Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model

Evidence-based Complementary and Alternative Medicine

Volumn 2017, Issue , 2017, Pages

  Xu, Guangyuan ^a   Yoshitomi, Hisae ^b   Sun, Wen ^a   Guo, Xuan ^a   Wu, Lili ^a   Guo, Xiangyu ^a   Qin, Lingling ^a   Fan, Yixin ^a   Xu, Tunhai ^a   Liu, Tonghua ^a   Gao, Ming ^b  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOBESITY AGENT; CHOLESTEROL; CYCLOCARYA PALIURUS EXTRACT; FATTY ACID; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; GLUTATHIONE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MALONALDEHYDE; NEUROPEPTIDE Y; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE P85; PLANT EXTRACT; PROOPIOMELANOCORTIN; PROTEIN KINASE B; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMICAL ANALYSIS; BODY MASS; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYCLOCARYA PALIURUS; DRUG MECHANISM; ENZYME BLOOD LEVEL; FAT MASS; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT; HYPOTHALAMUS; INSULIN BLOOD LEVEL; MALE; MEDICINAL PLANT; METABOLIC SYNDROME X; NONHUMAN; OBESITY; ORGAN WEIGHT; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WEIGHT REDUCTION;

EID: 85021631953     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2017/4602153     Document Type: Article

References (42)

