Cyclocarya paliurus extract activates insulin signaling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion

PLoS ONE

Volumn 12, Issue 8, 2017, Pages

  Yoshitomi, Hisae ^a   Tsuru, Rika ^a   Li, Linyi ^b   Zhou, Jingxin ^b   Kudo, Maya ^a   Liu, Tonghua ^b   Gao, Ming ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (N (7 NITROBENZ 2 OXA 1, 3 DIAZOYL 4 YL)AMINO) 2 DEOXYGLUCOSE; ANTIDIABETIC AGENT; CYCLOCARYA PALIURUS EXTRACT; DEOXYGLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN KINASE B; SIRTUIN 1; UNCLASSIFIED DRUG; 2-(N-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)AMINO)-2-DEOXYGLUCOSE; 4 CHLORO 7 NITROBENZOFURAZAN; HERBACEOUS AGENT; INSULIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE; SLC2A4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; C2C12 CELL LINE; CELL MEMBRANE; CELL VIABILITY ASSAY; CONTROLLED STUDY; CYCLOCARYA PALIURUS; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HYPERGLYCEMIA; IN VIVO STUDY; INSULIN LEVEL; INSULIN RELEASE; INSULIN SIGNALING; MALE; MEDICINAL PLANT; MOUSE; MUSCLE FIBER MEMBRANE; MYOTUBE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SINGLE DRUG DOSE; SKELETAL MUSCLE; UPREGULATION; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; FAGACEAE; GENE EXPRESSION REGULATION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE CELL; TRANSPORT AT THE CELLULAR LEVEL;

4-CHLORO-7-NITROBENZOFURAZAN; ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; DEOXYGLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DRUGS, CHINESE HERBAL; FAGACEAE; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; MICE; MICE, INBRED ICR; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 85028701867     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0183988     Document Type: Article

References (30)

