The effect of a plant extract enriched in stigmasterol and β-sitosterol on glycaemic status and glucose metabolism in alloxan-induced diabetic rats

Food and Function

Volumn 7, Issue 9, 2016, Pages 3999-4011

  Ramu, Ramith ^a   Shirahatti, Prithvi S ^a,b   Nayakavadi, Shivasharanappa ^c   Vadivelan, R ^d   Zameer, Farhan ^e   Dhananjaya, Bhadrapura Lakkappa ^f   Nagendra Prasad, M N ^b  

^a Sri Dharmasthala Manjunatheshwara College of Post Graduate Centre   (India)

^b SRI JAYACHAMARAJENDRA COLLEGE OF ENGINEERING   (India)

^c Department of Veterinary Pathology   (India)

^d JSS COLLEGE OF PHARMACY   (India)

^e Pooja Bhagavat Memorial Mahajana PG Centre   (India)

^f JAIN UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; AMINO ACIDS; BODY FLUIDS; ENZYME ACTIVITY; ENZYMES; FRUITS; GLUCOSE; INSULIN; METABOLISM; PHOSPHATASES; PLANT EXTRACTS; UREA;

ALKALINE PHOSPHATASE; FRUCTOSE-1 ,6-BISPHOSPHATASE; GLUCOSE METABOLISM; GLUCOSE-6-PHOSPHATASE; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; GLYCOGEN PHOSPHORYLASE; HISTOLOGICAL OBSERVATIONS; LACTATE DEHYDROGENASE;

RATS;

ALLOXAN; ANTIDIABETIC AGENT; BIOLOGICAL MARKER; GAMMA-SITOSTEROL; INSULIN; PLANT EXTRACT; SITOSTEROL DERIVATIVE; STIGMASTEROL;

ANIMAL; AYURVEDA; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DIET THERAPY; DIETARY SUPPLEMENT; ETHNOPHARMACOLOGY; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GROWTH, DEVELOPMENT AND AGING; HYPERGLYCEMIA; ISOLATION AND PURIFICATION; MALE; METABOLISM; MUSA; PANCREAS ISLET BETA CELL; PATHOLOGY; PLANT LEAF; RAT; SECRETION (PROCESS); TOXICITY TESTING; TUMOR CELL LINE; WISTAR RAT;

ALLOXAN; ANIMALS; BIOMARKERS; CELL LINE, TUMOR; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; ETHNOPHARMACOLOGY; FEMALE; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; MALE; MEDICINE, AYURVEDIC; MUSA; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; SITOSTEROLS; STIGMASTEROL; TOXICITY TESTS, ACUTE;

EID: 84987923125     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c6fo00343e     Document Type: Article

References (38)

