-
1
-
-
4544368258
-
Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: The HALE project
-
Knoops, K. T. et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA 292, 1433-1439 (2004).
-
(2004)
JAMA
, vol.292
, pp. 1433-1439
-
-
Knoops, K.T.1
-
2
-
-
66149137211
-
The preventable causes of death in the United States: Comparative risk assessment of dietary, lifestyle, and metabolic risk factors
-
Danaei, G. et al. The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med. 6, e1000058 (2009).
-
(2009)
PLoS Med.
, vol.6
, pp. e1000058
-
-
Danaei, G.1
-
3
-
-
0033533859
-
Bodymass index and mortality in a prospective cohort of U. S. Adults
-
Calle, E. E., Thun, M. J., Petrelli, J. M., Rodriguez, C. & Heath, C. W. Jr. Bodymass index and mortality in a prospective cohort of U. S. adults. N. Engl. J. Med 341, 1097-1105 (1999).
-
(1999)
N. Engl. J. Med
, vol.341
, pp. 1097-1105
-
-
Calle, E.E.1
Thun, M.J.2
Petrelli, J.M.3
Rodriguez, C.4
Heath, C.W.5
-
4
-
-
0035856017
-
Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
-
Hu, F. B. et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N. Engl. J. Med. 345, 790-797 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 790-797
-
-
Hu, F.B.1
-
5
-
-
0014976138
-
Serum cholesterol, lipoproteins, and the risk of coronary heart disease
-
Kannel, W. B., Castelli, W. P., Gordon, T. & McNamara, P. M. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann. Intern. Med. 74, 1-12 (1971).
-
(1971)
The Framingham Study. Ann. Intern. Med.
, vol.74
, pp. 1-12
-
-
Kannel, W.B.1
Castelli, W.P.2
Gordon, T.3
McNamara, P.M.4
-
6
-
-
0021350001
-
The lipid research clinics coronary primary prevention trial results I. Reduction in incidence of coronary heart disease
-
The Lipid Research Clinics Program
-
The Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 251, 351-364 (1984).
-
(1984)
JAMA
, vol.251
, pp. 351-364
-
-
-
7
-
-
26244432388
-
Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins
-
Baigent, C. et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins. Lancet 366, 1267-1278 (2005).
-
(2005)
Lancet
, vol.366
, pp. 1267-1278
-
-
Baigent, C.1
-
9
-
-
0037322022
-
Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease
-
Smith, G. D. & Ebrahim, S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int. J. Epidemiol. 32, 1-22 (2003).
-
(2003)
Int. J. Epidemiol
, vol.32
, pp. 1-22
-
-
Smith, G.D.1
Ebrahim, S.2
-
10
-
-
40849083720
-
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
-
Lawlor, D. A., Harbord, R. M., Sterne, J. A., Timpson, N. & Davey Smith, G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat. Med. 27, 1133-1163 (2008).
-
(2008)
Stat. Med.
, vol.27
, pp. 1133-1163
-
-
Lawlor, D.A.1
Harbord, R.M.2
Sterne, J.A.3
Timpson, N.4
Davey Smith, G.5
-
11
-
-
33748106661
-
Instruments for causal inference: An epidemiologist's dream
-
Hernan, M. A. & Robins, J. M. Instruments for causal inference: an epidemiologist's dream? Epidemiology 17, 360-372 (2006).
-
(2006)
Epidemiology
, vol.17
, pp. 360-372
-
-
Hernan, M.A.1
Robins, J.M.2
-
12
-
-
84885840876
-
Mendelian randomization analysis with multiple genetic variants using summarized data
-
Burgess, S., Butterworth, A. & Thompson, S. G. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet. Epidemiol. 37, 658-665 (2013).
-
(2013)
Genet. Epidemiol.
, vol.37
, pp. 658-665
-
-
Burgess, S.1
Butterworth, A.2
Thompson, S.G.3
-
13
-
-
84936755918
-
Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression
-
Bowden, J., Davey Smith, G. & Burgess, S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int. J. Epidemiol. 44, 512-525 (2015).
-
(2015)
Int. J. Epidemiol.
, vol.44
, pp. 512-525
-
-
Bowden, J.1
Davey Smith, G.2
Burgess, S.3
-
14
-
-
84943354221
-
-
EPIC-InterAct consortium. using published data in mendelian randomization: a blueprint for efficient identification of causal risk factors
-
Burgess, S., Scott, R. A., Timpson, N. J., Davey Smith, G. & Thompson, S. G., EPIC-InterAct Consortium. Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur. J. Epidemiol. 30, 543-552 (2015).