1. K. F. Adams, A. Schatzkin, T. B. Harris et al., "Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old,"The New England Journal ofMedicine, vol. 355, no. 8, pp. 763-778, 2006.
2. M. Ng, T. Fleming, M. Robinson, and et al, "Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013," The Lancet, vol. 384, no. 9945, pp. 766-781, 2014.
3. J. O. Hill, H. R. Wyatt, and J. C. Peters, "Energy balance and obesity," Circulation, vol. 126, no. 1, pp. 126-132, 2012.
4. M. K. Olsen, H. Johannessen, N. Cassie et al., "Steady-state energy balance in animal models of obesity and weight loss," Scandinavian Journal ofGastroenterology, vol. 52, no. 4, pp. 442-449, 2016.
5. A. P. Coll, I. S. Farooqi, B. G. Challis, G. S. H. Yeo, and S. O'Rahilly, "Proopiomelanocortin and energy balance: insights from human and murine genetics," Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2557-2562, 2004.
6. H.-R. Berthoud, "Metabolic and hedonic drives in the neural control of appetite: who is the boss?" Current Opinion in Neurobiology, vol. 21, no. 6, pp. 888-896, 2011.
7. D. Nuzzaci, A. Laderrière, A. Lemoine et al., "Plasticity of the melanocortin system: determinants and possible consequences on food intake," Frontiers in Endocrinology, vol. 6, 2015.
8. V. Y. Susanti, T. Sasaki, H. Yokota-Hashimoto et al., "Sirt1 rescues the obesity induced by insulin-resistant constitutivelynuclear FoxO1 in POMC neurons of male mice," Obesity, vol. 22, no. 10, pp. 2115-2119, 2014.
9. G. A. Bewick, J. V. Gardiner,W. S.Dhillo et al., "Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype," FASEB Journal, vol. 19, no. 12, pp. 1680-1682, 2005.
10. R. Stark, A. Reichenbach, and Z. B. Andrews, "Hypothalamic carnitine metabolism integrates nutrient and hormonal feedback to regulate energy homeostasis," Molecular and Cellular Endocrinology, vol. 418, pp. 9-16, 2015.
11. J. Havrankova, J. Roth, and M. Brownstein, "Insulin receptors are widely distributed in the central nervous system of the rat," Nature, vol. 272, no. 5656, pp. 827-829, 1978.
12. A. C. Hausen, J. Ruud, H. Jiang et al., "Insulin-dependent activation of mch neurons impairs locomotor activity and insulin sensitivity in obesity," Cell Reports, vol. 17, no. 10, pp. 2512-2521, 2016.
13. T. Kitamura, "Obesity and the central regulation of energy metabolism," Nihon Rinsho, vol. 71, no. 2, pp. 217-223, 2013.
14. K. D. Niswender, C. D.Morrison, D. J. Clegg et al., "Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia," Diabetes, vol. 52, no. 2, pp. 227-231, 2003.
15. M. F. M. Hoekman, F. M. J. Jacobs, M. P. Smidt, and J. P. H. Burbach, "Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain," Gene Expression Patterns, vol. 6, no. 2, pp. 134-140, 2006.
16. Y. Jeon, S. Aja, G. V. Ronnett, and E.-K. Kim, "D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway," Biochemical and Biophysical Research Communications, vol. 470, no. 4, pp. 818-823, 2016.
17. R. Chruvattil, S. Banerjee, S. Nath et al., "Dexamethasone alters the appetite regulation via induction of hypothalamic insulin resistance in rat brain," Molecular Neurobiology, pp. 1-14.
18. L. Plum, H. V. Lin, K. S. Aizawa, Y. Liu, and D. Accili, "InsR/ FoxO1 signaling curtails hypothalamic POMC neuron number," PLoS ONE, vol. 7, no. 2, Article ID e31487, 2012.
19. K. Iskandar, Y. Cao, Y. Hayashi et al., "PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake," American Journal of Physiology-Endocrinology andMetabolism, vol. 298, no. 4, pp. E787-E798, 2010.
20. H.-J. Kim, M. Kobayashi, T. Sasaki et al., "Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance," Endocrinology, vol. 153, no. 2, pp. 659-671, 2012.
21. S. A.He, Chinese Rare Plants Shanghai, vol. 19, Shanghai Science and Technology Press, Shanghai, China, 1988.
22. Plant Index Editorial Committee of the Chinese Academy of Science, The Plant Index of China, vol. 23, Scientific Press, Beijing, China, 1979.
23. Q.Wang, C. Jiang, S. Fang et al., "Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats," Journal of Ethnopharmacology, vol. 150, no. 3, pp. 1119-1127, 2013.
24. K. Wang and Y. Cao, "Research progress in the chemical constituents and pharmacologic activities of Cyclocaryapaliurus (Batal.) Iljinshaja," Heilongjiang Medical Journal, vol. 31, pp. 577-579, 2007.
25. C. Jiang, N. Yao, Q. Wang et al., "Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice," Journal of Ethnopharmacology, vol. 153, no. 2, pp. 344-351, 2014.
26. Y. Ma, C. Jiang, N. Yao et al., "Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice," Journal of Ethnopharmacology, vol. 166, pp. 286-296, 2015.
27. K. N. Zhu, C. H. Jiang, Y. S. Tian et al., "Two triterpeniods fromCyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: the relationship to AMPK activation," Phytomedicine, vol. 22, no. 9, pp. 837-846, 2015.
28. K. Kawai, T. Sakairi, S. Harada et al., "Diet modification and its influence on metabolic and related pathological alterations in the SHR/NDmcr-cp rat, an animal model of the metabolic syndrome," Experimental and Toxicologic Pathology, vol. 64, no. 4, pp. 333-338, 2012.
29. J.-H. Xie, M.-Y. Xie, S.-P.Nie, M.-Y. Shen, Y.-X.Wang, and C. Li, "Isolation, chemical composition and antioxidant activities of a water-soluble polysaccharide from Cyclocarya paliurus (Batal.) Iljinskaja," Food Chemistry, vol. 119, no. 4, pp. 1626-1632, 2010.
30. J.-H. Xie, M.-Y. Xie, M.-Y. Shen, S.-P. Nie, C. Li, and Y.-X. Wang, "Optimisation of microwave-assisted extraction of polysaccharides from Cyclocarya paliurus (Batal.) Iljinskaja using response surface methodology," Journal of the Science of Food and Agriculture, vol. 90, no. 8, pp. 1353-1360, 2010.
31. D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner, "Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man," Diabetologia, vol. 28, no. 7, pp. 412-419, 1985.
32. L. C.Cantley, "The phosphoinositide 3-kinase pathway," Science, vol. 296, no. 5573, pp. 1655-1657, 2002.
33. M. Sata and R. Nagai, "Phosphatidylinositol 3-kinase: a key regulator of vascular tone?" Circulation Research, vol. 91, no. 4, pp. 273-275, 2002.
34. M.-S. Kim, Y. K. Pak, P.-G. Jang et al., "Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis," Nature Neuroscience, vol. 9, no. 7, pp. 901-906, 2006.
35. G. R. Hajer, T. W. Van Haeften, and F. L. J. Visseren, "Adipose tissue dysfunction in obesity, diabetes, and vascular diseases," European Heart Journal, vol. 29, no. 24, pp. 2959-2971, 2008.
36. G. J. Morton, D. E. Cummings, D. G. Baskin, G. S. Barsh, and M.W. Schwartz, "Central nervous system control of food intake and body weight," Nature, vol. 443, no. 7109, pp. 289-295, 2006.
37. M. Thon, T. Hosoi, and K. Ozawa, "Possible integrative actions of leptin and insulin signaling in the hypothalamus targeting energy homeostasis," Frontiers in Endocrinology, vol. 7, 2016.
38. J.-W. Sohn, "Network of hypothalamic neurons that control appetite," BMB Reports, vol. 48, no. 4, pp. 229-233, 2015.
39. L. Shanshan, Z. Cuizhen, P. Gang et al., "Effects of starvation on the expression of feeding related neuropeptides in the larval zebrafish hypothalamus," Yi Chuan, vol. 38, no. 9, pp. 821-830, 2016.
40. H.V. Lin, L. Plum, H. Ono et al., "Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons," Diabetes, vol. 59, no. 2, pp. 337-346, 2010.
41. X.Guan, "TheCNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis,"American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 307, no. 6, pp. R585-R596, 2014.
42. E. Burgos-Ramos, Á. González-Rodríguez, S. Canelles et al., "Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide y and proopiomelanocortin expression in nondiabetic and diabetic IRS2 -/- mice," Endocrinology, vol. 153, no. 3, pp. 1129-1140, 2012.