Cyclocarya paliurus prevents high fat diet induced hyperlipidemia and obesity in Sprague–Dawley rats

Canadian Journal of Physiology and Pharmacology

Volumn 93, Issue 8, 2015, Pages 677-686

  Yao, Xiaoming ^a,b   Lin, Zi ^b,c   Jiang, Cuihua ^b   Gao, Meng ^b   Wang, Qingqing ^b,c   Yao, Nan ^b   Ma, Yonglan ^b,c   Li, Yue ^b   Fang, Shengzuo ^d   Shang, Xulan ^d   Ni, Yicheng ^b,e   Zhang, Jian ^b   Yin, Zhiqi ^c  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b Jiangsu Province Academy of Traditional Chinese Medicine   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

^d NANJING FORESTRY UNIVERSITY   (China)

^e DEPARTMENT OF IMAGING AND PATHOLOGY   (Belgium)

Author keywords

Antihyperlipidemic; ApoB48; Cyclocarya paliurus; Hyperlipidemia; MRI; Obesity; Visceral fat

Indexed keywords

ALCOHOL; ANTILIPEMIC AGENT; ANTIOBESITY AGENT; APOLIPOPROTEIN B48; CHOLESTEROL; CYCLOCARYA PALIURUS EXTRACT; GREEN TEA EXTRACT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; PROTECTIVE AGENT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLOCARYA PALIURUS; DIET INDUCED OBESITY; DIET RESTRICTION; DOSE RESPONSE; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; ETHNOPHARMACOLOGY; FAT MASS; HISTOPATHOLOGY; HYPERLIPIDEMIA; INTRAABDOMINAL FAT; JUGLANDACEAE; LIPID DIET; LIPID LIVER LEVEL; LIPID STORAGE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERIRENAL FAT; PRIORITY JOURNAL; RAT; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HYPERLIPIDEMIAS; INTESTINE; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; OBESITY; PATHOPHYSIOLOGY; PHYTOTHERAPY; PLANT LEAF; SPRAGUE DAWLEY RAT; TIME FACTOR; WEIGHT GAIN;

ADIPOSITY; ANIMALS; ANTI-OBESITY AGENTS; APOLIPOPROTEIN B-48; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; INTESTINES; INTRA-ABDOMINAL FAT; JUGLANDACEAE; MAGNETIC RESONANCE IMAGING; MALE; OBESITY; PHYTOTHERAPY; PLANT LEAVES; PLANTS, MEDICINAL; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRIGLYCERIDES; WEIGHT GAIN;

EID: 84938577830     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2014-0477     Document Type: Article

References (38)

