-
1
-
-
0028927372
-
Outer membrane proteins responsible for multiple drug resistance in pseudomonas aeruginosa
-
Masuda N, Sakagawa E, Ohya S. Outer membrane proteins responsible for multiple drug resistance in pseudomonas aeruginosa. Antimicrob Agents Chemother. 1995; 39: 645-649. http://dx.doi.org/10.1128/AAC.39.3.645
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 645-649
-
-
Masuda, N.1
Sakagawa, E.2
Ohya, S.3
-
2
-
-
79956140677
-
The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening
-
Vella P, Hussein WM, Leung EWW, Clayton D, Ollis DL, Mitic N, McGeary PR. The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening. Bioorg Med Chem Lett. 2011; 21: 3282-3285. http://dx.doi.org/10.1016/j.bmcl.2011.04.027
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 3282-3285
-
-
Vella, P.1
Hussein, W.M.2
Leung, E.W.W.3
Clayton, D.4
Ollis, D.L.5
Mitic, N.6
McGeary, P.R.7
-
3
-
-
0019326853
-
The structure of beta-lactamases
-
Ambler RP. The structure of beta-lactamases. Philos Trans R Soc London B. 1980; 289: 321-331. http://dx.doi.org/10.1098/rstb.1980.0049
-
(1980)
Philos Trans R Soc London B
, vol.289
, pp. 321-331
-
-
Ambler, R.P.1
-
4
-
-
0027409878
-
An overview of the kinetic parameters of class B beta-lactamases
-
Felici A, Amicosante G, Oratore A, Strom R, Ledent P, Joris B, Fanuel L, Frère JM. An overview of the kinetic parameters of class B beta-lactamases. Biochem J. 1993; 291: 151-155. http://www.ncbi.nlm.nih.gov/pubmed/8471035
-
(1993)
Biochem J
, vol.291
, pp. 151-155
-
-
Felici, A.1
Amicosante, G.2
Oratore, A.3
Strom, R.4
Ledent, P.5
Joris, B.6
Fanuel, L.7
Frère, J.M.8
-
5
-
-
0028788420
-
Isolation and structure determination of two novel phenazines from a streptomyces with inhibitory activity against metallo-enzymes, including metallo-β-lactamase
-
Gilpin ML, Fluston M, Payne D, Cramp R, Hood I. Isolation and structure determination of two novel phenazines from a streptomyces with inhibitory activity against metallo-enzymes, including metallo-β-lactamase. J Antibiot. 1995; 48: 1081-1085. http://dx.doi.org/10.7164/antibiotics.48.1081
-
(1995)
J Antibiot
, vol.48
, pp. 1081-1085
-
-
Gilpin, M.L.1
Fluston, M.2
Payne, D.3
Cramp, R.4
Hood, I.5
-
6
-
-
0031020833
-
Inhibition of metallo-beta-lactamases by a series of mercaptoacetic acid thiol ester derivatives
-
Payane DJ, Bateson JH, Gasson BC, Proctor D, Khushi T, Farmar TH, Tolson DA, Bell D, Skett PW, Marshall AC, Reid R, Ghosez L, Combret Y, Marchand-Brynaert J. Inhibition of metallo-beta-lactamases by a series of mercaptoacetic acid thiol ester derivatives. Antimicrob Agents Chemother. 1997; 41: 135-140. http://www.ncbi.nlm.nih.gov/pubmed/8980769
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 135-140
-
-
Payane, D.J.1
Bateson, J.H.2
Gasson, B.C.3
Proctor, D.4
Khushi, T.5
Farmar, T.H.6
Tolson, D.A.7
Bell, D.8
Skett, P.W.9
Marshall, A.C.10
Reid, R.11
Ghosez, L.12
Combret, Y.13
Marchand-Brynaert, J.14
-
7
-
-
0033530093
-
Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase
-
Greenlee ML, Laub JB, Balkovec JM, Hammond ML, Hammond GG, Pompliano DL, Epstein-Toney JH. Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase. Bioorg Med Chem Lett. 1999; 9: 2549-2554. http://dx.doi.org/10.1016/S0960-894X(99)00425-4
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 2549-2554
-
-
Greenlee, M.L.1
Laub, J.B.2
Balkovec, J.M.3
Hammond, M.L.4
Hammond, G.G.5
Pompliano, D.L.6
Epstein-Toney, J.H.7
-
8
-
-
0032080039
-
The mechanism of catalysis and the inhibition of the Bacillus cereuszinc-dependent β-lactamase
-
Bounanga S, Laws AP, Galleni M, Page MI. The mechanism of catalysis and the inhibition of the Bacillus cereuszinc-dependent β-lactamase. Biochem J. 1998; 331: 703-711. http://www.ncbi.nlm.nih.gov/pubmed/9560295
