Chromophore-linked substrate (CLS405): Probing metallo-β-lactamase activity and inhibition

ChemMedChem

Volumn 8, Issue 12, 2013, Pages 1923-1929

  Makena, Anne ^a   Van Berkel, Sander S ^a   Lejeune, Clarisse ^a   Owens, Raymond J ^a,b   Verma, Anil ^a,b   Salimraj, Ramya ^c   Spencer, James ^c   Brem, Jürgen ^a   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Division of Structural Biology   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

antibiotics; assays; chromogenic substrates; drug resistance; metallo lactamases; pan inhibitors

Indexed keywords

3 ((4 NITROPHENOXY)METHYL) 8 OXO 7 (2 PHENYLACETAMIDO) 5 THIA 1 AZABICYCLO[4.2.0]OCT 2 ENE 2 CARBOXYLIC ACID 5,5 DIOXIDE; AMPICILLIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CHROMACEF; CHROMOGENIC SUBSTRATE; CLS 405; KANAMYCIN; METALLOPROTEINASE; NITROCEFIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ABSORPTION SPECTROSCOPY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL STRUCTURE; CHROMATOPHORE; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; HYDROLYSIS; KINETICS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ANTIBIOTICS; ASSAYS; CHROMOGENIC SUBSTRATES; DRUG RESISTANCE; METALLO-Β-LACTAMASES; PAN INHIBITORS;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CEPHALOSPORINS; DRUG RESISTANCE, BACTERIAL; ENTEROBACTERIACEAE; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; PSEUDOMONAS AERUGINOSA; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THIAZOLES;

EID: 84889888845     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300350     Document Type: Article

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