Synthesis and biological evaluation of new rhodanine analogues bearing 2-chloroquinoline and benzo[h]quinoline scaffolds as anticancer agents

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 569-580

  Ramesh, Vadla ^a   Ananda Rao, Boddu ^a   Sharma, Pankaj ^a,b   Swarna, B ^b   Thummuri, Dinesh ^b   Srinivas, Kolupula ^b   Naidu, V G M ^b   Jayathirtha Rao, Vaidya ^a,b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

2 Chloroquinoline 3 carbaldehydes; Anilides Villsmeier reaction; Anticancer activity; Rhodanine derivatives

Indexed keywords

2 (PIPERIDIN 1 YL)QUINOLINE 3 CARBALDEHYDE; 2 [5 [(2 CHLORO 5,8 DIMETHOXYQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLORO 5,8 DIMETHYLQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLORO 6 METHOXYQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLORO 6 METHYLQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLORO 6,8 DIMETHYLQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLORO 8 ETHYLQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLOROBENZO[H]QUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(6 CHLORO [1,3]DIOXOLO[4,5 G]QUINOLIN 7 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 5 [(2 CHLORO 5,8 DIMETHYLQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 5,8 DIMETHYLQUINOLIN 3 YL)METHYLENE] 3 PHENYL 2 THIOXOTHIAZOLIN 4 ONE; 5 [(2 CHLORO 6 METHOXYQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 6 METHYLQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 6,7 DIMETHOXYQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 6,8 DIMETHYLQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 7 METHYLQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 8 ETHYLQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 8 METHYLQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLOROBENZO[H]QUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLOROBENZO[H]QUINOLIN 3 YL)METHYLENE] 3 PHENYL 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLOROQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(6 CHLORO [1,3]DIOXOLO[4,5 G]QUINOLIN 7 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 6 METHYL 2 (PIPERIDIN 1 YL)QUINOLINE 3 CARBALDEHYDE; 6 METHYL 2 MORPHOLINOQUINOLINE 3 CARBALDEHYDE; 8 ETHYL 2 (PIPERIDIN 1 YL)QUINOLINE 3 CARBALDEHYDE; 8 METHYL 2 (PIPERIDIN 1 YL)QUINOLINE 3 CARBALDEHYDE; ANTINEOPLASTIC AGENT; RHODANINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 2 [5 [(2 CHLORO 5,8 DIMETHOXYLQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLORO 6,7 DIMETHOXYLQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(2 CHLORO 6,8 DIMETHYLQUINOLIN 3 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[8 ETHYL 2 (PIPERIDIN 1 YL)QUINOLIN 3 YL]METHYLENE] 4 OXO 2 TIOXOTHIAZOLIDIN 3 YL] ACETIC ACID; 5 [(2 CHLORO 5,8 DIMETHOXYQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 5,8 DIMETHYLQUINOLIN 3 YL)METHYLENE] 3 PHENYL 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLORO 6,8 DIMETHYLQUINOLIN 3 YL)METHYLENE] 3 PHENYL 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [(2 CHLOROQUINOLIN 3 YL)METHYLENE] 2 THIOZOTHAIZOLIDIN 4 ONE; 5 [(6 METHYL 2 MORPHOLINOQUINOLIN 3 YL)METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 5 [[8 METHYL 2 (PIPERIDIN 1 YL)QUINOLIN 3 YL]METHYLENE] 2 THIOXOTHIAZOLIDIN 4 ONE; QUINOLINE DERIVATIVE; RHODANINE; ROSIGLITAZONE; 2-CHLOROQUINOLINE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONCENTRATION (PARAMETERS); CYCLIZATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; DU 145 CELL LINE; EVALUATION STUDY; HGC CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MCF 7 CELL LINE; MDAMB 231 CELL LINE; MNK 74 CELL LINE; PC 3 CELL LINE; POLYMERIZATION; PROSTATE CANCER CELL LINE; SYNTHESIS; TUMOR CELL LINE; BIOLOGICAL ACTIVITY; BREAST CANCER; CYTOTOXICITY; MALE; PROSTATE CANCER; STOMACH CANCER; CELL PROLIFERATION; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; QUINOLINES; RHODANINE;

EID: 84903786971     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.013     Document Type: Article

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