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Volumn 370, Issue 1-2, 2012, Pages 103-113

NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of pancreatic β-cells induced by very low-density lipoprotein

Author keywords

Apoptosis; NADPH oxidase 2; NIT 1 cells; Reactive oxygen species; VLDL

Indexed keywords

INSULIN; JANUS KINASE; LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMALL INTERFERING RNA; VERY LOW DENSITY LIPOPROTEIN;

EID: 84867332588     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1402-z     Document Type: Article
Times cited : (14)

References (32)
  • 1
    • 0035856943 scopus 로고    scopus 로고
    • Diabetes mellitus and genetically programmed defects in beta-cell function
    • 11742410 10.1038/414788a 1:CAS:528:DC%2BD38XhtlymtA%3D%3D
    • Bell GI, Polonsky KS (2001) Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 414(6865):788-791
    • (2001) Nature , vol.414 , Issue.6865 , pp. 788-791
    • Bell, G.I.1    Polonsky, K.S.2
  • 2
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
    • 12637977 1:CAS:528:DC%2BD3sXhtVKkt74%3D
    • Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46(1):3-19
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kahn, S.E.1
  • 3
    • 33748203658 scopus 로고    scopus 로고
    • Metabolic syndrome: Focus on dyslipidemia
    • 10.1038/oby.2006.281 10.1038/oby.2006.281 1:CAS:528:DC%2BD28XlsVeksL0%3D
    • Ginsberg HN, Zhang YL, Hernandez-Ono A (2006) Metabolic syndrome: focus on dyslipidemia. Obesity (Silver Spring) 14(Suppl 1):41S-49S. doi: 10.1038/oby.2006.281
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.SUPPL. 1
    • Ginsberg, H.N.1    Zhang, Y.L.2    Hernandez-Ono, A.3
  • 4
    • 0037898380 scopus 로고    scopus 로고
    • Diabetic dyslipidaemia: From basic research to clinical practice
    • 12774165 10.1007/s00125-003-1111-y
    • Taskinen MR (2003) Diabetic dyslipidaemia: from basic research to clinical practice. Diabetologia 46(6):733-749
    • (2003) Diabetologia , vol.46 , Issue.6 , pp. 733-749
    • Taskinen, M.R.1
  • 5
    • 0032567996 scopus 로고    scopus 로고
    • Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome
    • 9526809 10.1016/S0002-9149(98)00033-2 1:CAS:528:DyaK1cXktVKqs7g%3D
    • Grundy SM (1998) Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome. Am J Cardiol 81(4A):18B-25B
    • (1998) Am J Cardiol , vol.81 , Issue.4 A
    • Grundy, S.M.1
  • 6
    • 13544253065 scopus 로고    scopus 로고
    • Metabolic syndrome: A clinical and molecular perspective
    • 15660501 10.1146/annurev.med.56.082103.104751 1:CAS:528: DC%2BD2MXisVSrsLg%3D
    • Moller DE, Kaufman KD (2005) Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med 56:45-62
    • (2005) Annu Rev Med , vol.56 , pp. 45-62
    • Moller, D.E.1    Kaufman, K.D.2
  • 7
    • 0036300774 scopus 로고    scopus 로고
    • Hypertriglyceridemia: A review beyond low-density lipoprotein
    • 12047794 10.1097/00045415-200205000-00005
    • Rapp RJ (2002) Hypertriglyceridemia: a review beyond low-density lipoprotein. Cardiol Rev 10(3):163-172
    • (2002) Cardiol Rev , vol.10 , Issue.3 , pp. 163-172
    • Rapp, R.J.1
  • 8
    • 46249093117 scopus 로고    scopus 로고
    • Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome
    • 18565848 10.1161/ATVBAHA.107.160192 1:CAS:528:DC%2BD1cXmvFehsb4%3D
    • Adiels M, Olofsson SO, Taskinen MR, Boren J (2008) Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol 28(7):1225-1236
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.7 , pp. 1225-1236
    • Adiels, M.1    Olofsson, S.O.2    Taskinen, M.R.3    Boren, J.4
  • 10
    • 0033901233 scopus 로고    scopus 로고
    • Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age
    • 10623672 10.1016/S0002-9440(10)64724-4 1:CAS:528:DC%2BD3cXns1yluw%3D%3D
    • Cnop M, Grupping A, Hoorens A, Bouwens L, Pipeleers-Marichal M, Pipeleers D (2000) Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age. Am J Pathol 156(1):237-244
