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Volumn 10, Issue 5, 2015, Pages

Ceramide as a mediator of non-alcoholic fatty liver disease and associated atherosclerosis

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CERAMIDE; HIGH DENSITY LIPOPROTEIN; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; SPHINGOMYELIN; THERMOZYMOCIDIN; VERY LOW DENSITY LIPOPROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MONOUNSATURATED FATTY ACID;

EID: 84930640811     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126910     Document Type: Article
Times cited : (163)

References (62)
  • 1
    • 77956189968 scopus 로고    scopus 로고
    • The inflamed liver and atherosclerosis: A link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk
    • 19960252
    • Alkhouri N, Tamimi TA, Yerian L, Lopez R, Zein NN, Feldstein AE. (2010) The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk. Dig Dis Sci 55:2644-2650. doi: 10.1007/s10620-009-1075-y PMID: 19960252
    • (2010) Dig Dis Sci , vol.55 , pp. 2644-2650
    • Alkhouri, N.1    Tamimi, T.A.2    Yerian, L.3    Lopez, R.4    Zein, N.N.5    Feldstein, A.E.6
  • 2
    • 33644808371 scopus 로고    scopus 로고
    • Associations between liver histology and carotid intima-media thickness in patients with nonalcoholic fatty liver disease
    • 16306438
    • Targher G, Bertolini L, Padovani R, Zoppini G, Zenari L, Falezza G. (2005) Associations between liver histology and carotid intima-media thickness in patients with nonalcoholic fatty liver disease. ArteriosclerThromb Vasc Biol 25:2687-2688. PMID: 16306438
    • (2005) ArteriosclerThromb Vasc Biol , vol.25 , pp. 2687-2688
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Zoppini, G.4    Zenari, L.5    Falezza, G.6
  • 3
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal lipid and glucose metabolism in obesity: Implications for nonalcoholic fatty liver disease
    • 17498512
    • Parekh S, Anania FA (2007) Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology 132:2191-2207. PMID: 17498512
    • (2007) Gastroenterology , vol.132 , pp. 2191-2207
    • Parekh, S.1    Anania, F.A.2
  • 4
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • 3513311
    • Brown MS, Goldstein JL (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232:34-47. PMID: 3513311
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 6
    • 11244276995 scopus 로고    scopus 로고
    • The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk
    • 15576296
    • Walldius G, Jungner I, Aastveit AH, Holme I, Furberg CD, Sniderman AD (2004) The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk. Clin Chem Lab Med 42:1355-1363. PMID: 15576296
    • (2004) Clin Chem Lab Med , vol.42 , pp. 1355-1363
    • Walldius, G.1    Jungner, I.2    Aastveit, A.H.3    Holme, I.4    Furberg, C.D.5    Sniderman, A.D.6
  • 7
    • 84891922939 scopus 로고    scopus 로고
    • Ceramidesand Glucosylceramides are independent antagonists of insulin signaling
    • 24214972
    • Chavez JA, Siddique MM, Wang ST, Ching J, Shayman JA, Summers SA (2014) Ceramidesand Glucosylceramides are independent antagonists of insulin signaling. J Biol Chem 289:723-34. doi: 10. 1074/jbc. M113.522847 PMID: 24214972
    • (2014) J Biol Chem , vol.289 , pp. 723-734
    • Chavez, J.A.1    Siddique, M.M.2    Wang, S.T.3    Ching, J.4    Shayman, J.A.5    Summers, S.A.6
  • 8
    • 84862849621 scopus 로고    scopus 로고
    • Aroleforsphingolipids in the pathophysiology of obesity-induced inflammation
    • 22294100
    • Bikman BT (2012) Aroleforsphingolipids in the pathophysiology of obesity-induced inflammation. Cell Mol Life Sci 69:2135-2146. doi: 10.1007/s00018-012-0917-5 PMID: 22294100
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2135-2146
    • Bikman, B.T.1
  • 9
    • 84901936622 scopus 로고    scopus 로고
    • Sphingolipid metabolites in inflammatory disease
