HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response

Molecular Cell

Volumn 67, Issue 3, 2017, Pages 387-399.e5

  Morchikh, Mehdi ^a   Cribier, Alexandra ^a   Raffel, Raoul ^a   Amraoui, Sonia ^c   Cau, Julien ^a,d   Severac, Dany ^b   Dubois, Emeric ^b   Schwartz, Olivier ^c   Bennasser, Yamina ^a   Benkirane, Monsef ^a  

^a UNIV MONTPELLIER   (France)

^b Montpellier Genomics and Bioinformatics Facility   (France)

^c CNRS   (France)

^d University of Montpellier   (France)

Author keywords

cGAS; DNA PK; herpesvirus; HEXIM1; innate immune response; interferon stimulatory DNA; NEAT1; paraspeckles

Indexed keywords

CGAS PROTEIN; DNA; DNAPKC PROTEIN; INTERFERON REGULATORY FACTOR 3; KU ANTIGEN; KU80 PROTEIN; LONG NON CODING RNA HEXIM1; LONG NON CODING RNA NEAT1; LONG UNTRANSLATED RNA; MATRIN3 PROTEIN; NONO PROTEIN; PQBP1 PROTEIN; PSPC1 PROTEIN; RBM14 PROTEIN; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; SFPQ PROTEIN; STING PROTEIN; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; CIB1 PROTEIN, HUMAN; HEXIM1 PROTEIN, HUMAN; IRF3 PROTEIN, HUMAN; MATR3 PROTEIN, HUMAN; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; NEAT1 LONG NON-CODING RNA, HUMAN; NONO PROTEIN, HUMAN; NUCLEAR MATRIX PROTEIN; NUCLEAR PROTEIN; NUCLEOTIDYLTRANSFERASE; OCTAMER TRANSCRIPTION FACTOR; PROTEIN BINDING; PSPC1 PROTEIN, HUMAN; PTB ASSOCIATED SPLICING FACTOR; RBM14 PROTEIN, HUMAN; SIGNAL PEPTIDE; XRCC5 PROTEIN, HUMAN; XRCC6 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOPRECIPITATION; INNATE IMMUNITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN SECRETION; PROTEIN SUBUNIT; RNA SEQUENCE; SIGNAL TRANSDUCTION; SILVER STAINING; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; RNA INTERFERENCE; UMBILICAL VEIN ENDOTHELIAL CELL; VIROLOGY;

CALCIUM-BINDING PROTEINS; DNA; HEK293 CELLS; HELA CELLS; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KU AUTOANTIGEN; MEMBRANE PROTEINS; MULTIPROTEIN COMPLEXES; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; NUCLEOTIDYLTRANSFERASES; OCTAMER TRANSCRIPTION FACTORS; PROTEIN BINDING; PTB-ASSOCIATED SPLICING FACTOR; RNA INTERFERENCE; RNA, LONG NONCODING; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 85023596684     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.06.020     Document Type: Article

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