-
(1998)
Biochem J
, vol.331
, pp. 703-711
-
-
Bounanga, S.1
Laws, A.P.2
Galleni, M.3
Page, M.I.4
-
9
-
-
0001770918
-
Inhibition Studies on the Metallo-β-lactamase L1 from Stenotrophomonas maltophilia
-
Yang KW, Crowder MW. Inhibition Studies on the Metallo-β-lactamase L1 from Stenotrophomonas maltophilia. Arch Biochem Biophys. 1999; 368: 1-6. http://dx.doi.org/10.1006/abbi.1999.1293
-
(1999)
Arch Biochem Biophys
, vol.368
, pp. 1-6
-
-
Yang, K.W.1
Crowder, M.W.2
-
10
-
-
0035976960
-
Thiomandelic Acid, a Broad Spectrum Inhibitor of Zinc_β-Lactamases
-
Mollard C, Moali C, Papamicael C, Christian Damblon C, Vessilier S, Amicosante G, Schofield CJ, Galleni M, Frere J-M, Roberts GCK. Thiomandelic Acid, a Broad Spectrum Inhibitor of Zinc_β-Lactamases. J Biol Chem. 2001; 276: 45015-45023. http://dx.doi.org/10.1074/jbc.M107054200
-
(2001)
J Biol Chem
, vol.276
, pp. 45015-45023
-
-
Mollard, C.1
Moali, C.2
Papamicael, C.3
Christian, D.C.4
Vessilier, S.5
Amicosante, G.6
Schofield, C.J.7
Galleni, M.8
Frere, J.-M.9
Roberts, G.C.K.10
-
11
-
-
21244446747
-
Irreversible Inhibition of Metallo-b-lactamase (IMP-1) by 3-(3-Mercaptopropionylsulfanyl)-propionic Acid Pentafluorophenyl Ester
-
Kurosaki H, Yamaguchi Y, Higashi T, Soga K, Matsueda S, Yumoto H, Misumi S, Yamagata Y, Arakawa Y, Goto M. Irreversible Inhibition of Metallo-b-lactamase (IMP-1) by 3-(3-Mercaptopropionylsulfanyl)-propionic Acid Pentafluorophenyl Ester. Angew Chem Int Ed. 2005; 44: 3861-3864. http://dx.doi.org/10.1002/anie.200500835
-
(2005)
Angew Chem Int Ed
, vol.44
, pp. 3861-3864
-
-
Kurosaki, H.1
Yamaguchi, Y.2
Higashi, T.3
Soga, K.4
Matsueda, S.5
Yumoto, H.6
Misumi, S.7
Yamagata, Y.8
Arakawa, Y.9
Goto, M.10
-
12
-
-
12244297122
-
Thiols as Classical and Slow-Binding Inhibitors of IMP-1 and Other Binuclear Metallo-β-lactamases
-
Siemann S, Clarke AJ, Viswanatha T, Dmitrienko GI. Thiols as Classical and Slow-Binding Inhibitors of IMP-1 and Other Binuclear Metallo-β-lactamases. Biochemistry. 2003; 42: 1673-1683. http://dx.doi.org/10.1021/bi027072i
-
(2003)
Biochemistry
, vol.42
, pp. 1673-1683
-
-
Siemann, S.1
Clarke, A.J.2
Viswanatha, T.3
Dmitrienko, G.I.4
-
13
-
-
39149098822
-
-
Liénard BMR, Hüting R, Lassaux P, Galleni M, Frère J-M, Schofield CJ. Dynamic Combinatorial Mass Spectrometry Leads to Metallo-β-lactamase Inhibitors J Med Chem. 2008; 51: 684-688. http://dx.doi.org/10.1021/jm070866g
-
(2008)
Dynamic Combinatorial Mass Spectrometry Leads to Metallo-β-lactamase Inhibitors J Med Chem
, vol.51
, pp. 684-688
-
-
Liénard, B.M.R.1
Hüting, R.2
Lassaux, P.3
Galleni, M.4
Frère, J.-M.5
Schofield, C.J.6
-
14
-
-
0038419647
-
Coordination Geometries of Metal Ions in D-or L-Captopril-inhibited Metallo-β-lactamases
-
Heinz U, Bauer R, Wommer S, Meyer-Klaucke W, Papamichaels C, Bateson J, Adolph HW. Coordination Geometries of Metal Ions in D-or L-Captopril-inhibited Metallo-β-lactamases. J Biol Chem. 2003; 278: 20659-20666. http://dx.doi.org/10.1074/jbc.M212581200
-
(2003)
J Biol Chem
, vol.278
, pp. 20659-20666
-
-
Heinz, U.1
Bauer, R.2
Wommer, S.3
Meyer-Klaucke, W.4
Papamichaels, C.5
Bateson, J.6
Adolph, H.W.7
-
15
-
-
45449088355
-
Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols
-
Liénard BM, Garau G, Horsfall L, Karsisiotis AI, Damblon C, Lassaux P, Papamicael C, Roberts GC, Galleni M, Dideberg O, Frère JM, Schofield CJ. Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. Org Biomol Chem. 2008; 6: 2282-2294. http://dx.doi.org/10.1039/b802311e
-
(2008)
Org Biomol Chem
, vol.6
, pp. 2282-2294
-
-
Liénard, B.M.1
Garau, G.2
Horsfall, L.3
Karsisiotis, A.I.4
Damblon, C.5
Lassaux, P.6