    • 24899305
    • Maceyka M, Spiegel S (2014) Sphingolipid metabolites in inflammatory disease. Nature 510:58-67. doi: 10.1038/nature13475 PMID: 24899305
    • (2014) Nature , vol.510 , pp. 58-67
    • Maceyka, M.1    Spiegel, S.2
  • 11
    • 63249117466 scopus 로고    scopus 로고
    • Plasmaceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    • 19008343
    • Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, Defronzo RA, et al. (2009) Plasmaceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 58:337-343. doi: 10.2337/db08-1228 PMID: 19008343
    • (2009) Diabetes , vol.58 , pp. 337-343
    • Haus, J.M.1    Kashyap, S.R.2    Kasumov, T.3    Zhang, R.4    Kelly, K.R.5    Defronzo, R.A.6
  • 12
    • 80055030207 scopus 로고    scopus 로고
    • Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients
    • 21546935
    • Huang H, Kasumov T, Gatmaitan P, Heneghan HM, Kashyap SR, Schauer PR, et al. (2011) Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients. Obesity (Silver Spring) 19:2235-2240. doi: 10.1038/oby.2011.107 PMID: 21546935
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 2235-2240
    • Huang, H.1    Kasumov, T.2    Gatmaitan, P.3    Heneghan, H.M.4    Kashyap, S.R.5    Schauer, P.R.6
  • 13
    • 77957348390 scopus 로고    scopus 로고
    • Sphingolipids and insulin resistance: The five Ws
    • 20216312
    • Summers SA (2010) Sphingolipids and insulin resistance: the five Ws. CurrOpin Lipidol 21:128-135. doi: 10.1097/MOL0b013e3283373b66 PMID: 20216312
    • (2010) CurrOpin Lipidol , vol.21 , pp. 128-135
    • Summers, S.A.1
  • 15
    • 0028372227 scopus 로고
    • Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite
    • 8150717
    • Fujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, et al. (1994) Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo) 47:208-215. PMID: 8150717
    • (1994) J Antibiot (Tokyo) , vol.47 , pp. 208-215
    • Fujita, T.1    Inoue, K.2    Yamamoto, S.3    Ikumoto, T.4    Sasaki, S.5    Toyama, R.6
  • 16
    • 20844435949 scopus 로고    scopus 로고
    • Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice
    • 15545514
    • Park TS, Panek RL, Mueller SB, Hanselman JC, Rosebury WS, Robertson AW, et al. (2004) Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice. Circulation 110:3465-3471. PMID: 15545514
    • (2004) Circulation , vol.110 , pp. 3465-3471
    • Park, T.S.1    Panek, R.L.2    Mueller, S.B.3    Hanselman, J.C.4    Rosebury, W.S.5    Robertson, A.W.6
  • 17
    • 15444367538 scopus 로고    scopus 로고
    • Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice
    • 15590644
    • Hojjati MR, Li Z, Zhou H, Tang S, Huan C, Ooi E, et al. (2005) Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. J Biol Chem 280:10284-10289. PMID: 15590644
    • (2005) J Biol Chem , vol.280 , pp. 10284-10289
    • Hojjati, M.R.1    Li, Z.2    Zhou, H.3    Tang, S.4    Huan, C.5    Ooi, E.6
  • 18
    • 33750359322 scopus 로고    scopus 로고
    • Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice
    • 16458317
    • Park TS, Panek RL, Rekhter MD, Mueller SB, Rosebury WS, Robertson A, et al. (2006) Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice. Atherosclerosis 189:264-272. PMID: 16458317
    • (2006) Atherosclerosis , vol.189 , pp. 264-272
    • Park, T.S.1    Panek, R.L.2    Rekhter, M.D.3    Mueller, S.B.4    Rosebury, W.S.5    Robertson, A.6
  • 19
    • 84881029740 scopus 로고    scopus 로고
    • 2H2O-based high-density lipoprotein turnover method for the assessment of dynamic high-density lipoprotein function in mice
    • 23766259
    • Kasumov T, Willard B, Li L, Li M, Conger H, Buffa JA, et al. (2013) 2H2O-based high-density lipoprotein turnover method for the assessment of dynamic high-density lipoprotein function in mice. Arterioscler Thromb Vasc Biol 33:1994-2003. doi: 10.1161/ATVBAHA.113.301700 PMID: 23766259
