Clerodendrum volubile inhibits key enzymes linked to type 2 diabetes but induces cytotoxicity in human embryonic kidney (HEK293) cells via exacerbated oxidative stress and proinflammation

Biomedicine and Pharmacotherapy

Volumn 106, Issue , 2018, Pages 1144-1152

  Erukainure, Ochuko L ^a,b   Narainpersad, Nicholisha ^a   Singh, Moganavelli ^a   Olakunle, Sanni ^a   Islam, Md Shahidul ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b FEDERAL INSTITUTE OF INDUSTRIAL RESEARCH   (Nigeria)

Author keywords

Apoptosis; Cytotoxicity; Oxidative stress; Proinflammation; Type 2 diabetes

Indexed keywords

ACARBOSE; ACRIDINE ORANGE; ADENOSINE TRIPHOSPHATASE; ALPHA GLUCOSIDASE; AMYLASE; ASCORBIC ACID; CATALASE; DICHLOROMETHANE; ETHIDIUM BROMIDE; GLUTATHIONE; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; AUTACOID; BIOLOGICAL MARKER; ENZYME INHIBITOR; GLYCOSIDASE INHIBITOR; PLANT EXTRACT;

ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CLERODENDRUM; CLERODENDRUM VOLUBILE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FERRIC REDUCING ANTIOXIDANT POWER ASSAY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS FRAGMENTOGRAPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BLOOD; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; EPITHELIUM CELL; GLUCOSE BLOOD LEVEL; INFLAMMATION; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; PLANT LEAF;

ADENOSINE TRIPHOSPHATE; AMYLASES; APOPTOSIS; BIOMARKERS; BLOOD GLUCOSE; CELL SURVIVAL; CLERODENDRUM; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPITHELIAL CELLS; GLYCOSIDE HYDROLASE INHIBITORS; HEK293 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPASE; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT LEAVES;

EID: 85049874510     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2018.07.013     Document Type: Article

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