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Volumn 8, Issue 3, 2016, Pages

The potential protective action of vitamin D in hepatic insulin resistance and pancreatic islet dysfunction in type 2 diabetes mellitus

Author keywords

Calcitriol; Glucose homeostasis; HepG2; Hypovitaminosis D; Insulin secretion; Lipid metabolism

Indexed keywords

ADIPONECTIN; CALCIFEDIOL; CALCITRIOL; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM ION; COLECALCIFEROL; ERGOCALCIFEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RETINOL; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FKHR; VITAMIN D; VITAMIN D RECEPTOR; GLUCOSE BLOOD LEVEL;

EID: 84960106701     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8030147     Document Type: Review
Times cited : (125)

References (90)
  • 1
    • 84960101641 scopus 로고    scopus 로고
    • Hepatobiliary physiology
    • Leung, P.S., Ed.; Springer: Berlin, Germany
    • Black, D.D. Hepatobiliary physiology. In The Gastrointestinal System; Leung, P.S., Ed.; Springer: Berlin, Germany, 2014; pp. 237-324.
    • (2014) The Gastrointestinal System , pp. 237-324
    • Black, D.D.1
  • 4
    • 84903398617 scopus 로고    scopus 로고
    • The effects of vitamin D supplementation on hepatic dysfunction, vitamin D status, and glycemic control in children and adolescents with vitamin D deficiency and either type 1 and type 2 diabetes mellitus
    • Nwosu, B.U.; Maranda, L. The effects of vitamin D supplementation on hepatic dysfunction, vitamin D status, and glycemic control in children and adolescents with vitamin D deficiency and either type 1 and type 2 diabetes mellitus. PLoS ONE 2014, 9, e99646.
    • (2014) Plos ONE , vol.9
    • Nwosu, B.U.1    Maranda, L.2
  • 7
    • 79956190677 scopus 로고    scopus 로고
    • Physiology of the pancreas
    • Leung, P.S. Physiology of the pancreas. Adv. Exp. Med. Biol. 2010, 690, 13-27.
    • (2010) Adv. Exp. Med. Biol , vol.690 , pp. 13-27
    • Leung, P.S.1
  • 8
    • 79956222662 scopus 로고    scopus 로고
    • Current research of the RAS in T2DM
    • Leung, P.S. Current research of the RAS in T2DM. Adv. Exp. Med. Biol. 2010, 690, 131-153.
    • (2010) Adv. Exp. Med. Biol , vol.690 , pp. 131-153
    • Leung, P.S.1
  • 9
    • 84927913107 scopus 로고    scopus 로고
    • Vitamin D and diabetes: Where do we stand?
    • Mathieu, C. Vitamin D and diabetes: Where do we stand? Diabetes Res. Clin. Pract. 2015, 108, 201-209.
    • (2015) Diabetes Res. Clin. Pract , vol.108 , pp. 201-209
    • Mathieu, C.1
  • 11
    • 0029152846 scopus 로고
    • Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians
    • Boucher, B.J.; Mannan, N.; Noonan, K.; Hales, C.N.; Evans, S.J.W. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians. Diabetologia 1995, 38, 1239-1245.
    • (1995) Diabetologia , vol.38 , pp. 1239-1245
    • Boucher, B.J.1    Mannan, N.2    Noonan, K.3    Hales, C.N.4    Evans, S.J.W.5
  • 12
    • 84942990707 scopus 로고    scopus 로고
    • The new biology of diabetes
    • Pajvani, U.B.; Accili, D. The new biology of diabetes. Diabetologia 2015, 58, 2459-2468.
    • (2015) Diabetologia , vol.58 , pp. 2459-2468
    • Pajvani, U.B.1    Accili, D.2
  • 13
    • 84941204364 scopus 로고    scopus 로고
    • Involvement of the niacin receptor GPR109a in the local control of glucose uptake in small intestine of type 2 diabetic mice
    • Wong, T.P.; Chan, L.K.Y.; Leung, P.S. Involvement of the niacin receptor GPR109a in the local control of glucose uptake in small intestine of type 2 diabetic mice. Nutrients 2015, 7, 7543-7561.