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1994-2003
    • Kasumov, T.1    Willard, B.2    Li, L.3    Li, M.4    Conger, H.5    Buffa, J.A.6
  • 20
    • 84873056154 scopus 로고    scopus 로고
    • Reduced cardiovascular risk after bariatric surgery is linked to plasma ceramides, apolipoprotein-B100, and ApoB100/A1 ratio
    • 22264909
    • Heneghan HM, Huang H, Kashyap SR, Gornik HL, McCullough AJ, Schauer PR, et al. (2013) Reduced cardiovascular risk after bariatric surgery is linked to plasma ceramides, apolipoprotein-B100, and ApoB100/A1 ratio. Surg Obes Relat Dis 9:100-107. doi: 10.1016/j.soard.2011.11.018 PMID: 22264909
    • (2013) Surg Obes Relat Dis , vol.9 , pp. 100-107
    • Heneghan, H.M.1    Huang, H.2    Kashyap, S.R.3    Gornik, H.L.4    McCullough, A.J.5    Schauer, P.R.6
  • 21
    • 84856297712 scopus 로고    scopus 로고
    • LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease
    • 22295101
    • Bieghs V, Van Gorp PJ, Wouters K, Hendrikx T, Gijbels MJ, Lutjohann D, et al. (2012) LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLoS One 7:e30668. doi: 10.1371/journal.pone.0030668 PMID: 22295101
    • (2012) PLoS One , vol.7 , pp. e30668
    • Bieghs, V.1    Van Gorp, P.J.2    Wouters, K.3    Hendrikx, T.4    Gijbels, M.J.5    Lutjohann, D.6
  • 22
    • 33845595281 scopus 로고    scopus 로고
    • Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: Effects on plasma insulin, lipoproteins, and atherosclerosis
    • 16840797
    • Wu L, Vikramadithyan R, Yu S, Pau C, Hu Y, Goldberg IJ, et al. (2006) Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: effects on plasma insulin, lipoproteins, and atherosclerosis. J Lipid Res 47:2215-2222. PMID: 16840797
    • (2006) J Lipid Res , vol.47 , pp. 2215-2222
    • Wu, L.1    Vikramadithyan, R.2    Yu, S.3    Pau, C.4    Hu, Y.5    Goldberg, I.J.6
  • 23
    • 80051826073 scopus 로고    scopus 로고
    • Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice
    • 21690266
    • Subramanian S, Goodspeed L, Wang S, Kim J, Zeng L, Ioannou GN, et al. (2011) Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J Lipid Res 52:1626-1635. doi: 10.1194/jlr. M016246 PMID: 21690266
    • (2011) J Lipid Res , vol.52 , pp. 1626-1635
    • Subramanian, S.1    Goodspeed, L.2    Wang, S.3    Kim, J.4    Zeng, L.5    Ioannou, G.N.6
  • 24
    • 78649560195 scopus 로고    scopus 로고
    • Rosiglitazoneattenuates ageand diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice
    • 20938947
    • Gupte AA, Liu JZ, Ren Y, Minze LJ, Wiles JR, Collins AR, et al. (2010) Rosiglitazoneattenuates ageand diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (Baltimore, Md) 52:2001-2011. doi: 10.1002/hep. 23941 PMID: 20938947
    • (2010) Hepatology (Baltimore, Md) , vol.52 , pp. 2001-2011
    • Gupte, A.A.1    Liu, J.Z.2    Ren, Y.3    Minze, L.J.4    Wiles, J.R.5    Collins, A.R.6
  • 25
    • 36048989420 scopus 로고    scopus 로고
    • The results in rodent models of atherosclerosis are not interchangeable: The influence of diet and strain
    • 17651742
    • Joven J, Rull A, Ferrâe N, Escoláa-Gil JC, Marsillach J, Coll B, et al. (2007) The results in rodent models of atherosclerosis are not interchangeable: the influence of diet and strain. Atherosclerosis 195:e85-92. PMID: 17651742
    • (2007) Atherosclerosis , vol.195 , pp. e85-e92
    • Joven, J.1    Rull, A.2    Ferrâe, N.3    Escoláa-Gil, J.C.4    Marsillach, J.5    Coll, B.6
  • 26
    • 67649763475 scopus 로고    scopus 로고
    • Acid sphingomyelinase deficiency prevents diet-induced hepatictriacylglycerol accumulation and hyperglycemia in Mice
    • 19074137
    • Deevska GM, Rozenova KA, Giltiay NV, Chambers MA, White J, Boyanovsky BB, et al. (2009) Acid Sphingomyelinase Deficiency Prevents Diet-induced HepaticTriacylglycerol Accumulation and Hyperglycemia in Mice. The Journal of biological chemistry 284:8359-8368. doi: 10.1074/jbc. M807800200 PMID: 19074137