Papamicael, C.7
Roberts, G.C.8
Galleni, M.9
Dideberg, O.10
Frère, J.M.11
Schofield, C.J.12
-
16
-
-
77954347954
-
Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-β-lactamases
-
Lassaux P, Hamel M, Gulea M, Delbrück H, Mercuri PS, Horsfall L, Dehareng D, Kupper M, Frère JM, Hoffmann K, Galleni M, Bebrone C. Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-β-lactamases. J Med Chem. 2010; 53: 4862-4876. http://dx.doi.org/10.1021/jm100213c
-
(2010)
J Med Chem
, vol.53
, pp. 4862-4876
-
-
Lassaux, P.1
Hamel, M.2
Gulea, M.3
Delbrück, H.4
Mercuri, P.S.5
Horsfall, L.6
Dehareng, D.7
Kupper, M.8
Frère, J.M.9
Hoffmann, K.10
Galleni, M.11
Bebrone, C.12
-
17
-
-
37349001297
-
Crystallographic investigation of the inhibition mode of a VIM-2 metallo-beta-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor
-
Yamaguchi Y, Jin W, Matsunaga K, Ikemizu S, Yamagata Y, Wachino J, Shibata N, Arakawa Y, Kurosaki H. Crystallographic investigation of the inhibition mode of a VIM-2 metallo-beta-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor. J Med Chem. 2007; 50: 6647-6653. http://dx.doi.org/10.1021/jm701031n
-
(2007)
J Med Chem
, vol.50
, pp. 6647-6653
-
-
Yamaguchi, Y.1
Jin, W.2
Matsunaga, K.3
Ikemizu, S.4
Yamagata, Y.5
Wachino, J.6
Shibata, N.7
Arakawa, Y.8
Kurosaki, H.9
-
18
-
-
16644376850
-
Comparative study of the inhibition of metallo--lactamases (IMP-1 and VIM-2) by thiol compounds that contain a hydrophobic group
-
Jin W, Arakawa Y, Yasuzawa H, Taki T, Hashiguchi R, Mitsutani K, Shoga A, Yamaguchi Y, Kurosaki H, Shibata N, Ohta M, Goto M. Comparative study of the inhibition of metallo--lactamases (IMP-1 and VIM-2) by thiol compounds that contain a hydrophobic group. Biol Pharm Bull. 2004; 27: 851-856. http://dx.doi.org/10.1248/bpb.27.851
-
(2004)
Biol Pharm Bull
, vol.27
, pp. 851-856
-
-
Jin, W.1
Arakawa, Y.2
Yasuzawa, H.3
Taki, T.4
Hashiguchi, R.5
Mitsutani, K.6
Shoga, A.7
Yamaguchi, Y.8
Kurosaki, H.9
Shibata, N.10
Ohta, M.11
Goto, M.12
-
19
-
-
0034681922
-
Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor:Binding Determinants of a Potent, Broad-Spectrum Inhibitor
-
Concha NO, Janson CA, Rowling P, Pearson S, Cheever CA, Clarke BP, Lewis C, Galleni M, Frère JM, Payne DJ, Bateson JH, Abdel-Meguid SS. Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor:Binding Determinants of a Potent, Broad-Spectrum Inhibitor. Biochemistry. 2000; 39: 4288-4298. http://dx.doi.org/10.1021/bi992569m
-
(2000)
Biochemistry
, vol.39
, pp. 4288-4298
-
-
Concha, N.O.1
Janson, C.A.2
Rowling, P.3
Pearson, S.4
Cheever, C.A.5
Clarke, B.P.6
Lewis, C.7
Galleni, M.8
Frère, J.M.9
Payne, D.J.10
Bateson, J.H.11
Abdel-Meguid, S.S.12
-
20
-
-
0021832534
-
Fluoro ketone inhibitors of hydrolytic enzymes
-
Gelb MH, Svaren JP, Abeles RH. Fluoro ketone inhibitors of hydrolytic enzymes. Biochemistry. 1985; 24: 1813-1817. http://dx.doi.org/10.1021/bi00329a001
-
(1985)
Biochemistry
, vol.24
, pp. 1813-1817
-
-
Gelb, M.H.1
Svaren, J.P.2
Abeles, R.H.3
-
21
-
-
0025002985
-
Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: Comparison of slowly and rapidly equilibrating inhibitors
-
Brady K, Wei A, Ringe D, Abeles RH. Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors. Biochemistry. 1990; 29: 7600-7607. http://dx.doi.org/10.1021/bi00485a009
-
(1990)
Biochemistry
, vol.29
, pp. 7600-7607
-
-
Brady, K.1
Wei, A.2
Ringe, D.3
Abeles, R.H.4
-
22
-
-
0001128935
-
Complex between carboxypeptidase A and a possible transition-state analog: Mechanistic inferences from high-resolution x-ray structures of enzyme-inhibitor complexes
-
