메뉴 건너뛰기




Volumn 171, Issue , 2015, Pages 161-170

Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice

Author keywords

AMPK; Antidiabetic; GLUT4; KKAy mice; Off line HPLC NMR; Sophora flavescens

Indexed keywords

ADENYLATE KINASE; ANTIDIABETIC AGENT; FATTY ACID; FLAVONOID; GLUCOSE; GLUCOSE TRANSPORTER 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; SOPHORA FLAVESCENS EXTRACT; TRIACYLGLYCEROL; CHOLESTEROL; GLUCOSE BLOOD LEVEL;

EID: 84934930378     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.05.043     Document Type: Article
Times cited : (56)

References (45)
  • 2
    • 33845666593 scopus 로고    scopus 로고
    • Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action
    • L. Bai, Y. Wang, J. Fan, Y. Chen, W. Ji, A. Qu, P. Xu, D.E. James, and T. Xu Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action Cell Metab. 5 2007 47 57
    • (2007) Cell Metab. , vol.5 , pp. 47-57
    • Bai, L.1    Wang, Y.2    Fan, J.3    Chen, Y.4    Ji, W.5    Qu, A.6    Xu, P.7    James, D.E.8    Xu, T.9
  • 3
    • 84864508209 scopus 로고    scopus 로고
    • Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice
    • P. Bansal, P. Paul, J. Mudgal, P.G. Nayak, S.T. Pannakal, K.I. Priyadarsini, and M.K. Unnikrishnan Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice Exp. Toxicol. Pathol. 64 2012 651 658
    • (2012) Exp. Toxicol. Pathol. , vol.64 , pp. 651-658
    • Bansal, P.1    Paul, P.2    Mudgal, J.3    Nayak, P.G.4    Pannakal, S.T.5    Priyadarsini, K.I.6    Unnikrishnan, M.K.7
  • 4
    • 0347318052 scopus 로고    scopus 로고
    • The AMP-activated protein kinase cascade-a unifying system for energy control
    • D. Carling The AMP-activated protein kinase cascade-a unifying system for energy control Trends Biochem. Sci. 29 2004 18 24
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 18-24
    • Carling, D.1
  • 5
    • 3042714528 scopus 로고    scopus 로고
    • The prospective pioglitazone clinical trial in macrovascular events (PROactive): Can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients
    • B. Charbonnel, J. Dormandy, E. Erdmann, M. Massi-Benedetti, and A. Skene The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients Diabetes Care 27 2004 1647 1653
    • (2004) Diabetes Care , vol.27 , pp. 1647-1653
    • Charbonnel, B.1    Dormandy, J.2    Erdmann, E.3    Massi-Benedetti, M.4    Skene, A.5
  • 6
    • 33745697997 scopus 로고    scopus 로고
    • Solvent effect in 1H NMR spectra of 3'-hydroxy-4'-methoxy isoflavonoids from Astragalus membranaceus var. Mongholicus
    • X.G. Du, Y.J. Bai, H. Liang, Z.Y. Wang, Y.Y. Zhao, Q.Y. Zhang, and L. Huang Solvent effect in 1H NMR spectra of 3'-hydroxy-4'-methoxy isoflavonoids from Astragalus membranaceus var. mongholicus Magn. Reson. Chem. 44 2006 708 712
    • (2006) Magn. Reson. Chem. , vol.44 , pp. 708-712
    • Du, X.G.1    Bai, Y.J.2    Liang, H.3    Wang, Z.Y.4    Zhao, Y.Y.5    Zhang, Q.Y.6    Huang, L.7
  • 7
    • 75349099919 scopus 로고    scopus 로고
    • Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
    • S. Fogarty, and D.G. Hardie Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer Biochim. Biophys. Acta (BBA) - Proteins Proteomics 1804 2010 581 591
    • (2010) Biochim. Biophys. Acta (BBA) - Proteins Proteomics , vol.1804 , pp. 581-591
    • Fogarty, S.1    Hardie, D.G.2