1. Alwan, A. 2011. Global status report on noncommunicable diseases 2010. World Health Organization. [Available from http://www.who.int/nmh/publications/ncd_report2010/en/].
2. Aydin, S., Aksoy, A., Aydin, S., Kalayci, M., Yilmaz, M., Kuloglu, T., et al. 2014. Today’s and yesterday’s of pathophysiology: biochemistry of metabolic syndrome and animal models. Nutrition, 30(1): 1–9. doi:10.1016/j.nut.2013.05.013.PMID:24290591.
3. Bays, H.E., González-Campoy, J.M., Bray, G.A., Kitabchi, A.E., Bergman, D.A., Schorr, A.B., et al. 2008. Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev. Cardiovasc. Ther. 6(3): 343–368. doi:10.1586/14779072.6.3.343.PMID:18327995.
4. Chatterjee, S.S. 2012.Holistic psychopharmacology and promiscuous plants and principles of Ayurveda. Am. J. Plant Sci. 3(7): 1015–1021. doi:10.4236/ajps.2012.327120.
5. Chen, H.C., and Farese, R.V. 2002. Determination of adipocyte size by computer image analysis. J. Lipid Res. 43(6): 986–989.PMID:12032175.
6. Chow, H.S., Cai, Y., Hakim, I.A., Crowell, J.A., Shahi, F., Brooks, C.A., et al. 2003. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin. Cancer Res. 9(9): 3312–3319.PMID:12960117.
7. Cooper, R., Morré, D.J., and Morré, D.M. 2005. Medicinal benefits of green tea: Part I. Review of noncancer health benefits. J. Altern. Complement. Med. 11(3): 521–528. doi:10.1089/acm.2005.11.521.PMID:15992239.
8. Du, H., You, J.S., Zhao, X., Park, J.Y., Kim, S.H., and Chang, K.J. 2010. Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J. Biomed. Sci. 17 (Suppl. 1): S42. doi:10.1186/1423-0127-17-S1-S42.PMID:20804619.
9. Finelli, C., Sommella, L., Gioia, S., La Sala, N., and Tarantino, G. 2013. Should visceral fat be reduced to increase longevity? Ageing Res. Rev. 12(4): 996–1004. doi:10.1016/j.arr.2013.05.007.PMID:23764746.
10. Gao, Y., and Xiao, Y. 2002. Effect of hawthorn and hawthorn flavonoids extract on rats with hyperlipidemia. Chin. J. Food Hygiene, 14(3): 14–16. doi:10.3969/j.issn.1004-8456.2002.03.004.
11. Ge, X., Chen, T.T., Cai, J.Y., Huang, M.Q., Xu, W.F., and Wang, J.R. 2011. Study on the antioxidant activity of Cyclocarya paliurus polysaccharides. J. Chin. Inst. Food Sci. Technol. 11(5): 59–64. doi:10.3969/j.issn.1009-7848.2011.05.010.
12. Harp, J.B. 1998. An assessment of the efficacy and safety of orlistat for the long-term management of obesity. J. Nutr. Biochem. 9(9): 516–521. doi:10.1016/S0955-2863(98)00006-0.
13. Hauptman, J., Jeunet, F.S., and Hartmann, D. 1992. Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin). Am. J. Clin. Nutr. 55(1): 309S–313S. PMID:1728845.
14. Hotamisligil, G.S. 2006. Inflammation and metabolic disorders. Nature, 444(7121): 860–867. doi:10.1038/nature05485.PMID:17167474.
15. Huang, J.Y., Lou, L.Y., and Xu, P. 1986. Pharmacological studies of Cyclocarya paliurus. Tradit. Chin. Med. J. 11(11): 63–63.
16. Huang, W., and Liu, R. 2012.Reasearch progress of apolipoprotein B48. Chin. J. Arterioscl. 20(7): 668–672.
17. Huang, W., Liu, R., Ou, Y., Li, X., Qiang, O., Yu, T., and Tang, C.W. 2013. Octreotide promotes weight loss via suppression of intestinal MTP and apoB48 expression in diet-induced obesity rats. Nutrition, 29(10): 1259–1265. doi:10.1016/j.nut.2013.01.013.PMID:23911221.
18. Institute of Laboratory Animal Resources. 1996. Guide for the care and use of laboratory animals. National Academic Press. PMID:25121211.
19. Jiang, C., Yao, N., Wang, Q., Zhang, J., Sun, Y., Xiao, N., et al. 2014. Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice. J. Ethnopharmacol. 153(2): 344–351. doi:10.1016/j.jep.2014.02.003.PMID:24530856.
20. Klop, B., Elte, J.W., and Cabezas, M.C. 2013. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients, 5(4): 1218–1240. doi:10.3390/nu5041218.PMID:23584084.
