-
1
-
-
33645982255
-
From mice to men: Insights into the insulin resistance syndromes
-
Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol. 2006;68(1):123-158.
-
(2006)
Annu Rev Physiol.
, vol.68
, Issue.1
, pp. 123-158
-
-
Biddinger, S.B.1
Kahn, C.R.2
-
2
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell. 2000;6(1):87-97.
-
(2000)
Mol Cell.
, vol.6
, Issue.1
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
Previs, S.F.4
Shulman, G.I.5
Magnuson, M.A.6
Kahn, C.R.7
-
3
-
-
38649110496
-
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
-
Biddinger SB, Hernandez-OnoA,Rask-Madsen C,Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, CareyMC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008;7(2):125-134.
-
(2008)
Cell Metab.
, vol.7
, Issue.2
, pp. 125-134
-
-
Biddinger, S.B.1
Hernandez-Ono, A.2
Rask-Madsen, C.3
Haas, J.T.4
Alemán, J.O.5
Suzuki, R.6
Scapa, E.F.7
Agarwal, C.8
Carey, M.C.9
Stephanopoulos, G.10
Cohen, D.E.11
King, G.L.12
Ginsberg, H.N.13
Kahn, C.R.14
-
4
-
-
84862023939
-
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression
-
Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV, Jr, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012;15(6): 873-884.
-
(2012)
Cell Metab.
, vol.15
, Issue.6
, pp. 873-884
-
-
Haas, J.T.1
Miao, J.2
Chanda, D.3
Wang, Y.4
Zhao, E.5
Haas, M.E.6
Hirschey, M.7
Vaitheesvaran, B.8
Farese, R.V.9
Kurland, I.J.10
Graham, M.11
Crooke, R.12
Foufelle, F.13
Biddinger, S.B.14
-
5
-
-
84929148324
-
Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo
-
Titchenell PM, Chu Q, Monks BR, Birnbaum MJ. Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo. Nat Commun. 2015;6:7078.
-
(2015)
Nat Commun.
, vol.6
, pp. 7078
-
-
Titchenell, P.M.1
Chu, Q.2
Monks, B.R.3
Birnbaum, M.J.4
-
6
-
-
84929190974
-
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization
-
O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG. FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nat Commun. 2015;6: 7079.
-
(2015)
Nat Commun.
, vol.6
, pp. 7079
-
-
O-Sullivan, I.1
Zhang, W.2
Wasserman, D.H.3
Liew, C.W.4
Liu, J.5
Paik, J.6
DePinho, R.A.7
Stolz, D.B.8
Kahn, C.R.9
Schwartz, M.W.10
Unterman, T.G.11
-
7
-
-
34548175209
-
High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice
-
Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem. 2007; 282(32): 23672-23678
-
(2007)
J Biol Chem.
, vol.282
, Issue.32
, pp. 23672-23678
-
-
Cohen, S.E.1
Kokkotou, E.2
Biddinger, S.B.3
Kondo, T.4
Gebhardt, R.5
Kratzsch, J.6
Mantzoros, C.S.7
Kahn, C.R.8
-
8
-
-
45549090182
-
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
-
Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008;8(1):65-76.
-
(2008)
Cell Metab.
, vol.8
, Issue.1
, pp. 65-76
-
-
Dong, X.C.1
Copps, K.D.2
Guo, S.3
Li, Y.4
Kollipara, R.5
DePinho, R.A.6
White, M.F.7
-
9
-
-
84857934301
-
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
-
Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR, Birnbaum MJ. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med. 2012;18(3):388-395.
-
(2012)
Nat Med.
, vol.18
, Issue.3
, pp. 388-395
-
-
Lu, M.1
Wan, M.2
Leavens, K.F.3
Chu, Q.4
Monks, B.R.5
Fernandez, S.6
Ahima, R.S.7
Ueki, K.8
Kahn, C.R.9
Birnbaum, M.J.10
-
10
-
-
33747047885
-
Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action
-
Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM. Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Diabetes. 2006;55(7):2042-2050.
