Cyclocarya paliurus leaves tea improves dyslipidemia in diabetic mice: A lipidomics-based network pharmacology study

Frontiers in Pharmacology

Volumn 9, Issue AUG, 2018, Pages

  Zhai, Lixiang ^a   Ning, Zi Wan ^a   Huang, Tao ^a   Wen, Bo ^a   Liao, Cheng Hui ^a   Lin, Cheng Yuan ^a   Zhao, Ling ^a   Xiao, Hai Tao ^b   Bian, Zhao Xiang ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b Shenzhen University   (China)

Author keywords

Cyclocarya paliurus; Diabetic dyslipidemia; Hyperlipidemia; Lipidomic; Network pharmacology

Indexed keywords

AGENTS AFFECTING METABOLISM; ALOX12 PROTEIN; APP PROTEIN; CHOLESTEROL; CHOLESTEROL ESTER; CYCLOCARYA PALIURUS EXTRACT; CYTOCHROME P450 2C9; DIACYLGLYCEROL; GLIBENCLAMIDE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PLA2G(S) PROTEIN; PLANT EXTRACT; PLD2 PROTEIN; PROTEIN; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; SPHINGOMYELIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; CYCLOCARYA PALIURUS; DIABETES MELLITUS; DYSLIPIDEMIA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL; JUGLANDACEAE; LIPIDOMICS; LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL; MAPK SIGNALING; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PI3K/AKT SIGNALING; PLANT LEAF; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 85052818119     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2018.00973     Document Type: Article

References (52)