    • (2000) Am J Pathol , vol.156 , Issue.1 , pp. 237-244
    • Cnop, M.1    Grupping, A.2    Hoorens, A.3    Bouwens, L.4    Pipeleers-Marichal, M.5    Pipeleers, D.6
  • 11
    • 70949087785 scopus 로고    scopus 로고
    • Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell
    • 10.1007/s00125-009-1536-z 19809798 10.1007/s00125-009-1536-z 1:CAS:528:DC%2BD1MXhsVWls7jL
    • Newsholme P, Morgan D, Rebelato E, Oliveira-Emilio HC, Procopio J, Curi R, Carpinelli A (2009) Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia 52(12):2489-2498. doi: 10.1007/s00125-009-1536-z
    • (2009) Diabetologia , vol.52 , Issue.12 , pp. 2489-2498
    • Newsholme, P.1    Morgan, D.2    Rebelato, E.3    Oliveira-Emilio, H.C.4    Procopio, J.5    Curi, R.6    Carpinelli, A.7
  • 12
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • 8720919 10.1016/0891-5849(96)02051-5 1:CAS:528:DyaK28XhvVWitLw%3D
    • Lenzen S, Drinkgern J, Tiedge M (1996) Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 20(3):463-466
    • (1996) Free Radic Biol Med , vol.20 , Issue.3 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 13
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
    • 9356019 10.2337/diabetes.46.11.1733 1:CAS:528:DyaK2sXntVKis74%3D
    • Tiedge M, Lortz S, Drinkgern J, Lenzen S (1997) Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46(11):1733-1742
    • (1997) Diabetes , vol.46 , Issue.11 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 14
    • 53849124696 scopus 로고    scopus 로고
    • NOX family NADPH oxidases in liver and in pancreatic islets: A role in the metabolic syndrome and diabetes?
    • 10.1042/BST0360920 18793162 10.1042/BST0360920 1:CAS:528: DC%2BD1cXhtlSrt7zO
    • Guichard C, Moreau R, Pessayre D, Epperson TK, Krause KH (2008) NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans 36(Pt 5):920-929. doi: 10.1042/BST0360920
    • (2008) Biochem Soc Trans , vol.36 , Issue.PART 5 , pp. 920-929
    • Guichard, C.1    Moreau, R.2    Pessayre, D.3    Epperson, T.K.4    Krause, K.H.5
  • 15
    • 78650023333 scopus 로고    scopus 로고
    • Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells
    • 10.1111/j.1742-4658.2010.07911.x 21073655 10.1111/j.1742-4658.2010.07911. x 1:CAS:528:DC%2BC3cXhsFOmsbzO
    • Yuan H, Lu Y, Huang X, He Q, Man Y, Zhou Y, Wang S, Li J (2010) Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells. FEBS J 277(24):5061-5071. doi: 10.1111/j.1742-4658.2010.07911.x
    • (2010) FEBS J , vol.277 , Issue.24 , pp. 5061-5071
    • Yuan, H.1    Lu, Y.2    Huang, X.3    He, Q.4    Man, Y.5    Zhou, Y.6    Wang, S.7    Li, J.8
  • 16
    • 78650852744 scopus 로고    scopus 로고
    • NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of beta-cells via JNK, p38 MAPK and p53 pathways
    • 10.1371/journal.pone.0015726 21209957 10.1371/journal.pone.0015726 1:CAS:528:DC%2BC3MXltVamtA%3D%3D
    • Yuan H, Zhang X, Huang X, Lu Y, Tang W, Man Y, Wang S, Xi J, Li J (2010) NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of beta-cells via JNK, p38 MAPK and p53 pathways. PLoS ONE 5(12):e15726. doi: 10.1371/journal.pone.0015726
    • (2010) PLoS ONE , vol.5 , Issue.12 , pp. 15726
    • Yuan, H.1    Zhang, X.2    Huang, X.3    Lu, Y.4    Tang, W.5    Man, Y.6    Wang, S.7    Xi, J.8    Li, J.9
  • 17
    • 34547830983 scopus 로고    scopus 로고
    • Diabetes associated cell stress and dysfunction: Role of mitochondrial and non-mitochondrial ROS production and activity
    • 10.1113/jphysiol.2007.135871 17584843 10.1113/jphysiol.2007.135871 1:CAS:528:DC%2BD2sXhtVSqt7nF
    • Newsholme P, Haber EP, Hirabara SM, Rebelato EL, Procopio J, Morgan D, Oliveira-Emilio HC, Carpinelli AR, Curi R (2007) Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol 583(Pt 1):9-24. doi: 10.1113/jphysiol.2007.135871
    • (2007) J Physiol , vol.583 , Issue.PART 1 , pp. 9-24