-
(2006)
Diabetes.
, vol.55
, Issue.7
, pp. 2042-2050
-
-
Samuel, V.T.1
Choi, C.S.2
Phillips, T.G.3
Romanelli, A.J.4
Geisler, J.G.5
Bhanot, S.6
McKay, R.7
Monia, B.8
Shutter, J.R.9
Lindberg, R.A.10
Shulman, G.I.11
Veniant, M.M.12
-
11
-
-
80053927531
-
Postprandial hepatic lipid metabolism requires signaling through akt2 independent of the transcription factors foxa2, foxo1, and srebp1c
-
Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab. 2011;14(4):516-527.
-
(2011)
Cell Metab.
, vol.14
, Issue.4
, pp. 516-527
-
-
Wan, M.1
Leavens, K.F.2
Saleh, D.3
Easton, R.M.4
Guertin, D.A.5
Peterson, T.R.6
Kaestner, K.H.7
Sabatini, D.M.8
Birnbaum, M.J.9
-
12
-
-
78149272381
-
FoxOs function synergistically to promote glucose production
-
Haeusler RA, Kaestner KH, Accili D. FoxOs function synergistically to promote glucose production. J Biol Chem. 2010;285(46): 35245-35248.
-
(2010)
J Biol Chem.
, vol.285
, Issue.46
, pp. 35245-35248
-
-
Haeusler, R.A.1
Kaestner, K.H.2
Accili, D.3
-
13
-
-
84855427221
-
Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia
-
Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, Accili D. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab. 2012;15(1):65-74.
-
(2012)
Cell Metab.
, vol.15
, Issue.1
, pp. 65-74
-
-
Haeusler, R.A.1
Pratt-Hyatt, M.2
Welch, C.L.3
Klaassen, C.D.4
Accili, D.5
-
14
-
-
84862909028
-
Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
-
Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology. 2012;153(2):631-646.
-
(2012)
Endocrinology.
, vol.153
, Issue.2
, pp. 631-646
-
-
Zhang, K.1
Li, L.2
Qi, Y.3
Zhu, X.4
Gan, B.5
DePinho, R.A.6
Averitt, T.7
Guo, S.8
-
15
-
-
33846295218
-
FoxOs are lineagerestricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA. FoxOs are lineagerestricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 2007;128(2):309-323.
-
(2007)
Cell.
, vol.128
, Issue.2
, pp. 309-323
-
-
Paik, J.H.1
Kollipara, R.2
Chu, G.3
Ji, H.4
Xiao, Y.5
Ding, Z.6
Miao, L.7
Tothova, Z.8
Horner, J.W.9
Carrasco, D.R.10
Jiang, S.11
Gilliland, D.G.12
Chin, L.13
Wong, W.H.14
Castrillon, D.H.15
DePinho, R.A.16
-
16
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37(8):911-917.
-
(1959)
Can J Biochem Physiol.
, vol.37
, Issue.8
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
17
-
-
0348141022
-
The soluble leptin receptor is crucial for leptin action: Evidence from clinical and experimental data
-
Zastrow O, Seidel B, Kiess W, Thiery J, Keller E, Böttner A, Kratzsch J. The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data. Int J Obes Relat Metab Disord. 2003;27(12):1472-1478.
-
(2003)
Int J Obes Relat Metab Disord.
, vol.27
, Issue.12
, pp. 1472-1478
-
-
Zastrow, O.1
Seidel, B.2
Kiess, W.3
Thiery, J.4
Keller, E.5
Böttner, A.6
Kratzsch, J.7
-
18
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83(7):1263-1271.
-
(1995)
Cell.
