Effects of the 1-N-(4-Amino-2 S-hydroxybutyryl) and 6′- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics

ACS Infectious Diseases

Volumn 4, Issue 7, 2018, Pages 1114-1120

  Sonousi, Amr ^a,e   Sarpe, Vikram A ^a   Brilkova, Margarita ^b   Schacht, Jochen ^c   Vasella, Andrea ^d   Böttger, Erik C ^b   Crich, David ^a,e  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d ETH ZURICH   (Switzerland)

^e CAIRO UNIVERSITY   (Egypt)

Author keywords

aminoglycoside modifying enzymes; aminoglycosides; cell free translation assays; ribosomal methyltransferases; structure activity relationship

Indexed keywords

1 N BOC 4 AMINO 2 HYDROXYBUTYRIC ACID SISOMICIN; 6' (2 HYDROXYETHYL)SISOMICIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; APRAMYCIN; ARMA PROTEIN; GENTAMICIN C; METHYLTRANSFERASE; PLAZOMICIN; RIBOSOME PROTEIN; SISOMICIN; TOBRAMYCIN; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL RIBOSOME; BACTERIAL STRUCTURES; CHEMICAL MODIFICATION; COCHLEA; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; EC50; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; EX VIVO STUDY; HUMAN; INNER EAR DISEASE; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MITOCHONDRIAL RIBOSOME; MOUSE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RIBOSOME; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; MICROBIAL SENSITIVITY TEST; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PRECLINICAL STUDY; PROTEIN SYNTHESIS; SYNTHESIS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; HUMANS; MICROBIAL SENSITIVITY TESTS; PROTEIN BIOSYNTHESIS; RIBOSOMES; SISOMICIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85046537357     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.8b00052     Document Type: Article

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