Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

Molecular Cell

Volumn 6, Issue 5, 2000, Pages 1267-1273

  Boletta, Alessandra ^a   Qian, Feng ^a   Onuchic, Luiz F ^a   Bhunia, Anil K ^a   Phakdeekitcharoen, Bunyong ^a   Hanaoka, Kazushige ^a   Guggino, William ^a   Monaco, Lucia ^b   Germino, Gregory G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; POLYCYSTIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL PROLIFERATION; CONTROLLED STUDY; DOG; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; KIDNEY CELL CULTURE; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE; NONHUMAN; PHENOTYPE; TISSUE DIFFERENTIATION;

EID: 0033635231     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00123-4     Document Type: Article

References (21)

1. Hereditary polycystic kidney disease (adult form): A microdissection study of two cases at an early stage of the disease
2. Epithelial hyperplasia in human polycystic kidney diseases. Its role in pathogenesis and risk of neoplasia
3. Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease
4. The polycystic kidney disease gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16
5. Autosomal dominant polycystic kidney disease
6. Polycystin: In vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein
7. Renal cyst formation and multifocal neoplasia in transgenic mice carrying the simian virus 40 early region
8. Bcl-2 overexpression prevents apoptosis-induced Madin-Darby canine kidney simple epithelia cyst formation
9. Perinatal lethality with kidney and pancreas defects in mice with a targetted PKD1 mutation
10. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
11. Expression of recombinant human granulocyte colony-stimulating factor in CHO dhfr- cells: New insights into the in vitro amplification expression system
12. Identification of a fibroblast-derived epithelial morphogen as hepathocyte growth factor
13. New insights into the molecular pathophysiology of polycystic kidney disease
14. Proliferative activity of cyst epithelium in human renal cystic diseases
15. The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I
16. PKD1 interacts with PKD2 through a probable coiled-coil domain
17. An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors
18. C-myc as an inducer of polycystic kidney disease in transgenic mice
19. Bcl-2-deficient mice demonstrate fulminant lymphoyd apoptosis, polycystic kidneys, and hypopigmanted hair
20. Deregulation of cell survival in cystic and dysplastic renal development
21. Apoptosis and loss of renal tissue in polycystic kidney diseases