Christianson DW, Lipscomb WN. Complex between carboxypeptidase A and a possible transition-state analog: mechanistic inferences from high-resolution x-ray structures of enzyme-inhibitor complexes. J Am Chem Soc. 1986; 108: 4998-5003. http://dx.doi.org/10.1021/ja00276a048
-
(1986)
J Am Chem Soc
, vol.108
, pp. 4998-5003
-
-
Christianson, D.W.1
Lipscomb, W.N.2
-
23
-
-
0030598201
-
Trifluoromethyl alcohol and ketone inhibitors of metallo-β-lactamases
-
Walter MW, Felici A, Galleni M, Soto RP, Adlington RM, Baldwin JE, Frère J-M, Gololobov M, Schofield CJ. Trifluoromethyl alcohol and ketone inhibitors of metallo-β-lactamases. Bioorg Med Chem Lett. 1996; 6: 2455-2458. http://dx.doi.org/10.1016/0960-894X(96)00453-2
-
(1996)
Bioorg Med Chem Lett
, vol.6
, pp. 2455-2458
-
-
Walter, M.W.1
Felici, A.2
Galleni, M.3
Soto, R.P.4
Adlington, R.M.5
Baldwin, J.E.6
Frère, J.-M.7
Gololobov, M.8
Schofield, C.J.9
-
25
-
-
13144295022
-
Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallobeta-lactamase
-
Toney JH, Fitzgerald PM, Grover-Sharma N, Olson SH, May WJ, Sundelof JG, Vanderwall DE, Cleary KA, Grant SK, Wu JK, Kozarich JW, Pompliano DL, Hammond GG. Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallobeta-lactamase. Chem Biol. 1998; 5: 185-198. http://dx.doi.org/10.1016/S1074-5521(98)90632-9
-
(1998)
Chem Biol
, vol.5
, pp. 185-198
-
-
Toney, J.H.1
Fitzgerald, P.M.2
Grover-Sharma, N.3
Olson, S.H.4
May, W.J.5
Sundelof, J.G.6
Vanderwall, D.E.7
Cleary, K.A.8
Grant, S.K.9
Wu, J.K.10
Kozarich, J.W.11
Pompliano, D.L.12
Hammond, G.G.13
-
26
-
-
0033588861
-
Structure-activity relationships of biphenyl tetrazoles as metallo-β-lactamase inhibitors
-
Toney JH, Cleary KA, Hammond GG, Yuan X, May WJ, Hutchins SM, Ashton WT, Vanderwall DE. Structure-activity relationships of biphenyl tetrazoles as metallo-β-lactamase inhibitors. Bioorg Med Chem Lett. 1999; 9: 2741-2746. http://dx.doi.org/10.1016/S0960-894X(99)00458-8
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 2741-2746
-
-
Toney, J.H.1
Cleary, K.A.2
Hammond, G.G.3
Yuan, X.4
May, W.J.5
Hutchins, S.M.6
Ashton, W.T.7
Vanderwall, D.E.8
-
27
-
-
0035943678
-
Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase
-
Toney JH, Hammond GG, Fitzgerald PM, Sharma N, Balkovec JM, Rouen GP, Olson SH, Hammond ML, Greenlee ML, Gao YD. Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase. J Biol Chem. 2001; 276: 31913-31918. http://dx.doi.org/10.1074/jbc.M104742200
-
(2001)
J Biol Chem
, vol.276
, pp. 31913-31918
-
-
Toney, J.H.1
Hammond, G.G.2
Fitzgerald, P.M.3
Sharma, N.4
Balkovec, J.M.5
Rouen, G.P.6
Olson, S.H.7
Hammond, M.L.8
Greenlee, M.L.9
Gao, Y.D.10
-
28
-
-
12844264250
-
Novel IMP-1 metallo-β-lactamase inhibitors can reverse meropenem resistance in Escherichia coli expressing IMP-1
-
Moloughney JG, D. Thomas J, Toney JH. Novel IMP-1 metallo-β-lactamase inhibitors can reverse meropenem resistance in Escherichia coli expressing IMP-1. FEMS Microbiol Lett. 2005; 243: 65-71. http://dx.doi.org/10.1016/j.femsle.2004.11.042
-
(2005)
FEMS Microbiol Lett
, vol.243
, pp. 65-71
-
-
Moloughney, J.G.1
Thomas, D.J.2
Toney, J.H.3
-
29
-
-
33644774469
-
New leads of metallo-β-lactamase inhibitors from structure-based pharmacophore design
-
Olsen L, Jost S, Adolph H-W, Pettersson I, Hemmingsen L, Jørgensen FS. New leads of metallo-β-lactamase inhibitors from structure-based pharmacophore design. Bioorg Med Chem. 2006; 14: 2627-2635. http://dx.doi.org/10.1016/j.bmc.2005.11.046
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 2627-2635
-
-
Olsen, L.1
Jost, S.2
Adolph, H.-W.3
Pettersson, I.4
Hemmingsen, L.5
Jørgensen, F.S.6
-
30
-
-
68349152498
-
Metallo-β-lactamase inhibitory activity of phthalic acid derivatives
-
