andre, P.1    Song, H.2    Kim, W.3    Kispert, A.4    Yang, Y.5
  • 33
    • 79961245158 scopus 로고    scopus 로고
    • Cabernard, C. Cell division orientation in animals.
    • Gillies, T.E.; Cabernard, C. Cell division orientation in animals. Curr. Biol. 2011, 21, R599–R609.
    • (2011) Curr. Biol , vol.21 , pp. R599-R609
    • Gillies, T.E.1
  • 34
    • 82555187911 scopus 로고    scopus 로고
    • Oriented cell division in vertebrate embryogenesis
    • Castanon, I.; Gonzalez-Gaitan, M. Oriented cell division in vertebrate embryogenesis. Curr. Opin. Cell Biol. 2011, 23, 697–704.
    • (2011) Curr. Opin. Cell Biol , vol.23 , pp. 697-704
    • Castanon, I.1    Gonzalez-Gaitan, M.2
  • 35
    • 0031919709 scopus 로고    scopus 로고
    • Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: A time-lapse analysis
    • Concha, M.L.; Adams, R.J. Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: A time-lapse analysis. Development 1998, 125, 983–994.
    • (1998) Development , vol.125 , pp. 983-994
    • Concha, M.L.1    Adams, R.J.2
  • 36
    • 3943102141 scopus 로고    scopus 로고
    • Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation
    • Gong, Y.; Mo, C.; Fraser, S.E. Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 2004, 430, 689–693.
    • (2004) Nature , vol.430 , pp. 689-693
    • Gong, Y.1    Mo, C.2    Fraser, S.E.3
  • 38
    • 0042412309 scopus 로고    scopus 로고
    • Oriented cell divisions asymmetrically segregate aPKC and generate cell fate diversity in the early xenopus embryo
    • Chalmers, A.D.; Strauss, B.; Papalopulu, N. Oriented cell divisions asymmetrically segregate aPKC and generate cell fate diversity in the early xenopus embryo. Development 2003, 130, 2657–2668.
    • (2003) Development , vol.130 , pp. 2657-2668
    • Chalmers, A.D.1    Strauss, B.2    Papalopulu, N.3
  • 39
    • 34848907422 scopus 로고    scopus 로고
    • Oriented cell divisions in the extending germband of drosophila
    • Da Silva, S.M.; Vincent, J.P. Oriented cell divisions in the extending germband of drosophila. Development 2007, 134, 3049–3054.
    • (2007) Development , vol.134 , pp. 3049-3054
    • Da Silva, S.M.1    Vincent, J.P.2
  • 40
    • 84873805725 scopus 로고    scopus 로고
    • Genetic controls and cellular behaviors in branching morphogenesis of the renal collecting system
    • Costantini, F. Genetic controls and cellular behaviors in branching morphogenesis of the renal collecting system. Wiley Interdiscip. Rev. Dev. Biol. 2012, 1, 693–713.
    • (2012) Wiley Interdiscip. Rev. Dev. Biol , vol.1 , pp. 693-713
    • Costantini, F.1
  • 43
    • 77952946956 scopus 로고    scopus 로고
    • Patterning a complex organ: Branching morphogenesis and nephron segmentation in kidney development
    • Costantini, F.; Kopan, R. Patterning a complex organ: Branching morphogenesis and nephron segmentation in kidney development. Dev. Cell 2010, 18, 698–712.
    • (2010) Dev. Cell , vol.18 , pp. 698-712
    • Costantini, F.1    Kopan, R.2
  • 44
    • 84870478180 scopus 로고    scopus 로고
    • Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension
    • Lienkamp, S.S.; Liu, K.; Karner, C.M.; Carroll, T.J.; Ronneberger, O.; Wallingford, J.B.; Walz, G. Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension. Nat. Genet. 2012, 44, 1382–1387.
    • (2012) Nat. Genet , vol.44 , pp. 1382-1387
    • Lienkamp, S.S.1    Liu, K.2    Karner, C.M.3    Carroll, T.J.4    Ronneberger, O.5    Wallingford, J.B.6    Walz, G.7
  • 45
    • 0142106807 scopus 로고    scopus 로고
    • Role of polycystins in renal tubulogenesis
    • Boletta, A.; Germino, G.G. Role of polycystins in renal tubulogenesis. Trends Cell Biol. 2003, 13, 484–492.
