Loss of oriented cell division does not initiate cyst formation

Journal of the American Society of Nephrology

Volumn 21, Issue 2, 2010, Pages 295-302

  Nishio, Saori ^a   Tian, Xin ^a   Gallagher, Anna Rachel ^a   Yu, Zhiheng ^a   Patel, Vishal ^b   Igarashi, Peter ^b   Somlo, Stefan ^a,c  

^a Internal Medicine   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROCYSTIN; POLYCYSTIN 1; POLYCYSTIN 2; CELL SURFACE RECEPTOR; PKHD1 PROTEIN, MOUSE; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIC KIDNEY DISEASE 2 PROTEIN; POLYCYSTIN;

ANAPHASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL LOSS; DISEASE COURSE; GENE MUTATION; KIDNEY CYST; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE; MITOSIS; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; ANIMAL; CELL POLARITY; DISEASE MODEL; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIVISION; CELL POLARITY; DISEASE MODELS, ANIMAL; KIDNEY TUBULES; MICE; MICE, TRANSGENIC; MUTATION; POLYCYSTIC KIDNEY DISEASES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRPP CATION CHANNELS;

EID: 77949361893     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2009060603     Document Type: Article

References (32)

1. Harris PC, Torres VE: Polycystic kidney disease. Annu Rev Med 60: 321-337, 2009
2. Taulman P, Haycraft C, Balkovetz D, Yoder B: Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol Biol Cell 12: 589-599, 2001
3. Sun Z, Amsterdam A, Pazour GJ, Cole DG, Miller MS, Hopkins N: A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 131: 4085-4093, 2004
4. Hou X, Mrug M, Lefkowitz E, Yoder B, D'Eustachio P, Beier D, Guay-Woodford L: Cystin, a novel cilial-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Am Soc Nephrol 109: 533-540, 2002
5. Lin F, Hiesberger T, Cordes K, Sinclair AM, Goldstein LS, Somlo S, Igarashi P: Kidney-specific inactivation of the KIF3A subunit of kine-sin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci USA 100: 5286-5291, 2003
6. Li A, Davila S, Furu L, Qian Q, Tian X, Kamath PS, King BF, Torres VE, Somlo S: Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease. Am J Hum Genet 72: 691-703, 2003
7. Davila S, Furu L, Gharavi AG, Tian X, Onoe T, Qian Q, Li A, Cai Y, Kamath PS, King BF, Azurmendi PJ, Tahvanainen P, Kaariainen H, Hockerstedt K, Devuyst O, Pirson Y, Martin RS, Lifton RP, Tahvanainen E, Torres VE, Somlo S: Mutations in SEC63 cause autosomal dominant polycystic liver disease. Nat Genet 36: 575-577, 2004
8. Kishimoto N, Cao Y, Park A, Sun Z: Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev Cell 14: 954-961, 2008
9. Simons M, Mlodzik M: Planar cell polarity signaling: From fly development to human disease. Annu Rev Genet 42: 517-540, 2008
10. Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Kronig C, Schermer B, Benzing T, Cabello OA, Jenny A, Mlodzik M, Polok B, Driever W, Obara T, Walz G: Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet 37: 537-543, 2005
11. Germino GG: Linking cilia to Wnts. Nat Genet 37: 455-457, 2005
12. Gong Y, Mo C, Fraser SE: Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 430: 689-693, 2004
13. Fischer E, Legue E, Doyen A, Nato F, Nicolas JF, Torres V, Yaniv M, Pontoglio M: Defective planar cell polarity in polycystic kidney disease. Nat Genet 38: 21-23, 2006
14. Patel V, Li L, Cobo-Stark P, Shao X, Somlo S, Lin F, Igarashi P: Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet 17: 1578-1590, 2008
15. Saburi S, Hester I, Fischer E, Pontoglio M, Eremina V, Gessler M, Quaggin SE, Harrison R, Mount R, McNeill H: Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet 40: 1010-1015, 2008
16. Gallagher A, Esquivel E, Briere T, Tian X, Mitobe M, Menezes L, Markowitz G, Jain D, Onuchic L, Somlo S: Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1. Am J Pathol 172: 417-429, 2008
17. Williams S, Cobo-Stark P, James L, Somlo S, Igarashi P: Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease. Pediatr Nephrol 23: 733-741, 2008
18. Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S: Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 17: 1505-1516, 2008
19. Forde A, Constien R, Grone HJ, Hammerling G, Arnold B: Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements. Genesis 33: 191-197, 2002
20. Guo C, Yang W, Lobe CG: A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis 32: 8-18, 2002
21. Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG: A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med 13: 1490-1495, 2007
22. Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ: Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 41: 793-799, 2009
23. Garcia-Gonzalez M, Menezes L, Piontek K, Kaimori J, Huso D, Watnick T, Onuchic L, Guay-Woodford L, Germino G: Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet 16: 1940-1950, 2007
24. Ciruna B, Jenny A, Lee D, Mlodzik M, Schier AF: Planar cell polarity signalling couples cell division and morphogenesis during neurula-tion. Nature 439: 220-224, 2006
25. Qian F, Watnick TJ, Onuchic LF, Germino GG: The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. Cell 87: 979-987, 1996
26. Moser M, Matthiesen S, Kirfel J, Schorle H, Bergmann C, Senderek J, Rudnik-Schoneborn S, Zerres K, Buettner R: A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD). Hepatology 41: 1113-1121, 2005
27. Woollard J, Punyashtiti R, Richardson S, Masyuk T, Whelan S, Huang B, Lager D, vanDeursen J, Torres V, Gattone V, LaRusso N, Harris P, Ward C: A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation. Kidney Int 72: 328-336, 2007
28. Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP: A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136: 161-171, 2009
29. Lantinga-van Leeuwen IS, Leonhard WN, van der Wal A, Breuning MH, de Heer E, Peters DJ: Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet 16: 3188-3196, 2007
30. Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochi-zuki T: Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. J Clin Invest 115: 910-918, 2005
31. Takakura A, Contrino L, Zhou X, Bonventre JV, Sun Y, Humphreys BD, Zhou J: Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet 18: 2523-2531, 2009
32. Happe H, Leonhard WN, van der Wal A, van de Water B, Lantinga-van Leeuwen IS, Breuning MH, de Heer E, Peters DJ: Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. Hum Mol Genet 18: 2532-2542, 2009