PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions

Biochemical and Biophysical Research Communications

Volumn 488, Issue 1, 2017, Pages 116-121

  Sugiyama, Mariko ^a   Banno, Ryoichi ^a   Mizoguchi, Akira ^a   Tominaga, Takashi ^a   Tsunekawa, Taku ^a   Onoue, Takeshi ^a   Hagiwara, Daisuke ^a   Ito, Yoshihiro ^a   Morishita, Yoshiaki ^a   Iwama, Shintaro ^a,b   Goto, Motomitsu ^a   Suga, Hidetaka ^a   Arima, Hiroshi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

AgRP; Hypothalamus; Insulin; PTP1B

Indexed keywords

AGOUTIRELATED PROTEIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG; AGOUTI RELATED PROTEIN; AGRP PROTEIN, MOUSE; INSULIN; PTPN1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; FEMALE; HYPOPHOSPHATASIA; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TREATMENT; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT CHANGE; ANIMAL; BLOOD; DEFICIENCY; GENE EXPRESSION PROFILING; GENETICS; HYPOTHALAMUS; KNOCKOUT MOUSE; METABOLISM;

AGOUTI-RELATED PROTEIN; ANIMALS; DIET, HIGH-FAT; GENE EXPRESSION PROFILING; HYPOTHALAMUS; INSULIN; INSULIN RESISTANCE; MICE; MICE, KNOCKOUT; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RNA, MESSENGER;

EID: 85018458682     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2017.05.019     Document Type: Article

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