A Post-translational Metabolic Switch Enables Complete Decoupling of Bacterial Growth from Biopolymer Production in Engineered Escherichia coli

ACS Synthetic Biology

Volumn 7, Issue 11, 2018, Pages 2686-2697

  Durante Rodríguez, Gonzalo ^a   De Lorenzo, Víctor ^b   Nikel, Pablo I ^c  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^c Chalmers University of Technology   (Denmark)

Author keywords

Escherichia coli; metabolic engineering; pathway engineering; PHB; proteolysis; synthetic biology

Indexed keywords

ACETYL COENZYME A; BACTERIAL ENZYME; BIOPOLYMER; GLUCOSE; GREEN FLUORESCENT PROTEIN; POLY(3 HYDROXYBUTYRIC ACID); PROTEASOME; 3-KETOACID COA-TRANSFERASE; COENZYME A TRANSFERASE; ESCHERICHIA COLI PROTEIN; HYDROXYBUTYRIC ACID; POLY-BETA-HYDROXYBUTYRATE; POLYESTER;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; BIOTECHNOLOGICAL PRODUCTION; CARBON SOURCE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ESCHERICHIA COLI; FLOW CYTOMETRY; GENE CLUSTER; GENE SWITCHING; GLUCOSE INTAKE; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN PROCESSING; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PROCEDURES;

ACETYL COENZYME A; COENZYME A-TRANSFERASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROXYBUTYRATES; METABOLIC ENGINEERING; POLYESTERS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS;

EID: 85055682023     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.8b00345     Document Type: Article

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