Hiraiwa Y, Morinaka A, Fukushima T, Kudo T. Metallo-β-lactamase inhibitory activity of phthalic acid derivatives. Bioorg Med Chem Lett. 2009; 19: 5162-5165. http://dx.doi.org/10.1016/j.bmcl.2009.07.018
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5162-5165
-
-
Hiraiwa, Y.1
Morinaka, A.2
Fukushima, T.3
Kudo, T.4
-
31
-
-
0032830274
-
Hydroxamate Inhibitors ofAeromonas hydrophilaAE036 Metallo-B-lactamase
-
Walter MW, Valladares MH, Adlington RM, Amicosante G, Baldwin JE, Frère J-M, Galleni M, Rossolini GR, Schofield CJ. Hydroxamate Inhibitors ofAeromonas hydrophilaAE036 Metallo-B-lactamase. Bioorg Chem. 1999; 27: 35-40. http://dx.doi.org/10.1006/bioo.1998.1111
-
(1999)
Bioorg Chem
, vol.27
, pp. 35-40
-
-
Walter, M.W.1
Valladares, M.H.2
Adlington, R.M.3
Amicosante, G.4
Baldwin, J.E.5
Frère, J.-M.6
Galleni, M.7
Rossolini, G.R.8
Schofield, C.J.9
-
32
-
-
33846680313
-
Inhibitors of the FEZ-1 metallo-β-lactamase
-
Liénard BMR, Horsfall LE, Galleni M, Frère J-M, Schofield CJ. Inhibitors of the FEZ-1 metallo-β-lactamase. Bioorg Med Chem Lett. 2007; 17: 964-968. http://dx.doi.org/10.1016/j.bmcl.2006.11.053
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 964-968
-
-
Liénard, B.M.R.1
Horsfall, L.E.2
Galleni, M.3
Frère, J.-M.4
Schofield, C.J.5
-
33
-
-
0032879868
-
Carbapenem derivatives as potential inhibitors of various β-lactamases, including class B metallo-β-lactamases
-
Nagano R, Adachi Y, Imamura H, Yamada K, Hashizume T, Morishima H. Carbapenem derivatives as potential inhibitors of various β-lactamases, including class B metallo-β-lactamases. Antimicrob Agents Chemother. 1999; 43: 2497-2503. http://www.ncbi.nlm.nih.gov/pubmed/10508031
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 2497-2503
-
-
Nagano, R.1
Adachi, Y.2
Imamura, H.3
Yamada, K.4
Hashizume, T.5
Morishima, H.6
-
34
-
-
0034051621
-
In vitro antibacterial activity and mechanism of action of J.-111,225, a novel 1β-methylcarbapenem, against transferable IMP-1 metallo-β-lactamase producers
-
Nagano R, Adachi Y, Hashizume T, Morishima H. In vitro antibacterial activity and mechanism of action of J.-111,225, a novel 1β-methylcarbapenem, against transferable IMP-1 metallo-β-lactamase producers. J Antimicrob Chemother. 2000; 45: 271-276. http://dx.doi.org/10.1093/jac/45.3.271
-
(2000)
J Antimicrob Chemother
, vol.45
, pp. 271-276
-
-
Nagano, R.1
Adachi, Y.2
Hashizume, T.3
Morishima, H.4
-
35
-
-
0028892329
-
Synthesis and rearrangment of potential zinc β-lactamase inhibitors
-
Hovel FV, Vanwetswinkell S, Marchand-Brynaertt J, FasWez J. Synthesis and rearrangment of potential zinc β-lactamase inhibitors. Tetrahedron Lett. 1995; 36: 9313-9316. http://dx.doi.org/10.1016/0040-4039(95)02028-N
-
(1995)
Tetrahedron Lett
, vol.36
, pp. 9313-9316
-
-
Hovel, F.V.1
Vanwetswinkell, S.2
Marchand-Brynaertt, J.3
Faswez, J.4
-
36
-
-
1242316384
-
Penicillin-derived inhibitors that simultaneously target both metallo-and serine-β-lactamases
-
Buynak JD, Chen H, Vogeti L, Gadhachanda VR, Buchanan CA, Palzkill T, Shaw RW, Spencer J, Walsh TR. Penicillin-derived inhibitors that simultaneously target both metallo-and serine-β-lactamases. Bioorg Med Chem Lett. 2004; 14: 1299-1304. http://dx.doi.org/10.1016/j.bmcl.2003.12.037
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 1299-1304
-
-
Buynak, J.D.1
Chen, H.2
Vogeti, L.3
Gadhachanda, V.R.4
Buchanan, C.A.5
Palzkill, T.6
Shaw, R.W.7
Spencer, J.8
Walsh, T.R.9
-
37
-
-
1542404603
-
The inhibition of metallo-β-lactamase by thioxo-cephalosporin derivatives
-
Tsang WY, Dhanda A, Schofield CJ, Frère J-M, Galleni M, Page MI. The inhibition of metallo-β-lactamase by thioxo-cephalosporin derivatives. Bioorg Med Chem Lett. 2004; 14: 1737-1739. http://dx.doi.org/10.1016/j.bmcl.2004.01.047