    • Newsholme, P.1    Haber, E.P.2    Hirabara, S.M.3    Rebelato, E.L.4    Procopio, J.5    Morgan, D.6    Oliveira-Emilio, H.C.7    Carpinelli, A.R.8    Curi, R.9
  • 18
    • 35748977935 scopus 로고    scopus 로고
    • Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo
    • 10.2337/db07-0279 17682092 10.2337/db07-0279 1:CAS:528: DC%2BD2sXhtlWitL%2FF
    • Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A (2007) Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo. Diabetes 56(11):2722-2731. doi: 10.2337/db07-0279
    • (2007) Diabetes , vol.56 , Issue.11 , pp. 2722-2731
    • Tang, C.1    Han, P.2    Oprescu, A.I.3    Lee, S.C.4    Gyulkhandanyan, A.V.5    Chan, G.N.6    Wheeler, M.B.7    Giacca, A.8
  • 20
    • 33847620225 scopus 로고    scopus 로고
    • Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases
    • 10.1016/j.exger.2006.10.011 17126513 10.1016/j.exger.2006.10.011 1:CAS:528:DC%2BD2sXivVanurs%3D
    • Krause KH (2007) Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol 42(4):256-262. doi: 10.1016/j.exger.2006.10.011
    • (2007) Exp Gerontol , vol.42 , Issue.4 , pp. 256-262
    • Krause, K.H.1
  • 21
    • 0037645789 scopus 로고    scopus 로고
    • Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase
    • 12765957 10.2337/diabetes.52.6.1457 1:CAS:528:DC%2BD3sXmt1Sjsrg%3D
    • Oliveira HR, Verlengia R, Carvalho CR, Britto LR, Curi R, Carpinelli AR (2003) Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase. Diabetes 52(6):1457-1463
    • (2003) Diabetes , vol.52 , Issue.6 , pp. 1457-1463
    • Oliveira, H.R.1    Verlengia, R.2    Carvalho, C.R.3    Britto, L.R.4    Curi, R.5    Carpinelli, A.R.6
  • 22
    • 0346103675 scopus 로고    scopus 로고
    • Visualizing lipid structure and raft domains in living cells with two-photon microscopy
    • 10.1073/pnas.25343861002534386100 14673117 10.1073/pnas.2534386100 1:CAS:528:DC%2BD2cXhtVCitw%3D%3D
    • Gaus K, Gratton E, Kable EP, Jones AS, Gelissen I, Kritharides L, Jessup W (2003) Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Proc Natl Acad Sci USA 100(26):15554-15559. doi: 10.1073/pnas.25343861002534386100
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.26 , pp. 15554-15559
    • Gaus, K.1    Gratton, E.2    Kable, E.P.3    Jones, A.S.4    Gelissen, I.5    Kritharides, L.6    Jessup, W.7
  • 23
    • 16544379437 scopus 로고    scopus 로고
    • The very low-density lipoprotein (VLDL) receptor: Characterization and functions as a peripheral lipoprotein receptor
    • 15356379 10.5551/jat.11.200 1:CAS:528:DC%2BD2cXosVyhtbo%3D
    • Takahashi S, Sakai J, Fujino T, Hattori H, Zenimaru Y, Suzuki J, Miyamori I, Yamamoto TT (2004) The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor. J Atheroscler Thromb 11(4):200-208
    • (2004) J Atheroscler Thromb , vol.11 , Issue.4 , pp. 200-208
    • Takahashi, S.1    Sakai, J.2    Fujino, T.3    Hattori, H.4    Zenimaru, Y.5    Suzuki, J.6    Miyamori, I.7    Yamamoto, T.T.8
  • 24
    • 0036721312 scopus 로고    scopus 로고
    • Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification
    • 12193557 10.1210/en.2002-220273 1:CAS:528:DC%2BD38XmsVSgtbg%3D
    • Cnop M, Hannaert JC, Grupping AY, Pipeleers DG (2002) Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification. Endocrinology 143(9):3449-3453
    • (2002) Endocrinology , vol.143 , Issue.9 , pp. 3449-3453
    • Cnop, M.1    Hannaert, J.C.2    Grupping, A.Y.3    Pipeleers, D.G.4
  • 25
    • 70450228396 scopus 로고    scopus 로고
    • Mechanism for endogenously expressed ApoE modulation of adipocyte very low density lipoprotein metabolism: Role in endocytic and lipase-mediated metabolic pathways
    • 10.1074/jbc.M109.004754 19767394 10.1074/jbc.M109.004754 1:CAS:528:DC%2BD1MXhtlyjsLrN
    • Huang ZH, Minshall RD, Mazzone T (2009) Mechanism for endogenously expressed ApoE modulation of adipocyte very low density lipoprotein metabolism: role in endocytic and lipase-mediated metabolic pathways. J Biol Chem 284(46):31512-31522. doi: 10.1074/jbc.M109.004754
