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Volumn 159, Issue 3, 2018, Pages 1253-1263

FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; CHOLINE ETHANOLAMINE PHOSPHOTRANSFERASE 1; CHOLINE KINASE; CRE RECOMBINASE; DIACYLGLYCEROL; GLUCOSE; GLUCOSE 6 PHOSPHATASE; INSULIN; INSULIN RECEPTOR; LEPTIN; LEPTIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; FATTY ACID; LIPID; TRIACYLGLYCEROL;

EID: 85042639298     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2017-00870     Document Type: Article
Times cited : (23)

References (54)
  • 1
    • 33645982255 scopus 로고    scopus 로고
    • From mice to men: Insights into the insulin resistance syndromes
    • Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol. 2006;68(1):123-158.
    • (2006) Annu Rev Physiol. , vol.68 , Issue.1 , pp. 123-158
    • Biddinger, S.B.1    Kahn, C.R.2
  • 2
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell. 2000;6(1):87-97.
    • (2000) Mol Cell. , vol.6 , Issue.1 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3    Previs, S.F.4    Shulman, G.I.5    Magnuson, M.A.6    Kahn, C.R.7
  • 5
    • 84929148324 scopus 로고    scopus 로고
    • Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo
    • Titchenell PM, Chu Q, Monks BR, Birnbaum MJ. Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo. Nat Commun. 2015;6:7078.
    • (2015) Nat Commun. , vol.6 , pp. 7078
    • Titchenell, P.M.1    Chu, Q.2    Monks, B.R.3    Birnbaum, M.J.4
  • 7
    • 34548175209 scopus 로고    scopus 로고
    • High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice
    • Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem. 2007; 282(32): 23672-23678
    • (2007) J Biol Chem. , vol.282 , Issue.32 , pp. 23672-23678
    • Cohen, S.E.1    Kokkotou, E.2    Biddinger, S.B.3    Kondo, T.4    Gebhardt, R.5    Kratzsch, J.6    Mantzoros, C.S.7    Kahn, C.R.8
  • 8
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    • Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008;8(1):65-76.
    • (2008) Cell Metab. , vol.8 , Issue.1 , pp. 65-76
    • Dong, X.C.1    Copps, K.D.2    Guo, S.3    Li, Y.4    Kollipara, R.5    DePinho, R.A.6    White, M.F.7
  • 12
    • 78149272381 scopus 로고    scopus 로고
    • FoxOs function synergistically to promote glucose production
    • Haeusler RA, Kaestner KH, Accili D. FoxOs function synergistically to promote glucose production. J Biol Chem. 2010;285(46): 35245-35248.
    • (2010) J Biol Chem. , vol.285 , Issue.46 , pp. 35245-35248
    • Haeusler, R.A.1    Kaestner, K.H.2    Accili, D.3
  • 13
    • 84855427221 scopus 로고    scopus 로고
    • Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia
    • Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, Accili D. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab. 2012;15(1):65-74.
    • (2012) Cell Metab. , vol.15 , Issue.1 , pp. 65-74
    • Haeusler, R.A.1    Pratt-Hyatt, M.2    Welch, C.L.3    Klaassen, C.D.4    Accili, D.5
  • 14
    • 84862909028 scopus 로고    scopus 로고
    • Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
    • Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology. 2012;153(2):631-646.
    • (2012) Endocrinology. , vol.153 , Issue.2 , pp. 631-646
    • Zhang, K.1    Li, L.2    Qi, Y.3    Zhu, X.4    Gan, B.5    DePinho, R.A.6    Averitt, T.7    Guo, S.8
  • 16
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37(8):911-917.
    • (1959) Can J Biochem Physiol. , vol.37 , Issue.8 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 19
    • 0035794211 scopus 로고    scopus 로고
    • Modulation of circulating leptin levels by its soluble receptor
    • Huang L, Wang Z, Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem. 2001;276(9):6343-6349.
    • (2001) J Biol Chem. , vol.276 , Issue.9 , pp. 6343-6349
    • Huang, L.1    Wang, Z.2    Li, C.3
  • 20
    • 0034801977 scopus 로고    scopus 로고
    • Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors
    • Maamra M, Bidlingmaier M, Postel-Vinay MC,Wu Z, Strasburger CJ, Ross RJ. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology. 2001;142(10):4389-4393.