    • (2015) Nutrients , vol.7 , pp. 7543-7561
    • Wong, T.P.1    Chan, L.K.Y.2    Leung, P.S.3
  • 14
    • 84922250464 scopus 로고    scopus 로고
    • Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets
    • Chen, L.; So, W.Y.; Li, S.Y.T.; Cheng, Q.; Boucher, B.J.; Leung, P.S. Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. Mol. Cell. Endocriol. 2015, 404, 56-66.
    • (2015) Mol. Cell. Endocriol , vol.404 , pp. 56-66
    • Chen, L.1    So, W.Y.2    Li, S.Y.T.3    Cheng, Q.4    Boucher, B.J.5    Leung, P.S.6
  • 15
    • 42949109202 scopus 로고    scopus 로고
    • Sunlight, UV-radiation, vitamin D and skin cancer
    • Holick, M.F. Sunlight, UV-radiation, vitamin D and skin cancer. Adv. Exp. Med. Biol. 2008, 624, 1-15.
    • (2008) Adv. Exp. Med. Biol , vol.624 , pp. 1-15
    • Holick, M.F.1
  • 18
    • 0036194928 scopus 로고    scopus 로고
    • Stat1-vitamin D receptor interactions antagonize 1,25-dihyroxyvitamin D transcriptional activity and enhance stat1-mediated transcription
    • Vidal, M.; Ramana, C.V.; Busso, A.S. Stat1-vitamin D receptor interactions antagonize 1,25-dihyroxyvitamin D transcriptional activity and enhance stat1-mediated transcription. Mol. Cell. Biol. 2002, 22, 2777-2787.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 2777-2787
    • Vidal, M.1    Ramana, C.V.2    Busso, A.S.3
  • 19
    • 0242417170 scopus 로고    scopus 로고
    • Identification of a vitamin D response element in the human insulin receptor gene promoter
    • Maestro, B.; Davila, N.; Carranza, M.C.; Calle, C. Identification of a vitamin D response element in the human insulin receptor gene promoter. J. Steroid Biochem. Mol. Biol. 2003, 84, 223-230.
    • (2003) J. Steroid Biochem. Mol. Biol , vol.84 , pp. 223-230
    • Maestro, B.1    Davila, N.2    Carranza, M.C.3    Calle, C.4
  • 20
    • 3242795010 scopus 로고    scopus 로고
    • Functional genetic polymorphisms in cytokines and metabolic genes as additional genetic markers for susceptibility to develop type 1 diabetes
    • Eerligh, P.; Koeleman, B.P.; Dudbridge, F.; Bruining, J.G.; Roep, B.O.; Giphart, M.J. Functional genetic polymorphisms in cytokines and metabolic genes as additional genetic markers for susceptibility to develop type 1 diabetes. Genes Immun. 2004, 5, 36-40.
    • (2004) Genes Immun , vol.5 , pp. 36-40
    • Eerligh, P.1    Koeleman, B.P.2    Dudbridge, F.3    Bruining, J.G.4    Roep, B.O.5    Giphart, M.J.6
  • 21
    • 77953949137 scopus 로고    scopus 로고
    • The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function
    • Leung, P.S.; Cheng, Q. The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function. Adv. Exp. Med. Biol. 2010, 654, 339-361.
    • (2010) Adv. Exp. Med. Biol , vol.654 , pp. 339-361
    • Leung, P.S.1    Cheng, Q.2
  • 22
    • 77950447766 scopus 로고    scopus 로고
    • Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis
    • Alvarez, J.A.; Ashraf, A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int. J. Endocrinol. 2010, 2010, 351-385.
    • (2010) Int. J. Endocrinol , vol.2010 , pp. 351-2385
    • Alvarez, J.A.1    Ashraf, A.2
  • 24
    • 84925375185 scopus 로고    scopus 로고
    • InterAct Consortium; Langenberg, C.; Wareham, N.J.; Forouhi, N.G. Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: A mendelian randomization study
    • Ye, Z.; Sharp, S.J.; Burgess, S.; Scott, R.A.; Imamura, F.; InterAct Consortium; Langenberg, C.; Wareham, N.J.; Forouhi, N.G. Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: A mendelian randomization study. Lancet Diabetes Endocrinol. 2015, 3, 35-42.
