HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

Nature

Volumn 536, Issue 7616, 2016, Pages 349-353

  Jacques, David A ^a   McEwan, William A ^a   Hilditch, Laura ^b   Price, Amanda J ^a,c   Towers, Greg J ^b   James, Leo C ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BENZENE DERIVATIVE; HEXACARBOXYBENZENE; NUCLEOTIDE; UNCLASSIFIED DRUG; VIRUS DNA; BENZOIC ACID DERIVATIVE; MELLITIC ACID;

AMINO ACID; BENZENE; DNA; ELECTRIC FIELD; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; INFECTIVITY; NUCLEIC ACID; PORE SPACE; PROTEIN;

ARTICLE; BINDING AFFINITY; CHANNEL GATING; CONTROLLED STUDY; DIFFUSION; DISSOCIATION; DNA SYNTHESIS; GENETIC CONSERVATION; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRINAE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; VIRUS CAPSID; VIRUS INFECTIVITY; ACTIVE TRANSPORT; BINDING COMPETITION; BIOSYNTHESIS; CHEMISTRY; DNA REPLICATION; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEK293 CELL LINE; HELA CELL LINE; HUMAN; KINETICS; METABOLISM; MOLECULAR MODEL; POROSITY;

HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE;

ARGININE; BENZOATES; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT, ACTIVE; CAPSID; DIFFUSION; DNA REPLICATION; DNA, VIRAL; HEK293 CELLS; HELA CELLS; HIV-1; HUMANS; KINETICS; MODELS, MOLECULAR; NUCLEOTIDES; POROSITY; REVERSE TRANSCRIPTION;

EID: 84983288654     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature19098     Document Type: Article

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