    • (2001) Endocrinology. , vol.142 , Issue.10 , pp. 4389-4393
    • Maamra, M.1    Bidlingmaier, M.2    Postel-Vinay, M.C.3    Wu, Z.4    Strasburger, C.J.5    Ross, R.J.6
  • 21
    • 0036792050 scopus 로고    scopus 로고
    • Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
    • Yabe D, Brown MS, Goldstein JL. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA. 2002;99(20):12753-12758.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , Issue.20 , pp. 12753-12758
    • Yabe, D.1    Brown, M.S.2    Goldstein, J.L.3
  • 22
    • 0037453007 scopus 로고    scopus 로고
    • Liverspecific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
    • Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS. Liverspecific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci USA. 2003;100(6): 3155-3160.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , Issue.6 , pp. 3155-3160
    • Yabe, D.1    Komuro, R.2    Liang, G.3    Goldstein, J.L.4    Brown, M.S.5
  • 24
    • 0041948340 scopus 로고    scopus 로고
    • Profound changes in the gh-igf-i system in adolescent girls with iddm: Can igfbp1 be used to reflect overall glucose regulation
    • Halldin MU, Hagenäs L, Tuvemo T, Gustafsson J. Profound changes in the GH-IGF-I system in adolescent girls with IDDM: can IGFBP1 be used to reflect overall glucose regulation Pediatr Diabetes. 2000;1(3):121-130.
    • (2000) Pediatr Diabetes , vol.1 , Issue.3 , pp. 121-130
    • Halldin, M.U.1    Hagenäs, L.2    Tuvemo, T.3    Gustafsson, J.4
  • 25
    • 0027447079 scopus 로고
    • Serum levels of growth hormone-binding protein and insulin-like growth factor i in children and adolescents with type 1 (insulindependent) diabetes mellitus
    • Massa G, Dooms L, Bouillon R, Vanderschueren-Lodeweyckx M. Serum levels of growth hormone-binding protein and insulin-like growth factor I in children and adolescents with type 1 (insulindependent) diabetes mellitus. Diabetologia. 1993;36(3):239-243.
    • (1993) Diabetologia. , vol.36 , Issue.3 , pp. 239-243
    • Massa, G.1    Dooms, L.2    Bouillon, R.3    Vanderschueren-Lodeweyckx, M.4
  • 26
    • 85018351007 scopus 로고    scopus 로고
    • Skeletal growth and bone mineral acquisition in type 1 diabetic children; Abnormalities of the gh/igf-1 axis
    • Raisingani M, Preneet B, Kohn B, Yakar S. Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis. Growth Horm IGF Res. 2017;34:13-21.
    • (2017) Growth Horm IGF Res. , vol.34 , pp. 13-21
    • Raisingani, M.1    Preneet, B.2    Kohn, B.3    Yakar, S.4
  • 29
    • 77955458427 scopus 로고    scopus 로고
    • Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor
    • Lou PH, Yang G, Huang L, Cui Y, Pourbahrami T, Radda GK, Li C, Han W. Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. PLoS One. 2010;5(7):e11669.
    • (2010) PLoS One. , vol.5 , Issue.7 , pp. e11669
    • Lou, P.H.1    Yang, G.2    Huang, L.3    Cui, Y.4    Pourbahrami, T.5    Radda, G.K.6    Li, C.7    Han, W.8
  • 30
    • 37349060346 scopus 로고    scopus 로고
    • Soluble receptor inhibits leptin transport
    • Tu H, Kastin AJ, Hsuchou H, Pan W. Soluble receptor inhibits leptin transport. J Cell Physiol. 2008;214(2):301-305.
    • (2008) J Cell Physiol. , vol.214 , Issue.2 , pp. 301-305
    • Tu, H.1    Kastin, A.J.2    Hsuchou, H.3    Pan, W.4
  • 31
    • 2542450776 scopus 로고    scopus 로고
    • Modulation of direct leptin signaling by soluble leptin receptor
    • Yang G, Ge H, Boucher A, Yu X, Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol. 2004;18(6): 1354-1362.
    • (2004) Mol Endocrinol. , vol.18 , Issue.6 , pp. 1354-1362
    • Yang, G.1    Ge, H.2    Boucher, A.3    Yu, X.4    Li, C.5
  • 32
    • 85019649050 scopus 로고    scopus 로고
    • Roles of diacylglycerols and ceramides in hepatic insulin resistance
    • Petersen MC, Shulman GI. Roles of diacylglycerols and ceramides in hepatic insulin resistance. Trends Pharmacol Sci. 2017;38(7): 649-665.
    • (2017) Trends Pharmacol Sci. , vol.38 , Issue.7 , pp. 649-665
    • Petersen, M.C.1    Shulman, G.I.2
  • 37
    • 84884562454 scopus 로고    scopus 로고
    • Glycerol-3-phosphate acyltransferase (gpat)-1, but not gpat4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation
    • Wendel AA, Cooper DE, Ilkayeva OR, Muoio DM, Coleman RA. Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation. J Biol Chem. 2013;288(38): 27299-27306.