    • (2015) Lancet Diabetes Endocrinol , vol.3 , pp. 35-42
    • Ye, Z.1    Sharp, S.J.2    Burgess, S.3    Scott, R.A.4    Imamura, F.5
  • 25
  • 26
    • 84896830606 scopus 로고    scopus 로고
    • Prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea
    • Ryu, O.H.; Lee, S.; Yu, J.; Choi, M.G.; Yoo, H.J.; Mantero, F. A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea. Endocr. J. 2014, 61, 167-176.
    • (2014) Endocr. J , vol.61 , pp. 167-176
    • Ryu, O.H.1    Lee, S.2    Yu, J.3    Choi, M.G.4    Yoo, H.J.5    Mantero, F.A.6
  • 28
    • 84937229030 scopus 로고    scopus 로고
    • Effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes (SUNNY Trial): A randomized placebo-controlled trial
    • Krul-Poel, Y.H.; Westra, S.; ten Boekel, E.; ter Wee, M.M.; van Schoor, N.M.; van Wijland, H.; Stam, F.; Lips, P.T.; Simsek, S. Effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes (SUNNY Trial): A randomized placebo-controlled trial. Diabetes Care 2015, 38, 1420-1426.
    • (2015) Diabetes Care , vol.38 , pp. 1420-1426
    • Krul-Poel, Y.H.1    Westra, S.2    Ten Boekel, E.3    Ter Wee, M.M.4    Van Schoor, N.M.5    Van Wijland, H.6    Stam, F.7    Lips, P.T.8    Simsek, S.9
  • 29
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki, M.; Nolan, C.J. Islet beta cell failure in type 2 diabetes. J. Clin. Investig. 2006, 116, 1802-1812.
    • (2006) J. Clin. Investig , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 32
    • 70549113397 scopus 로고    scopus 로고
    • S. Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies
    • Del Prato, S. Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies. Diabet. Med. 2009, 26, 1185-1192.
    • (2009) Diabet. Med , vol.26 , pp. 1185-1192
    • Prato, D.1
  • 33
    • 78651272137 scopus 로고    scopus 로고
    • Hormonal regulation of gluconeogenic gene transcription in the liver
    • Yabaluri, N.; Bashyam, M.D. Hormonal regulation of gluconeogenic gene transcription in the liver. J. Biosci. 2010, 35, 473-484.
    • (2010) J. Biosci , vol.35 , pp. 473-484
    • Yabaluri, N.1    Bashyam, M.D.2
  • 36
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil, G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140, 900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 38
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose ultilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi, T.; Kamon, J.; Minokoshi, Y.; Ito, Y.; Waki, H.; Uchida, S.; Yamashita, S.; Noda, M.; Kita, S.; Ueki, K. et al. Adiponectin stimulates glucose ultilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 2002, 8, 1288-1295.
    • (2002) Nat. Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3    Ito, Y.4    Waki, H.5    Uchida, S.6    Yamashita, S.7    Noda, M.8    Kita, S.9    Ueki, K.10
  • 39
    • 50049105823 scopus 로고    scopus 로고
    • The regulation of AMP-activated protein kinase by upstream kinases
    • Carling, D.; Sanders, M.J.; Woods, A. The regulation of AMP-activated protein kinase by upstream kinases. Int. J. Obes. (Lond.) 2008, 32, S55-S59.
    • (2008) Int. J. Obes. (Lond.) , vol.32 , pp. S55-S59
    • Carling, D.1    Sanders, M.J.2    Woods, A.3
  • 40
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • Long, Y.C.; Zierath, J.R. AMP-activated protein kinase signaling in metabolic regulation. J. Clin. Investig. 2006, 116, 1776-1783.
    • (2006) J. Clin. Investig , vol.116 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 41
    • 0036320801 scopus 로고    scopus 로고
    • Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase
    • Barthel, A.; Schmoll, D.; Krüger, K.D.; Roth, R.A.; Joost, H.G. Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase. Endocrinology 2002, 143, 3183-3186.