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 8359-8368
    • Deevska, G.M.1    Rozenova, K.A.2    Giltiay, N.V.3    Chambers, M.A.4    White, J.5    Boyanovsky, B.B.6
  • 27
    • 0141988889 scopus 로고    scopus 로고
    • Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: Comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement)
    • 12907460
    • Teupser D, Persky AD, Breslow JL (2003) Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement). Arteriosclerosis, thrombosis, and vascular biology 23:1907-1913. PMID: 12907460
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , pp. 1907-1913
    • Teupser, D.1    Persky, A.D.2    Breslow, J.L.3
  • 28
    • 48249099359 scopus 로고    scopus 로고
    • Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes
    • 18346984
    • Goldberg IJ, Hu Y, Noh HL, Wei J, Huggins LA, Rackmill MG, et al. (2008) Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes. Diabetes 57:1674-1682. doi: 10.2337/db08-0083 PMID: 18346984
    • (2008) Diabetes , vol.57 , pp. 1674-1682
    • Goldberg, I.J.1    Hu, Y.2    Noh, H.L.3    Wei, J.4    Huggins, L.A.5    Rackmill, M.G.6
  • 31
    • 0035824678 scopus 로고    scopus 로고
    • Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity, and insulin resistance
    • 11598138
    • Siri P, Candela N, Zhang YL, Ko C, Eusufzai S, Ginsberg HN, et al. (2001) Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity, and insulin resistance. J Biol Chem 276:46064-46072. PMID: 11598138
    • (2001) J Biol Chem , vol.276 , pp. 46064-46072
    • Siri, P.1    Candela, N.2    Zhang, Y.L.3    Ko, C.4    Eusufzai, S.5    Ginsberg, H.N.6
  • 32
    • 77951091722 scopus 로고    scopus 로고
    • Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry
    • 20178771
    • Kasumov T, Huang H, Chung YM, Zhang R, McCullough AJ, Kirwan JP (2010) Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Biochem 401:154-161. doi: 10.1016/j.ab.2010.02.023 PMID: 20178771
    • (2010) Anal Biochem , vol.401 , pp. 154-161
    • Kasumov, T.1    Huang, H.2    Chung, Y.M.3    Zhang, R.4    McCullough, A.J.5    Kirwan, J.P.6
  • 33
    • 77649198926 scopus 로고    scopus 로고
    • Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart
    • 19967553
    • Kasumov T, Sharma N, Huang H, Kombu RS, Cendrowski A, Stanley WC, et al. (2009) Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart. Cardiovasc Drugs Ther 23:459-469. doi: 10.1007/s 10557-009-6208-1 PMID: 19967553
    • (2009) Cardiovasc Drugs Ther , vol.23 , pp. 459-469
    • Kasumov, T.1    Sharma, N.2    Huang, H.3    Kombu, R.S.4    Cendrowski, A.5    Stanley, W.C.6
  • 34
    • 77954457487 scopus 로고    scopus 로고
    • Headspace analyses of acetone: A rapid method for measuring the 2H-labeling of water
    • 20488158
    • Shah V, Herath K, Previs SF, Hubbard BK, Roddy TP (2010) Headspace analyses of acetone: a rapid method for measuring the 2H-labeling of water. Anal Biochem 404:235-237. doi: 10.1016/j.ab.2010.05.010 PMID: 20488158
    • (2010) Anal Biochem , vol.404 , pp. 235-237
    • Shah, V.1    Herath, K.2    Previs, S.F.3    Hubbard, B.K.4    Roddy, T.P.5
  • 35
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • 13671378
    • Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917. PMID: 13671378
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 36
    • 79959261143 scopus 로고    scopus 로고
    • Quantifying cholesterol synthesis in vivo using (2) H (2) O: Enabling back-to-back studies in the same subject
    • 21498887
    • Previs SF, Mahsut A, Kulick A, Dunn K, Andrews-Kelly G, Johnson C, et al. (2011) Quantifying cholesterol synthesis in vivo using (2) H (2) O: enabling back-to-back studies in the same subject. J Lipid Res 52:1420-1428. doi: 10.1194/jlr. D014993 PMID: 21498887
    • (2011) J Lipid Res , vol.52 , pp. 1420-1428
