NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

Cell

Volumn 175, Issue 2, 2018, Pages 488-501.e22

  Lahaye, Xavier ^a   Gentili, Matteo ^a   Silvin, Aymeric ^a   Conrad, Cécile ^a   Picard, Léa ^b,c   Jouve, Mabel ^a   Zueva, Elina ^a   Maurin, Mathieu ^a   Nadalin, Francesca ^a   Knott, Gavin J ^d   Zhao, Baoyu ^e   Du, Fenglei ^e   Rio, Marlène ^f,g   Amiel, Jeanne ^f,g   Fox, Archa H ^d,h   Li, Pingwei ^e   Etienne, Lucie ^b   Bond, Charles S ^d   Colleaux, Laurence ^f,g   Manel, Nicolas ^a  

^a PSL RESEARCH UNIVERSITY   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITÉ LYON 1   (France)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e TEXAS A AND M UNIVERSITY   (United States)

^f INSERM   (France)

^g HÔPITAL NECKER ENFANTS MALADES   (France)

^h PATHWEST LABORATORY MEDICINE   (Australia)

Author keywords

capsid; cGAS; dendritic cells; HIV 1; HIV 2; innate immune sensors; innate immunity; macrophages; NONO; STING

Indexed keywords

CAPSID PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; CYCLIC GMP AMP SYNTHASE; NONO PROTEIN; NUCLEOTIDYLTRANSFERASE; UNCLASSIFIED DRUG; VIRUS DNA; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; NONO PROTEIN, HUMAN; NUCLEAR MATRIX PROTEIN; OCTAMER TRANSCRIPTION FACTOR; RNA BINDING PROTEIN;

ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CELL NUCLEUS; ENZYME ACTIVATION; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IMMUNOREGULATION; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; VIRUS ESCAPE MUTATION; VIRUS MUTATION; DENDRITIC CELL; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; MACROPHAGE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; VIRUS CAPSID;

CAPSID; CAPSID PROTEINS; CELL NUCLEUS; DENDRITIC CELLS; DNA, VIRAL; HIV INFECTIONS; HIV-1; HIV-2; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; MACROPHAGES; MEMBRANE PROTEINS; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEOTIDYLTRANSFERASES; OCTAMER TRANSCRIPTION FACTORS; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 85054455225     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.08.062     Document Type: Article

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