Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Nature Genetics

Volumn 50, Issue 5, 2018, Pages 668-681

  Wray, Naomi R ^a   Ripke, Stephan ^b,c,d   Mattheisen, Manuel ^e,f,g   Trzaskowski, MacIej ^a   Byrne, Enda M ^a   Abdellaoui, Abdel ^h   Adams, Mark J ⁱ   Agerbo, Esben ^e,f   Air, Tracy M ^j   Andlauer, Till M F ^k,l   Bacanu, Silviu Alin ^m   Bækvad Hansen, Marie ^f,n   Beekman, Aartjan F T ^o   Bigdeli, Tim B ^m,p   Binder, Elisabeth B ^k,q   Blackwood, Douglas R H ⁱ   Bryois, Julien ^g   Buttenschøn, Henriette N ^e,f   Bybjerg Grauholm, Jonas ^f,n   Cai, Na ^r,s   Castelao, Enrique ^t   Christensen, Jane Hvarregaard ^e,f   Clarke, Toni Kim ⁱ   Coleman, Jonathan I R ^u   Colodro Conde, Lucía ^v   Couvy Duchesne, Baptiste ^a   Craddock, Nick ^w   Crawford, Gregory E ^x,y   Crowley, Cheynna A ^z   Dashti, Hassan S ^b,c   Davies, Gail ⁱ   Deary, Ian J ⁱ   Degenhardt, Franziska ^aa   Derks, Eske M ^v   DIrek, Nese ^ab,ac   Dolan, Conor V ^h   Dunn, Erin C ^b,c   Eley, Thalia C ^u   Eriksson, Nicholas ^ad   Escott Price, Valentina ^w   Kiadeh, Farnush Hassan Farhadi ^ae   Finucane, Hilary K ^af,ag   Forstner, Andreas J ^aa,ah,ai   Frank, Josef ^aj   Gaspar, Héléna A ^u   Gill, Michael ^ak   Giusti Rodríguez, Paola ^al   Goes, Fernando S ^am   Gordon, Scott D ^v   Grove, Jakob ^e,f   Hall, Lynsey S ^i,an   Hannon, Eilis ^ao   Hansen, Christine Søholm ^f,n   Hansen, Thomas F ^ap,aq,ar   Herms, Stefan ^aa,ai   Hickie, Ian B ^as   Hoffmann, Per ^aa,ai   Homuth, Georg ^at   Horn, Carsten ^au   Hottenga, Jouke Jan ^h   Hougaard, David M ^f,n   Hu, Ming ^av   Hyde, Craig L ^aw   Ising, Marcus ^k   Jansen, Rick ^o   Jin, Fulai ^ax,ay   Jorgenson, Eric ^az   Knowles, James A ^ba   Kohane, Isaac S ^bb,bc,bd   Kraft, Julia ^d   Kretzschmar, Warren W ^be   Krogh, Jesper ^bf   Kutalik, Zoltán ^bg,bh   Lane, Jacqueline M ^b,c   Li, Yihan ^be   Li, Yun ^z,al   Lind, Penelope A ^v   Liu, Xiaoxiao ^ay   Lu, Leina ^ay   MacIntyre, Donald J ^bi,bj   MacKinnon, Dean F ^am   Maier, Robert M ^a   Maier, Wolfgang ^aa   Marchini, Jonathan ^bk   Mbarek, Hamdi ^h   McGrath, Patrick ^bl   McGuffin, Peter ^u   Medland, Sarah E ^v   Mehta, DIvya ^a,bm   Middeldorp, Christel M ^a,h,bn   Mihailov, Evelin ^bo   Milaneschi, Yuri ^o   Milani, Lili ^bo   Mill, Jonathan ^ao   Mondimore, Francis M ^am   Montgomery, Grant W ^a   Mostafavi, Sara ^ae   Mullins, Niamh ^u   Nauck, Matthias ^bp,bq   Ng, Bernard ^ae   Nivard, Michel G ^h   Nyholt, Dale R ^bm   O'Reilly, Paul F ^u   Oskarsson, Hogni ^br   Owen, Michael J ^w   Painter, Jodie N ^v   Pedersen, Carsten Bøcker ^e,f   Pedersen, Marianne Giørtz ^e,f   Peterson, Roseann E ^m,bs   Pettersson, Erik ^g   Peyrot, Wouter J ^o   Pistis, Giorgio ^t   Posthuma, Danielle ^o,bt   Purcell, Shaun M ^bc   Quiroz, Jorge A ^bu   Qvist, Per ^e,f   Rice, John P ^bv   Riley, Brien P ^m   Rivera, Margarita ^u,bw   Saeed Mirza, Saira ^ac   Saxena, Richa ^b,c   Schoevers, Robert ^bx   Schulte, Eva C ^by   Shen, Ling ^az   Shi, Jianxin ^bz   Shyn, Stanley I ^ca   Sigurdsson, Engilbert ^cb   Sinnamon, Grant B C ^cc   Smit, Johannes H ^o   Smith, Daniel J ^cd   Stefansson, Hreinn ^ce   Steinberg, Stacy ^ce   Stockmeier, Craig A ^cf   Streit, Fabian ^aj   Strohmaier, Jana ^aj   Tansey, Katherine E ^w   Teismann, Henning ^cg   Teumer, Alexander ^bq   Thompson, Wesley ^f,aq,ch,ci   Thomson, Pippa A ⁱ   Thorgeirsson, Thorgeir E ^ce   Tian, Chao ^ad   Traylor, Matthew ^cj   Treutlein, Jens ^aj   Trubetskoy, Vassily ^d   Uitterlinden, André G ^ac   Umbricht, Daniel ^au   Van Der Auwera, Sandra ^bq   Van Hemert, Albert M ^ck   Viktorin, Alexander ^g   Visscher, Peter M ^a   Wang, Yunpeng ^f,aq,ch   Webb, Bradley T ^bs   Weinsheimer, Shantel Marie ^f,aq   Wellmann, Jürgen ^cg   Willemsen, Gonneke ^h   Witt, Stephanie H ^aj   Wu, Yang ^a   Xi, Hualin S ^aw   Yang, Jian ^a   Zhang, Futao ^a   Arolt, Volker ^cg   Baune, Bernhard T ^j   Berger, Klaus ^cg   Boomsma, Dorret I ^h   Cichon, Sven ^aa,ai,cl,cm   Dannlowski, Udo ^cg   De Geus, E C J ^h,o   Depaulo, J Raymond ^am   Domenici, Enrico ^cn   Domschke, Katharina ^co   Esko, Tõnu ^b,bo   Grabe, Hans J ^bq   Hamilton, Steven P ^ca   Hayward, Caroline ^cp   Heath, Andrew C ^bv   Hinds, David A ^ad   Kendler, Kenneth S ^m   Kloiber, Stefan ^k,cq,cr   Lewis, Glyn ^cs   Li, Qingqin S ^ct   Lucae, Susanne ^k   Madden, Pamela F A ^bv   Magnusson, Patrik K ^g   Martin, Nicholas G ^v   McIntosh, Andrew M ⁱ   Metspalu, Andres ^bo,cu   Mors, Ole ^f,cv   Mortensen, Preben Bo ^e,f   Müller Myhsok, Bertram ^k,l,cw   Nordentoft, Merete ^f,cx   Nöthen, Markus M ^aa   O'Donovan, Michael C ^w   Paciga, Sara A ^aw   Pedersen, Nancy L ^g   Penninx, Brenda W J H ^o   Perlis, Roy H ^c,bd   Porteous, David J ⁱ   Potash, James B ^cy   Preisig, Martin ^t   Rietschel, Marcella ^aj   Schaefer, Catherine ^az   Schulze, Thomas G ^{aj,am,by,cz,da}   Smoller, Jordan W ^b,c   Stefansson, Kari ^cb,ce   Tiemeier, Henning ^ac   Uher, Rudolf ^db   Völzke, Henry ^bq   Weissman, Myrna M ^bl,dc   Werge, Thomas ^f,aq,dd   Winslow, Ashley R ^aw,de   Lewis, Cathryn M ^u   Levinson, Douglas F ^df   Breen, Gerome ^u   Børglum, Anders D ^e,f   Sullivan, Patrick F ^g,al   more..