    • (2013) J Biol Chem. , vol.288 , Issue.38 , pp. 27299-27306
    • Wendel, A.A.1    Cooper, D.E.2    Ilkayeva, O.R.3    Muoio, D.M.4    Coleman, R.A.5
  • 38
    • 67349112100 scopus 로고    scopus 로고
    • Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis
    • Wendel AA, Lewin TM, Coleman RA. Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis. Biochim Biophys Acta. 2009;1791(6):501-506.
    • (2009) Biochim Biophys Acta. , vol.1791 , Issue.6 , pp. 501-506
    • Wendel, A.A.1    Lewin, T.M.2    Coleman, R.A.3
  • 39
    • 77956244443 scopus 로고    scopus 로고
    • Hepatic foxo1 ablation exacerbates lipid abnormalities during hyperglycemia
    • Haeusler RA, Han S, Accili D. Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia. J Biol Chem. 2010; 285(35):26861-26868.
    • (2010) J Biol Chem. , vol.285 , Issue.35 , pp. 26861-26868
    • Haeusler, R.A.1    Han, S.2    Accili, D.3
  • 41
    • 70349324370 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    • HottaY,NakamuraH,Konishi M,Murata Y, TakagiH,Matsumura S, Inoue K, Fushiki T, Itoh N. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology. 2009;150(10): 4625-4633.
    • (2009) Endocrinology. , vol.150 , Issue.10 , pp. 4625-4633
    • Hotta, Y.1    Nakamura, H.2    Konishi, M.3    Murata, Y.4    Takagi, H.5    Matsumura, S.6    Inoue, K.7    Fushiki, T.8    Itoh, N.9
  • 42
    • 70349472910 scopus 로고    scopus 로고
    • Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
    • Li X, Ge H, Weiszmann J, Hecht R, Li YS, Véniant MM, Xu J, Wu X, Lindberg R, Li Y. Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice. FEBS Lett. 2009;583(19):3230-3234.
    • (2009) FEBS Lett. , vol.583 , Issue.19 , pp. 3230-3234
    • Li, X.1    Ge, H.2    Weiszmann, J.3    Hecht, R.4    Li, Y.S.5    Véniant, M.M.6    Xu, J.7    Wu, X.8    Lindberg, R.9    Li, Y.10
  • 43
    • 84867898251 scopus 로고    scopus 로고
    • Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress
    • Lond
    • Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y. Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress. Nutr Metab (Lond). 2012;9(1):94.
    • (2012) Nutr Metab , vol.9 , Issue.1 , pp. 94
    • Yang, C.1    Wang, C.2    Ye, M.3    Jin, C.4    He, W.5    Wang, F.6    McKeehan, W.L.7    Luo, Y.8
  • 45
    • 0023618690 scopus 로고
    • Studies of acute effects of insulin-like growth factors i and II in human fat cells
    • Bolinder J, Lindblad A, Engfeldt P, Arner P. Studies of acute effects of insulin-like growth factors I and II in human fat cells. J Clin Endocrinol Metab. 1987;65(4):732-737.
    • (1987) J Clin Endocrinol Metab. , vol.65 , Issue.4 , pp. 732-737
    • Bolinder, J.1    Lindblad, A.2    Engfeldt, P.3    Arner, P.4
  • 47
    • 0036864411 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins: Transcriptional activators of lipid synthesis
    • Horton JD. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans. 2002;30(6): 1091-1095.
    • (2002) Biochem Soc Trans. , vol.30 , Issue.6 , pp. 1091-1095
    • Horton, J.D.1
  • 48
    • 2142814381 scopus 로고    scopus 로고
    • Insig: A significant integrator of nutrient and hormonal signals
    • Attie AD. Insig: a significant integrator of nutrient and hormonal signals. J Clin Invest. 2004;113(8):1112-1114.
    • (2004) J Clin Invest. , vol.113 , Issue.8 , pp. 1112-1114
    • Attie, A.D.1
  • 53
    • 0032568557 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
    • Horton JD, Bashmakov Y, Shimomura I, Shimano H. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA. 1998;95(11):5987-5992.
    • (1998) Proc Natl Acad Sci USA. , vol.95 , Issue.11 , pp. 5987-5992
    • Horton, J.D.1    Bashmakov, Y.2    Shimomura, I.3    Shimano, H.4
  • 54


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.