, vol.83
, Issue.7
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
Deng, N.4
Culpepper, J.5
Devos, R.6
Richards, G.J.7
Campfield, L.A.8
Clark, F.T.9
Deeds, J.10
Muir, C.11
Sanker, S.12
Moriarty, A.13
Moore, K.J.14
Smutko, J.S.15
Mays, G.G.16
Wool, E.A.17
Monroe, C.A.18
Tepper, R.I.19
-
19
-
-
0035794211
-
Modulation of circulating leptin levels by its soluble receptor
-
Huang L, Wang Z, Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem. 2001;276(9):6343-6349.
-
(2001)
J Biol Chem.
, vol.276
, Issue.9
, pp. 6343-6349
-
-
Huang, L.1
Wang, Z.2
Li, C.3
-
20
-
-
0034801977
-
Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors
-
Maamra M, Bidlingmaier M, Postel-Vinay MC,Wu Z, Strasburger CJ, Ross RJ. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology. 2001;142(10):4389-4393.
-
(2001)
Endocrinology.
, vol.142
, Issue.10
, pp. 4389-4393
-
-
Maamra, M.1
Bidlingmaier, M.2
Postel-Vinay, M.C.3
Wu, Z.4
Strasburger, C.J.5
Ross, R.J.6
-
21
-
-
0036792050
-
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
-
Yabe D, Brown MS, Goldstein JL. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA. 2002;99(20):12753-12758.
-
(2002)
Proc Natl Acad Sci USA.
, vol.99
, Issue.20
, pp. 12753-12758
-
-
Yabe, D.1
Brown, M.S.2
Goldstein, J.L.3
-
22
-
-
0037453007
-
Liverspecific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
-
Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS. Liverspecific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci USA. 2003;100(6): 3155-3160.
-
(2003)
Proc Natl Acad Sci USA.
, vol.100
, Issue.6
, pp. 3155-3160
-
-
Yabe, D.1
Komuro, R.2
Liang, G.3
Goldstein, J.L.4
Brown, M.S.5
-
23
-
-
3342958797
-
The tsc1-2 tumor suppressor controls insulin-pi3k signaling via regulation of irs proteins
-
Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol. 2004;166(2):213-223.
-
(2004)
J Cell Biol.
, vol.166
, Issue.2
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
Gout, I.11
Downes, C.P.12
Lamb, R.F.13
-
24
-
-
0041948340
-
Profound changes in the gh-igf-i system in adolescent girls with iddm: Can igfbp1 be used to reflect overall glucose regulation
-
Halldin MU, Hagenäs L, Tuvemo T, Gustafsson J. Profound changes in the GH-IGF-I system in adolescent girls with IDDM: can IGFBP1 be used to reflect overall glucose regulation Pediatr Diabetes. 2000;1(3):121-130.
-
(2000)
Pediatr Diabetes
, vol.1
, Issue.3
, pp. 121-130
-
-
Halldin, M.U.1
Hagenäs, L.2
Tuvemo, T.3
Gustafsson, J.4
-
25
-
-
0027447079
-
Serum levels of growth hormone-binding protein and insulin-like growth factor i in children and adolescents with type 1 (insulindependent) diabetes mellitus
-
Massa G, Dooms L, Bouillon R, Vanderschueren-Lodeweyckx M. Serum levels of growth hormone-binding protein and insulin-like growth factor I in children and adolescents with type 1 (insulindependent) diabetes mellitus. Diabetologia. 1993;36(3):239-243.
-
(1993)
Diabetologia.
, vol.36
, Issue.3
, pp. 239-243
-
-
Massa, G.1
Dooms, L.2
Bouillon, R.3
Vanderschueren-Lodeweyckx, M.4
-
26
-
-
85018351007
-
Skeletal growth and bone mineral acquisition in type 1 diabetic children; Abnormalities of the gh/igf-1 axis
-
Raisingani M, Preneet B, Kohn B, Yakar S. Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis. Growth Horm IGF Res. 2017;34:13-21.
