Genome-wide association study identifies 74 loci associated with educational attainment

Nature

Volumn 533, Issue 7604, 2016, Pages 539-542

  Okbay, Aysu ^a,b,c   Beauchamp, Jonathan P ^d   Fontana, Mark Alan ^e   Lee, James J ^f   Pers, Tune H ^g,h,i,j   Rietveld, Cornelius A ^a,b,c   Turley, Patrick ^d   Chen, Guo Bo ^k   Emilsson, Valur ^l,m   Meddens, S Fleur W ^c,n,o   Oskarsson, Sven ^p   Pickrell, Joseph K ^q   Thom, Kevin ^r   Timshel, Pascal ^h,s   De Vlaming, Ronald ^a,b,c   Abdellaoui, Abdel ⁿ   Ahluwalia, Tarunveer S ^i,t,u   Bacelis, Jonas ^v   Baumbach, Clemens ^w   Bjornsdottir, Gyda ^x   Brandsma, Johannes H ^b   Pina Concas, Maria ^y   Derringer, Jaime ^z   Furlotte, Nicholas A ^aa   Galesloot, Tessel E ^ab   Girotto, Giorgia ^ac   Gupta, Richa ^ad   Hall, Leanne M ^ae,af   Harris, Sarah E ^ag   Hofer, Edith ^ah   Horikoshi, Momoko ^ai,aj   Huffman, Jennifer E ^ag   Kaasik, Kadri ^ad   Kalafati, Ioanna P ^ak   Karlsson, Robert ^al   Kong, Augustine ^x   Lahti, Jari ^ad,am   Van Der Lee, Sven J ^b   Deleeuw, Christiaan ^n,an   Lind, Penelope A ^ao   Lindgren, Karl Oskar ^p   Liu, Tian ^ap   Mangino, Massimo ^aq,ar   Marten, Jonathan ^ag   Mihailov, Evelin ^as   Miller, Michael B ^f   Van Der Most, Peter J ^at   Oldmeadow, Christopher ^au,av   Payton, Antony ^aw,ax   Pervjakova, Natalia ^as,ay   Peyrot, Wouter J ⁿ   Qian, Yong ^az   Raitakari, Olli ^ba   Rueedi, Rico ^bb,bc   Salvi, Erika ^bd   Schmidt, Börge ^be   Schraut, Katharina E ^bf   Shi, Jianxin ^bg   Smith, Albert V ^l,m   Poot, Raymond A ^b   St Pourcain, Beate ^bi   Teumer, Alexander ^bj   Thorleifsson, Gudmar ^x   Verweij, Niek ^at   Vuckovic, Dragana ^ac   Wellmann, Juergen ^bk   Westra, Harm Jan ^h,bl,bm   Yang, Jingyun ^bn,bo   Zhao, Wei ^bp   Zhu, Zhihong ^k   Alizadeh, Behrooz Z ^at   Amin, Najaf ^b   Bakshi, Andrew ^k   Baumeister, Sebastian E ^bj,bq   Biino, Ginevra ^br   Bønnelykke, Klaus ^t   Boyle, Patricia A ^bn,bo   Campbell, Harry ^bf   Cappuccio, Francesco P ^bs   Davies, Gail ^ag   De Neve, Jan Emmanuel ^bt   Deloukas, Panos ^bu,bv   Demuth, Ilja ^bw   Ding, Jun ^az   Eibich, Peter ^ai,bx   Eisele, Lewin ^be   Eklund, Niina ^ay   Evans, David M ^k,bi   Faul, Jessica D ^bp   Feitosa, Mary F ^by   Forstner, Andreas J ^bz   Gandin, Ilaria ^ac   Gunnarsson, Bjarni ^x   Halldórsson, Bjarni V ^x,ca   Harris, Tamara B ^az   Holliday, Elizabeth G ^au,av   Heath, Andrew C ^by   Hocking, Lynne J ^cb   Homuth, Georg ^bj   Horan, Michael A ^cc   Hottenga, Jouke Jan ⁿ   De Jager, Philip L ^h,bl,cd   Joshi, Peter K ^bf   Jugessur, Astanand ^ce   Kaakinen, Marika A ^cf   Kähönen, Mika ^cg,ch   Kanoni, Stavroula ^bu   Keltigangas Järvinen, Liisa ^ad   Kiemeney, Lambertus A L M ^ab   Kolcic, Ivana ^ci   Koskinen, Seppo ^ay   Kraja, Aldi T ^by   Kroh, Martin ^bx   Kutalik, Zoltan ^bb,bc,cj   Latvala, Antti ^ad   Launer, Lenore J ^az   Lebreton, Maël P ^o   Levinson, Douglas F ^ck   Lichtenstein, Paul ^al   Lichtner, Peter ^w   Liewald, David C M ^ag   Loukola, Anu ^ad   Madden, Pamela A ^by   Mägi, Reedik ^as   Mäki Opas, Tomi ^ay   Marioni, Riccardo E ^k,ag   Marques Vidal, Pedro ^cl   Meddens, Gerardus A ^cm   Mcmahon, George ^bi   Meisinger, Christa ^w   Meitinger, Thomas ^w   Milaneschi, Yusplitri ⁿ   Milani, Lili ^as   Montgomery, Grant W ^ao   Myhre, Ronny ^ce   Nelson, Christopher P ^ae,af   Nyholt, Dale R ^ao,cn   Ollier, William E R ^aw   Palotie, Aarno ^h,ad,co   Paternoster, Lavinia ^bi   Pedersen, Nancy L ^al   Petrovic, Katja E ^ah   Porteous, David J ^ag   Raïkkönen, Katri ^ad,am   Ring, Susan M ^bi   Robino, Antonietta ^cp   Rostapshova, Olga ^d,cq   Rudan, Igor ^bf   Rustichini, Aldo ^f   Salomaa, Veikko ^ay   Sanders, Alan R ^cr,cs   Sarin, Antti Pekka ^ad,ay   Schmidt, Helena ^ah,ct   Scott, Rodney J ^au,av   Smith, Blair H ^cu   Smith, Jennifer A ^bp   Staessen, Jan A ^cv,cw   Steinhagen Thiessen, Elisabeth ^bw   Strauch, Konstantin ^w,cx   Terracciano, Antonio ^cy   Tobin, Martin D ^ae   Ulivi, Sheila ^cp   Vaccargiu, Simona ^y   Quaye, Lydia ^aq   Van Rooij, Frank J A ^b   Venturini, Cristina ^aq,ar   Vinkhuyzen, Anna A E ^k   Völker, Uwe ^bj   Völzke, Henry ^bj   Vonk, Judith M ^at   Vozzi, Diego ^cq   Waage, Johannes ^t,u   Ware, Erin B ^bp   Willemsen, Gonneke ⁿ   Attia, John R ^au,av   Bennett, David A ^bn,bo   Berger, Klaus ^at   Bertram, Lars ^cz,da   Bisgaard, Hans ^t   Boomsma, Dorret I ⁿ   Borecki, Ingrid B ^by   Bültmann, Ute ^db   Chabris, Christopher F ^dc   Cucca, Francesco ^br   Cusi, Daniele ^bd,br   Deary, Ian J ^ag   Dedoussis, George V ^ak   Van Duijn, Cornelia M ^b   Eriksson, Johan G ^ad,am   Franke, Barbara ^dd   Franke, Lude ^at   Gasparini, Paolo ^ac,cp,de   Gejman, Pablo V ^cr,cs   Gieger, Christian ^w   Grabe, Hans Jörgen ^bj,df   Gratten, Jacob ^k   Groenen, Patrick J F ^dg   Gudnason, Vilmundur ^l,m   Van Der Harst, Pim ^at,dh   Hayward, Caroline ^ag   Hinds, David A ^aa   Hoffmann, Wolfgang ^bj   Hyppönen, Elina ^di,dj,dk   Iacono, William G ^f   Jacobsson, Bo ^v,ce   Järvelin, Marjo Riitta ^dl,dm,dn,do   Jöckel, Karl Heinz ^be   Kaprio, Jaakko ^ad,ay   Kardia, Sharon L R ^bp   Lehtimäki, Terho ^ch,dp   Lehrer, Steven F ^dq,dr   Magnusson, Patrik K E ^al   Martin, Nicholas G ^ao   Mcgue, Matt ^f   Metspalu, Andres ^as,ds   Pendleton, Neil ^ax,dt   Penninx, Brenda W J H ⁿ   Perola, Markus ^as,ay   Pirastu, Nicola ^ac   Pirastu, Mario ^y   Polasek, Ozren ^bf,ci   Posthuma, Danielle ^n,du   Power, Christine ^dk   Province, Michael A ^by   Samani, Nilesh J ^ae,af   Schlessinger, David ^az   Schmidt, Reinhold ^ah   Sørensen, Thorkild I A ^i,bi,dv   Spector, Tim D ^aq   Stefansson, Kari ^m,x   Thorsteinsdottir, Unnur ^m,x   Thurik, A Roy ^a,c,dw,dx   Timpson, Nicholas J ^bi   Tiemeier, Henning ^b   Tung, Joyce Y ^aa   Uitterlinden, André G ^b   Vitart, Veronique ^ag   Vollenweider, Peter ^cl   Weir, David R ^bp   Wilson, James F ^ag,bf   Wright, Alan F ^ag   Conley, Dalton C ^r,dy   Krueger, Robert F ^f   Davey Smith, George ^bi   Hofman, Albert ^b   Laibson, David I ^d   Medland, Sarah E ^ao   Meyer, Michelle N ^dz   Yang, Jian ^k   Johannesson, Magnus ^ea   Visscher, Peter M ^k   Esko, Toñu ^g,h,as,bl   Koellinger, Philipp D ^c,n,o   Cesarini, David ^r,bh   Benjamin, Daniel J ^e   more..