    • (2002) Endocrinology , vol.143 , pp. 3183-3186
    • Barthel, A.1    Schmoll, D.2    Krüger, K.D.3    Roth, R.A.4    Joost, H.G.5
  • 42
    • 79955661493 scopus 로고    scopus 로고
    • Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
    • Li, Y.; Xu, S.; Giles, A.; Nakamura, K.; Lee, J.W.; Hou, X.; Donmez, G.; Li, J.; Luo, Z.; Walsh, K. et al. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB. J. 2011, 25, 1664-1679.
    • (2011) FASEB. J , vol.25 , pp. 1664-1679
    • Li, Y.1    Xu, S.2    Giles, A.3    Nakamura, K.4    Lee, J.W.5    Hou, X.6    Donmez, G.7    Li, J.8    Luo, Z.9    Walsh, K.10
  • 44
    • 79960152007 scopus 로고    scopus 로고
    • Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes
    • Barchetta, I.; Angelico, F.; Del Ben, M.; Baroni, M.G.; Pozzilli, P.; Morini, S.; Cavallo, M.G. Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med. 2011, 9, 85.
    • (2011) BMC Med , vol.9 , pp. 85
    • Barchetta, I.1    Angelico, F.2    Del Ben, M.3    Baroni, M.G.4    Pozzilli, P.5    Morini, S.6    Cavallo, M.G.7
  • 45
    • 84883259255 scopus 로고    scopus 로고
    • Vitamin D and nonalcoholic fatty liver disease (NAFLD): Is it more than just an association?
    • Kwok, R.M.; Torres, D.M.; Harrison, S.A. Vitamin D and nonalcoholic fatty liver disease (NAFLD): Is it more than just an association? Hepatology 2013, 58, 1166-1174.
    • (2013) Hepatology , vol.58 , pp. 1166-1174
    • Kwok, R.M.1    Torres, D.M.2    Harrison, S.A.3
  • 46
    • 84860455885 scopus 로고    scopus 로고
    • The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    • Farese, R.V.; Zechner, R.; Newgard, C.B.; Walther, T.C. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 2012, 15, 570-573.
    • (2012) Cell Metab , vol.15 , pp. 570-573
    • Farese, R.V.1    Zechner, R.2    Newgard, C.B.3    Walther, T.C.4
  • 47
    • 66349088529 scopus 로고    scopus 로고
    • Hepatic triacylglycerol accumulation and insulin resistance
    • Nagle, C.A.; Klett, E.L.; Coleman, R.A. Hepatic triacylglycerol accumulation and insulin resistance. J. Lipid Res. 2009, 50, S74-S79.
    • (2009) J. Lipid Res , vol.50 , pp. S74-S79
    • Nagle, C.A.1    Klett, E.L.2    Coleman, R.A.3
  • 48
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • Samuel, V.T.; Petersen, K.F.; Shulman, G.I. Lipid-induced insulin resistance: Unravelling the mechanism. Lancet 2010, 375, 2267-2277.
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 49
  • 51
    • 0035856943 scopus 로고    scopus 로고
    • Diabetes mellitus and genetically programmed defects in beta-cell function
    • Bell, G.I.; Polonsky, K.S. Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 2001, 414, 788-791.
    • (2001) Nature , vol.414 , pp. 788-791
    • Bell, G.I.1    Polonsky, K.S.2
  • 52
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich, J.E. The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity. Endocr. Rev. 1998, 19, 491-503.
    • (1998) Endocr. Rev , vol.19 , pp. 491-503
    • Gerich, J.E.1
  • 53
    • 0012873550 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: The relative contribution of insulin resistance and impaired insulin secretion
    • Groop, L. Pathogenesis of type 2 diabetes: The relative contribution of insulin resistance and impaired insulin secretion. Int. J. Clin. Pract. Suppl. 2000, 113, 3-13.
    • (2000) Int. J. Clin. Pract , vol.113 , pp. 3-13
    • Groop, L.1
  • 55
    • 9644270397 scopus 로고    scopus 로고
    • Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells
    • Bernal-Mizrachi, E.; Fatrai, S.; Johnson, J.D.; Ohsugi, M.; Otani, K.; Han, Z.; Polonsky, K.S.; Permutt, M.A. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells. J. Clin. Investig. 2004, 114, 928-936.