1. Andriankaja, O. M., and Joshipura, K. (2014). Potential association between prediabetic conditions and gingival and/or periodontal inflammation. J. Diabetes Investig. 5, 108-114. doi: 10.1111/jdi.12122
2. Association, A. D. (2015). Standards of medical care in diabetes-2015 abridged for primary care providers. Clin. Diabetes 33, 97-111. doi: 10.2337/diaclin.33.2.97
3. Bachleda, P., Vrzal, R., and Dvorák, Z. (2009). Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes. Gen. Physiol. Biophys. 28, 316-320. doi: 10.4149/gpb_2009_03_316
4. Beger, R. D., Dunn, W., Schmidt, M. A., Gross, S. S., Kirwan, J. A., Cascante, M., et al. (2016). Metabolomics enables precision medicine:"a white paper, community perspective.". Metabolomics 12:149. doi: 10.1007/s11306-016-1094-6
5. Bradley, R. M., Marvyn, P. M., Henao, J. J. A., Mardian, E. B., George, S., Aucoin, M. G., et al. (2015). Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Biochim. Biophys. Acta 1851, 1566-1576. doi: 10.1016/j.bbalip.2015.09.005
6. De Chiara, G., Marcocci, M. E., Torcia, M., Lucibello, M., Rosini, P., Bonini, P., et al. (2006). Bcl-2 phosphorylation by p38 MAPK Identification of target sites and biologic consequences. J. Biol. Chem. 281, 21353-21361. doi: 10.1074/jbc.M511052200
7. Dixit, A. K., Dey, R., Suresh, A., Chaudhuri, S., Panda, A. K., Mitra, A., et al. (2014). The prevalence of dyslipidemia in patients with diabetes mellitus of ayurveda Hospital. J. Diabetes Metab. Disord. 13:58. doi: 10.1186/2251-6581-13-58
8. Grab, L. T., Kearns, M. W., Morris, A. J., and Daniel, L. W. (2004). Differential role for phospholipase D1 and phospholipase D2 in 12-O-tetradecanoyl-13-phorbol acetate-stimulated MAPK activation, Cox-2 and IL-8 expression. Biochim. Biophys. Acta 1636, 29-39. doi: 10.1016/j.bbalip.2003.12.002
9. Gregory, K. E., Bird, S. S., Gross, V. S., Marur, V. R., Lazarev, A. V., Walker, W. A., et al. (2013). Method development for fecal lipidomics profiling. Anal. Chem. 85, 1114-1123. doi: 10.1021/ac303011k
10. Guo, C., Yang, R.-J., Jang, K., Zhou, X., and Liu, Y. (2017). Protective effects of pretreatment with quercetin against lipopolysaccharide-induced apoptosis and the inhibition of osteoblast differentiation via the mapk and wnt/β-catenin pathways in MC3T3-E1 cells. Cell. Physiol. Biochem. 43, 1547-1561. doi: 10.1159/000481978
11. Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., et al. (2017). Systems biology guided by XCMS Online metabolomics. Nat. Methods 14, 461-462. doi: 10.1038/nmeth.4260
12. Huang, T., Mi, H., Lin, C., Zhao, L., Zhong, L. L. D., Liu, F., et al. (2017). MOST: most-similar ligand based approach to target prediction. BMC Bioinformatics 18:165. doi: 10.1186/s12859-017-1586-z
13. Huang, T., Ning, Z., Hu, D., Zhang, M., Zhao, L., Lin, C., et al. (2018). Uncovering the mechanisms of Chinese Herbal Medicine (MaZiRenWan) for functional constipation by focused network pharmacology approach. Front. Pharmacol. 9:270. doi: 10.3389/fphar.2018.00270
14. Jiang, C., Wang, Q., Wei, Y., Yao, N., Wu, Z., Ma, Y., et al. (2015). Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus leave in hyperlipidemic mice. J. Ethnopharmacol. 176, 17-26. doi: 10.1016/j.jep.2015.10.006
15. Jiang, C., Yao, N., Wang, Q., Zhang, J., Sun, Y., Xiao, N., et al. (2014). Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice. J. Ethnopharmacol. 153, 344-351. doi: 10.1016/j.jep.2014.02.003
16. Jung, U. J., and Choi, M.-S. (2014). Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int. J. Mol. Sci. 15, 6184-6223. doi: 10.3390/ijms15046184
17. Kasumov, T., Li, L., Li, M., Gulshan, K., Kirwan, J. P., Liu, X., et al. (2015). Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis. PLoS One 10:e0126910. doi: 10.1371/journal.pone.0126910
18. Kurihara, H., Asami, S., Shibata, H., Fukami, H., and Tanaka, T. (2003). Hypolipemic Effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice. Biol. Pharm. Bull. 26, 383-385. doi: 10.1248/bpb.26.383
