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Volumn 61, Issue , 2017, Pages

Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

Author keywords

Anti diabetic agents; Glucose transporter 4 (GLUT4); Insulin resistance; KK Ay mice; L6 cells; Stigmasterol

Indexed keywords

CHOLESTEROL; GLUCOSE TRANSPORTER 4; METFORMIN; SOYBEAN OIL; STIGMASTEROL; TRIACYLGLYCEROL;

EID: 85049007944     PISSN: 16546628     EISSN: None     Source Type: Journal    
DOI: 10.1080/16546628.2017.1364117     Document Type: Article
Times cited : (99)

References (49)
  • 1
    • 82955247909 scopus 로고    scopus 로고
    • IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
    • Whiting DR, Guariguata L, Weil C, et al. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94:311–321.
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 311-321
    • Whiting, D.R.1    Guariguata, L.2    Weil, C.3
  • 2
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet P, Alberti KGMM, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782–787.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.M.M.2    Shaw, J.3
  • 3
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995–2025: Prevalence, numerical estimates, and projections
    • King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998;21:1414–1431.
    • (1998) Diabetes Care , vol.21 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 4
    • 84896719880 scopus 로고    scopus 로고
    • The pharmacogenetics of type 2 diabetes: A systematic review
    • Maruthur NM, Gribble MO, Bennett WL, et al. The pharmacogenetics of type 2 diabetes: a systematic review. Diabetes Care. 2014;37:876–886.
    • (2014) Diabetes Care , vol.37 , pp. 876-886
    • Maruthur, N.M.1    Gribble, M.O.2    Bennett, W.L.3
  • 5
    • 0033044252 scopus 로고    scopus 로고
    • Rapidly available glucose in foods: An in vitro measurement that reflects the glycemic response
    • Englyst KN, Englyst HN, Hudson GJ, et al. Rapidly available glucose in foods: an in vitro measurement that reflects the glycemic response. Am J Clin Nutr. 1999;69:448–454.
    • (1999) Am J Clin Nutr , vol.69 , pp. 448-454
    • Englyst, K.N.1    Englyst, H.N.2    Hudson, G.J.3
  • 6
    • 34248581989 scopus 로고    scopus 로고
    • Disordered lipid metabolism and the pathogenesis of insulin resistance
    • Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev. 2007;87:507–520.
    • (2007) Physiol Rev , vol.87 , pp. 507-520
    • Savage, D.B.1    Petersen, K.F.2    Shulman, G.I.3
  • 7
    • 84976260652 scopus 로고    scopus 로고
    • Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus
    • Tahrani AA, Barnett AH, Bailey CJ. Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nat Rev Endocrinol. 2016;12:566–592.
    • (2016) Nat Rev Endocrinol , vol.12 , pp. 566-592
    • Tahrani, A.A.1    Barnett, A.H.2    Bailey, C.J.3
  • 8
    • 40749137409 scopus 로고    scopus 로고
    • Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway
    • Tan M-J, Ye J-M, Turner N, et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol. 2008;15:263–273.
    • (2008) Chem Biol , vol.15 , pp. 263-273
    • Tan, M.-J.1    Ye, J.-M.2    Turner, N.3
  • 9
    • 84946904064 scopus 로고    scopus 로고
    • Effects of berberine and pomegranate seed oil on plasma phospholipid metabolites associated with risks of type 2 diabetes mellitus by U-HPLC/Q-TOF-MS
    • Wu X, Li Y, Wang Q, et al. Effects of berberine and pomegranate seed oil on plasma phospholipid metabolites associated with risks of type 2 diabetes mellitus by U-HPLC/Q-TOF-MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;1007:110–120.
    • (2015) J Chromatogr B Analyt Technol Biomed Life Sci , vol.1007 , pp. 110-120
    • Wu, X.1    Li, Y.2    Wang, Q.3
  • 10
    • 84963681273 scopus 로고    scopus 로고
    • Quercetin-rich Guava (Psidium guajava) juice in combination with trehalose reduces autophagy, apoptosis and pyroptosis formation in the kidney and pancreas of type II diabetic rats
    • Lin C-F, Kuo Y-T, Chen T-Y, et al. Quercetin-rich Guava (Psidium guajava) juice in combination with trehalose reduces autophagy, apoptosis and pyroptosis formation in the kidney and pancreas of type II diabetic rats. Molecules. 2016;21:334.