    • (2004) J. Clin. Investig , vol.114 , pp. 928-936
    • Bernal-Mizrachi, E.1    Fatrai, S.2    Johnson, J.D.3    Ohsugi, M.4    Otani, K.5    Han, Z.6    Polonsky, K.S.7    Permutt, M.A.8
  • 56
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β cells (INS-1)
    • Wrede, C.; Dickson, L.M.; Lingohr, M.K.; Briaud, I.; Rhodes, C.J. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β cells (INS-1). J. Biol. Chem. 2002, 277, 49676-49684.
    • (2002) J. Biol. Chem , vol.277 , pp. 49676-49684
    • Wrede, C.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    Rhodes, C.J.5
  • 58
    • 42449126643 scopus 로고    scopus 로고
    • Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
    • Martinez, S.; Tanabe, K.; Cras-Méneur, C.; Abumrad, N.A.; Bernal-Mizrachi, E.; Permutt, M.A. Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 2008, 57, 846-859.
    • (2008) Diabetes , vol.57 , pp. 846-859
    • Martinez, S.1    Tanabe, K.2    Cras-Méneur, C.3    Abumrad, N.A.4    Bernal-Mizrachi, E.5    Permutt, M.A.6
  • 60
    • 15944375438 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3β in mouse insulinoma cells
    • Srinivasan, S.; Ohsugi, M.; Liu, Z.G.; Fatrai, S.; Mizrachi, E.B.; Permutt, M.A. Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3β in mouse insulinoma cells. Diabetes 2005, 54, 968-975.
    • (2005) Diabetes , vol.54 , pp. 968-975
    • Srinivasan, S.1    Ohsugi, M.2    Liu, Z.G.3    Fatrai, S.4    Mizrachi, E.B.5    Permutt, M.A.6
  • 61
    • 84884530768 scopus 로고    scopus 로고
    • The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle
    • Henriksen, E.J.; Prasannarong, M. The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle. Mol. Cell Endocrinol. 2013, 378, 15-22.
    • (2013) Mol. Cell Endocrinol , vol.378 , pp. 15-22
    • Henriksen, E.J.1    Prasannarong, M.2
  • 62
    • 84899511284 scopus 로고    scopus 로고
    • Ang (1-7) protects islet endothelial cells from palmitate-induced apopotosis by AKT, eNOS, p38 MAPK, and JNK pathways
    • Yuan, L.; Lu, C.L.; Wang, Y.; Li, Y.; Li, X.Y. Ang (1-7) protects islet endothelial cells from palmitate-induced apopotosis by AKT, eNOS, p38 MAPK, and JNK pathways. J. Diabetes Res. 2014, 2014, 391-476.
    • (2014) J. Diabetes Res , vol.2014 , pp. 391-476
    • Yuan, L.1    Lu, C.L.2    Wang, Y.3    Li, Y.4    Li, X.Y.5
  • 63
    • 79960566170 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and candesartan additively improve glucolipotoxicity in pancreatic beta-cells
    • Wang, H.W.; Mizuta, M.; Saitoh, Y.; Noma, K.; Ueno, H.; Nakazato, M. Glucagon-like peptide-1 and candesartan additively improve glucolipotoxicity in pancreatic beta-cells. Metabolism 2011, 60, 1081-1089.
    • (2011) Metabolism , vol.60 , pp. 1081-1089
    • Wang, H.W.1    Mizuta, M.2    Saitoh, Y.3    Noma, K.4    Ueno, H.5    Nakazato, M.6
  • 64
    • 84977889955 scopus 로고    scopus 로고
    • The renin-angiotensin system: Current research progress in the pancreas. In Advances in Experimental Medicine and Biology; Springer: Dordrecht
    • Leung, P.S. The renin-angiotensin system: Current research progress in the pancreas. In Advances in Experimental Medicine and Biology; Springer: Dordrecht, The Netherlands, 2010; Volume 690, p. 207.