-
(2015)
Eur. J. Epidemiol.
, vol.30
, pp. 543-552
-
-
Burgess, S.1
Scott, R.A.2
Timpson, N.J.3
Davey Smith, G.4
Thompson, S.G.5
-
15
-
-
84940648792
-
Mendelian randomization: New applications in the coming age of hypothesis-free causality
-
Evans, D. M. & Davey Smith, G. Mendelian randomization: new applications in the coming age of hypothesis-free causality. Annu. Rev. Genom. Hum. Genet. 16, 327-350 (2015).
-
(2015)
Annu. Rev. Genom. Hum. Genet.
, vol.16
, pp. 327-350
-
-
Evans, D.M.1
Davey Smith, G.2
-
16
-
-
84968649781
-
Detection and interpretation of shared genetic influences on 42 human traits
-
Pickrell, J. K., Berisa, T., Liu, J. Z., Segurel, L., Tung, J. Y. & Hinds, D. A. Detection and interpretation of shared genetic influences on 42 human traits. Nat. Genet. 48, 709-717 (2016).
-
(2016)
Nat. Genet.
, vol.48
, pp. 709-717
-
-
Pickrell, J.K.1
Berisa, T.2
Liu, J.Z.3
Segurel, L.4
Tung, J.Y.5
Hinds, D.A.6
-
17
-
-
84961927084
-
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
-
Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481-487 (2016).
-
(2016)
Nat. Genet.
, vol.48
, pp. 481-487
-
-
Zhu, Z.1
-
18
-
-
84949998712
-
Combining information on multiple instrumental variables in Mendelian randomization: Comparison of allele score and summarized data methods
-
Burgess, S., Dudbridge, F. & Thompson, S. G. Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods. Stat. Med. 35, 1880-1906 (2016).
-
(2016)
Stat. Med.
, vol.35
, pp. 1880-1906
-
-
Burgess, S.1
Dudbridge, F.2
Thompson, S.G.3
-
19
-
-
84906838227
-
Mendelian randomization: Genetic anchors for causal inference in epidemiological studies
-
Davey Smith, G. & Hemani, G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum. Mol. Genet. 23, R89-R98 (2014).
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. R89-R98
-
-
Davey Smith, G.1
Hemani, G.2
-
20
-
-
84887058576
-
Common variants associated with plasma triglycerides and risk for coronary artery disease
-
Do, R. et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat. Genet. 45, 1345-1352 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 1345-1352
-
-
Do, R.1
-
21
-
-
84864845456
-
Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
-
Voight, B. F. et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 380, 572-580 (2012).
-
(2012)
Lancet
, vol.380
, pp. 572-580
-
-
Voight, B.F.1
-
22
-
-
84976604384
-
A plethora of pleiotropy across complex traits
-
Visscher, P. M. & Yang, J. A plethora of pleiotropy across complex traits. Nat. Genet. 48, 707-708 (2016).
-
(2016)
Nat Genet.
, vol.48
, pp. 707-708
-
-
Visscher, P.M.1
Yang, J.2
-
23
-
-
84925146347
-
Adjusting for heritable covariates can bias effect estimates in genome-wide association studies
-
Aschard, H., Vilhjalmsson, B. J., Joshi, A. D., Price, A. L. & Kraft, P. Adjusting for heritable covariates can bias effect estimates in genome-wide association studies. Am. J. Hum. Genet. 96, 329-339 (2015).
-
(2015)
Am. J. Hum. Genet.
, vol.96
, pp. 329-339
-
-
Aschard, H.1
Vilhjalmsson, B.J.2
Joshi, A.D.3
Price, A.L.4
Kraft, P.5
-
24
-
-
84923171580
-
Genetic studies of body mass index yield new insights for obesity biology
-
Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206 (2015).
-
(2015)
Nature
, vol.518
, pp. 197-206
-
-
Locke, A.E.1
-
25
-
-
84923169934
-
New genetic loci link adipose and insulin biology to body fat distribution
-
Shungin, D. et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518, 187-196 (2015).
-
(2015)
Nature
, vol.518
, pp. 187-196
-
-
Shungin, D.1
-
26
-
-
84887099827
-
Discovery and refinement of loci associated with lipid levels
-
Global Lipids Genetics Consortium et al
-
Global Lipids Genetics Consortium et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45, 1274-1283 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 1274-1283
-
-
-
27
-
-
84926430250
-
UK biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age
-
Sudlow, C. et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).
-
(2015)
PLoS Med.