    • (2016) Molecules , vol.21 , pp. 334
    • Lin, C.-F.1    Kuo, Y.-T.2    Chen, T.-Y.3
  • 12
    • 58749104741 scopus 로고    scopus 로고
    • Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials
    • Abumweis SS, Barake R, Jones PJ. Plant sterols/stanols as cholesterol lowering agents: a meta-analysis of randomized controlled trials. Food Nutr Res. 2008;52:1811.
    • (2008) Food Nutr Res , vol.52 , pp. 1811
    • Abumweis, S.S.1    Barake, R.2    Jones, P.J.3
  • 13
    • 84936931513 scopus 로고    scopus 로고
    • Stigmasterol protects against Ang II-induced proliferation of the A7r5 aortic smooth muscle cell-line
    • Li C, Liu Y, Xie Z, et al. Stigmasterol protects against Ang II-induced proliferation of the A7r5 aortic smooth muscle cell-line. Food Funct. 2015;6:2266–2272.
    • (2015) Food Funct , vol.6 , pp. 2266-2272
    • Li, C.1    Liu, Y.2    Xie, Z.3
  • 14
    • 72449191694 scopus 로고    scopus 로고
    • Stigmasterol: A phytosterol with potentialanti-osteoarthritic properties
    • Gabay O, Sanchez C, Salvat C, et al. Stigmasterol: a phytosterol with potentialanti-osteoarthritic properties. Osteoarthritis Cartilage. 2010;18:106–116.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 106-116
    • Gabay, O.1    Sanchez, C.2    Salvat, C.3
  • 15
    • 84902377171 scopus 로고    scopus 로고
    • Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)
    • Zielińska S, Matkowski A. Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae). Phytochem Rev. 2014;13:391–416.
    • (2014) Phytochem Rev , vol.13 , pp. 391-416
    • Zielińska, S.1    Matkowski, A.2
  • 16
    • 84952793802 scopus 로고    scopus 로고
    • Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents
    • Casal JJ, Bollini M, Lombardo ME, et al. Thalidomide analogues: tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents. Eur J Pharm Sci. 2016;83:114–119.
    • (2016) Eur J Pharm Sci , vol.83 , pp. 114-119
    • Casal, J.J.1    Bollini, M.2    Lombardo, M.E.3
  • 17
    • 84906825009 scopus 로고    scopus 로고
    • Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells
    • Kim Y-S, Li X-F, Kang K-H, et al. Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells. BMB Rep. 2014;47:433–438.
    • (2014) BMB Rep , vol.47 , pp. 433-438
    • Kim, Y.-S.1    Li, X.-F.2    Kang, K.-H.3
  • 18
    • 84987923125 scopus 로고    scopus 로고
    • The effect of a plant extract enriched in stigmasterol and β-sitosterol on glycaemic status and glucose metabolism in alloxan-induced diabetic rats
    • Ramu R, Shirahatti PS, Nayakavadi S, et al. The effect of a plant extract enriched in stigmasterol and β-sitosterol on glycaemic status and glucose metabolism in alloxan-induced diabetic rats. Food Funct. 2016;7:3999–4011.
    • (2016) Food Funct , vol.7 , pp. 3999-4011
    • Ramu, R.1    Shirahatti, P.S.2    Nayakavadi, S.3
  • 19
    • 0037308195 scopus 로고    scopus 로고
    • Biosynthesis of β-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units
    • De-Eknamkul W, Potduang B. Biosynthesis of β-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. Phytochemistry. 2003;62:389–398.
    • (2003) Phytochemistry , vol.62 , pp. 389-398
    • De-Eknamkul, W.1    Potduang, B.2
  • 20
    • 85026630192 scopus 로고    scopus 로고
    • Anti-adipogenic effects of Tropaeolum majus (Nasturtium) ethanol extract on 3T3-L1 cells
    • Kim G-C, Kim J-S, Kim G-M, et al. Anti-adipogenic effects of Tropaeolum majus (nasturtium) ethanol extract on 3T3-L1 cells. Food Nutr Res. 2017;61:1339555.