    • (2010) The Netherlands , vol.690 , pp. 207
    • Leung, P.S.1
  • 65
    • 1542374750 scopus 로고    scopus 로고
    • Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
    • Lau, T.; Carlsson, P.O.; Leung, P.S. Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia 2004, 47, 240-248.
    • (2004) Diabetologia , vol.47 , pp. 240-248
    • Lau, T.1    Carlsson, P.O.2    Leung, P.S.3
  • 66
    • 33644781780 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes
    • Chu, K.Y.; Lau, T.; Carlsson, P.O.; Leung, P.S. Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes. Diabetes 2006, 55, 367-374.
    • (2006) Diabetes , vol.55 , pp. 367-374
    • Chu, K.Y.1    Lau, T.2    Carlsson, P.O.3    Leung, P.S.4
  • 67
    • 21344467929 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor inhibition improves the blood perfusion, oxygen tension and first phase of glucose-stimulated insulin secretion in revascularized syngeneic mouse islet grafts
    • Kampf, C.; Lau, T.; Olsson, R.; Leung, P.S.; Carlsson, P.O. Angiotensin II type 1 receptor inhibition improves the blood perfusion, oxygen tension and first phase of glucose-stimulated insulin secretion in revascularized syngeneic mouse islet grafts. Diabetologia 2005, 48, 1159-1167.
    • (2005) Diabetologia , vol.48 , pp. 1159-1167
    • Kampf, C.1    Lau, T.2    Olsson, R.3    Leung, P.S.4    Carlsson, P.O.5
  • 68
    • 34250333856 scopus 로고    scopus 로고
    • Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice
    • Chu, K.Y.; Leung, P.S. Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice. Antioxid. Redox Signal. 2007, 9, 869-878.
    • (2007) Antioxid. Redox Signal , vol.9 , pp. 869-878
    • Chu, K.Y.1    Leung, P.S.2
  • 69
    • 57349099271 scopus 로고    scopus 로고
    • Combination of the dipeptidyl peptidase IV inhibitor LAF237 with the angiotensin II type 1 receptor antagonist valsartan enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes
    • Cheng, Q.; Law, P.K.; de Gasparo, M.; Leung, P.S. Combination of the dipeptidyl peptidase IV inhibitor LAF237 with the angiotensin II type 1 receptor antagonist valsartan enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes. J. Pharmacol. Exp. Ther. 2008, 327, 683-691.
    • (2008) J. Pharmacol. Exp. Ther , vol.327 , pp. 683-691
    • Cheng, Q.1    Law, P.K.2    De Gasparo, M.3    Leung, P.S.4
  • 70
    • 0036073755 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 is a negiatve endocrine regulator of the renin-angiotensin system
    • Li, Y.C.; Kong, J.; Wei, M.; Chen, Z.F.; Liu, S.Q.; Cao, L.P. 1,25-Dihydroxyvitamin D3 is a negiatve endocrine regulator of the renin-angiotensin system. J. Clin. Investig. 2002, 110, 229-238.
    • (2002) J. Clin. Investig , vol.110 , pp. 229-238
    • Li, Y.C.1    Kong, J.2    Wei, M.3    Chen, Z.F.4    Liu, S.Q.5    Cao, L.P.6
  • 71
    • 3042594296 scopus 로고    scopus 로고
    • Vitamin D: A negative endocrine regulator of the renin-angiotensin system and blood pressure
    • Li, Y.C.; Qiao, G.; Uskokovic, M.; Xiang, W.; Zheng, W.; Kong, J. Vitamin D: A negative endocrine regulator of the renin-angiotensin system and blood pressure. J. Steroid Biochem. Mol. Biol. 2004, 90, 387-392.
    • (2004) J. Steroid Biochem. Mol. Biol , vol.90 , pp. 387-392
    • Li, Y.C.1    Qiao, G.2    Uskokovic, M.3    Xiang, W.4    Zheng, W.5    Kong, J.6
  • 72
    • 34347266963 scopus 로고    scopus 로고
    • The role of vitamin D and calcium in type 2 diabetes: A systemic review and meta-analysis
    • Pittas, A.G.; Lau, J.; Hu, F.B.; Dawson-Gughes, B. The role of vitamin D and calcium in type 2 diabetes: A systemic review and meta-analysis. J. Clin. Endocrinol. Metab. 2007, 92, 2017-2029.