    • Previs, S.F.1    Mahsut, A.2    Kulick, A.3    Dunn, K.4    Andrews-Kelly, G.5    Johnson, C.6
  • 37
    • 38149019756 scopus 로고    scopus 로고
    • Quantitative assay for mouse atherosclerosis in the aortic root
    • 17085806
    • Baglione J, Smith JD (2006) Quantitative assay for mouse atherosclerosis in the aortic root. Methods Mol Med 129:83-95. PMID: 17085806
    • (2006) Methods Mol Med , vol.129 , pp. 83-95
    • Baglione, J.1    Smith, J.D.2
  • 38
    • 34548207269 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance
    • 17545163
    • Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, et al. (2007) Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem 282:23829-23840. PMID: 17545163
    • (2007) J Biol Chem , vol.282 , pp. 23829-23840
    • Xue, B.1    Kim, Y.B.2    Lee, A.3    Toschi, E.4    Bonner-Weir, S.5    Kahn, C.R.6
  • 39
    • 84867352935 scopus 로고    scopus 로고
    • Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/-mice fed on a high-fat diet
    • 22712892
    • Deevska GM, Sunkara M, Morris AJ, Nikolova-Karakashian MN (2012) Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/-mice fed on a high-fat diet. Biosci Rep 32:479-490. doi: 10.1042/BSR20120036 PMID: 22712892
    • (2012) Biosci Rep , vol.32 , pp. 479-490
    • Deevska, G.M.1    Sunkara, M.2    Morris, A.J.3    Nikolova-Karakashian, M.N.4
  • 40
    • 84861430523 scopus 로고    scopus 로고
    • Quantifying apoprotein synthesis in rodents: Coupling LC-MS/MS analyses with the administration of labeled water
    • 22389331
    • Zhou H, Li W, Wang SP, Mendoza V, Rosa R, Hubert J, et al. (2012) Quantifying apoprotein synthesis in rodents: coupling LC-MS/MS analyses with the administration of labeled water. J Lipid Res 53:1223-1231. doi: 10.1194/jlr. D021295 PMID: 22389331
    • (2012) J Lipid Res , vol.53 , pp. 1223-1231
    • Zhou, H.1    Li, W.2    Wang, S.P.3    Mendoza, V.4    Rosa, R.5    Hubert, J.6
  • 41
    • 4644305245 scopus 로고    scopus 로고
    • Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: Role of visceral fat accumulation
    • 15451925
    • Targher G, Bertolini L, Padovani R, Zenari L, Zoppini G, Falezza G (2004) Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: role of visceral fat accumulation. Diabetes Care 27:2498-2500. PMID: 15451925
    • (2004) Diabetes Care , vol.27 , pp. 2498-2500
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Zenari, L.4    Zoppini, G.5    Falezza, G.6
  • 42
    • 49649110937 scopus 로고    scopus 로고
    • Dietary cholesterol, ratherthan liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    • 18666236
    • Wouters K, Van Gorp PJ, Bieghs V, Gijbels MJ, Duimel H, Lütjohann D, et al. (2008) Dietary cholesterol, ratherthan liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48:474-486. doi: 10.1002/hep. 22363 PMID: 18666236
    • (2008) Hepatology , vol.48 , pp. 474-486
    • Wouters, K.1    Van Gorp, P.J.2    Bieghs, V.3    Gijbels, M.J.4    Duimel, H.5    Lütjohann, D.6
  • 43
    • 64249150743 scopus 로고    scopus 로고
    • Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes
    • 19265038
    • Collins AR, Lyon CJ, Xia X, Liu JZ, Tangirala RK, Yin F, et al. (2009) Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res 104:e42-54. doi: 10.1161/CIRCRESAHA.108.188771 PMID: 19265038
    • (2009) Circ Res , vol.104 , pp. e42-e54
    • Collins, A.R.1    Lyon, C.J.2    Xia, X.3    Liu, J.Z.4    Tangirala, R.K.5    Yin, F.6
  • 44
    • 0141988889 scopus 로고    scopus 로고
    • Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: Comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement)
    • 12907460
    • Teupser D, Persky AD, Breslow JL (2003) Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement). Arterioscler Thromb Vasc Biol 23:1907-1913. PMID: 12907460
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1907-1913