    • (2017) Food Nutr Res , vol.61
    • Kim, G.-C.1    Kim, J.-S.2    Kim, G.-M.3
  • 21
    • 84992458351 scopus 로고    scopus 로고
    • Hypoglycemic activity and the potential mechanism of the flavonoid rich extract from Sophora tonkinensis Gagnep. In KK-Ay mice
    • Huang M, Deng S-H, Han Q-Q, et al. Hypoglycemic activity and the potential mechanism of the flavonoid rich extract from Sophora tonkinensis Gagnep. in KK-Ay mice. Front Pharmacol. 2016;5(7):288.
    • (2016) Front Pharmacol , vol.5 , Issue.7 , pp. 288
    • Huang, M.1    Deng, S.-H.2    Han, Q.-Q.3
  • 22
    • 84975217605 scopus 로고    scopus 로고
    • Antidiabetic activity of perylenequinonoid-rich extract from Shiraia bambu-sicola in KK-Ay mice with spontaneous type 2 diabetes mellitus
    • Huang M, Zhao P, Xiong MR, et al. Antidiabetic activity of perylenequinonoid-rich extract from Shiraia bambu-sicola in KK-Ay mice with spontaneous type 2 diabetes mellitus. J Ethnopharmacol. 2016;191:71–81.
    • (2016) J Ethnopharmacol , vol.191 , pp. 71-81
    • Huang, M.1    Zhao, P.2    Xiong, M.R.3
  • 23
    • 77953200528 scopus 로고    scopus 로고
    • Fat cell-specific ablation of rictor in mice impairs insulin-regu-lated fat cell and whole-body glucose and lipid metabolism
    • Kumar A, Lawrence JC Jr, Jung D-Y, et al. Fat cell-specific ablation of rictor in mice impairs insulin-regu-lated fat cell and whole-body glucose and lipid metabolism. Diabetes. 2010;59:1397–1406.
    • (2010) Diabetes , vol.59 , pp. 1397-1406
    • Kumar, A.1    Lawrence, J.C.2    Jung, D.-Y.3
  • 24
    • 61349198937 scopus 로고    scopus 로고
    • Intracellular retention and insulin-stimulated mobilization of GLUT4 glucose transporters
    • Rubin BR, Bogan JS. Intracellular retention and insulin-stimulated mobilization of GLUT4 glucose transporters. Vitam Horm. 2009;80:155–192.
    • (2009) Vitam Horm , vol.80 , pp. 155-192
    • Rubin, B.R.1    Bogan, J.S.2
  • 25
    • 0001044381 scopus 로고
    • Inbred strains originated came from Japanese native mice
    • Kondo K, Nozawa K, Tomita T, et al. Inbred strains originated came from Japanese native mice. Bull Exp Anim. 1957;6:107.
    • (1957) Bull Exp Anim , vol.6 , pp. 107
    • Kondo, K.1    Nozawa, K.2    Tomita, T.3
  • 26
    • 0001651621 scopus 로고
    • Breeding of mice strains for diabetes mellitus
    • Nishimura M. Breeding of mice strains for diabetes mellitus. Exp Anim. 1969;18:147–157.
    • (1969) Exp Anim , vol.18 , pp. 147-157
    • Nishimura, M.1
  • 27
    • 52749087214 scopus 로고    scopus 로고
    • Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
    • Kato T, Shimano H, Yamamoto T, et al. Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets. Diabetes. 2008;57:2382–2392.
    • (2008) Diabetes , vol.57 , pp. 2382-2392
    • Kato, T.1    Shimano, H.2    Yamamoto, T.3
  • 28
    • 84920025605 scopus 로고    scopus 로고
    • Metformin in patients with type 2 diabetes and kidney disease: A systematic review
    • Inzucchi SE, Lipska KJ, Mayo H, et al. Metformin in patients with type 2 diabetes and kidney disease: a systematic review. JAMA. 2014;312:2668–2675.