-
(2017)
Growth Horm IGF Res.
, vol.34
, pp. 13-21
-
-
Raisingani, M.1
Preneet, B.2
Kohn, B.3
Yakar, S.4
-
27
-
-
0033594893
-
Normal growth and development in the absence of hepatic insulin-like growth factor i
-
Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA. 1999;96(13):7324-7329.
-
(1999)
Proc Natl Acad Sci USA.
, vol.96
, Issue.13
, pp. 7324-7329
-
-
Yakar, S.1
Liu, J.L.2
Stannard, B.3
Butler, A.4
Accili, D.5
Sauer, B.6
LeRoith, D.7
-
28
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, Mombaerts P, Friedman JM. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest. 2001;108(8):1113-1121.
-
(2001)
J Clin Invest.
, vol.108
, Issue.8
, pp. 1113-1121
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
Montez, J.M.4
Rohani, S.C.5
Feinstein, P.6
Mombaerts, P.7
Friedman, J.M.8
-
29
-
-
77955458427
-
Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor
-
Lou PH, Yang G, Huang L, Cui Y, Pourbahrami T, Radda GK, Li C, Han W. Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. PLoS One. 2010;5(7):e11669.
-
(2010)
PLoS One.
, vol.5
, Issue.7
, pp. e11669
-
-
Lou, P.H.1
Yang, G.2
Huang, L.3
Cui, Y.4
Pourbahrami, T.5
Radda, G.K.6
Li, C.7
Han, W.8
-
30
-
-
37349060346
-
Soluble receptor inhibits leptin transport
-
Tu H, Kastin AJ, Hsuchou H, Pan W. Soluble receptor inhibits leptin transport. J Cell Physiol. 2008;214(2):301-305.
-
(2008)
J Cell Physiol.
, vol.214
, Issue.2
, pp. 301-305
-
-
Tu, H.1
Kastin, A.J.2
Hsuchou, H.3
Pan, W.4
-
31
-
-
2542450776
-
Modulation of direct leptin signaling by soluble leptin receptor
-
Yang G, Ge H, Boucher A, Yu X, Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol. 2004;18(6): 1354-1362.
-
(2004)
Mol Endocrinol.
, vol.18
, Issue.6
, pp. 1354-1362
-
-
Yang, G.1
Ge, H.2
Boucher, A.3
Yu, X.4
Li, C.5
-
32
-
-
85019649050
-
Roles of diacylglycerols and ceramides in hepatic insulin resistance
-
Petersen MC, Shulman GI. Roles of diacylglycerols and ceramides in hepatic insulin resistance. Trends Pharmacol Sci. 2017;38(7): 649-665.
-
(2017)
Trends Pharmacol Sci.
, vol.38
, Issue.7
, pp. 649-665
-
-
Petersen, M.C.1
Shulman, G.I.2
-
33
-
-
84959104290
-
Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
-
Luukkonen PK, Zhou Y, Sädevirta S, Leivonen M, Arola J, Oresic M, Hyötyläinen T, Yki-Järvinen H. Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. J Hepatol. 2016;64(5):1167-1175.
-
(2016)
J Hepatol.
, vol.64
, Issue.5
, pp. 1167-1175
-
-
Luukkonen, P.K.1
Zhou, Y.2
Sädevirta, S.3
Leivonen, M.4
Arola, J.5
Oresic, M.6
Hyötyläinen, T.7
Yki-Järvinen, H.8
-
34
-
-
84861647226
-
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
-
Magkos F, Su X, Bradley D, Fabbrini E, Conte C, Eagon JC, Varela JE, Brunt EM, Patterson BW, Klein S. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology. 2012;142(7):1444-1446.e2.
-
(2012)
Gastroenterology.