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d HARVARD UNIVERSITY   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁱ Capital Region   (Denmark)

^j STATENS SERUM INSTITUT   (Denmark)

^k UNIVERSITY OF QUEENSLAND   (Australia)

^l ICELANDIC HEART ASSOCIATION   (Iceland)

^m UNIVERSITY OF ICELAND   (Iceland)

ⁿ VU UNIVERSITY AMSTERDAM   (Netherlands)

^o UNIVERSITY OF AMSTERDAM   (Netherlands)

^p UPPSALA UNIVERSITY   (Sweden)

^q NEW YORK GENOME CENTER   (United States)

^r NEW YORK UNIVERSITY   (United States)

^s TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^t UNIVERSITY OF COPENHAGEN   (Denmark)

^u STENO DIABETES CENTER   (Denmark)

^v SAHLGRENSKA ACADEMY AT UNIVERSITY OF GOTHENBURG   (Sweden)

^w INSTITUTE OF EPIDEMIOLOGY   (Germany)

^x DECODE GENETICS   (Iceland)

^y Milan Unit   (Italy)

^z UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^aa 23andMe Inc ^*  (United States)

^ab RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^ac UNIVERSITY OF TRIESTE   (Italy)

^ad UNIVERSITY OF HELSINKI   (Finland)

^ae UNIVERSITY OF LEICESTER   (United Kingdom)

^af GLENFIELD HOSPITAL   (United Kingdom)

^ag UNIVERSITY OF EDINBURGH   (United Kingdom)

^ah MEDICAL UNIVERSITY OF GRAZ   (Austria)

^ai UNIVERSITY OF OXFORD   (United Kingdom)

^aj UNIVERSITY OF OXFORD   (United Kingdom)

^ak HAROKOPIO UNIVERSITY   (Greece)

^al KAROLINSKA INSTITUTE   (Sweden)

^am FOLKHÄLSAN RESEARCH CENTER   (Finland)

^an RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^ao QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^ap MAX PLANCK INSTITUTE FOR HUMAN DEVELOPMENT   (Germany)

^aq KING'S COLLEGE LONDON   (United Kingdom)

^ar GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^as UNIVERSITY OF TARTU   (Estonia)