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 2017-2029
    • Pittas, A.G.1    Lau, J.2    Hu, F.B.3    Dawson-Gughes, B.4
  • 74
    • 79955467663 scopus 로고    scopus 로고
    • An update on the islet renin-angiotensin system
    • Cheng, Q.; Leung, P.S. An update on the islet renin-angiotensin system. Peptides 2011, 32, 1087-1095.
    • (2011) Peptides , vol.32 , pp. 1087-1095
    • Cheng, Q.1    Leung, P.S.2
  • 75
    • 78650868648 scopus 로고    scopus 로고
    • The roles of vitamin D in modulation of the pancreatic renin-angiotensin system
    • Miura, H., Sasaki, Y., Eds.; Nova Science Publishers: New York, NY, USA
    • Leung, P.S.; Boucher, B.J. The roles of vitamin D in modulation of the pancreatic renin-angiotensin system. In Angiotensin Research Progress; Miura, H., Sasaki, Y., Eds.; Nova Science Publishers: New York, NY, USA, 2008; pp. 201-220.
    • (2008) Angiotensin Research Progress , pp. 201-220
    • Leung, P.S.1    Boucher, B.J.2
  • 76
    • 79960895149 scopus 로고    scopus 로고
    • Novel role for vitamin D: Modulation of expression and function of the local renin-angiotensin system in mouse pancreatic islets
    • Cheng, Q.; Li, Y.C.; Boucher, B.J.; Leung, P.S. A novel role for vitamin D: Modulation of expression and function of the local renin-angiotensin system in mouse pancreatic islets. Diabetologia 2011, 54, 2077-2081.
    • (2011) Diabetologia , vol.54 , pp. 2077-2081
    • Cheng, Q.1    Li, Y.C.2    Boucher, B.J.3    Leung, P.4
  • 77
    • 84878344721 scopus 로고    scopus 로고
    • Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin-angiotensin system in mice
    • Cheng, Q.; Boucher, B.J.; Leung, P.S. Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin-angiotensin system in mice. Diabetologia 2013, 56, 553-562.
    • (2013) Diabetologia , vol.56 , pp. 553-562
    • Cheng, Q.1    Boucher, B.J.2    Leung, P.S.3
  • 78
    • 84884383929 scopus 로고    scopus 로고
    • Current progress in stem cell research and its potential for islet cell transplantation
    • Leung, P.S.; Ng, K.Y. Current progress in stem cell research and its potential for islet cell transplantation. Curr. Mol. Med. 2013, 13, 109-125.
    • (2013) Curr. Mol. Med , vol.13 , pp. 109-125
    • Leung, P.S.1    Ng, K.Y.2
  • 79
    • 39649092092 scopus 로고    scopus 로고
    • PDZ-domain-containing 2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells
    • Suen, P.M.; Chan, J.C.; Lau, T.K.; Yao, K.M.; Leung, P.S. PDZ-domain-containing 2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells. Int. J. Biochem. Cell Biol. 2008, 40, 789-803.
    • (2008) Int. J. Biochem. Cell Biol , vol.40 , pp. 789-803
    • Suen, P.M.1    Chan, J.C.2    Lau, T.K.3    Yao, K.M.4    Leung, P.S.5
  • 80
    • 70349414656 scopus 로고    scopus 로고
    • PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization
    • Leung, K.K.; Suen, P.M.; Lau, T.K.; Ko, W.H.; Yao, K.M.; Leung, P.S. PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization. Stem Cell Dev. 2009, 18, 979-989.
    • (2009) Stem Cell Dev , vol.18 , pp. 979-989
    • Leung, K.K.1    Suen, P.M.2    Lau, T.K.3    Ko, W.H.4    Yao, K.M.5    Leung, P.S.6
  • 81
    • 84857460623 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation
    • Leung, K.K.; Liang, J.; Ma, M.T.; Leung, P.S. Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation. Stem Cells 2012, 30, 525-536.
