Polycystin-1 is a cardiomyocyte mechanosensor that governs L-type Ca2+ channel protein stability

Circulation

Volumn 131, Issue 24, 2015, Pages 2131-2142

  Pedrozo, Zully ^a,c,d   Criollo, Alfredo ^a,c   Battiprolu, Pavan K ^a   Morales, Cyndi R ^a   Contreras Ferrat, Ariel ^c   Fernández, Carolina ^c   Jiang, Nan ^a   Luo, Xiang ^a   Caplan, Michael J ^e   Somlo, Stefan ^e   Rothermel, Beverly A ^a,b   Gillette, Thomas G ^a   Lavandero, Sergio ^a,c,d   Hill, Joseph A ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF CHILE   (Chile)

^d UNIVERSITY OF CHILE   (Chile)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiomegaly; Cellular; Mechanotransduction

Indexed keywords

CALCIUM CHANNEL L TYPE; POLYCYSTIN 1; BIOLOGICAL MARKER; HYBRID PROTEIN; HYPOTONIC SOLUTION; L-TYPE CALCIUM CHANNEL ALPHA(1C); POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CELL ENGINEERING; CELL GROWTH; CONTROLLED STUDY; HEART FUNCTION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MECHANICAL STRESS; MECHANOTRANSDUCTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; RAT; ANIMAL; BIOSYNTHESIS; CARDIOMEGALY; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; FIBROSIS; GENETICS; HYPERTROPHY; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN TERTIARY STRUCTURE; RNA INTERFERENCE; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; BIOMARKERS; CALCIUM CHANNELS, L-TYPE; CARDIOMEGALY; CELLS, CULTURED; FIBROSIS; HYPERTROPHY; HYPOTONIC SOLUTIONS; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, KNOCKOUT; MYOCYTES, CARDIAC; PROTEIN INTERACTION MAPPING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; STRESS, MECHANICAL; TRPP CATION CHANNELS;

EID: 84936119043     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.013537     Document Type: Article

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