1. Herder C, Schneitler S, Rathmann W, Haastert B, Schneitler H, Winkler H, et al. Low-grade inflammation, obesity, and insulin resistance in adolescents. J Clin Endocrinol Metab. 2007; 92: 4569–4574. https://doi.org/10.1210/jc.2007-0955 PMID: 17911172
2. Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med. 1997; 14 Suppl 5: S1–85
3. Khan AH, Pessin JE. Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia. 2002; 45: 1475–1483. https://doi.org/10.1007/s00125-002-0974-7 PMID: 12436329
4. Chen MQ, Liang JY, Jiao ZH, Guo YH, Meng GZ, Shen XQ, et al. Clinical observation on regulation action of Green Qian Willow tea on blood lipid level. Chin. J. Pract. Chin. Mod. Med. 2. 2002; 863–865
5. Li L, Xie M, Yi X. Study on reducing blood sugar of polysaccharide from Cyclocarya paliurus (Batal.) Iljinsk. Zhong Yao Cai. 2002; 25: 39–41. PMID: 12583243
6. Shu RG, Xu CR, Li LN, Yu ZL. Cyclocariosides II and III: two secodammarane triterpenoid saponins from Cyclocarya paliurus. Planta Med. 1995; 61: 551–553. https://doi.org/10.1055/s-2006-959369 PMID: 8824950
7. Kurihara H, Fukami H, Kusumoto A, Toyoda Y, Shibata H, Matsui Y, et al. Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice. Biosci Biotechnol Biochem. 2003; 67: 877–880. https://doi.org/10.1271/bbb.67.877 PMID: 12784631
8. Wang Q, Jiang C, Fang S, Wang J, Ji Y, Shang X, et al. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. J Ethnopharmacol. 2013; 150: 1119–1127 https://doi.org/10.1016/j.jep.2013.10.040 PMID: 24184190
9. Siddiqui MA, Kashyap MP, Kumar V, Al-Khedhairy AA, Musarrat J, Pant AB. Protective potential of trans-resveratrol against 4-hydroxynonenal induced damage in PC12 cells. Toxicol In Vitro. 2010; 24: 1592–1598 https://doi.org/10.1016/j.tiv.2010.06.008 PMID: 20600804
10. Cordero-Herrera I, Martín MA, Bravo L, Goya L, Ramos S. Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells. Mol Nutr Food Res. 2013; 57: 974–985. https://doi.org/10.1002/mnfr.201200500 PMID: 23456781
11. Sun XJ, Rothenberg P, Kahn CR, Backer JM. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature. 1991; 352: 73–77. https://doi.org/10.1038/352073a0 PMID: 1648180
12. Johnson TO, Ermolieff J, Jirousek MR. Protein tyrosine phosphatases 1B inhibitors for diabetes. Nat Rev Drug Discov. 2002; 1:696–709 https://doi.org/10.1038/nrd895 PMID: 12209150
13. Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C. Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. Mol Cell Biol. 1997; 17:6633–6644. PMID: 9343427
14. Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, et.al. A phosphatidylinositol 3-kinase/ Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci U S A. 2001; 10:4640–4645.
15. Liang F, Kume S, Koya D. SIRT1 and insulin resistance. Nat Rev Endocrinol. 2009; 5: 367–373. https://doi.org/10.1038/nrendo.2009.101 PMID: 19455179
16. Gray AM, Flatt PR. Antihyperglycemic actions of Eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. J Nutr. 1998; 128: 2319–2323. PMID: 9868176
17. Abe D, Saito T, Sekiya K. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sci. 2006; 79: 1027–1033. https://doi.org/10.1016/j.lfs.2006.03.007 PMID: 16603199
18. Zhu KN, Jiang CH, Tian YS, Xiao N, Wu ZF, Ma YL, et al. Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation. Phytomedicine. 2015; 22: 837–846. https://doi.org/10.1016/j.phymed.2015.05.058 PMID: 26220631
19. DeFronzo RA, Ferrannini E, Sato Y, Felig P, Wahren J. Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest. 1981; 68: 1468–1474. https://doi.org/10.1172/ JCI110399 PMID: 7033285
20. Ramm G, Larance M, Guilhaus M, James DE. A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160. J Biol Chem. 2006; 281: 29174–29180. https://doi.org/10.1074/jbc.M603274200 PMID: 16880201
21. Hubbard SR, Wei L, Ellis L, Hendrickson WA. Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature. 1994; 372: 746–754. https://doi.org/10.1038/372746a0 PMID: 7997262
22. Zhang B, Salituro G, Szalkowski D, Li Z, Zhang Y, Royo I, et al. Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science. 1999; 284: 974–977. PMID: 10320380
23. Liu X, Kim JK, Li Y, Li J, Liu F, Chen X. Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. J Nutr. 2005; 135: 165–171. PMID: 15671208
24. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001; 13:799–806.
25. Zick Y. Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol. 2001; 11:437–441. PMID: 11684411
26. Sykiotis GP, Papavassiliou AG. Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance. Mol Endocrinol. 2001; 15:1864–1869. https://doi.org/10.1210/mend.15.11.0725 PMID: 11682617
27. Jing M, Cheruvu VK, Ismail-Beigi F. Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways. Am J Physiol Cell Physiol. 2008; 295: C1071–1082. https://doi.org/10.1152/ajpcell.00040.2008 PMID: 18701654
28. Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, et al. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010; 298: E751–760. https://doi.org/10.1152/ajpendo.00745.2009 PMID: 20103737
29. Li S, Cui B, Liu Q, Tang L, Yang Y, Jin X, et al. New triterpenoids from the leaves of Cyclocarya paliurus. Planta Med. 2012; 78: 290–296. https://doi.org/10.1055/s-0031-1280411 PMID: 22161740
30. Shu R, Liu Y, Chen J, Shu J. Studies on the triterpenoids of Cyclocarya paliurus (Batal.) Iljinsk. Zhong Yao Cai. 2005; 28: 558–559. PMID: 16252722