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 1737-1739
-
-
Tsang, W.Y.1
Dhanda, A.2
Schofield, C.J.3
Frère, J.-M.4
Galleni, M.5
Page, M.I.6
-
38
-
-
20544440614
-
Inhibitors of Metallo-β-lactamase Generated from β-Lactam Antibiotics
-
Badarau A, Llinás A, Laws AP, Damblon C, Page MI. Inhibitors of Metallo-β-lactamase Generated from β-Lactam Antibiotics. Biochemistry. 2005; 44: 8578-8589. http://dx.doi.org/10.1021/bi050302j
-
(2005)
Biochemistry
, vol.44
, pp. 8578-8589
-
-
Badarau, A.1
Llinás, A.2
Laws, A.P.3
Damblon, C.4
Page, M.I.5
-
39
-
-
0347694723
-
Evaluation of penicillin-based inhibitors of the class A and B β-lactamases from Bacillus anthracis
-
Beharry Z, Chen H, Gadhachanda VR, Buynak JD, Palzkill T. Evaluation of penicillin-based inhibitors of the class A and B β-lactamases from Bacillus anthracis. Biochem Biophys Res Commun. 2004; 313: 541-545. http://dx.doi.org/10.1016/j.bbrc.2003.11.158
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 541-545
-
-
Beharry, Z.1
Chen, H.2
Gadhachanda, V.R.3
Buynak, J.D.4
Palzkill, T.5
-
40
-
-
61349126689
-
Approaches to the simultaneous inactivation of metallo-and serine-beta-lactamases
-
Ganta SR, Perumal S, Pagadala SR, Samuelsen O, Spencer J, Pratt RF, Buynak JD. Approaches to the simultaneous inactivation of metallo-and serine-beta-lactamases. Bioorg Med Chem Lett. 2009; 19: 1618-1622. http://dx.doi.org/10.1016/j.bmcl.2009.02.018
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 1618-1622
-
-
Ganta, S.R.1
Perumal, S.2
Pagadala, S.R.3
Samuelsen, O.4
Spencer, J.5
Pratt, R.F.6
Buynak, J.D.7
-
41
-
-
77950411087
-
Cyclobutanone analogues of beta-lactams revisited: Insights into conformational requirements for inhibition of serine-and metallo-beta-lactamase
-
Johnson JW, Gretes M, Goodfellow VJ, Marrone L, Heynen ML, Strynadka NC, Dmitrienko GI. Cyclobutanone analogues of beta-lactams revisited: insights into conformational requirements for inhibition of serine-and metallo-beta-lactamases. J Am Chem Soc. 2010; 132: 2558-2560. http://dx.doi.org/10.1021/ja9086374
-
(2010)
J Am Chem So
, vol.13
, pp. 2558-2560
-
-
Johnso, J.1
Grete, M.2
Goodfello, V.3
Marron, L.4
Heyne, M.5
Strynadk, N.6
Dmitrienk, G.I.7
-
42
-
-
14744282967
-
A specific peptide inhibitor of the class B metallo-beta-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display
-
Sanschagrin F, Levesque RC. A specific peptide inhibitor of the class B metallo-beta-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display. J Antimicrob Chemother. 2005; 55: 252-255. http://dx.doi.org/10.1093/jac/dkh550
-
(2005)
J Antimicrob Chemother
, vol.55
, pp. 252-255
-
-
Sanschagrin, F.1
Levesque, R.C.2
-
43
-
-
0035078014
-
Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase
-
Bounaga S, Galleni M, Laws AP, Page MI. Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase. Bioorg Med Chem. 2001; 9: 503-510. http://dx.doi.org/10.1016/S0968-0896(00)00257-1
-
(2001)
Bioorg Med Chem
, vol.9
, pp. 503-510
-
-
Bounaga, S.1
Galleni, M.2
Laws, A.P.3
Page, M.I.4
-
44
-
-
33747348451
-
Homo-cysteinyl peptide inhibitors of the L1 metallo-β-lactamase, and SAR as determined by combinatorial library synthesis
-
Sun Q, Law A, Crowder MW, Geysen HM. Homo-cysteinyl peptide inhibitors of the L1 metallo-β-lactamase, and SAR as determined by combinatorial library synthesis. Bioorg Med Chem Lett. 2006; 16: 5169-5175. http://dx.doi.org/10.1016/j.bmcl.2006.07.001
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 5169-5175
-
-
Sun, Q.1
Law, A.2
Crowder, M.W.3
Geysen, H.M.4
-
45
-
-
34250214527
-
Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila
-