    • Teupser, D.1    Persky, A.D.2    Breslow, J.L.3
  • 45
    • 84873029099 scopus 로고    scopus 로고
    • Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance
    • 23139352
    • Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, et al. (2013) Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes 62:401-410. doi: 10.2337/db12-0686 PMID: 23139352
    • (2013) Diabetes , vol.62 , pp. 401-410
    • Boon, J.1    Hoy, A.J.2    Stark, R.3    Brown, R.D.4    Meex, R.C.5    Henstridge, D.C.6
  • 46
    • 84907978697 scopus 로고    scopus 로고
    • Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance
    • 25295788
    • Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, et al. (2014) Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab 20:678-686. doi: 10.1016/j.cmet.2014.08.002 PMID: 25295788
    • (2014) Cell Metab , vol.20 , pp. 678-686
    • Turpin, S.M.1    Nicholls, H.T.2    Willmes, D.M.3    Mourier, A.4    Brodesser, S.5    Wunderlich, C.M.6
  • 47
    • 77953561361 scopus 로고    scopus 로고
    • Mammalian ceramide synthases
    • 20222015
    • Levy M, Futerman AH (2010) Mammalian ceramide synthases. IUBMB Life 62:347-356. doi: 10.1002/iub.319 PMID: 20222015
    • (2010) IUBMB Life , vol.62 , pp. 347-356
    • Levy, M.1    Futerman, A.H.2
  • 48
    • 77951216913 scopus 로고    scopus 로고
    • A critical role for ceramide synthase 2 in liver homeostasis: II. Insights into molecular changes leading to hepatopathy
    • 20110366
    • Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, et al. (2010) A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem 285:10911-10923. doi: 10.1074/jbc. M109.077610 PMID: 20110366
    • (2010) J Biol Chem , vol.285 , pp. 10911-10923
    • Pewzner-Jung, Y.1    Brenner, O.2    Braun, S.3    Laviad, E.L.4    Ben-Dor, S.5    Feldmesser, E.6
  • 49
    • 84907984591 scopus 로고    scopus 로고
    • CerS2 haploinsufficiency inhibits beta-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance
    • 25295789
    • Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, et al. (2014) CerS2 haploinsufficiency inhibits beta-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metab 20:687-695. doi: 10.1016/j.cmet.2014.09.015 PMID: 25295789
    • (2014) Cell Metab , vol.20 , pp. 687-695
    • Raichur, S.1    Wang, S.T.2    Chan, P.W.3    Li, Y.4    Ching, J.5    Chaurasia, B.6
  • 50
    • 84873295041 scopus 로고    scopus 로고
    • Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes
    • 22911490
    • Park JW, Park WJ, Kuperman Y, Boura-Halfon S, Pewzner-Jung Y, Futerman AH. (2013) Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes. Hepatology 57:525-532. doi: 10.1002/hep. 26015 PMID: 22911490
    • (2013) Hepatology , vol.57 , pp. 525-532
    • Park, J.W.1    Park, W.J.2    Kuperman, Y.3    Boura-Halfon, S.4    Pewzner-Jung, Y.5    Futerman, A.H.6
  • 51
    • 84920401295 scopus 로고    scopus 로고
    • IntestinalfarnesoidX receptorsignaling promotes nonalcoholic fatty liver disease
    • 25500885
    • Jiang C, Xie C, Li F, Zhang L, Nichols RG, Krausz KW, et al. (2015) IntestinalfarnesoidX receptorsignaling promotes nonalcoholic fatty liver disease. J Clin Invest 125:386-402. doi: 10.1172/JCI76738 PMID: 25500885
    • (2015) J Clin Invest , vol.125 , pp. 386-402
    • Jiang, C.1    Xie, C.2    Li, F.3    Zhang, L.4    Nichols, R.G.5    Krausz, K.W.6
  • 52
    • 84876152661 scopus 로고    scopus 로고
    • Ceramide expression and cell homeostasis in chronic obstructive pulmonary disease
    • 23018286
    • Scarpa MC, Baraldo S, Marian E, Turato G, Calabrese F, Saetta M, et al. (2013) Ceramide expression and cell homeostasis in chronic obstructive pulmonary disease. Respiration 85:342-349. doi: 10. 1159/000341185 PMID: 23018286
    • (2013) Respiration , vol.85 , pp. 342-349
    • Scarpa, M.C.1    Baraldo, S.2    Marian, E.3    Turato, G.4    Calabrese, F.5    Saetta, M.6
  • 53
