Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases

Bioorganic and Medicinal Chemistry

Volumn 26, Issue 11, 2018, Pages 2928-2936

  Zhang, Dong ^a   Markoulides, Marios S ^a   Stepanovs, Dmitrijs ^a,f   Rydzik, Anna M ^a,g   El Hussein, Ahmed ^a,c   Bon, Corentin ^a,h   Kamps, Jos J A G ^a   Umland, Klaus Daniel ^a,i   Collins, Patrick M ^b   Cahill, Samuel T ^a   Wang, David Y ^a   von Delft, Frank ^b,d,e   Brem, Jürgen ^a   McDonough, Michael A ^a   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b DIAMOND LIGHT SOURCE LTD   (United Kingdom)

^c Cairo University   (Egypt)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF JOHANNESBURG   (South Africa)

^f LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^g BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^h ECOLE POLYTECHNIQUE   (France)

ⁱ Vifor (International) Inc   (Switzerland)

Author keywords

Antibiotic resistance; Carbapenemase; Inhibitors; Metallo lactamase; Structure activity relationships

Indexed keywords

ENETHIOL DERIVATIVE; MANDELIC ACID; METALLO BETA LACTAMASE; PHENOL DERIVATIVE; PHENYLACETIC ACID; RHODANINE; UNCLASSIFIED DRUG; ZINC ION; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; ENEDIYNE; THIOL DERIVATIVE;

AEROMONAS HYDROPHILA; ARTICLE; BACILLUS CEREUS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROLYSIS; IC50; MOLECULAR WEIGHT; NONHUMAN; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; SYNTHESIS;

BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; ENEDIYNES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; RHODANINE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 85045295907     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2018.02.043     Document Type: Article

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