^at UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^au HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^av UNIVERSITY OF NEWCASTLE   (Australia)

^aw UNIVERSITY OF MANCHESTER   (United Kingdom)

^ax UNIVERSITY OF MANCHESTER   (United Kingdom)

^ay NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^az NATIONAL INSTITUTE ON AGING   (United States)

^ba UNIVERSITY OF TURKU   (Finland)

^bb UNIVERSITY OF LAUSANNE   (Switzerland)

^bc SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^bd UNIVERSITY OF MILAN   (Italy)

^be UNIVERSITY HOSPITAL ESSEN   (Germany)

^bf UNIVERSITY OF EDINBURGH   (United Kingdom)

^bg NATIONAL CANCER INSTITUTE   (United States)

^bh RESEARCH INSTITUTE OF INDUSTRIAL ECONOMICS IFN   (Sweden)

^bi UNIVERSITY OF BRISTOL   (United Kingdom)

^bj UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^bk UNIVERSITY OF MÜNSTER   (Germany)

^bl HARVARD MEDICAL SCHOOL   (United States)

^bm LABORATORY FOR MOLECULAR MEDICINE   (United States)

^bn RUSH UNIVERSITY MEDICAL CENTER   (United States)

^bo RUSH UNIVERSITY   (United States)

^bp UNIVERSITY OF MICHIGAN   (United States)

^bq UNIVERSITY OF REGENSBURG   (Germany)

^br CNR   (Italy)

^bs UNIVERSITY OF WARWICK   (United Kingdom)

^bt UNIVERSITY OF OXFORD   (United Kingdom)

^bu QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^bv KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^bw CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^bx DIW BERLIN   (Germany)

^by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bz UNIVERSITY OF BONN   (Germany)

^ca REYKJAVIK UNIVERSITY   (Iceland)

^cb UNIVERSITY OF ABERDEEN   (United Kingdom)

^cc UNIVERSITY OF MANCHESTER   (United Kingdom)

^cd BRIGHAM AND WOMEN S HOSPITAL   (United States)

^ce NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^cf IMPERIAL COLLEGE LONDON   (United Kingdom)

^cg TAMPERE UNIVERSITY HOSPITAL   (Finland)

^ch TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^ci UNIVERSITY OF SPLIT   (Croatia)

^cj UNIVERSITY OF LAUSANNE   (Switzerland)

^ck STANFORD UNIVERSITY   (United States)

^cl LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^cm Tema BV   (Netherlands)

^cn QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^co MASSACHUSETTS GENERAL HOSPITAL   (United States)

^cp INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^cq Social Impact Inc   (United States)

^cr NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^cs UNIVERSITY OF CHICAGO   (United States)

^ct UNIVERSITY OF GRAZ   (Austria)

^cu UNIVERSITY OF DUNDEE   (United Kingdom)

^cv UNIVERSITY OF LEUVEN   (Belgium)

^cw MAASTRICHT UNIVERSITY   (Netherlands)

^cx Institute of Medical Informatics Biometry and Epidemiology   (Germany)

^cy FLORIDA STATE UNIVERSITY   (United States)

^cz UNIVERSITY OF LÜBECK   (Germany)

^da Faculty of Medicine   (United Kingdom)

^db UNIVERSITY OF GRONINGEN   (Netherlands)

^dc UNION COLLEGE   (United States)

^dd RADBOUD UNIVERSITY   (Netherlands)

^de Experimental Genetics Division   (Qatar)

^df Department of Psychiatry and Psychotherapy   (Germany)

^dg Erasmus University Rotterdam   (Netherlands)

^dh INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NETHERLANDS   (Netherlands)

^di UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^dj SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^dk UNIVERSITY COLLEGE LONDON   (United Kingdom)

^dl Centre for Environment and Health   (United Kingdom)

^dm UNIVERSITY OF OULU   (Finland)

^dn OULU UNIVERSITY HOSPITAL   (Finland)

^do UNIVERSITY OF OULU   (Finland)

^dp FIMLAB LABORATORIES   (Finland)

^dq NEW YORK UNIVERSITY SHANGHAI   (China)