1. International Diabetes Federation (IDF), IDF Diabetes Atlas, International Diabetes Federation, Brussels, Belgium, 6th edn, 2013
2. R. Ramith S. S. Prithvi Z. Farhan M. N. P. Nagendra Investigation of antihyperglycaemic activity of banana (Musa sp. var. Nanjangud rasa bale) pseudostem in normal and diabetic rats J. Sci. Food Agric. 2015 95 165 173
3. D. Monireh A quick look at biochemistry: Carbohydrate metabolism Clin. Biochem. 2013 46 1339 1352
4. P. P. Prabhakaran G. D. Vishalakshiamma R. Thankappan Effects of coconut water on carbohydrate metabolism and pancreatic pathology of alloxan induced diabetic rats Eur. J. Intern. Med. 2013 5 234 240
5. H. P. Rang, M. M. Dale and J. M. Rittar, The endocrine system Pharmacology, in Pharmacology, Longman Group Ltd., UK, 2nd edn, 1991, pp. 504-508
6. R. Ramith S. S. Prithvi Z. Farhan V. R. Lakshmi M. N. P. Nagendra Inhibitory effect of banana (Musa sp. var. Nanjangud rasa bale) flower extract and its constituents Umbelliferone and Lupeol on α-glucosidase, aldose reductase and glycation at multiple stages S. Afr. J. Bot. 2014 95 54 63
7. I. R. Syed M. Neetu Traditional Indian Medicines Used for the Management of Diabetes Mellitus J. Diabetes Res. 2013 712092 10.1155/2013/712092
8. World Health Organisation (WHO), WHO Expert Committee on Diabetes Mellitus: second report, World Health Organ Technical Report Series, 1980, 646, 1 80
9. C. Shuxia S. Xiaoqing C. Siqiong L. Panpan D. Junna C. Yanxia M. Huanwen Evaluation of Garlic Cultivars for Polyphenolic Content and Antioxidant Properties PLoS One 2013 8 e79730
10. H. B. Rajesh R. J. Mukul A. J. Pradip et al. Synthesis and antidiabetic activity of 2,5-disubstituted3-imidazol-2-yl-pyrrolo [2,3- b] pyridines and thieno [2,3- b] pyridines Bioorg. Med. Chem. 2007 15 6782 6795
11. OECD Guidelines for the Testing of Chemicals, Acute Oral Toxicity-Acute Toxic Class Method: OECD 423. Organisation for Economic Cooperation and Development, Paris, 2001
12. L. M. Gail Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar Anal. Chem. 1959 31 426 428
13. L. D. David A. J. Harold Spectrophotometric studies: spectrophotometric constants for common haemoglobin derivatives in human, dog and rabbit blood J. Biol. Chem. 1932 98 719 733
14. S. S. Nayak T. N. Pattabiraman A new colorimetric method for the estimation of glycosylated hemoglobin Clin. Chim. Acta 1981 109 267 274
15. O. H. Lowry J. R. Nira F. A. Lewis J. R. Rose Protein measurement with the Folin phenol reagent J. Biol. Chem. 1951 193 265 275
16. A. Kemp J. M. K. V. H. Adrienne A colorimetric micro-method for the determination of glycogen in tissues Biochem. J. 1954 56 646 648
17. L. F. Leloir and S. H. Goldemberg, Glycogen synthetase from rat liver: (Glucose) n + (UDPG) → (Glucose) n + 1 + UDP, in Methods in Enzymology, ed., S. P. Colowick, and, N. O. Kalpan, Academic Press, New York, 1962, pp. 145-147
18. M. Cornblath P. J. Randle A. Parmeggiani H. E. Morgan Regulation of glycogenolysis in muscle. Effects of glucagon and anoxia on lactate production, glycogen content, and phosphorylase activity in the perfused isolated rat heart J. Biol. Chem. 1963 238 1592 1597
19. M. Raju S. Subramani A. Natarajan Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats Biochimie 2013 95 1848 1854
20. V. Mahmood H. Mina V. Mohammad Antidiabetic effects of quercetin in streptozocin-induced diabetic rats Comp. Biochem. Physiol., Part C 2003 135 357 364
21. J. King, in Practical Clinical Enzymology, Princeton MJ (fol) Van D Nostrand Company, London, 1965, p. 363
22. C. I. Pogson R. M. Denton Effect of alloxan diabetes, starvation and re-feeding on glycolytic kinase activities in rat epididymal adipose tissue Nature 1967 216 156 157
23. G. Luna, Manual of Histological Staining Method of the Armed Forces Institute of Pathology, McGraw-Hill Book Company, New York, 3rd edn, 1968
24. S. P. C. Venkata P. Indra Isolation of Stigmasterol and β-Sitosterol from the dichloromethane extract of Rubussuavissimus Int. Curr. Pharm. J. 2012 1 239 242
25. K. T. Ashok M. J. Rao Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects Curr. Sci. 2002 83 30 38
26. R. Ankur A. Shahjad Alloxan induced diabetes: mechanisms and effects Int. J. Res. Pharm. Biomed. Sci. 2012 3 819 821
27. S. Indradevia S. Ilavenila B. Kaleeswarana S. Srigopalram S. Ravikumar Ethanolic extract of Crinum asiaticum attenuates hyperglycemia-mediated oxidative stress and protects hepatocytes in alloxan induced experimental diabetic rats J. King Saud Univ., Sci. 2012 24 171 177
28. R. A. DeFronzo D. Simonson E. Ferrannini Hepatic and peripheral insulin resistance: A common feature of Type 2 (non-insulin-dependent) and Type 1 (insulin-dependent) diabetes mellitus Diabetologia 1982 23 313 319
29. M. D. Ivorra M. P. D'Ocon M. Paya A. Villar Antihyperglycemic and insulin-releasing effects of beta-sitosterol 3-beta-D-glucoside and its aglycone, beta-sitosterol Arch. Int. Pharmacodyn. Ther. 1988 296 224 231
30. S. Panda M. Jafri A. Kara B. K. Meheta Thyroid inhibitory, antiperoxidative and hypoglycemic effects of stigmasterol isolated from Buteamonosperma Fitoterapia 2009 80 123 126
31. M. N. Chatterjea and S. Rana, Text Book of Medical Biochemistry, JaypeeBrothers Medical Publishers, New Delhi, India, 5th edn, 2002
32. K. Naourez N. Rim M. Kais H. Khaled B. Olfa B. Tahia E. F. Abdelfattah N. Moncef Antioxidative and ACE inhibitory activities of protein hydrolysates from zebra blenny (Salariabasilisca) in alloxan-induced diabetic rats Process Biochem. 2014 49 890 897
33. L. C. Brian B. A. Ashley T. Parvin G. H. Billy G. K. Raja Unusual susceptibility of heme proteins to damage by glucose during non-enzymatic glycation Biophys. Chem. 2003 105 743 755
34. P. R. Saraswathi G. Swaminathan Effect of sodium molybdate on carbohydrate metabolizing enzymes in alloxan-induced diabetic rats J. Nutr. Biochem. 2002 13 21 26
35. B. Rangachari D. Veeramuthu I. Savarimuthu Antidiabetic activity of γ-sitosterol isolated from Lippianodiflora L. in streptozotocin induced diabetic rats Eur. J. Pharmacol. 2011 667 410 418
36. F. M. El-Demerdash M. I. Yousef E. N. I. Abou Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats Food Chem. Toxicol. 2005 43 57 63
37. A. Larcan H. Lambert M. C. Laprevote-Heully N. Delorme Light and electron microscopic study of hepatic lesions in the course of hyperlactatemia in diabetic patients (author's transl) Diabetes Metab. 1979 5 103 112
38. S. Ramalingam N. Rajendran S. Palanivelu S. Panchanatham Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats Phytomedicine 2013 20 577 584