Horsfall LE, Garau G, Liénard BMR, Dideberg O, Schofield CJ. Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila. Antimicrob Agents Chemother. 2007; 51: 2136-2142. http://dx.doi.org/10.1128/AAC.00866-06
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 2136-2142
-
-
Horsfall, L.E.1
Garau, G.2
Liénard, B.M.R.3
Dideberg, O.4
Schofield, C.J.5
-
46
-
-
77952921254
-
Inhibition of metallo-beta-lactamases by pyridine monothiocarboxylic acid analogs
-
Roll DM, Yang Y, Wildey MJ, Bush K, Lee MD. Inhibition of metallo-beta-lactamases by pyridine monothiocarboxylic acid analogs. J Antibiot. 2010; 63: 255-257. http://dx.doi.org/10.1038/ja.2010.20
-
(2010)
J Antibiot
, vol.63
, pp. 255-257
-
-
Roll, D.M.1
Yang, Y.2
Wildey, M.J.3
Bush, K.4
Lee, M.D.5
-
47
-
-
0036096423
-
Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallobeta-lactamases
-
Payne DJ, Hueso-Rodríguez JA, Boyd H, Concha NO, Janson CA, Gilpin M, Bateson JH, Cheever C, Niconovich NL, Pearson S, Rittenhouse S, Tew D, Díez E, Pérez P, De La Fuente J, Rees M, RiveraSagredo A. Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallobeta-lactamases. Antimicrob Agents Chemother. 2002; 46:1880-1886. http://dx.doi.org/10.1128/AAC.46.6.1880-1886.2002
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 1880-1886
-
-
Payne, D.J.1
Hueso-Rodríguez, J.A.2
Boyd, H.3
Concha, N.O.4
Janson, C.A.5
Gilpin, M.6
Bateson, J.H.7
Cheever, C.8
Niconovich, N.L.9
Pearson, S.10
Rittenhouse, S.11
Tew, D.12
Díez, E.13
Pérez, P.14
de la Fuente, J.15
Rees, M.16
Riverasagredo, A.17
-
48
-
-
0037133377
-
The flavonoid galangin inhibits the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia
-
Denny BJ, Lambert PA, West PWJ. The flavonoid galangin inhibits the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia. FEMS Microbiol Lett. 2002; 208: 21-24. http://www.ncbi.nlm.nih.gov/pubmed/11934488
-
(2002)
FEMS Microbiol Lett
, vol.208
, pp. 21-24
-
-
Denny, B.J.1
Lambert, P.A.2
West, P.W.J.3
-
49
-
-
34948859355
-
Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily
-
Bebrone C. Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily. Biochem Pharmacol. 2007; 74: 1686-1701. http://dx.doi.org/10.1016/j.bcp.2007.05.021
-
(2007)
Biochem Pharmacol
, vol.74
, pp. 1686-1701
-
-
Bebrone, C.1
-
50
-
-
17444363393
-
Metallo-beta-lactamases: The quiet before the storm?
-
Walsh TR, Tolemman MA, Poirel L, Nordmann P. Metallo-beta-lactamases: the quiet before the storm? Clin Microb Rev. 2005; 18: 306-325. http://www.ncbi.nlm.nih.gov/pubmed/15831827
-
(2005)
Clin Microb Rev
, vol.18
, pp. 306-325
-
-
Walsh, T.R.1
Tolemman, M.A.2
Poirel, L.3
Nordmann, P.4
-
51
-
-
0037329156
-
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases
-
Docquier JD, Lamotte-Brasseur J, Galleni M, Amicosante G, Frere JM, Rossolini GM. On functional and structural heterogeneity of VIM-type metallo-beta-lactamases. J Antimicrob Chemother. 2003; 51: 257-266. http://dx.doi.org/10.1093/jac/dkg067
-
(2003)
J Antimicrob Chemother
, vol.51
, pp. 257-266
-
-
Docquier, J.D.1
Lamotte-Brasseur, J.2
Galleni, M.3
Amicosante, G.4
Frere, J.M.5
Rossolini, G.M.6
-
52
-
-
67650227781
-
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries
-
Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P. Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries. Bioorg Med Chem. 2009; 17: 5027-5037. http://dx.doi.org/10.1016/j.bmc.2009.05.070
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 5027-5037
-
-
Minond, D.1
Saldanha, S.A.2
Subramaniam, P.3
Spaargaren, M.4
Spicer, T.5
Fotsing, J.R.6
Weide, T.7
Fokin, V.V.8
Sharpless, K.B.9
Galleni, M.10
Bebrone, C.11
Lassaux, P.12
Hodder, P.13
-
53
-
-
77955915532
-
NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies
-