    • (2003) Trends Cell Biol , vol.13 , pp. 484-492
    • Boletta, A.1    Germino, G.G.2
  • 46
    • 78349286779 scopus 로고    scopus 로고
    • The cell biology of polycystic kidney disease
    • Chapin, H.C.; Caplan, M.J. The cell biology of polycystic kidney disease. J Cell Biol. 2010, 191, 701–710.
    • (2010) J Cell Biol , vol.191 , pp. 701-710
    • Chapin, H.C.1    Caplan, M.J.2
  • 48
    • 0036785149 scopus 로고    scopus 로고
    • The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    • Yoder, B.K.; Hou, X.; Guay-Woodford, L.M. The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J. Am. Soc. Nephrol. 2002, 13, 2508–2516.
    • (2002) J. Am. Soc. Nephrol , vol.13 , pp. 2508-2516
    • Yoder, B.K.1    Hou, X.2    Guay-Woodford, L.M.3
  • 49
    • 33645456243 scopus 로고    scopus 로고
    • Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells
    • Yamaguchi, T.; Hempson, S.J.; Reif, G.A.; Hedge, A.M.; Wallace, D.P. Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells. J. Am. Soc. Nephrol. 2006, 17, 178–187.
    • (2006) J. Am. Soc. Nephrol , vol.17 , pp. 178-187
    • Yamaguchi, T.1    Hempson, S.J.2    Reif, G.A.3    Hedge, A.M.4    Wallace, D.P.5
  • 50
    • 0037317302 scopus 로고    scopus 로고
    • Quinn, S.J.; et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
    • Nauli, S.M.; Alenghat, F.J.; Luo, Y.; Williams, E.; Vassilev, P.; Li, X.; Elia, A.E.; Lu, W.; Brown, E.M.; Quinn, S.J.; et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 2003, 33, 129–137.
    • (2003) Nat. Genet , vol.33 , pp. 129-137
    • Nauli, S.M.1    Alenghat, F.J.2    Luo, Y.3    Williams, E.4    Vassilev, P.5    Li, X.6    Elia, A.E.7    Lu, W.8    Brown, E.M.9
  • 51
    • 84890352250 scopus 로고    scopus 로고
    • Direct recording and molecular identification of the calcium channel of primary cilia
    • DeCaen, P.G.; Delling, M.; Vien, T.N.; Clapham, D.E. Direct recording and molecular identification of the calcium channel of primary cilia. Nature 2013, 504, 315–318.
    • (2013) Nature , vol.504 , pp. 315-318
    • Decaen, P.G.1    Delling, M.2    Vien, T.N.3    Clapham, D.E.4
  • 52
    • 84890345523 scopus 로고    scopus 로고
    • Primary cilia are specialized calcium signalling organelles
    • Delling, M.; DeCaen, P.G.; Doerner, J.F.; Febvay, S.; Clapham, D.E. Primary cilia are specialized calcium signalling organelles. Nature 2013, 504, 311–314.
    • (2013) Nature , vol.504 , pp. 311-314
    • Delling, M.1    Decaen, P.G.2    Doerner, J.F.3    Febvay, S.4    Clapham, D.E.5
  • 53
    • 78650482131 scopus 로고    scopus 로고
    • Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the g protein-coupled receptor proteolytic site
    • Chapin, H.C.; Rajendran, V.; Caplan, M.J. Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the g protein-coupled receptor proteolytic site. Mol. Biol. Cell 2010, 21, 4338–4348.
    • (2010) Mol. Biol. Cell , vol.21 , pp. 4338-4348
    • Chapin, H.C.1    Rajendran, V.2    Caplan, M.J.3
  • 54
    • 33646764178 scopus 로고    scopus 로고
    • Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif
    • Geng, L.; Okuhara, D.; Yu, Z.; Tian, X.; Cai, Y.; Shibazaki, S.; Somlo, S. Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. J. Cell Sci. 2006, 119, 1383–1395.
