CGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

Nature

Volumn 549, Issue 7672, 2017, Pages 394-398

  Andreeva, Liudmila ^a   Hiller, Björn ^a   Kostrewa, Dirk ^a   Lässig, Charlotte ^a   De Oliveira Mann, Carina C ^a,c   Jan Drexler, David ^a   Maiser, Andreas ^a   Gaidt, Moritz ^a   Leonhardt, Heinrich ^a,b   Hornung, Veit ^a,b   Hopfner, Karl Peter ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b Munich Center for Integrated Protein Science   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP AMP SYNTHASE; DIMER; DNA; HIGH MOBILITY GROUP B1 PROTEIN; HOST FACTOR; HU PROTEIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; SYNTHETASE; UNCLASSIFIED DRUG; CYCLIC GUANOSINE MONOPHOSPHATE-ADENOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE; DNA BINDING PROTEIN; HIGH MOBILITY GROUP B PROTEIN; HIGH MOBILITY GROUP PROTEIN; MB21D1 PROTEIN, HUMAN; MB21D1 PROTEIN, MOUSE; MITOCHONDRIAL PROTEIN; NUCLEOTIDYLTRANSFERASE; TFAM PROTEIN, HUMAN; TFAM PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ACTIVATION ENERGY; BACTERIUM; CELLS AND CELL COMPONENTS; CHEMICAL BINDING; GENETIC ANALYSIS; IMMUNE RESPONSE; MITOCHONDRIAL DNA; MOLECULAR ANALYSIS; PATHOGEN; PROTEIN;

ARTICLE; DNA STRUCTURE; ENUCLEATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN STRUCTURE; ANIMAL; CELL LINE; CHEMISTRY; CONFORMATION; FEMALE; METABOLISM; MOLECULAR MODEL; MOUSE; PROTEIN MULTIMERIZATION;

BACTERIA (MICROORGANISMS);

ANIMALS; CELL LINE; DNA; DNA-BINDING PROTEINS; FEMALE; HIGH MOBILITY GROUP PROTEINS; HMGB PROTEINS; HUMANS; MICE; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEOTIDES, CYCLIC; NUCLEOTIDYLTRANSFERASES; PROTEIN MULTIMERIZATION; TRANSCRIPTION FACTORS;

EID: 85029768412     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature23890     Document Type: Article

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