19. Li, S., Fan, T.-P., Jia, W., Lu, A., and Zhang, W. (2014). Network pharmacology in traditional chinese medicine. Evid. Based Complement. Altern. Med. 2014:138460. doi: 10.1155/2014/138460
20. Lin, Z., Wu, Z.-F., Jiang, C.-H., Zhang, Q.-W., Ouyang, S., Che, C.-T., et al. (2016). The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. Phytomedicine 23, 1475-1483. doi: 10.1016/j.phymed.2016.08.003
21. Ling, A. V., Gearing, M. E., Semova, I., Shin, D.-J., Clements, R., Lai, Z. W., et al. (2017). FoxO1 is required for most of the metabolic and hormonal perturbations produced by hepatic insulin receptor deletion in male mice. Endocrinology 159, 1253-1263. doi: 10.1210/en.2017-00870
22. Ma, Y., Jiang, C., Yao, N., Li, Y., Wang, Q., Fang, S., et al. (2015). Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice. J. Ethnopharmacol. 166, 286-296. doi: 10.1016/j.jep.2015.03.030
23. Niebergall, L. J., Jacobs, R. L., Chaba, T., and Vance, D. E. (2011). Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. Biochim. Biophys. Acta 1811, 1177-1185. doi: 10.1016/j.bbalip.2011.06.021
24. Parhofer, K. G. (2015). Interaction between glucose and lipid metabolism: more than diabetic dyslipidemia. Diabetes Metab. J. 39, 353-362. doi: 10.4093/dmj.2015.39.5.353
25. Payne, F., Lim, K., Girousse, A., Brown, R. J., Kory, N., Robbins, A., et al. (2014). Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease. Proc. Natl. Acad. Sci. U.S.A. 111, 8901-8906. doi: 10.1073/pnas.1408523111
26. Perry, R. J., Samuel, V. T., Petersen, K. F., and Shulman, G. I. (2014). The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510, 84-91. doi: 10.1038/nature13478
27. Rahmani, M., Aust, M. M., Attkisson, E., Williams, D. C. J., Ferreira-Gonzalez, A., and Grant, S. (2013). Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3-and Bim-dependent mechanism. Cancer Res. 73, 1340-1351. doi: 10.1158/0008-5472.CAN-12-1365
28. Ramachandran, V., and Saravanan, R. (2015). Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats. Hum. Exp. Toxicol. 34, 884-893. doi: 10.1177/0960327114561663
29. Richhariya, A., Fox, K. M., Punekar, R. S., Gandra, S. R., Fisher, M. D., Cziraky, M. J., et al. (2015). Gender Differences in Recurrent Cardiovascular Events Among High-risk Patients With Hyperlipidemia. Circ. Cardiovasc. Qual. Outcomes 8:A307. doi: 10.1161/circoutcomes.8.suppl_2.307
30. Rosenson, R. S., Brewer, H. B. Jr., Ansell, B. J., Barter, P., Chapman, M. J., Heinecke, J. W., et al. (2016). Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat. Rev. Cardiol. 13, 48-60. doi: 10.1038/nrcardio.2015.124
31. Sattar, N., Preiss, D., Robinson, J. G., Djedjos, C. S., Elliott, M., Somaratne, R., et al. (2016). Lipid-lowering efficacy of the PCSK9 inhibitor evolocumab (AMG 145) in patients with type 2 diabetes: a meta-analysis of individual patient data. Lancet Diabetes Endocrinol. 4, 403-410. doi: 10.1016/S2213-8587(16)00003-6
32. Spence, J. D., Urquhart, B. L., and Bang, H. (2016). Effect of renal impairment on atherosclerosis: only partially mediated by homocysteine. Nephrol. Dial. Transplant. 31, 937-944. doi: 10.1093/ndt/gfv380
33. Stern, C., and Castera, L. (2017). Non-invasive diagnosis of hepatic steatosis. Hepatol. Int. 11, 70-78. doi: 10.1007/s12072-016-9772-z
34. Sugiyama, M., Banno, R., Mizoguchi, A., Tominaga, T., Tsunekawa, T., Onoue, T., et al. (2017). PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions. Biochem. Biophys. Res. Commun. 488, 116-121. doi: 10.1016/j.bbrc.2017.05.019
35. Szczepaniak, L. S., Nurenberg, P., Leonard, D., Browning, J. D., Reingold, J. S., Grundy, S., et al. (2005). Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am. J. Physiol. Metab. 288, E462-E468. doi: 10.1152/ajpendo.00064.2004