    • (2006) J. Cell Sci , vol.119 , pp. 1383-1395
    • Geng, L.1    Okuhara, D.2    Yu, Z.3    Tian, X.4    Cai, Y.5    Shibazaki, S.6    Somlo, S.7
  • 60
    • 84883455352 scopus 로고    scopus 로고
    • Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease
    • Ma, M.; Tian, X.; Igarashi, P.; Pazour, G.J.; Somlo, S. Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat. Genet. 2013, 45, 1004–1012.
    • (2013) Nat. Genet , vol.45 , pp. 1004-1012
    • Ma, M.1    Tian, X.2    Igarashi, P.3    Pazour, G.J.4    Somlo, S.5
  • 62
    • 0037168674 scopus 로고    scopus 로고
    • Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations
    • Qian, F.; Boletta, A.; Bhunia, A.K.; Xu, H.; Liu, L.; Ahrabi, A.K.; Watnick, T.J.; Zhou, F.; Germino, G.G. Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc. Natl. Acad. Sci. USA 2002, 99, 16981–16986.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16981-16986
    • Qian, F.1    Boletta, A.2    Bhunia, A.K.3    Xu, H.4    Liu, L.5    Ahrabi, A.K.6    Watnick, T.J.7    Zhou, F.8    Germino, G.G.9
  • 65
    • 33645458872 scopus 로고    scopus 로고
    • Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway
    • Boca, M.; Distefano, G.; Qian, F.; Bhunia, A.K.; Germino, G.G.; Boletta, A. Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway. J. Am. Soc. Nephrol. 2006, 17, 637–647.
    • (2006) J. Am. Soc. Nephrol , vol.17 , pp. 637-647
    • Boca, M.1    Distefano, G.2    Qian, F.3    Bhunia, A.K.4    Germino, G.G.5    Boletta, A.6
  • 66
    • 0037133954 scopus 로고    scopus 로고
    • PKD1 induces p21(Waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
    • Bhunia, A.K.; Piontek, K.; Boletta, A.; Liu, L.; Qian, F.; Xu, P.N.; Germino, F.J.; Germino, G.G. PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 2002, 109, 157–168.
    • (2002) Cell , vol.109 , pp. 157-168
    • Bhunia, A.K.1    Piontek, K.2    Boletta, A.3    Liu, L.4    Qian, F.5    Xu, P.N.6    Germino, F.J.7    Germino, G.G.8
  • 69
    • 65449176538 scopus 로고    scopus 로고
    • Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1
    • Distefano, G.; Boca, M.; Rowe, I.; Wodarczyk, C.; Ma, L.; Piontek, K.B.; Germino, G.G.; Pandolfi, P.P.; Boletta, A. Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol. Cell Biol. 2009, 29, 2359–2371.
    • (2009) Mol. Cell Biol , vol.29 , pp. 2359-2371
    • Distefano, G.1    Boca, M.2    Rowe, I.3    Wodarczyk, C.4    Ma, L.5    Piontek, K.B.6    Germino, G.G.7    Pandolfi, P.P.8    Boletta, A.9
  • 70
    • 51749085397 scopus 로고    scopus 로고
    • Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha
    • Liang, G.; Yang, J.; Wang, Z.; Li, Q.; Tang, Y.; Chen, X.Z. Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha. Hum. Mol. Genet. 2008, 17, 3254–3262.
    • (2008) Hum. Mol. Genet , vol.17 , pp. 3254-3262
    • Liang, G.1    Yang, J.2    Wang, Z.3    Li, Q.4    Tang, Y.5    Chen, X.Z.6
  • 73
    • 0037205429 scopus 로고    scopus 로고
    • Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins
    • Parnell, S.C.; Magenheimer, B.S.; Maser, R.L.; Zien, C.A.; Frischauf, A.M.; Calvet, J.P. Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins. J. Biol. Chem. 2002, 277, 19566–19572.