    • (2012) Stem Cells , vol.30 , pp. 525-536
    • Leung, K.K.1    Liang, J.2    Ma, M.T.3    Leung, P.S.4
  • 82
    • 78751647214 scopus 로고    scopus 로고
    • Vitamin D and vitamin A receptor expression and the proliferative effects of ligand activation of these receptors on the development of pancreatic progenitor cells derived from human fetal pancreas
    • Ng, K.Y.; Ma, M.T.; Leung, K.K.; Leung, P.S. Vitamin D and vitamin A receptor expression and the proliferative effects of ligand activation of these receptors on the development of pancreatic progenitor cells derived from human fetal pancreas. Stem Cell Rev. 2011, 7, 53-63.
    • (2011) Stem Cell Rev , vol.7 , pp. 53-63
    • Ng, K.Y.1    Ma, M.T.2    Leung, K.K.3    Leung, P.S.4
  • 83
    • 45549091674 scopus 로고    scopus 로고
    • Retinoic acid in development: Towards an integrated view
    • Niederreither, K.; Dollé, P. Retinoic acid in development: Towards an integrated view. Nat. Rev. Genet. 2008, 9, 541-553.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 541-553
    • Niederreither, K.1    Dollé, P.2
  • 84
    • 50949102657 scopus 로고    scopus 로고
    • Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells
    • Oström, M.; Loffler, K.A.; Edfalk, S. Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells. PLoS ONE 2008, 3, e2841.
    • (2008) Plos ONE , vol.3
    • Oström, M.1    Loffler, K.A.2    Edfalk, S.3
  • 85
    • 18444407829 scopus 로고    scopus 로고
    • Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid
    • Shi, Y.; Hou, L.; Tang, F. Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid. Stem Cells 2005, 23, 656-662.
    • (2005) Stem Cells , vol.23 , pp. 656-662
    • Shi, Y.1    Hou, L.2    Tang, F.3
  • 86
    • 84897466695 scopus 로고    scopus 로고
    • Human fetal liver stromal cells co-culture enhances the differentiation of pancreatic progenitor cells into islet-like cell clusters
    • Liang, J.; Ng, K.Y.; Cheng, Q.; Xia, Y.; Wang, C.C.; Leung, P.S. Human fetal liver stromal cells co-culture enhances the differentiation of pancreatic progenitor cells into islet-like cell clusters. Stem Cell Rev. 2014, 10, 280-294.
    • (2014) Stem Cell Rev , vol.10 , pp. 280-294
    • Liang, J.1    Ng, K.Y.2    Cheng, Q.3    Xia, Y.4    Wang, C.C.5    Leung, P.S.6
  • 87
    • 84930082028 scopus 로고    scopus 로고
    • Maternal high-fat-diet programs rat offspring liver fatty acid metabolism
    • Seet, E.L.; Yee, J.K.; Jellyman, J.K.; Hun, G.; Ross, M.G. Maternal high-fat-diet programs rat offspring liver fatty acid metabolism. Lipids 2015, 50, 565-573.
    • (2015) Lipids , vol.50 , pp. 565-573
    • Seet, E.L.1    Yee, J.K.2    Jellyman, J.K.3    Hun, G.4    Ross, M.G.5
  • 88
    • 84945449820 scopus 로고    scopus 로고
    • Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population
    • Fan, H.R.; Lin, L.Q.; Ma, H.; Li, Y.; Sun, C.H. Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. J. Genet. 2015, 94, 473-478.
    • (2015) J. Genet , vol.94 , pp. 473-478
    • Fan, H.R.1    Lin, L.Q.2    Ma, H.3    Li, Y.4    Sun, C.H.5
  • 90
    • 84940467056 scopus 로고    scopus 로고
    • Maternal high-fat-diet programs rat offspring liver fatty acid metabolism: Might reduced vitamin D availability due to increases in maternal body fat contribute to this effect?
    • Boucher, B.J.; Leung, P.S. “Maternal high-fat-diet programs rat offspring liver fatty acid metabolism”: Might reduced vitamin D availability due to increases in maternal body fat contribute to this effect? Lipids 2015, 50, 837-838.
    • (2015) Lipids , vol.50 , pp. 837-838
    • Boucher, B.J.1    Leung, P.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.