Hypoglycemic activity and the potential mechanism of the flavonoid rich extract from Sophora tonkinensis Gagnep. in KK-Ay mice

Frontiers in Pharmacology

Volumn 7, Issue SEP, 2016, Pages

  Huang, Mi ^a   Deng, Shihao ^a   Han, Qianqian ^a   Zhao, Ping ^a   Zhou, Qi ^a   Zheng, Sijian ^a   Ma, Xinhua ^a   Xu, Chan ^a   Yang, Jing ^a   Yang, Xinzhou ^a,b,c  

^a SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

GLUT4; Hypoglycemic agents; KK Ay mice; P AMPK; Sophora tonkinensis Gagnep.

Indexed keywords

CHOLESTEROL; COMPOUND C; FATTY ACID; FLAVONOID; GLUCOSE; GLUCOSE TRANSPORTER 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; PLANT EXTRACT; SOPHORATON KINENSIS EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FATTY ACID BLOOD LEVEL; GENE TRANSLOCATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HISTOLOGY; IN VIVO STUDY; INSULIN BLOOD LEVEL; LIQUID CHROMATOGRAPHY; LIVER; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ORAL GLUCOSE TOLERANCE TEST; PROTEIN EXPRESSION; SKELETAL MUSCLE; SOPHORA; SOPHORA TONKINENSIS; TRIACYLGLYCEROL BLOOD LEVEL; ULTRAVIOLET SPECTROSCOPY; WEIGHT REDUCTION; WESTERN BLOTTING;

EID: 84992458351     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2016.00288     Document Type: Article

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