The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells

PLoS Pathogens

Volumn 11, Issue 5, 2015, Pages

  Shingai, Masashi ^a   Welbourn, Sarah ^a   Brenchley, Jason M ^a   Acharya, Priyamvada ^a   Miyagi, Eri ^a   Plishka, Ronald J ^a   Buckler White, Alicia ^a   Kwong, Peter D ^a   Nishimura, Yoshiaki ^a   Strebel, Klaus ^a   Martin, Malcolm A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; PEPTIDES AND PROTEINS; PHYCOERYTHRIN; UNCLASSIFIED DRUG; VIRUS RNA; VPX PROTEIN; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; SAMHD1 PROTEIN, HUMAN; VIRAL PROTEIN; VPX PROTEIN, SIMIAN IMMUNODEFICIENCY VIRUS;

ARTICLE; CD4+ T LYMPHOCYTE; CELL LINEAGE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPHENOTYPING; NONHUMAN; PHENOTYPE; POINT MUTATION; PROTEIN DEGRADATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHESUS MONKEY; SAMHD1 GENE; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIREMIA; VIRION; AMINO ACID SUBSTITUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; GENE DELETION; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PROTEIN PROCESSING; SIMIAN IMMUNODEFICIENCY VIRUS; VIROLOGY;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 2; MACACA; MACACA MULATTA; SIMIAN IMMUNODEFICIENCY VIRUS;

AMINO ACID SUBSTITUTION; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; GENE DELETION; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOLOGIC MEMORY; MACACA MULATTA; MONOMERIC GTP-BINDING PROTEINS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; POINT MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; RECOMBINANT PROTEINS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIREMIA;

EID: 84930350499     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004928     Document Type: Article

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