Structural basis for the inhibition of the eukaryotic ribosome

Nature

Volumn 513, Issue 7519, 2014, Pages 517-522

  Garreau De Loubresse, Nicolas ^a   Prokhorova, Irina ^a   Holtkamp, Wolf ^b   Rodnina, Marina V ^b   Yusupova, Gulnara ^a   Yusupov, Marat ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANISOMYCIN; ANTIBIOTIC AGENT; ANTIBIOTIC G 418; BLASTICIDIN S; CRYPTOPLEURINE; CYCLOHEXIMIDE; EDEINE; FUNGAL PROTEIN; FUNGAL RNA; GLUTARIMIDE; HOMOHARRINGTONINE; LACTIMIDOMYCIN; LYCORINE; MESSENGER RNA; NAGILACTONE C; NARCICLASINE; PACTAMYCIN; PEPTIDYLTRANSFERASE; PHYLLANTHOSIDE; RIBOSOME PROTEIN; T 2 TOXIN; TRANSFER RNA; UNCLASSIFIED DRUG; VERRUCARIN A; VOMITOXIN; MACROLIDE; PIPERIDONE DERIVATIVE; PROTEIN SYNTHESIS INHIBITOR;

EUKARYOTE; MICROBIAL ACTIVITY; MOLECULAR ANALYSIS; PROTEIN; RNA; YEAST;

5' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CELL PROLIFERATION; CELL STRUCTURE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; FLUORESCENCE; FUNGAL CELL; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; RIBOSOME; RNA BINDING; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; TRANSLATION INITIATION; X RAY CRYSTALLOGRAPHY; YEAST CELL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; ENZYME SPECIFICITY; ENZYMOLOGY; EUKARYOTIC CELL; GENETICS; KINETICS; LARGE RIBOSOMAL SUBUNIT; METABOLISM; MOLECULAR WEIGHT; MOLECULARLY TARGETED THERAPY; NUCLEOTIDE SEQUENCE; SPECIES DIFFERENCE;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

BASE SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXIMIDE; DRUG RESISTANCE; EUKARYOTIC CELLS; KINETICS; MACROLIDES; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; MOLECULAR WEIGHT; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PEPTIDYL TRANSFERASES; PIPERIDONES; PROTEIN SYNTHESIS INHIBITORS; RIBOSOME SUBUNITS, LARGE, EUKARYOTIC; RIBOSOMES; RNA, MESSENGER; RNA, TRANSFER; SACCHAROMYCES CEREVISIAE; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 84908546298     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13737     Document Type: Article

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