, vol.142
, Issue.7
, pp. 1444-1446e2
-
-
Magkos, F.1
Su, X.2
Bradley, D.3
Fabbrini, E.4
Conte, C.5
Eagon, J.C.6
Varela, J.E.7
Brunt, E.M.8
Patterson, B.W.9
Klein, S.10
-
35
-
-
84907978697
-
Obesity-induced CerS6-dependent C16: 0 ceramide production promotes weight gain and glucose intolerance
-
Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM,Mauer J, Xu E,Hammerschmidt P, BrönnekeHS, Trifunovic A, LoSasso G,Wunderlich FT, Kornfeld JW, BlüherM, Krönke M, Brüning JC. Obesity-induced CerS6-dependent C16: 0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 2014;20(4):678-686.
-
(2014)
Cell Metab.
, vol.20
, Issue.4
, pp. 678-686
-
-
Turpin, S.M.1
Nicholls, H.T.2
Willmes, D.M.3
Mourier, A.4
Brodesser, S.5
Wunderlich, C.M.6
Mauer, J.7
Xu, E.8
Hammerschmidt, P.9
Brönneke, H.S.10
Trifunovic, A.11
LoSasso, G.12
Wunderlich, F.T.13
Kornfeld, J.W.14
Blüher, M.15
Krönke, M.16
Brüning, J.C.17
-
36
-
-
80053627289
-
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
-
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci USA. 2011; 108(39):16381-16385.
-
(2011)
Proc Natl Acad Sci USA.
, vol.108
, Issue.39
, pp. 16381-16385
-
-
Kumashiro, N.1
Erion, D.M.2
Zhang, D.3
Kahn, M.4
Beddow, S.A.5
Chu, X.6
Still, C.D.7
Gerhard, G.S.8
Han, X.9
Dziura, J.10
Petersen, K.F.11
Samuel, V.T.12
Shulman, G.I.13
-
37
-
-
84884562454
-
Glycerol-3-phosphate acyltransferase (gpat)-1, but not gpat4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation
-
Wendel AA, Cooper DE, Ilkayeva OR, Muoio DM, Coleman RA. Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation. J Biol Chem. 2013;288(38): 27299-27306.
-
(2013)
J Biol Chem.
, vol.288
, Issue.38
, pp. 27299-27306
-
-
Wendel, A.A.1
Cooper, D.E.2
Ilkayeva, O.R.3
Muoio, D.M.4
Coleman, R.A.5
-
38
-
-
67349112100
-
Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis
-
Wendel AA, Lewin TM, Coleman RA. Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis. Biochim Biophys Acta. 2009;1791(6):501-506.
-
(2009)
Biochim Biophys Acta.
, vol.1791
, Issue.6
, pp. 501-506
-
-
Wendel, A.A.1
Lewin, T.M.2
Coleman, R.A.3
-
39
-
-
77956244443
-
Hepatic foxo1 ablation exacerbates lipid abnormalities during hyperglycemia
-
Haeusler RA, Han S, Accili D. Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia. J Biol Chem. 2010; 285(35):26861-26868.
-
(2010)
J Biol Chem.
, vol.285
, Issue.35
, pp. 26861-26868
-
-
Haeusler, R.A.1
Han, S.2
Accili, D.3
-
40
-
-
34249686631
-
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
-
Inagaki T,Dutchak P, Zhao G, DingX, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5(6):415-425.
-
(2007)
Cell Metab.
, vol.5
, Issue.6
, pp. 415-425
-
-
Inagaki, T.1
Dutchak, P.2
Zhao, G.3
Ding, X.4
Gautron, L.5
Parameswara, V.6
Li, Y.7
Goetz, R.8
Mohammadi, M.9
Esser, V.10
Elmquist, J.K.11
Gerard, R.D.12
Burgess, S.C.13
Hammer, R.E.14
Mangelsdorf, D.J.15
Kliewer, S.A.16
-
41
-
-
70349324370
-
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
-
HottaY,NakamuraH,Konishi M,Murata Y, TakagiH,Matsumura S, Inoue K, Fushiki T, Itoh N. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology. 2009;150(10): 4625-4633.
