Integrated Serum Pharmacochemistry of TCM and Metabolomics Strategies for Innovative Drug Discovery

Serum Pharmacochemistry of Traditional Chinese Medicine: Technologies, Strategies and Applications

Volumn , Issue , 2017, Pages 15-21

  Wang, Xijun ^a   Zhang, Aihua ^a   Sun, Hui ^a   Han, Ying ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Chinmedomics; Combination therapies; Kidney yang deficiency syndrome; Metabolomics; SPT; TCM; TCM efficacy

Indexed keywords

EID: 85027280304     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-811147-5.00003-0     Document Type: Chapter

References (20)

1. Cai S.Q., Wang X., Shang M.Y., Xu F., Liu G.X. "Efficacy Theory" may help to explain characteristic advantages of traditional Chinese medicines. Zhongguo Zhong Yao Za Zhi 2015, 40(17):3435-3443.
2. Cao H., Zhang A., Zhang H., Sun H., Wang X. The application of metabolomics in traditional Chinese medicine opens up a dialogue between Chinese and Western medicine. Phytother. Res. 2015, 29(2):159-166.
3. Chen J., Zhou J., Wei S., Xie Z., Wen C., Xu G. Effect of a traditional Chinese medicine prescription Quzhuotongbi decoction on hyperuricemia model rats studied by using serum metabolomics based on gas chromatography-mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2015, 1026:272-278. pii:S1570-0232(15) 30250-6.
4. Chu H., Zhang A., Han Y., Lu S., Kong L., Han J., Liu Z., Sun H., Wang X. Metabolomics approach to explore the effects of Kai-Xin-San on Alzheimer's disease using UPLC/ESI-Q-TOF mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2016, 1015-1016:50-61.
5. 1H NMR metabolomics. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2016, 1026:87-96. pii:S1570-0232(16) 30046-0.
6. Lu C., Zhao X., Li Y., Li Y., Yuan C., Xu F., Meng X., Hou L., Xu G. Serum metabolomics study of traditional Chinese medicine formula intervention to polycystic ovary syndrome. J. Pharm. Biomed. Anal. 2016, 120:127-133.
7. Nan Y., Zhou X., Liu Q., Zhang A., Guan Y., Lin S., Kong L., Han Y., Wang X. Serum metabolomics strategy for understanding pharmacological effects of ShenQi pill acting on kidney yang deficiency syndrome. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2015, 1026:217-226. pii:S1570-0232(15) 30328-7.
8. Tang F., Tang Q., Tian Y., Fan Q., Huang Y., Tan X. Network pharmacology-based prediction of the active ingredients and potential targets of Mahuang Fuzi Xixin decoction for application to allergic rhinitis. J. Ethnopharmacol. 2015, 176:402-412.
9. Thompson P.A., Shpall E.J., Keating M.J. Shifting paradigms in the treatment of chronic lymphocytic leukemia. Future Oncol. 2015, 11(4):641-657.
10. Tian J.S., Peng G.J., Wu Y.F., Zhou J.J., Xiang H., Gao X.X., Zhou Y.Z., Qin X.M., Du G.H. A GC-MS urinary quantitative metabolomics analysis in depressed patients treated with TCM formula of Xiaoyaosan. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2015, 1026:227-235. pii:S1570-0232(15) 30352-4.
11. Wang X., Zhang A., Wang P., Sun H., Wu G., Sun W., Lv H., Jiao G., Xu H., Yuan Y., Liu L., Zou D., Wu Z., Han Y., Yan G., Dong W., Wu F., Dong T., Yu Y., Zhang S., Wu X., Tong X., Meng X. Metabolomics coupled with proteomics advancing drug discovery toward more agile development of targeted combination therapies. Mol. Cell Proteom. 2013, 12(5):1226-2338.
12. Wang X., Wang Q., Zhang A., Zhang F., Zhang H., Sun H., Cao H., Zhang H. Metabolomics study of intervention effects of Wen-Xin-Formula using ultra high-performance liquid chromatography/mass spectrometry coupled with pattern recognition approach. J. Pharm. Biomed. Anal. 2013, 74:22-30.
13. Xie B., Zhang Z., Gong T., Zhang N., Wang H., Zou H. Application of metabonomic strategy to discover an unreported active ingredient in LiuWeiDiHuang pills suppressing beta-glucuronidase. Anal. Bioanal. Chem. 2015, 407(2):609-614.
14. Yang Z., Hou J.J., Qi P., Yang M., Yan B.P., Bi Q.R., Feng R.H., Yang W.Z., Wu W.Y., Guo D.A. Colon-derived uremic biomarkers induced by the acute toxicity of Kansui radix: a metabolomics study of rat plasma and intestinal contents by UPLC-QTOF-MSE. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2015, 1026:193-203. pii:S1570-0232(15) 30197-5.
15. Zhang A., Sun H., Qiu S., Wang X. Advancing drug discovery and development from active constituents of yinchenhao tang, a famous traditional chinese medicine formula. Evid. Based Complement Alternat. Med. 2013, 2013.
16. Zhang H., Fu P., Ke B., Wang S., Li M., Han L., Peng C., Zhang W., Liu R. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang. J. Ethnopharmacol. 2014, 154(1):55-64.
17. Zhang A.H., Sun H., Yan G.L., Wang P., Han Y., Wang X.J. Chinmedomics: a new strategy for research of traditional Chinese medicine. Zhongguo Zhong Yao Za Zhi 2015, 40(4):569-576.
18. Zhang Y., Mao X., Guo Q., Bai M., Zhang B., Liu C., Sun Y., Li S., Lin N. Pathway of PPAR-gamma coactivators in thermogenesis: a pivotal traditional Chinese medicine-associated target for individualized treatment of rheumatoid arthritis. Oncotarget 2016, 10.18632/oncotarget.7419.
19. Zhang A., Yan G., Zhou X., Wang Y., Han Y., Guan Y., Sun H., Wang X. High resolution metabolomics technology reveals widespread pathway changes of alcoholic liver disease. Mol. Biosyst. 2016, 12(1):262-273.
20. Zhang A., Liu Q., Zhao H., Zhou X., Sun H., Nan Y., Zou S., Ma C.W., Wang X. Phenotypic characterization of nanshi oral liquid alters metabolic signatures during disease prevention. Sci. Rep. 2016, 6:19333.