    • 84876803025 scopus 로고    scopus 로고
    • Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: Evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction
    • 23466071
    • Dekker MJ, Baker C, Naples M, Samsoondar J, Zhang R, Qiu W, et al. (2013) Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. Atherosclerosis 228:98-109. doi: 10.1016/j.atherosclerosis.2013.01.041 PMID: 23466071
    • (2013) Atherosclerosis , vol.228 , pp. 98-109
    • Dekker, M.J.1    Baker, C.2    Naples, M.3    Samsoondar, J.4    Zhang, R.5    Qiu, W.6
  • 54
    • 84891396246 scopus 로고    scopus 로고
    • Sphingomyelin depletion impairs anionic phospholipid inward translocation and induces cholesterol efflux
    • 24220029
    • Gulshan K, Brubaker G, Wang S, Hazen SL, Smith JD (2013) Sphingomyelin depletion impairs anionic phospholipid inward translocation and induces cholesterol efflux. J Biol Chem 288:37166-37179. doi:10.1074/jbc. M113.512244 PMID: 24220029
    • (2013) J Biol Chem , vol.288 , pp. 37166-37179
    • Gulshan, K.1    Brubaker, G.2    Wang, S.3    Hazen, S.L.4    Smith, J.D.5
  • 55
    • 84863205222 scopus 로고    scopus 로고
    • Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex
    • 22586587
    • Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, et al. (2012) Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes 61:1848-1859. doi: 10.2337/db11-1399 PMID: 22586587
    • (2012) Diabetes , vol.61 , pp. 1848-1859
    • Zhang, Q.J.1    Holland, W.L.2    Wilson, L.3    Tanner, J.M.4    Kearns, D.5    Cahoon, J.M.6
  • 56
    • 64349124701 scopus 로고    scopus 로고
    • Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry
    • 18832345
    • Wiesner P, Leidl K, Boettcher A, Schmitz G, Liebisch G (2009) Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 50:574-585. doi:10.1194/jlr. D800028-JLR200 PMID: 18832345
    • (2009) J Lipid Res , vol.50 , pp. 574-585
    • Wiesner, P.1    Leidl, K.2    Boettcher, A.3    Schmitz, G.4    Liebisch, G.5
  • 58
    • 0025106508 scopus 로고
    • Macrophage uptake of cholesterol-containing particles derived from LDLand isolated from atherosclerotic lesions
    • 2151186
    • Hoff HF, O'Neil J, Pepin JM, Cole TB (1990) Macrophage uptake of cholesterol-containing particles derived from LDLand isolated from atherosclerotic lesions. European heart journal 11:105-115. PMID: 2151186
    • (1990) European Heart Journal , vol.11 , pp. 105-115
    • Hoff, H.F.1    O'Neil, J.2    Pepin, J.M.3    Cole, T.B.4
  • 59
    • 62249186734 scopus 로고    scopus 로고
    • Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol
    • 19416652
    • Li Z, Park TS, Li Y, Pan X, Iqbal J, Lu D, et al. (2009) Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol. BiochimBiophysActa 1791:297-306. doi: 10.1016/j.bbalip. 2009.01.010 PMID: 19416652
    • (2009) BiochimBiophysActa , vol.1791 , pp. 297-306
    • Li, Z.1    Park, T.S.2    Li, Y.3    Pan, X.4    Iqbal, J.5    Lu, D.6
  • 61
    • 0033929797 scopus 로고    scopus 로고
    • Lipid transporters: Membrane transport systems for cholesterol and fatty acids
    • 10929670
    • Abumurad NA, Sfeir Z (2000) Lipid transporters: membrane transport systems for cholesterol and fatty acids. CurrOpinClin Nutr Metab Care 3:255-262. PMID: 10929670
    • (2000) CurrOpinClin Nutr Metab Care , vol.3 , pp. 255-262
    • Abumurad, N.A.1    Sfeir, Z.2
  • 62
    • 51649099019 scopus 로고    scopus 로고
    • Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts)
    • 18700980
    • Ehehalt R, Sparla R, Kulaksiz H, Herrmann T, Fullekrug J, Stremmel W (2008) Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). BMC Cell Biol 9:45. doi: 10.1186/1471-2121-9-45 PMID: 18700980
    • (2008) BMC Cell Biol , vol.9 , pp. 45
    • Ehehalt, R.1    Sparla, R.2    Kulaksiz, H.3    Herrmann, T.4    Fullekrug, J.5    Stremmel, W.6


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