  • 10
    • 80053035284 scopus 로고    scopus 로고
    • AMP-activated protein kinase - An energy sensor that regulates all aspects of cell function
    • D.G. Hardie AMP-activated protein kinase - an energy sensor that regulates all aspects of cell function Genes Dev. 25 2011 1895 1908
    • (2011) Genes Dev. , vol.25 , pp. 1895-1908
    • Hardie, D.G.1
  • 12
    • 29144455044 scopus 로고    scopus 로고
    • Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor
    • P.I. Hillerns, and M. Wink Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor Planta Med. 71 2005 1065 1068
    • (2005) Planta Med. , vol.71 , pp. 1065-1068
    • Hillerns, P.I.1    Wink, M.2
  • 13
    • 49749122118 scopus 로고    scopus 로고
    • Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts
    • H.A. Jung, N.Y. Yoon, S.S. Kang, Y.S. Kim, and J.S. Choi Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts J. Pharm. Pharmacol. 9 2008 1227 1236
    • (2008) J. Pharm. Pharmacol. , vol.9 , pp. 1227-1236
    • Jung, H.A.1    Yoon, N.Y.2    Kang, S.S.3    Kim, Y.S.4    Choi, J.S.5
  • 15
    • 34347208670 scopus 로고    scopus 로고
    • Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase
    • E.J. Kim, S.N. Jung, K.H. Son, S.R. Kim, T.Y. Ha, and M.G. Park Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase Mol. Pharmacol. 72 2007 62 72
    • (2007) Mol. Pharmacol. , vol.72 , pp. 62-72
    • Kim, E.J.1    Jung, S.N.2    Son, K.H.3    Kim, S.R.4    Ha, T.Y.5    Park, M.G.6
  • 18
    • 0015724432 scopus 로고
    • Constituents of Chinese crude drug "kushen" (the root of Sophora flavescens Ait.). Isolation of five new flavonoids and formononetin
    • K. Kyogoku, K. Hatayama, and M. Komatsu Constituents of Chinese crude drug "Kushen" (the root of Sophora flavescens Ait.). Isolation of five new flavonoids and formononetin Chem. Pharm. Bull. 21 1973 2733 2738
    • (1973) Chem. Pharm. Bull. , vol.21 , pp. 2733-2738
    • Kyogoku, K.1    Hatayama, K.2    Komatsu, M.3
  • 20
    • 34247357752 scopus 로고    scopus 로고
    • Oral antidiabetic agents in type 2 diabetes
    • C. Levetan Oral antidiabetic agents in type 2 diabetes Curr. Med. Res. Opin. 23 2007 945 952
    • (2007) Curr. Med. Res. Opin. , vol.23 , pp. 945-952
    • Levetan, C.1
  • 21
    • 79955399980 scopus 로고    scopus 로고
    • A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells
    • Z. Lian, Y. Li, J. Gao, K. Qu, J. Li, L. Hao, S. Wu, and H. Zhu A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells Lipids Health Dis. 10 2011 67
    • (2011) Lipids Health Dis. , vol.10 , pp. 67
    • Lian, Z.1    Li, Y.2    Gao, J.3    Qu, K.4    Li, J.5    Hao, L.6    Wu, S.7    Zhu, H.8
  • 22
    • 84872153680 scopus 로고    scopus 로고
    • Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats
    • S.Z. Liu, Y.X. Deng, B. Chen, X.J. Zhang, Q.Z. Shi, and X.M. Qiu Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats J. Ethnopharmacol. 145 2013 490 498
    • (2013) J. Ethnopharmacol. , vol.145 , pp. 490-498
    • Liu, S.Z.1    Deng, Y.X.2    Chen, B.3    Zhang, X.J.4    Shi, Q.Z.5    Qiu, X.M.6
  • 23
    • 84902987419 scopus 로고    scopus 로고
    • Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae
    • Z. Lu, M. Li, J. Wang, D. Wei, Q. Liu, and L. Kong Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae Reprod. Toxicol. 47 2014 33 41