    • (2009) J Biol Chem , vol.284 , Issue.46 , pp. 31512-31522
    • Huang, Z.H.1    Minshall, R.D.2    Mazzone, T.3
  • 26
    • 31744443116 scopus 로고    scopus 로고
    • Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells
    • 10.1161/10.1161/01.HYP.0000196727.53300.62 16344372 10.1161/10.1161/01. HYP.0000196727.53300.62 1:CAS:528:DC%2BD2MXhtlWjsr7P
    • Zhang AY, Yi F, Zhang G, Gulbins E, Li PL (2006) Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells. Hypertension 47(1):74-80. doi: 10.1161/10.1161/01.HYP.0000196727.53300.62
    • (2006) Hypertension , vol.47 , Issue.1 , pp. 74-80
    • Zhang, A.Y.1    Yi, F.2    Zhang, G.3    Gulbins, E.4    Li, P.L.5
  • 27
    • 77950023207 scopus 로고    scopus 로고
    • Oxidative stress and oxidative damage in carcinogenesis
    • 10.1177/0192623309356453 20019356 10.1177/0192623309356453 1:CAS:528:DC%2BC3cXjt1ajtb4%3D
    • Klaunig JE, Kamendulis LM, Hocevar BA (2010) Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol 38(1):96-109. doi: 10.1177/0192623309356453
    • (2010) Toxicol Pathol , vol.38 , Issue.1 , pp. 96-109
    • Klaunig, J.E.1    Kamendulis, L.M.2    Hocevar, B.A.3
  • 28
    • 77950052431 scopus 로고    scopus 로고
    • Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: Protective role of arjunolic acid
    • 10.1016/j.taap.2009.12.024 20053369 10.1016/j.taap.2009.12.024 1:CAS:528:DC%2BC3cXjvFKhtr0%3D
    • Manna P, Ghosh J, Das J, Sil PC (2010) Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: protective role of arjunolic acid. Toxicol Appl Pharmacol 244(2):114-129. doi: 10.1016/j.taap.2009.12.024
    • (2010) Toxicol Appl Pharmacol , vol.244 , Issue.2 , pp. 114-129
    • Manna, P.1    Ghosh, J.2    Das, J.3    Sil, P.C.4
  • 29
    • 10744227975 scopus 로고    scopus 로고
    • Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase
    • 14633849 10.2337/diabetes.52.12.2896 1:CAS:528:DC%2BD3sXpsFagsLg%3D
    • Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, Miyatsuka T, Watada H, Leibiger IB, Yamasaki Y, Hori M (2003) Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 52(12):2896-2904
    • (2003) Diabetes , vol.52 , Issue.12 , pp. 2896-2904
    • Kawamori, D.1    Kajimoto, Y.2    Kaneto, H.3    Umayahara, Y.4    Fujitani, Y.5    Miyatsuka, T.6    Watada, H.7    Leibiger, I.B.8    Yamasaki, Y.9    Hori, M.10
  • 30
    • 34250326302 scopus 로고    scopus 로고
    • The emerging role of FOXO transcription factors in pancreatic beta cells
    • 10.1677/JOE-06-0191 17470511 10.1677/JOE-06-0191 1:CAS:528: DC%2BD2sXlvFKkur4%3D
    • Glauser DA, Schlegel W (2007) The emerging role of FOXO transcription factors in pancreatic beta cells. J Endocrinol 193(2):195-207. doi: 10.1677/JOE-06-0191
    • (2007) J Endocrinol , vol.193 , Issue.2 , pp. 195-207
    • Glauser, D.A.1    Schlegel, W.2
  • 31
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • 10.1038/ng890ng890 12219087 10.1038/ng890 1:CAS:528:DC%2BD38XotlaisLw%3D
    • Nakae J, Biggs WH 3rd, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D (2002) Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 32(2):245-253. doi: 10.1038/ng890ng890
    • (2002) Nat Genet , vol.32 , Issue.2 , pp. 245-253
    • Nakae, J.1    Biggs III, W.H.2    Kitamura, T.3    Cavenee, W.K.4    Wright, C.V.5    Arden, K.C.6    Accili, D.7
  • 32
    • 33644865024 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
    • 10.1074/jbc.M508510200 16282329 10.1074/jbc.M508510200 1:CAS:528:DC%2BD28XitF2rsw%3D%3D
    • Kawamori D, Kaneto H, Nakatani Y, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y (2006) The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem 281(2):1091-1098. doi: 10.1074/jbc.M508510200
    • (2006) J Biol Chem , vol.281 , Issue.2 , pp. 1091-1098
    • Kawamori, D.1    Kaneto, H.2    Nakatani, Y.3    Matsuoka, T.A.4    Matsuhisa, M.5    Hori, M.6    Yamasaki, Y.7


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