The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

Immunity

Volumn 48, Issue 5, 2018, Pages 979-991.e8

  Filipello, Fabia ^a,g   Morini, Raffaella ^b   Corradini, Irene ^b,c   Zerbi, Valerio ^d   Canzi, Alice ^a   Michalski, Bernadeta ^e   Erreni, Marco ^b   Markicevic, Marija ^d   Starvaggi Cucuzza, Chiara ^b   Otero, Karel ^f   Piccio, Laura ^g   Cignarella, Francesca ^g   Perrucci, Fabio ^b   Tamborini, Matteo ^b   Genua, Marco ^b   Rajendran, Lawrence ^h   Menna, Elisabetta ^b,c   Vetrano, Stefania ^a   Fahnestock, Margaret ^e   Paolicelli, Rosa Chiara ^h   Matteoli, Michela ^b,c   more..

^a HUMANITAS UNIVERSITY   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c CNR   (Italy)

^d ETH ZURICH   (Switzerland)

^e MCMASTER UNIVERSITY   (Canada)

^f BIOGEN   (United States)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

autism; development; microglia; PSD95; synapse; synaptic pruning; TREM2

Indexed keywords

TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; BRAIN DEVELOPMENT; COMPULSION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DISEASE SEVERITY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; FUNCTIONAL CONNECTIVITY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MALE; MICROGLIA; MOUSE; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; SOCIAL DISABILITY; SYMPTOM; SYNAPSE; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; SYNAPTIC TRANSMISSION;

ANIMALS; AUTISTIC DISORDER; BRAIN; CELLS, CULTURED; HUMANS; MEMBRANE GLYCOPROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NEURONS; RECEPTORS, IMMUNOLOGIC; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 85046738379     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.04.016     Document Type: Article

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