    • (2014) JAMA , vol.312 , pp. 2668-2675
    • Inzucchi, S.E.1    Lipska, K.J.2    Mayo, H.3
  • 29
    • 82455209029 scopus 로고    scopus 로고
    • Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
    • Stephenne X, Foretz M, Taleux N, et al. Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia. 2011;54:3101–3110.
    • (2011) Diabetologia , vol.54 , pp. 3101-3110
    • Stephenne, X.1    Foretz, M.2    Taleux, N.3
  • 30
    • 84958568314 scopus 로고    scopus 로고
    • Evaluation of Trigonella foenum-graecum extract in combination with swimming exercise compared to glib-enclamide consumption on type 2 diabetic rodents
    • Arshadi S, Azarbayjani MA, Hajiaghaalipour F, et al. Evaluation of Trigonella foenum-graecum extract in combination with swimming exercise compared to glib-enclamide consumption on type 2 diabetic rodents. Food Nutr Res. 2015;59:29717.
    • (2015) Food Nutr Res , vol.59
    • Arshadi, S.1    Azarbayjani, M.A.2    Hajiaghaalipour, F.3
  • 31
    • 84905396983 scopus 로고    scopus 로고
    • The molecular mechanisms underpinning the therapeutic properties of oleano-lic acid, its isomer and derivatives for type 2 diabetes and associated complications
    • Camer D, Yu Y, Szabo A, et al. The molecular mechanisms underpinning the therapeutic properties of oleano-lic acid, its isomer and derivatives for type 2 diabetes and associated complications. Mol Nutr Food Res. 2014;58:1750–1759.
    • (2014) Mol Nutr Food Res , vol.58 , pp. 1750-1759
    • Camer, D.1    Yu, Y.2    Szabo, A.3
  • 32
    • 84960104258 scopus 로고    scopus 로고
    • Involvement of dietary saturated fats, from all sources or of dairy origin only, in insulin resistance and type 2 diabetes
    • Morio B, Fardet A, Legrand P, et al. Involvement of dietary saturated fats, from all sources or of dairy origin only, in insulin resistance and type 2 diabetes. Nutr Rev. 2016;74:33–47.
    • (2016) Nutr Rev , vol.74 , pp. 33-47
    • Morio, B.1    Fardet, A.2    Legrand, P.3
  • 33
    • 84864025055 scopus 로고    scopus 로고
    • Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes
    • Schofield CJ, Sutherland C. Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes. Diabet Med. 2012;29:972–979.
    • (2012) Diabet Med , vol.29 , pp. 972-979
    • Schofield, C.J.1    Sutherland, C.2
  • 34
    • 85073554946 scopus 로고    scopus 로고
    • Recent advances in obesity-induced inflammation and insulin resistance
    • Sanshiro T, Francis K, Yoshikazu T. Recent advances in obesity-induced inflammation and insulin resistance. Front Endocrinol (Lausanne). 2013;4:93.
    • (2013) Front Endocrinol (Lausanne) , vol.4 , pp. 93
    • Sanshiro, T.1    Francis, K.2    Yoshikazu, T.3
  • 35
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112:1821– 1830.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 36
    • 84860252542 scopus 로고    scopus 로고
    • Different adipose depots: Their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents
    • Bjørndal B, Burri L, Staalesen V, et al. Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. J Obes. 2011;2011:1–15.
    • (2011) J Obes , vol.2011 , pp. 1-15
    • Bjørndal, B.1    Burri, L.2    Staalesen, V.3
  • 37
    • 84960106701 scopus 로고    scopus 로고
    • The potential protective action of vitamin D in hepatic insulin resistance and pancreatic islet dysfunction in type 2 diabetes mellitus
    • Leung PS. The potential protective action of vitamin D in hepatic insulin resistance and pancreatic islet dysfunction in type 2 diabetes mellitus. Nutrients. 2016;8:147.
    • (2016) Nutrients , vol.8 , pp. 147
    • Leung, P.S.1
  • 38
    • 84867332588 scopus 로고    scopus 로고
    • NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of pancreatic β-cells induced by very low-density lipoprotein
    • Jiao J, Dou L, Li M, et al. NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of pancreatic β-cells induced by very low-density lipoprotein. Mol Cell Biochem. 2012;370:103–113.