-
(2009)
Endocrinology.
, vol.150
, Issue.10
, pp. 4625-4633
-
-
Hotta, Y.1
Nakamura, H.2
Konishi, M.3
Murata, Y.4
Takagi, H.5
Matsumura, S.6
Inoue, K.7
Fushiki, T.8
Itoh, N.9
-
42
-
-
70349472910
-
Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
-
Li X, Ge H, Weiszmann J, Hecht R, Li YS, Véniant MM, Xu J, Wu X, Lindberg R, Li Y. Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice. FEBS Lett. 2009;583(19):3230-3234.
-
(2009)
FEBS Lett.
, vol.583
, Issue.19
, pp. 3230-3234
-
-
Li, X.1
Ge, H.2
Weiszmann, J.3
Hecht, R.4
Li, Y.S.5
Véniant, M.M.6
Xu, J.7
Wu, X.8
Lindberg, R.9
Li, Y.10
-
43
-
-
84867898251
-
Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress
-
Lond
-
Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y. Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress. Nutr Metab (Lond). 2012;9(1):94.
-
(2012)
Nutr Metab
, vol.9
, Issue.1
, pp. 94
-
-
Yang, C.1
Wang, C.2
Ye, M.3
Jin, C.4
He, W.5
Wang, F.6
McKeehan, W.L.7
Luo, Y.8
-
44
-
-
84922709227
-
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
-
Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015;160(4):745-758.
-
(2015)
Cell.
, vol.160
, Issue.4
, pp. 745-758
-
-
Perry, R.J.1
Camporez, J.P.2
Kursawe, R.3
Titchenell, P.M.4
Zhang, D.5
Perry, C.J.6
Jurczak, M.J.7
Abudukadier, A.8
Han, M.S.9
Zhang, X.M.10
Ruan, H.B.11
Yang, X.12
Caprio, S.13
Kaech, S.M.14
Sul, H.S.15
Birnbaum, M.J.16
Davis, R.J.17
Cline, G.W.18
Petersen, K.F.19
Shulman, G.I.20
more..
-
45
-
-
0023618690
-
Studies of acute effects of insulin-like growth factors i and II in human fat cells
-
Bolinder J, Lindblad A, Engfeldt P, Arner P. Studies of acute effects of insulin-like growth factors I and II in human fat cells. J Clin Endocrinol Metab. 1987;65(4):732-737.
-
(1987)
J Clin Endocrinol Metab.
, vol.65
, Issue.4
, pp. 732-737
-
-
Bolinder, J.1
Lindblad, A.2
Engfeldt, P.3
Arner, P.4
-
46
-
-
0031467631
-
Direct effects of leptin on brown and white adipose tissue
-
Siegrist-Kaiser CA, Pauli V, Juge-Aubry CE, Boss O, Pernin A, Chin WW, Cusin I, Rohner-Jeanrenaud F, Burger AG, Zapf J, Meier CA. Direct effects of leptin on brown and white adipose tissue. J Clin Invest. 1997;100(11):2858-2864.
-
(1997)
J Clin Invest.
, vol.100
, Issue.11
, pp. 2858-2864
-
-
Siegrist-Kaiser, C.A.1
Pauli, V.2
Juge-Aubry, C.E.3
Boss, O.4
Pernin, A.5
Chin, W.W.6
Cusin, I.7
Rohner-Jeanrenaud, F.8
Burger, A.G.9
Zapf, J.10
Meier, C.A.11
-
47
-
-
0036864411
-
Sterol regulatory element-binding proteins: Transcriptional activators of lipid synthesis
-
Horton JD. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans. 2002;30(6): 1091-1095.
-
(2002)
Biochem Soc Trans.