Weide T, Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder PS, Fokin VV. NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies. ACS Med Chem Lett. 2010; 1: 150-154. http://dx.doi.org/10.1021/ml900022q
-
(2010)
ACS Med Chem Lett
, vol.1
, pp. 150-154
-
-
Weide, T.1
Saldanha, S.A.2
Minond, D.3
Spicer, T.P.4
Fotsing, J.R.5
Spaargaren, M.6
Frère, J.M.7
Bebrone, C.8
Sharpless, K.B.9
Hodder, P.S.10
Fokin, V.V.11
-
54
-
-
84655167173
-
3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors
-
Faridoon, Hussein WM, Vella P, Islam NU, Ollis DL, Schenk G, McGeary RP. 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors. Bioorg Med Chem Lett. 2012; 22: 380-386. http://dx.doi.org/10.1016/j.bmcl.2011.10.116
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 380-386
-
-
Faridoon, H.W.M.1
Vella, P.2
Islam, N.U.3
Ollis, D.L.4
Schenk, G.5
McGeary, R.P.6
-
55
-
-
79951590708
-
Metallo-β-lactamase-Catalyzed Hydrolysis of Cephalosporins: Some Mechanistic Insights into the Effect of Heterocyclic Thiones on Enzyme Activity
-
Tamilselvi A, Mugesh G. Metallo-β-lactamase-Catalyzed Hydrolysis of Cephalosporins: Some Mechanistic Insights into the Effect of Heterocyclic Thiones on Enzyme Activity. Inorg Chem. 2011; 50: 749-756. http://dx.doi.org/10.1021/ic100253k
-
(2011)
Inorg Chem
, vol.50
, pp. 749-756
-
-
Tamilselvi, A.1
Mugesh, G.2
-
56
-
-
80955151611
-
Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa
-
Mohamed MS, Hussein WM, McGeary RP, Vella P, Schenk G, Abd El-hameed RH. Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Eur J Med Chem. 2011;46: 6075-6082. http://dx.doi.org/10.1016/j.ejmech.2011.10.030
-
(2011)
Eur J Med Chem
, vol.46
, pp. 6075-6082
-
-
Mohamed, M.S.1
Hussein, W.M.2
McGeary, R.P.3
Vella, P.4
Schenk, G.5
Abd El-hameed, R.H.6
-
57
-
-
70349104766
-
Antibiotic resistance in bacteria: Novel metalloenzyme inhibitors
-
Kim S-K, Sims CL, Wozniak SE, Drude SH, Whitson D, Shaw RW. Antibiotic resistance in bacteria: novel metalloenzyme inhibitors. Chem Biol Drug Des. 2009; 74: 343-348. http://dx.doi.org/10.1111/j.1747-0285.2009.00879.x
-
(2009)
Chem Biol Drug Des
, vol.74
, pp. 343-348
-
-
Kim, S.-K.1
Sims, C.L.2
Wozniak, S.E.3
Drude, S.H.4
Whitson, D.5
Shaw, R.W.6
-
58
-
-
0035991840
-
N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-beta-lactamase
-
Siemann S, Evanoff DP, Marrone L, Clarke AJ, Viswanatha T, Dmitrienko GI. N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-beta-lactamase. Antimicrob Agents Chemother. 2002; 46: 2450-2457. http://dx.doi.org/10.1128/AAC.46.8.2450-2457.2002
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 2450-2457
-
-
Siemann, S.1
Evanoff, D.P.2
Marrone, L.3
Clarke, A.J.4
Viswanatha, T.5
Dmitrienko, G.I.6
-
59
-
-
0032510815
-
Unanticipated inhibition of the metallo-beta-lactamase from Bacteroides fragilis by 4-morpholineethanesulfonic acid (MES): A crystallographic study at 1.85-A resolution
-
Fitzgerald PMD, Wu JK, Toney JH. Unanticipated inhibition of the metallo-beta-lactamase from Bacteroides fragilis by 4-morpholineethanesulfonic acid (MES): a crystallographic study at 1.85-A resolution. Biochemistry. 1998; 37: 6791-6800. http://dx.doi.org/10.1021/bi9730339
-
(1998)
Biochemistry
, vol.37
, pp. 6791-6800
-
-
Fitzgerald, P.M.D.1
Wu, J.K.2
Toney, J.H.3
-
60
-
-
18844429967
-
Bulgecin A: A novel inhibitor of binuclear metallo-beta-lactamases
-
Simm AM, Loveridge EJ, Crosby J, Avison MB, Walsh TR, Bennett PM. Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamases. Biochem J. 2005; 387: 585-590. http://dx.doi.org/10.1042/BJ20041542/ul
-
(2005)
Biochem J
, vol.387
, pp. 585-590
-
-
Simm, A.M.1
Loveridge, E.J.2
Crosby, J.3
Avison, M.B.4
Walsh, T.R.5
Bennett, P.M.6
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