    • (2002) J. Biol. Chem , vol.277 , pp. 19566-19572
    • Parnell, S.C.1    Magenheimer, B.S.2    Maser, R.L.3    Zien, C.A.4    Frischauf, A.M.5    Calvet, J.P.6
  • 74
    • 34948834648 scopus 로고    scopus 로고
    • Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion
    • Boca, M.; D’Amato, L.; Distefano, G.; Polishchuk, R.S.; Germino, G.G.; Boletta, A. Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion. Mol. Biol. Cell 2007, 18, 4050–4061.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 4050-4061
    • Boca, M.1    D’Amato, L.2    Distefano, G.3    Polishchuk, R.S.4    Germino, G.G.5    Boletta, A.6
  • 75
    • 29744470060 scopus 로고    scopus 로고
    • Polycystin-1, STAT6, and p100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease
    • Low, S.H.; Vasanth, S.; Larson, C.H.; Mukherjee, S.; Sharma, N.; Kinter, M.T.; Kane, M.E.; Obara, T.; Weimbs, T. Polycystin-1, STAT6, and p100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev. Cell 2006, 10, 57–69.
    • (2006) Dev. Cell , vol.10 , pp. 57-69
    • Low, S.H.1    Vasanth, S.2    Larson, C.H.3    Mukherjee, S.4    Sharma, N.5    Kinter, M.T.6    Kane, M.E.7    Obara, T.8    Weimbs, T.9
  • 80
    • 0036175934 scopus 로고    scopus 로고
    • The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells
    • Nickel, C.; Benzing, T.; Sellin, L.; Gerke, P.; Karihaloo, A.; Liu, Z.X.; Cantley, L.G.; Walz, G. The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. J. Clin. Investig. 2002, 109, 481–489.
    • (2002) J. Clin. Investig , vol.109 , pp. 481-489
    • Nickel, C.1    Benzing, T.2    Sellin, L.3    Gerke, P.4    Karihaloo, A.5    Liu, Z.X.6    Cantley, L.G.7    Walz, G.8
  • 81
    • 33644861926 scopus 로고    scopus 로고
    • Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells
    • Grimm, D.H.; Karihaloo, A.; Cai, Y.; Somlo, S.; Cantley, L.G.; Caplan, M.J. Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells. J. Biol. Chem. 2006, 281, 137–144.
    • (2006) J. Biol. Chem , vol.281 , pp. 137-144
    • Grimm, D.H.1    Karihaloo, A.2    Cai, Y.3    Somlo, S.4    Cantley, L.G.5    Caplan, M.J.6
  • 82
    • 84855952173 scopus 로고    scopus 로고
    • The gamma-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism
    • Merrick, D.; Chapin, H.; Baggs, J.E.; Yu, Z.; Somlo, S.; Sun, Z.; Hogenesch, J.B.; Caplan, M.J. The gamma-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism. Dev. Cell 2012, 22, 197–210.
    • (2012) Dev. Cell , vol.22 , pp. 197-210
    • Merrick, D.1    Chapin, H.2    Baggs, J.E.3    Yu, Z.4    Somlo, S.5    Sun, Z.6    Hogenesch, J.B.7    Caplan, M.J.8
  • 83
    • 84894581749 scopus 로고    scopus 로고
    • Impaired glomerulogenesis and endothelial cell migration in PKD1-deficient renal organ cultures
    • Rowe, I.; Chiaravalli, M.; Piontek, K.B.; Germino, G.G.; Boletta, A. Impaired glomerulogenesis and endothelial cell migration in PKD1-deficient renal organ cultures. Biochem. Biophys. Res. Commun. 2014, 444, 473–479.
    • (2014) Biochem. Biophys. Res. Commun , vol.444 , pp. 473-479
    • Rowe, I.1    Chiaravalli, M.2    Piontek, K.B.3    Germino, G.G.4    Boletta, A.5
  • 87
    • 34547604466 scopus 로고    scopus 로고
    • Cdc42 and noncanonical wnt signal transduction pathways cooperate to promote cell polarity
    • Schlessinger, K.; McManus, E.J.; Hall, A. Cdc42 and noncanonical wnt signal transduction pathways cooperate to promote cell polarity. J. Cell Biol. 2007, 178, 355–361.
    • (2007) J. Cell Biol , vol.178 , pp. 355-361
    • Schlessinger, K.1    McManus, E.J.2    Hall, A.3
  • 88
    • 5444257614 scopus 로고    scopus 로고
    • Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in drosophila
    • Harris, T.J.; Peifer, M. Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in drosophila. J. Cell Biol. 2004, 167, 135–147.