, vol.30
, Issue.6
, pp. 1091-1095
-
-
Horton, J.D.1
-
48
-
-
2142814381
-
Insig: A significant integrator of nutrient and hormonal signals
-
Attie AD. Insig: a significant integrator of nutrient and hormonal signals. J Clin Invest. 2004;113(8):1112-1114.
-
(2004)
J Clin Invest.
, vol.113
, Issue.8
, pp. 1112-1114
-
-
Attie, A.D.1
-
49
-
-
84897387992
-
Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins
-
Miao J, Haas JT, Manthena P, Wang Y, Zhao E, Vaitheesvaran B, Kurland IJ, Biddinger SB. Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. J Lipid Res. 2014;55(4):659-667.
-
(2014)
J Lipid Res.
, vol.55
, Issue.4
, pp. 659-667
-
-
Miao, J.1
Haas, J.T.2
Manthena, P.3
Wang, Y.4
Zhao, E.5
Vaitheesvaran, B.6
Kurland, I.J.7
Biddinger, S.B.8
-
50
-
-
84969951733
-
Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production
-
Titchenell PM, Quinn WJ, Lu M, Chu Q, Lu W, Li C, Chen H, Monks BR, Chen J, Rabinowitz JD, Birnbaum MJ. Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production. Cell Metab. 2016;23(6): 1154-1166.
-
(2016)
Cell Metab.
, vol.23
, Issue.6
, pp. 1154-1166
-
-
Titchenell, P.M.1
Quinn, W.J.2
Lu, M.3
Chu, Q.4
Lu, W.5
Li, C.6
Chen, H.7
Monks, B.R.8
Chen, J.9
Rabinowitz, J.D.10
Birnbaum, M.J.11
-
51
-
-
84922754155
-
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
-
Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, Accili D. Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. Nat Commun. 2014;5:5190.
-
(2014)
Nat Commun.
, vol.5
, pp. 5190
-
-
Haeusler, R.A.1
Hartil, K.2
Vaitheesvaran, B.3
Arrieta-Cruz, I.4
Knight, C.M.5
Cook, J.R.6
Kammoun, H.L.7
Febbraio, M.A.8
Gutierrez-Juarez, R.9
Kurland, I.J.10
Accili, D.11
-
52
-
-
85031770271
-
Selective inhibition of FOXO1 activator/repressor balance modulates hepatic glucose handling
-
Langlet F, Haeusler RA, Linden D, Ericson E, Norris T, Johansson A, Cook JR, Aizawa K, Wang L, Buettner C, Accili D. Selective inhibition of FOXO1 activator/repressor balance modulates hepatic glucose handling. Cell. 2017;171(4):824-835.e18.
-
(2017)
Cell.
, vol.171
, Issue.4
, pp. 824-824e18
-
-
Langlet, F.1
Haeusler, R.A.2
Linden, D.3
Ericson, E.4
Norris, T.5
Johansson, A.6
Cook, J.R.7
Aizawa, K.8
Wang, L.9
Buettner, C.10
Accili, D.11
-
53
-
-
0032568557
-
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
-
Horton JD, Bashmakov Y, Shimomura I, Shimano H. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA. 1998;95(11):5987-5992.
-
(1998)
Proc Natl Acad Sci USA.
, vol.95
, Issue.11
, pp. 5987-5992
-
-
Horton, J.D.1
Bashmakov, Y.2
Shimomura, I.3
Shimano, H.4
-
54
-
-
2442489891
-
Hepatic glucokinase is required for the synergistic action of chrebp and srebp-1c on glycolytic and lipogenic gene expression
-
Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem. 2004; 279(19):20314-20326.
-
(2004)
J Biol Chem.
, vol.279
, Issue.19
, pp. 20314-20326
-
-
Dentin, R.1
Pégorier, J.P.2
Benhamed, F.3
Foufelle, F.4
Ferré, P.5
Fauveau, V.6
Magnuson, M.A.7
Girard, J.8
Postic, C.9
|