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e AARHUS UNIVERSITY   (Denmark)

^f IPSYCH   (Denmark)

^g KAROLINSKA INSTITUTE   (Sweden)

^h UNIVERSITY OF AMSTERDAM   (Netherlands)

ⁱ UNIVERSITY OF EDINBURGH   (United Kingdom)

^j UNIVERSITY OF ADELAIDE   (Australia)

^k MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^l Germany 3 Munich Cluster for Systems Neurology   (Germany)

^m VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ STATENS SERUM INSTITUT   (Denmark)

^o VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^p Institute for Psychiatric and Behavioral Genetics   (United States)

^q EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^r EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

^s WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^t LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^u KING'S COLLEGE LONDON   (United Kingdom)

^v QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^w CARDIFF UNIVERSITY   (United Kingdom)

^x DUKE UNIVERSITY   (United States)

^y DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^z IL   (United States)

^aa UNIVERSITY OF BONN   (Germany)

^ab DOKUZ EYLUL UNIVERSITY   (Turkey)

^ac ERASMUS MEDICAL CENTER   (Netherlands)

^ad Harvard T H Chan School of Public Health ^*  (United States)

^ae UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^af HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^ag MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^ah UNIVERSITY OF BASEL   (Switzerland)

^ai UNIVERSITY OF BASEL   (Switzerland)

^aj UNIVERSITY OF HEIDELBERG   (Germany)

^ak TRINITY COLLEGE DUBLIN   (Ireland)

^al UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^am JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^an NEWCASTLE UNIVERSITY   (United Kingdom)

^ao UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^ap Rigshospitalet   (Denmark)

^aq Mental Health Centre Sct Hans   (Denmark)

^ar H LUNDBECK A S   (Denmark)

^as UNIVERSITY OF SYDNEY   (Australia)

^at UNIVERSITY OF GREIFSWALD   (Germany)

^au F HOFFMANN LA ROCHE LTD   (Switzerland)

^av LERNER RESEARCH INSTITUTE   (United States)

^aw PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^ax CASE WESTERN RESERVE UNIVERSITY   (United States)

^ay CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^az DIVISION OF RESEARCH   (United States)

^ba UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^bb BOSTON CHILDREN S HOSPITAL   (United States)

^bc BRIGHAM AND WOMEN S HOSPITAL   (United States)

^bd HARVARD MEDICAL SCHOOL   (United States)

^be UNIVERSITY OF OXFORD   (United Kingdom)

^bf GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^bg SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^bh UNIVERSITY OF LAUSANNE   (Switzerland)

^bi HEALTHCARE IMPROVEMENT SCOTLAND   (United Kingdom)

^bj UNIVERSITY OF EDINBURGH   (United Kingdom)

^bk UNIVERSITY OF OXFORD   (United Kingdom)

^bl Solid Biosciences ^*  (United States)

^bm QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^bn LADY CILENTO CHILDREN S HOSPITAL   (Australia)

^bo UNIVERSITY OF TARTU   (Estonia)

^bp DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^bq UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^br Humus   (Iceland)

^bs VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^bt VU UNIVERSITY AMSTERDAM   (Netherlands)

^bu Solid Biosciences   (United States)

^bv WASHINGTON UNIVERSITY   (United States)

^bw UNIVERSITY OF GRANADA   (Spain)

^bx UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^by LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^bz NATIONAL CANCER INSTITUTE   (United States)

^ca KAISER PERMANENTE   (United States)

^cb UNIVERSITY OF ICELAND   (Iceland)

^cc JAMES COOK UNIVERSITY   (Australia)

^cd UNIVERSITY OF GLASGOW   (United Kingdom)

^ce DECODE GENETICS   (Iceland)

^cf UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^cg UNIVERSITY OF MÜNSTER   (Germany)

^ch OSLO UNIVERSITY HOSPITAL   (Norway)

^ci UNIVERSITY OF CALIFORNIA   (United States)

^cj UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^ck LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^cl FORSCHUNGSZENTRUM JÜLICH   (Germany)

^cm UNIVERSITY HOSPITAL BASEL   (Switzerland)

^cn UNIVERSITY OF TRENTO   (Italy)

^co UNIVERSITY OF FREIBURG   (Germany)

^cp UNIVERSITY OF EDINBURGH   (United Kingdom)

^cq CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^cr UNIVERSITY OF TORONTO   (Canada)

^cs UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ct JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^cu UNIVERSITY OF TARTU   (Estonia)

^cv AARHUS UNIVERSITY HOSPITAL   (Denmark)

^cw UNIVERSITY OF LIVERPOOL   (United Kingdom)

^cx Mental Health Services CPH   (Denmark)

^cy UNIVERSITY OF IOWA   (United States)

^cz NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^da UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^db DALHOUSIE UNIVERSITY   (Canada)

^dc NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^dd UNIVERSITY OF COPENHAGEN   (Denmark)

^de UNIVERSITY OF PENNSYLVANIA   (United States)

^df STANFORD UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT;

ARTICLE; BODY MASS; BRAIN REGION; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; EDUCATIONAL STATUS; GENE LOCUS; GENE STRUCTURE; GENETIC CORRELATION; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; RNA SPLICING; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; META ANALYSIS; MULTIFACTORIAL INHERITANCE; PROCEDURES; RISK FACTOR;

CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MULTIFACTORIAL INHERITANCE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SCHIZOPHRENIA;

EID: 85046022254     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0090-3     Document Type: Article

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