, vol.12
, pp. e1001779
-
-
Sudlow, C.1
-
28
-
-
84930213392
-
Second-generation PLINK: Rising to the challenge of larger and richer data sets
-
Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer data sets. Gigascience 4, 7 (2015).
-
(2015)
Gigascience
, vol.4
, pp. 7
-
-
Chang, C.C.1
-
29
-
-
84939422197
-
Characterizing race/ethnicity and genetic ancestry for 100, 000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
-
Banda, Y. et al. Characterizing race/ethnicity and genetic ancestry for 100, 000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics 200, 1285-1295 (2015).
-
(2015)
Genetics
, vol.200
, pp. 1285-1295
-
-
Banda, Y.1
-
30
-
-
85000692305
-
An atlas of genetic correlations across human diseases and traits
-
Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236-1241 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 1236-1241
-
-
Bulik-Sullivan, B.1
-
31
-
-
58149345887
-
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
-
de Bakker, P. I. et al. Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum. Mol. Genet. 17, R122-R128 (2008).
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. R122-R128
-
-
De Bakker, P.I.1
-
32
-
-
84981164833
-
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
-
Fritsche, L. G. et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat. Genet. 48, 134-143 (2016).
-
(2016)
Nat Genet.
, vol.48
, pp. 134-143
-
-
Fritsche, L.G.1
-
33
-
-
0024591825
-
The atherosclerosis risk in communities (ARIC) Study: Design and objectives
-
The ARIC Investigators
-
The ARIC Investigators. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am. J. Epidemiol. 129, 687-702 (1989).
-
(1989)
Am. J. Epidemiol.
, vol.129
, pp. 687-702
-
-
-
34
-
-
84975742565
-
The 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing
-
The 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 467, 1061-1073 (2010).
-
(2010)
Nature
, vol.467
, pp. 1061-1073
-
-
-
35
-
-
77957690115
-
Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: Four-year results of the Look AHEAD trial
-
Look, A. R. G. & Wing, R. R. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch. Intern. Med. 170, 1566-1575 (2010).
-
(2010)
Arch. Intern. Med.
, vol.170
, pp. 1566-1575
-
-
Look, A.R.G.1
Wing, R.R.2
-
36
-
-
84905401194
-
Effects of BMI, fat mass, and lean mass on asthma in childhood: A Mendelian randomization study
-
Granell, R. et al. Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study. PLoS Med. 11, e1001669 (2014).
-
(2014)
PLoS Med.
, vol.11
, pp. e1001669
-
-
Granell, R.1
-
37
-
-
4344607828
-
A high body mass index protects against femoral neck osteoporosis in healthy elderly subjects
-
Barrera, G. et al. A high body mass index protects against femoral neck osteoporosis in healthy elderly subjects. Nutrition 20, 769-771 (2004).
-
(2004)
Nutrition
, vol.20
, pp. 769-771
-
-
Barrera, G.1
-
38
-
-
16544372782
-
Risk factors for osteoporosis at the knee in the spinal cord injury population
-
Garland, D. E., Adkins, R. H., Kushwaha, V. & Stewart, C. Risk factors for osteoporosis at the knee in the spinal cord injury population. J. Spinal Cord. Med. 27, 202-206 (2004).
-
(2004)
J. Spinal Cord. Med.
, vol.27
, pp. 202-206
-
-
Garland, D.E.1
Adkins, R.H.2
Kushwaha, V.3
Stewart, C.4
-
39
-
-
77549087054
-
Statins and risk of incident diabetes: A collaborative metaanalysis of randomised statin trials
-
Sattar, N. et al. Statins and risk of incident diabetes: a collaborative metaanalysis of randomised statin trials. Lancet 375, 735-742 (2010).
-
(2010)
Lancet
, vol.375
, pp. 735-742
-
-
Sattar, N.1
-
40
-
-
84906242912
-
HDL and cardiovascular disease
-
Rader, D. J. & Hovingh, G. K. HDL and cardiovascular disease. Lancet 384, 618-625 (2014).
-
(2014)
Lancet
, vol.384
, pp. 618-625
-
-
Rader, D.J.1
Hovingh, G.K.2
-
41
-
-
70450081001
-
Major lipids, apolipoproteins, and risk of vascular disease
-
Emerging Risk Factors Colaboration et al
-
Emerging Risk Factors Colaboration et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA 302, 1993-2000 (2009).