^dr QUEEN S UNIVERSITY   (Canada)

^ds UNIVERSITY OF TARTU   (Estonia)

^dt HOPE HOSPITAL   (United Kingdom)

^du Medical Centre   (Netherlands)

^dv The Capital Region   (Denmark)

^dw MONTPELLIER BUSINESS SCHOOL   (France)

^dx NONE   (Netherlands)

^dy NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^dz MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^ea STOCKHOLM SCHOOL OF ECONOMICS   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; COGNITION; DISEASE INCIDENCE; EDUCATION; EDUCATIONAL ATTAINMENT; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC MARKER; PHENOTYPE;

ACADEMIC ACHIEVEMENT; ARTICLE; AUTISM; BIOINFORMATICS; COGNITION; ENVIRONMENTAL FACTOR; ERYTHROBLASTOSIS; FETAL BRAIN; GENE CLUSTER; GENE EXPRESSION; GENE LOCUS; GENETIC CORRELATION; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HEREDITY; HUMAN; INTELLECTUAL IMPAIRMENT; META ANALYSIS (TOPIC); NERVE CELL DIFFERENTIATION; NEUROLOGIC DISEASE; PHENOTYPE; PRENATAL PERIOD; PRIORITY JOURNAL; SCHIZOPHRENIA; SCHOOL; SOCIAL ASPECT; ALZHEIMER DISEASE; BIOLOGY; BIPOLAR DISORDER; BRAIN; EDUCATIONAL STATUS; FETUS; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; METABOLISM; MOLECULAR GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

UNITED KINGDOM;

ALZHEIMER DISEASE; BIPOLAR DISORDER; BRAIN; COGNITION; COMPUTATIONAL BIOLOGY; EDUCATIONAL STATUS; FETUS; GENE EXPRESSION REGULATION; GENE-ENVIRONMENT INTERACTION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MOLECULAR SEQUENCE ANNOTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; UNITED KINGDOM;

EID: 84969760786     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17671     Document Type: Article

References (17)

1. Rietveld, C. A. et al. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science 340, 1467-1471 (2013).
2. Rietveld, C. A. et al. Replicability and robustness of genome-wide-association studies for behavioral traits. Psychol. Sci. 25, 1975-1986 (2014).
3. Yang, J. et al. Genomic inflation factors under polygenic inheritance. Eur. J. Hum. Genet. 19, 807-812 (2011).
4. Bulik-Sullivan, B. K. et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291-295 (2015).
5. Sudlow, C. et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).
6. Fowler, T., Zammit, S., Owen, M. J., Rasmussen, F. A population-based study of shared genetic variation between premorbid IQ and psychosis among male twin pairs and sibling pairs from Sweden. Arch. Gen. Psychiatry 69, 460-466 (2012).
7. Tambs, K., Sundet, J. M., Magnus, P., Berg, K. Genetic and environmental contributions to the covariance between occupational status, educational attainment, and IQ: a study of twins. Behav. Genet. 19, 209-222 (1989).
8. Thompson, L. A., Detterman, D. K., Plomin, R. Associations between cognitive abilities and scholastic achievement: Genetic overlap but environmental differences. Psychol. Sci. 2, 158-165 (1991).
9. Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236-1241 (2015).
10. Ardlie, K. G. et al.; GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348, 648-660 (2015).
11. Pers, T. H. et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat. Commun. 6, 5890 (2015).
12. Allen Institute for Brain Science. BrainSpan atlas of the developing human brain http://www.brainspan.org (2015).
13. Purcell, S. M. et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748-752 (2009).
14. Krapohl, E. et al. The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence. Proc. Natl Acad. Sci. USA 111, 15273-15278 (2014).
15. Branigan, A. R., McCallum, K. J., Freese, J. Variation in the heritability of educational attainment: An international meta-analysis. Social Forces 92, 109-140 (2013).
16. Heath, A. C. et al. Education policy and the heritability of educational attainment. Nature 314, 734-736 (1985).
17. Finucane, H. K. et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genetics 47, 1228-1235 (2015).