    • (2014) Reprod. Toxicol. , vol.47 , pp. 33-41
    • Lu, Z.1    Li, M.2    Wang, J.3    Wei, D.4    Liu, Q.5    Kong, L.6
  • 24
    • 84885677247 scopus 로고    scopus 로고
    • AMPK in myocardial infarction and diabetes: The yin/yang effect
    • A. Moussa, and J. Li AMPK in myocardial infarction and diabetes: the yin/yang effect Acta Pharmacol. Sin. 2 2012 368 378
    • (2012) Acta Pharmacol. Sin. , vol.2 , pp. 368-378
    • Moussa, A.1    Li, J.2
  • 26
    • 84861019724 scopus 로고    scopus 로고
    • Targeting peroxisome proliferator-activated receptors (PPARs): Development of modulators
    • C. Pirat, A. Farce, N. Lebègue, N. Renault, C. Furman, R. Millet, and P. Chavatte Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators J. Med. Chem. 55 2012 4027 4061
    • (2012) J. Med. Chem. , vol.55 , pp. 4027-4061
    • Pirat, C.1    Farce, A.2    Lebègue, N.3    Renault, N.4    Furman, C.5    Millet, R.6    Chavatte, P.7
  • 28
    • 58349089703 scopus 로고    scopus 로고
    • Microsatellite analysis in two populations of Kunming mice
    • H.T. Shang, H. Wei, B.F. Yue, P. Xu, and H.G. Huang Microsatellite analysis in two populations of Kunming mice Lab. Anim. 43 2009 34 40
    • (2009) Lab. Anim. , vol.43 , pp. 34-40
    • Shang, H.T.1    Wei, H.2    Yue, B.F.3    Xu, P.4    Huang, H.G.5
  • 29
    • 84934943220 scopus 로고    scopus 로고
    • Studies on prevention of diabetogenous cataract by Chinese crude drug Sophora
    • H.C. Shi, and Q.Y. Huang Studies on prevention of diabetogenous cataract by Chinese crude drug Sophora Strait Pharm. J. 11 1999 15 17
    • (1999) Strait Pharm. J. , vol.11 , pp. 15-17
    • Shi, H.C.1    Huang, Q.Y.2
  • 31
    • 54449083139 scopus 로고    scopus 로고
    • Antidiabetic activity of 50% ethanolic extract of Ricinus communis and its purified fractions
    • P. Shokeen, P. Anand, Y.K. Murali, and V. Tandon Antidiabetic activity of 50% ethanolic extract of Ricinus communis and its purified fractions Food Chem. Toxicol. 46 2008 3458 3466
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 3458-3466
    • Shokeen, P.1    Anand, P.2    Murali, Y.K.3    Tandon, V.4
  • 32
    • 0037826011 scopus 로고    scopus 로고
    • Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity
    • J.K. Son, J.S. Park, A.K. Kim, Y.S. Kim, S.R. Chung, and S.H. Lee Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity Planta Med. 69 2003 559 561
    • (2003) Planta Med. , vol.69 , pp. 559-561
    • Son, J.K.1    Park, J.S.2    Kim, A.K.3    Kim, Y.S.4    Chung, S.R.5    Lee, S.H.6
  • 33
    • 84859157035 scopus 로고    scopus 로고
    • Hypertriglyceridemia secondary to obesity and diabetes
    • S. Subramanian, and A. Chait Hypertriglyceridemia secondary to obesity and diabetes Biochim. Biophys. Acta 1821 2012 819 825
    • (2012) Biochim. Biophys. Acta , vol.1821 , pp. 819-825
    • Subramanian, S.1    Chait, A.2
  • 35
    • 48449084609 scopus 로고    scopus 로고
    • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
    • N. Turner, J.Y. Li, A. Gosby, S.W. To, Z. Cheng, H. Miyoshi, M.M. Taketo, G.J. Cooney, E.W. Kraegen, D.E. James, L.H. Hu, J. Li, and J.M. Ye Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action Diabetes 5 2008 1414 1418
    • (2008) Diabetes , vol.5 , pp. 1414-1418