    • (2004) J. Cell Biol , vol.167 , pp. 135-147
    • Harris, T.J.1    Peifer, M.2
  • 89
    • 34247593781 scopus 로고    scopus 로고
    • APKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development
    • Harris, T.J.; Peifer, M. aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development. Dev. Cell 2007, 12, 727–738.
    • (2007) Dev. Cell , vol.12 , pp. 727-738
    • Harris, T.J.1    Peifer, M.2
  • 90
    • 80052153568 scopus 로고    scopus 로고
    • Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells
    • Steigelman, K.A.; Lelli, A.; Wu, X.; Gao, J.; Lin, S.; Piontek, K.; Wodarczyk, C.; Boletta, A.; Kim, H.; Qian, F.; et al. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J. Neurosci. 2011, 31, 12241–12250.
    • (2011) J. Neurosci , vol.31 , pp. 12241-12250
    • Steigelman, K.A.1    Lelli, A.2    Wu, X.3    Gao, J.4    Lin, S.5    Piontek, K.6    Wodarczyk, C.7    Boletta, A.8    Kim, H.9    Qian, F.10
  • 91
    • 84938800652 scopus 로고    scopus 로고
    • Mechanosensory genes PKD1 and PKD2 contribute to the planar polarization of brain ventricular epithelium
    • Ohata, S.; Herranz-Pérez, V.; Nakatani, J.; Boletta, A.; García-Verdugo, J.; Álvarez-Buylla, A. Mechanosensory genes PKD1 and PKD2 contribute to the planar polarization of brain ventricular epithelium. J. Neurosci. 2015, 35, 11153–11168.
    • (2015) J. Neurosci , vol.35 , pp. 11153-11168
    • Ohata, S.1    Herranz-Pérez, V.2    Nakatani, J.3    Boletta, A.4    García-Verdugo, J.5    Álvarez-Buylla, A.6
  • 92
    • 70349906831 scopus 로고    scopus 로고
    • Planar cell polarity and the kidney
    • McNeill, H. Planar cell polarity and the kidney. J. Am. Soc. Nephrol. 2009, 20, 2104–2111.
    • (2009) J. Am. Soc. Nephrol , vol.20 , pp. 2104-2111
    • McNeill, H.1
  • 97
    • 84859863721 scopus 로고    scopus 로고
    • Disruption of ift complex a causes cystic kidneys without mitotic spindle misorientation
    • Jonassen, J.A.; SanAgustin, J.; Baker, S.P.; Pazour, G.J. Disruption of ift complex a causes cystic kidneys without mitotic spindle misorientation. J. Am. Soc. Nephrol. 2012, 23, 641–651.
    • (2012) J. Am. Soc. Nephrol , vol.23 , pp. 641-651
    • Jonassen, J.A.1    Sanagustin, J.2    Baker, S.P.3    Pazour, G.J.4
  • 98
    • 78149237338 scopus 로고    scopus 로고
    • The planar cell polarity gene vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation
    • Yates, L.L.; Papakrivopoulou, J.; Long, D.A.; Goggolidou, P.; Connolly, J.O.; Woolf, A.S.; Dean, C.H. The planar cell polarity gene vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum. Mol. Genet. 2010, 19, 4663–4676.
    • (2010) Hum. Mol. Genet , vol.19 , pp. 4663-4676
    • Yates, L.L.1    Papakrivopoulou, J.2    Long, D.A.3    Goggolidou, P.4    Connolly, J.O.5    Woolf, A.S.6    Dean, C.H.7
  • 100
  • 101
    • 44349116202 scopus 로고    scopus 로고
    • Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia
    • Patel, V.; Li, L.; Cobo-Stark, P.; Shao, X.; Somlo, S.; Lin, F.; Igarashi, P. Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum. Mol. Genet. 2008, 17, 1578–1590.
    • (2008) Hum. Mol. Genet , vol.17 , pp. 1578-1590
    • Patel, V.1    Li, L.2    Cobo-Stark, P.3    Shao, X.4    Somlo, S.5    Lin, F.6    Igarashi, P.7


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