-
(2009)
JAMA
, vol.302
, pp. 1993-2000
-
-
-
42
-
-
85018678582
-
Mendelian randomization implicates highdensity lipoprotein cholesterol-associated mechanisms in etiology of age-related macular degeneration
-
Burgess, S. & Davey Smith, G. Mendelian randomization implicates highdensity lipoprotein cholesterol-associated mechanisms in etiology of age-related macular degeneration. Ophthalmology 124, 1165-1174 (2017).
-
(2017)
Ophthalmology
, vol.124
, pp. 1165-1174
-
-
Burgess, S.1
Davey Smith, G.2
-
43
-
-
85090484362
-
Epidemiology of age-related macular degeneration (AMD): Associations with cardiovascular disease phenotypes and lipid factors
-
Pennington, K. L. & DeAngelis, M. M. Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors. Eye Vis. 3, 34 (2016).
-
(2016)
Eye Vis.
, vol.3
, pp. 34
-
-
Pennington, K.L.1
DeAngelis, M.M.2
-
44
-
-
1842608799
-
Cholesterol and age-related macular degeneration: Is there a link
-
van Leeuwen, R. et al. Cholesterol and age-related macular degeneration: is there a link? Am. J. Ophthalmol. 137, 750-752 (2004).
-
(2004)
Am J. Ophthalmol.
, vol.137
, pp. 750-752
-
-
Van Leeuwen, R.1
-
45
-
-
84941340935
-
Cross sectional and longitudinal associations between cardiovascular risk factors and age related macular degeneration in the EPICNorfolk Eye Study
-
Yip, J. L. et al. Cross sectional and longitudinal associations between cardiovascular risk factors and age related macular degeneration in the EPICNorfolk Eye Study. PLoS ONE 10, e0132565 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0132565
-
-
Yip, J.L.1
-
46
-
-
0025347391
-
Blood pressure, stroke, and coronary heart disease Part 2, Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context
-
Collins, R. et al. Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335, 827-838 (1990).
-
(1990)
Lancet
, vol.335
, pp. 827-838
-
-
Collins, R.1
-
47
-
-
0042330455
-
EURopean trial on reduction of cardiac events with perindopril in stable coronary artery disease investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: Randomised, double-blind, placebo-controlled, multicentre trial (the europa study)
-
Fox, K. M., EURopean Trial on Reduction of Cardiac Events with Perindopril in Stable Coronary Artery Disease Investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 362, 782-788 (2003).
-
(2003)
Lancet
, vol.362
, pp. 782-788
-
-
Fox, K.M.1
-
48
-
-
84908890496
-
Defining the role of common variation in the genomic and biological architecture of adult human height
-
Wood, A. R. et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet. 46, 1173-1186 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 1173-1186
-
-
Wood, A.R.1
-
49
-
-
84969760786
-
Genome-wide association study identifies 74 loci associated with educational attainment
-
Okbay, A. et al. Genome-wide association study identifies 74 loci associated with educational attainment. Nature 533, 539-542 (2016).
-
(2016)
Nature
, vol.533
, pp. 539-542
-
-
Okbay, A.1
-
50
-
-
84867603343
-
Cognitive reserve in ageing and Alzheimer's disease
-
Stern, Y. Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol. 11, 1006-1012 (2012).
-
(2012)
Lancet Neurol.
, vol.11
, pp. 1006-1012
-
-
Stern, Y.1
-
52
-
-
84991449483
-
Sensitivity analyses for robust causal inference from mendelian randomization analyses with multiple genetic variants
-
Burgess, S., Bowden, J., Fall, T., Ingelsson, E. & Thompson, S. G. Sensitivity analyses for robust causal inference from mendelian randomization analyses with multiple genetic variants. Epidemiology 28, 30-42 (2017).
-
(2017)
Epidemiology
, vol.28
, pp. 30-42
-
-
Burgess, S.1
Bowden, J.2
Fall, T.3
Ingelsson, E.4
Thompson, S.G.5
-
53
-
-
84862832570
-
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
-
Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369-375 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 369-375
-
-
Yang, J.1
-
54
-
-
84923946495
-
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
-
Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291-295 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 291-295
-
-
Bulik-Sullivan, B.K.1
-
55
-
-
67651222400
-
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
-
Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).
-
(2009)
PLoS Genet
, vol.5
, pp. e1000529
-
-
Howie, B.N.1
Donnelly, P.2
Marchini, J.3
-
56
-
-
78650856517
-
GCTA: A tool for genome-wide complex trait analysis
-
Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76-82 (2011).
-
(2011)
Am. J. Hum. Genet.
, vol.88
, pp. 76-82
-
-
Yang, J.1
Lee, S.H.2
Goddard, M.E.3
Visscher, P.M.4
|