    • Turner, N.1    Li, J.Y.2    Gosby, A.3    To, S.W.4    Cheng, Z.5    Miyoshi, H.6    Taketo, M.M.7    Cooney, G.J.8    Kraegen, E.W.9    James, D.E.10    Hu, L.H.11    Li, J.12    Ye, J.M.13
  • 36
    • 84874901744 scopus 로고    scopus 로고
    • Herbal natural products as a source of monoamine oxidase inhibitors: A review
    • D. Vina, S. Serra, M. Lamela, and G. Delogu Herbal natural products as a source of monoamine oxidase inhibitors: a review Curr. Top. Med. Chem. 12 2012 2131 2144
    • (2012) Curr. Top. Med. Chem. , vol.12 , pp. 2131-2144
    • Vina, D.1    Serra, S.2    Lamela, M.3    Delogu, G.4
  • 38
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes estimates for the year 2000 and projections for 2030
    • S. Wild, G. Roglic, A. Green, R. Sicree, and H. King Global prevalence of diabetes estimates for the year 2000 and projections for 2030 Diabetes Care 27 2004 1047 1053
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 39
    • 23644460869 scopus 로고    scopus 로고
    • Phytochemistry in the microgram domain - A LC-NMR perspective
    • J.L. Wolfender, E.F. Queiroz, and K. Hostettmann Phytochemistry in the microgram domain - a LC-NMR perspective Magn. Reson. Chem. 43 2005 697 709
    • (2005) Magn. Reson. Chem. , vol.43 , pp. 697-709
    • Wolfender, J.L.1    Queiroz, E.F.2    Hostettmann, K.3
  • 42
    • 22144431872 scopus 로고    scopus 로고
    • AMP-activated protein kinase and malonyl-CoA: Targets for treating insulin resistance?
    • J.M. Ye, N.B. Ruderman, and E.W. Kraegen AMP-activated protein kinase and malonyl-CoA: targets for treating insulin resistance? Drug Discov. Today: Ther. Strateg. 2 2005 157 163
    • (2005) Drug Discov. Today: Ther. Strateg. , vol.2 , pp. 157-163
    • Ye, J.M.1    Ruderman, N.B.2    Kraegen, E.W.3
  • 43
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An emerging drug target for diabetes and the metabolic syndrome
    • B.B. Zhang, G. Zhou, and C. Li AMPK: an emerging drug target for diabetes and the metabolic syndrome Cell Metab. 9 2009 407 416
    • (2009) Cell Metab. , vol.9 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3
  • 44
    • 33744548069 scopus 로고    scopus 로고
    • Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced β cell dysfunction in isolated pancreatic islets
    • C.Y. Zhang, L.E. Parton, C.P. Ye, S. Krauss, R.C. Shen, C.T. Lin, J.A. Porco Jr., and B.B. Lowell Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced β cell dysfunction in isolated pancreatic islets Cell Metab. 3 2006 417 427
    • (2006) Cell Metab. , vol.3 , pp. 417-427
    • Zhang, C.Y.1    Parton, L.E.2    Ye, C.P.3    Krauss, S.4    Shen, R.C.5    Lin, C.T.6    Porco, Jr.J.A.7    Lowell, B.B.8
  • 45
    • 84878396398 scopus 로고    scopus 로고
    • A novel flavonoid isolated from Sophora flavescens exhibited anti-angiogenesis activity, decreased VEGF expression and caused G0/G1 cell cycle arrest in vitro
    • X.L. Zhang, M.A. Cao, L.P. Pu, S.S. Huang, Q.X. Gao, C.S. Yuan, and C.M. Wang A novel flavonoid isolated from Sophora flavescens exhibited anti-angiogenesis activity, decreased VEGF expression and caused G0/G1 cell cycle arrest in vitro Pharmazie 68 2013 369 375
    • (2013) Pharmazie , vol.68 , pp. 369-375
    • Zhang, X.L.1    Cao, M.A.2    Pu, L.P.3    Huang, S.S.4    Gao, Q.X.5    Yuan, C.S.6    Wang, C.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.