    • (2012) Mol Cell Biochem , vol.370 , pp. 103-113
    • Jiao, J.1    Dou, L.2    Li, M.3
  • 39
    • 84861444859 scopus 로고    scopus 로고
    • Regulation of glucose transport by insulin: Traffic control of GLUT4
    • Leto D, Saltiel AR. Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol. 2012;13:383–396.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 383-396
    • Leto, D.1    Saltiel, A.R.2
  • 40
    • 0036270751 scopus 로고    scopus 로고
    • Regulated transport of the glucose transporter GLUT4
    • Bryant NJ, Govers R, James DE. Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol. 2002;3:267–277.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 267-277
    • Bryant, N.J.1    Govers, R.2    James, D.E.3
  • 41
    • 61449130618 scopus 로고    scopus 로고
    • Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization
    • Liu F, Dallas YQ, Castriota G, et al. Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization. Biochem J. 2009;418:413–420.
    • (2009) Biochem J , vol.418 , pp. 413-420
    • Liu, F.1    Dallas, Y.Q.2    Castriota, G.3
  • 42
    • 0031888070 scopus 로고    scopus 로고
    • Regulation of GLUT4 protein and glycogen synthase during muscle glycogen synthesis after exercise
    • Ivy JL, Kuo C-H. Regulation of GLUT4 protein and glycogen synthase during muscle glycogen synthesis after exercise. Acta Physiol Scand. 1998;162:295–304.
    • (1998) Acta Physiol Scand , vol.162 , pp. 295-304
    • Ivy, J.L.1    Kuo, C.-H.2
  • 43
    • 0024309742 scopus 로고
    • Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting
    • Berger J, Biswas C, Vicario PP, et al. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature. 1989;340:70–72.
    • (1989) Nature , vol.340 , pp. 70-72
    • Berger, J.1    Biswas, C.2    Vicario, P.P.3
  • 44
    • 0024386710 scopus 로고
    • Regulation of glucose transporter messenger RNA in insulin-deficient states
    • Sivitz WI, DeSautel SL, Kayano T, et al. Regulation of glucose transporter messenger RNA in insulin-deficient states. Nature. 1989;340:72–74.
    • (1989) Nature , vol.340 , pp. 72-74
    • Sivitz, W.I.1    Desautel, S.L.2    Kayano, T.3
  • 45
    • 0028051967 scopus 로고
    • Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene
    • Treadway JL, Hargrove DM, Nardone NA, et al. Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene. J Biol Chem. 1994;269:29956–29961.
    • (1994) J Biol Chem , vol.269 , pp. 29956-29961
    • Treadway, J.L.1    Hargrove, D.M.2    Nardone, N.A.3
  • 46
    • 84934930378 scopus 로고    scopus 로고
    • Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice
    • Yang X-Z, Yang J, Xu C, et al. Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice. J Ethnopharmacol. 2015;171:161–170.
    • (2015) J Ethnopharmacol , vol.171 , pp. 161-170
    • Yang, X.-Z.1    Yang, J.2    Xu, C.3
  • 47
    • 84902537676 scopus 로고    scopus 로고
    • Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities
    • Wang C, Yang J, Zhao P, et al. Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities. Bioorg Med Chem Lett. 2014;24:3096–3099.
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 3096-3099
    • Wang, C.1    Yang, J.2    Zhao, P.3
  • 48
    • 0035825643 scopus 로고    scopus 로고
    • Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    • Abel ED, Peroni O, Kim JK, et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 2001;409:729–733.
    • (2001) Nature , vol.409 , pp. 729-733
    • Abel, E.D.1    Peroni, O.2    Kim, J.K.3
  • 49
    • 0033834248 scopus 로고    scopus 로고
    • Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    • Zisman A, Peroni OD, Abel ED, et al. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med. 2000;6:924–928.
    • (2000) Nat Med , vol.6 , pp. 924-928
    • Zisman, A.1    Peroni, O.D.2    Abel, E.D.3


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