36. Szklarczyk, D., Franceschini, A., Wyder, S., Forslund, K., Heller, D., Huerta-Cepas, J., et al. (2014). STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43, D447-D452. doi: 10.1093/nar/gku1003
37. Wang, Q., Jiang, C., Fang, S., Wang, J., Ji, Y., Shang, X., et al. (2013). Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. J. Ethnopharmacol. 150, 1119-1127. doi: 10.1016/j.jep.2013.10.040
38. Wang, X., Zhang, A., Sun, H., and Han, Y. (2017). "Integrated serum pharmacochemistry of TCM and metabolomics strategies for innovative drug discovery," in Serum Pharmacochemistry of Traditional Chinese Medicine, eds X. Wang, A. Zhang, and H. Sun (New York, NY: Elsevier), 15-21
39. Wang, Z., Xie, J., Yang, Y., Zhang, F., Wang, S., Wu, T., et al. (2017). Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice. Sci. Rep. 7:40402. doi: 10.1038/srep40402
40. Wouters, K., van Gorp, P. J., Bieghs, V., Gijbels, M. J., Duimel, H., Lütjohann, D., et al. (2008). Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48, 474-486. doi: 10.1002/hep.22363
41. Wu, Z., Gao, T., Zhong, R., Lin, Z., Jiang, C., Ouyang, S., et al. (2017). Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats. Pharm. Biol. 55, 712-721. doi: 10.1080/13880209.2016.1267231
42. Xia, J., Sinelnikov, I. V., Han, B., and Wishart, D. S. (2015). MetaboAnalyst 3.0-making metabolomics more meaningful. Nucleic Acids Res. 43, W251-W257. doi: 10.1093/nar/gkv380
43. Xiao, H., Wen, B., Ning, Z., Zhai, L., Liao, C., Lin, C., et al. (2017). Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis. Sci. Rep. 7:9155. doi: 10.1038/s41598-017-09641-z
44. Xu, G., Yoshitomi, H., Sun, W., Guo, X., Wu, L., Guo, X., et al. (2017). Cyclocarya paliurus (Batal.) Ijinskaja aqueous extract (CPAE) ameliorates obesity by improving insulin signaling in the hypothalamus of a metabolic syndrome rat model. Evid. Based Complement. Altern. Med. 2017:4602153. doi: 10.1155/2017/4602153
45. Yan, G., Wang, X., Zhang, A., Shi, H., Zhou, Y., and Sun, H. (2017). "Serum pharmacochemistry of TCM for determining the active ingredients of shuanghuanglian formulae," in Serum Pharmacochemistry of Traditional Chinese Medicine, eds X. Wang, A. Zhang, and H. Sun (New York, NY: Elsevier), 155-169. doi: 10.1016/B978-0-12-811147-5.00011-X
46. Yang, Z.-W., Ouyang, K.-H., Zhao, J., Chen, H., Xiong, L., and Wang, W.-J. (2016). Structural characterization and hypolipidemic effect of Cyclocarya paliurus polysaccharide in rat. Int. J. Biol. Macromol. 91, 1073-1080. doi: 10.1016/j.ijbiomac.2016.06.063
47. Yao, X., Lin, Z., Jiang, C., Gao, M., Wang, Q., Yao, N., et al. (2015). Cyclocarya paliurus prevents high fat diet induced hyperlipidemia and obesity in Sprague-Dawley rats. Can. J. Physiol. Pharmacol. 93, 677-686. doi: 10.1139/cjpp-2014-0477
48. Yoshitomi, H., Tsuru, R., Li, L., Zhou, J., Kudo, M., Liu, T., et al. (2017). Cyclocarya paliurus extract activates insulin signaling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion. PLoS One 12:e0183988. doi: 10.1371/journal.pone.0183988
49. Zafrir, B., and Jain, M. (2014). Lipid-lowering therapies, glucose control and incident diabetes: evidence, mechanisms and clinical implications. Cardiovasc. Drugs Ther. 28, 361-377. doi: 10.1007/s10557-014-6534-9
50. Zhang, P., Xu, D., Wang, S., Fu, H., Wang, K., Zou, Y., et al. (2011). Inhibition of aldehyde dehydrogenase 2 activity enhances antimycin-induced rat cardiomyocytes apoptosis through activation of MAPK signaling pathway. Biomed. Pharmacother. 65, 590-593. doi: 10.1016/j.biopha.2009.12.001
51. Zhao, J., O'Donnell, V. B., Balzar, S., Croix, C. M. S., Trudeau, J. B., and Wenzel, S. E. (2011). 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 108, 14246-14251. doi: 10.1073/pnas.1018075108
52. Zhao, X., Zheng, X., Fan, T.-P., Li, Z., Zhang, Y., and Zheng, J. (2015). A novel drug discovery strategy inspired by traditional medicine philosophies. Science 347, S38-S40