21. Kurihara, H., Asami, S., Shibata, H., Fukami, H., and Tanaka, T. 2003a. Hypolipemic effect of Cyclocarya paliurus (Batal.) Iljinskaja in lipid-loaded mice. Biol. Pharm. Bull. 26(3): 383–385. doi:10.1248/bpb.26.383.PMID:12612454.
22. Kurihara, H., Fukami, H., Kusumoto, A., Toyoda, Y., Shibata, H., Matsui, Y., et al. 2003b. Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice. Biosci. Biotechnol. Biochem. 67(4): 877–880. doi:10.1271/bbb.67.877.PMID:12784631.
23. Leng, R.X. 1994. Basic theoretical research and clinical observation of Cyclocarya paliurus. Jiangxi J. Tradit. Chin. Med. 25(2): 64–65.
24. Li, G.L., Zhang, H., and Xu, Y.Y. 2013. Lipid-lowering strategies for dyslipidemia. China Pract. Med. 8(19): 204–205.
25. Lin, J.-K., and Lin-Shiau, S.-Y. 2006. Mechanisms of hypolipidemic and antiobesity effects of tea and tea polyphenols. Mol. Nutr. Food Res. 50(2): 211–217. doi:10.1002/mnfr.200500138.PMID:16404708.
26. Ma, Y., Jiang, C., Yao, N., Li, Y., Wang, Q., Fang, S., et al. 2015. Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice. J. Ethnopharmacol. 166: 286–296. doi:10.1016/j.jep.2015.03.030.PMID:25794806.
27. Morgan, K., Uyuni, A., Nandgiri, G., Mao, L., Castaneda, L., Kathirvel, E., et al. 2008. Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease. Eur. J. Gastroenterol. Hepatol. 20(9): 843–854. doi:10.1097/MEG.0b013e3282f9b203.PMID:18794597.
28. Nzekwu, M., Ball, G., Jetha, M., Beaulieu, C., and Proctor, S. 2007. Apolipoprotein B48: a novel marker of metabolic risk in overweight children? Biochem. Soc. Trans. 35(3): 484–486. doi:10.1042/BST0350484.PMID:17511634.
29. Oda, N., Imamura, S., Fujita, T., Uchida, Y., Inagaki, K., Kakizawa, H., et al. 2008. The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism, 57(2): 268–273. doi:10.1016/j.metabol.2007.09.011.PMID: 18191059.
30. Pal, S., Semorine, K., Watts, G.F., and Mamo, J. 2003. Identification of lipoproteins of intestinal origin in human atherosclerotic plaque. Clin. Chem. Lab. Med. 41(6): 792–795. doi:10.1515/CCLM.2003.120.PMID:12880143.
31. Pang, X.Y., Yao, M.H., Lu, Y.Q., and Gong, Q.Y. 2002. Effect of soy isoflavones on malondialdehyde and superoxide dismutase of blood and liver in hypercholesterolemia rats. Chin. J. New Drugs Clin. Rem. 21(5): 257–261.
32. Rahmouni, K., Correia, M.L., Haynes, W.G., and Mark, A.L. 2005. Obesityassociated hypertension: new insights into mechanisms. Hypertension, 45(1): 9–14. doi:10.1161/01.HYP.0000151325.83008.b4.PMID:15583075.
33. Unger, R.H. 2002. Lipotoxic diseases. Annu. Rev. Med. 53(1): 319–336. doi:10.1146/annurev.med.53.082901.104057.PMID:11818477.
34. Wang, K.-Q., and Cao, Y. 2007. Research progress in the chemical constituents and pharmacologic activities of Cyclocarya paliurus (Batal.) Iljinshaja. Heilongjiang Med. J. 31(8): 577–579. doi:10.3969/j.issn.1004-5775.2007.08.009.
35. Wang, Q., Jiang, C., Fang, S., Wang, J., Ji, Y., Shang, X., et al. 2013. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. J. Ethnopharmacol. 150(3): 1119–1127. doi:10.1016/j.jep.2013.10.040.PMID:24184190.
36. Xie, M.Y., and Li, L. 2001. Review in studies on chemical constituents and bioactivities of Cyclocarya paliurus. Chin. Tradit. Herb. Drugs, 32(4): 365–366. doi: 10.3321/j.issn:0253-2670.2001.04.039.
37. Yang, L., Chen, J.-H., Xu, T., Zhou, A.-S., and Yang, H.-K. 2012.Rice protein improves oxidative stress by regulating glutathione metabolism and attenuating oxidative damage to lipids and proteins in rats. Life Sci. 91(11–12): 389–394. doi:10.1016/j.lfs.2012.08.003.PMID:22906634.
38. Zhou, X.H., Dong, Y., Xiao, X., Wang, Y., Xu, Y., Xu, B., et al. 2011. A 90-day toxicology study of high-amylose transgenic rice grain in Sprague-Dawley rats. Food Chem. Toxicol. 49(12): 3112–3118. doi:10.1016/j.fct.2011.09.024.PMID:21967780.