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5
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37249052235
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Defining an extended-spectrum β-lactamase
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Livermore D.M. Defining an extended-spectrum β-lactamase. Clinical Microbiology & Infection 2008, 14(Suppl. 1):3-10.
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(2008)
Clinical Microbiology & Infection
, vol.14
, Issue.SUPPL. 1
, pp. 3-10
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Livermore, D.M.1
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7
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34948859355
-
Metallo-β-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily
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Bebrone C. Metallo-β-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily. Biochemical Pharmacology 2007, 74:1686-1701.
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(2007)
Biochemical Pharmacology
, vol.74
, pp. 1686-1701
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Bebrone, C.1
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10
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-
73849084148
-
Diversity, epidemiology, and genetics of class D β-lactamases
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Poirel L., Naas T., Nordmann P. Diversity, epidemiology, and genetics of class D β-lactamases. Antimicrobial Agents & Chemotherapy 2010, 54:24-38.
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(2010)
Antimicrobial Agents & Chemotherapy
, vol.54
, pp. 24-38
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Poirel, L.1
Naas, T.2
Nordmann, P.3
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11
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77957770819
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Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
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Bush K. Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. Current Opinion in Microbiology 2010, 13:558-564.
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(2010)
Current Opinion in Microbiology
, vol.13
, pp. 558-564
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Bush, K.1
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12
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33947163441
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CTX-M: changing the face of ESBLs in Europe
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Livermore D.M., Canton R., Gniadkowski M., Nordmann P., Rossolini G.M., Arlet G., Ayala J., Coque T.M., Kern-Zdanowicz I., Luzzaro F., et al. CTX-M: changing the face of ESBLs in Europe. Journal of Antimicrobial Chemotherapy 2007, 59:165-174.
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(2007)
Journal of Antimicrobial Chemotherapy
, vol.59
, pp. 165-174
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Livermore, D.M.1
Canton, R.2
Gniadkowski, M.3
Nordmann, P.4
Rossolini, G.M.5
Arlet, G.6
Ayala, J.7
Coque, T.M.8
Kern-Zdanowicz, I.9
Luzzaro, F.10
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13
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69949174478
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Has the era of untreatable infections arrived?
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Livermore D.M. Has the era of untreatable infections arrived?. Journal of Antimicrobial Chemotherapy 2009, 64(Suppl. 1):i29-i36.
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(2009)
Journal of Antimicrobial Chemotherapy
, vol.64
, Issue.SUPPL. 1
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-
Livermore, D.M.1
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15
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80052592445
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Development of antibiotics for Gram-negatives: where now?
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Bassetti M., Ginocchio F., Giacobbe D.R., Mikulska M. Development of antibiotics for Gram-negatives: where now?. Development 2011, 1:211-227.
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(2011)
Development
, vol.1
, pp. 211-227
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Bassetti, M.1
Ginocchio, F.2
Giacobbe, D.R.3
Mikulska, M.4
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18
-
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77951060664
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Current challenges in antimicrobial chemotherapy: focus on β-lactamase inhibition
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Bebrone C., Lassaux P., Vercheval L., Sohier J.S., Jehaes A., Sauvage E., Galleni M. Current challenges in antimicrobial chemotherapy: focus on β-lactamase inhibition. Drugs 2010, 70:651-679.
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(2010)
Drugs
, vol.70
, pp. 651-679
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Bebrone, C.1
Lassaux, P.2
Vercheval, L.3
Sohier, J.S.4
Jehaes, A.5
Sauvage, E.6
Galleni, M.7
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19
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78649683457
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Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-β-lactam β-lactamase inhibitor
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Stachyra T., Péchereau M.C., Bruneau J.M., Claudon M., Frère J.M., Miossec C., Coleman K., Black M.T. Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-β-lactam β-lactamase inhibitor. Antimicrobial Agents & Chemotherapy 2010, 54:5132-5138.
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(2010)
Antimicrobial Agents & Chemotherapy
, vol.54
, pp. 5132-5138
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Stachyra, T.1
Péchereau, M.C.2
Bruneau, J.M.3
Claudon, M.4
Frère, J.M.5
Miossec, C.6
Coleman, K.7
Black, M.T.8
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20
-
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84877041841
-
High resolution crystal structure of CTX-M-15 in complex with the new β-lactamase inhibitor NXL104
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Docquier J.D., Stachyra T., Benvenuti M., Rossolini G.M., Mangani S., Pechereau M.C., Bruneau J.M., Claudon M., Barbosa F., Miossec C., Black M.T. High resolution crystal structure of CTX-M-15 in complex with the new β-lactamase inhibitor NXL104. 49th International Congress of Antimicrobial Agents & Chemotherapy 2009, C1-C1098.
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(2009)
49th International Congress of Antimicrobial Agents & Chemotherapy
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-
Docquier, J.D.1
Stachyra, T.2
Benvenuti, M.3
Rossolini, G.M.4
Mangani, S.5
Pechereau, M.C.6
Bruneau, J.M.7
Claudon, M.8
Barbosa, F.9
Miossec, C.10
Black, M.T.11
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21
-
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4444347175
-
In vitro activity of AVE1330A, an innovative broad-spectrum non-β-lactam β-lactamase inhibitor
-
Bonnefoy A., Dupuis-Hamelin C., Steier V., Delachaume C., Seys C., Stachyra T., Fairley M., Guitton M., Lampilas M. In vitro activity of AVE1330A, an innovative broad-spectrum non-β-lactam β-lactamase inhibitor. Journal of Antimicrobial Chemotherapy 2004, 54:410-417.
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(2004)
Journal of Antimicrobial Chemotherapy
, vol.54
, pp. 410-417
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-
Bonnefoy, A.1
Dupuis-Hamelin, C.2
Steier, V.3
Delachaume, C.4
Seys, C.5
Stachyra, T.6
Fairley, M.7
Guitton, M.8
Lampilas, M.9
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22
-
-
84857234787
-
In vitro activity of the class A and C β-lactamase inhibitor MK-7655
-
Young K., Raghoobar S.L., Hairston N.N., Painter R.E., Racine F., Dorso K.L., Park Y.-W., Ogawa A.M., Wisniewski D., Hermes J., Blizzard T.A., et al. In vitro activity of the class A and C β-lactamase inhibitor MK-7655. 50th International Congress of Antimicrobial Agents & Chemotherapy 2010, F1-F2139.
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(2010)
50th International Congress of Antimicrobial Agents & Chemotherapy
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-
Young, K.1
Raghoobar, S.L.2
Hairston, N.N.3
Painter, R.E.4
Racine, F.5
Dorso, K.L.6
Park, Y.-W.7
Ogawa, A.M.8
Wisniewski, D.9
Hermes, J.10
Blizzard, T.A.11
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23
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84857238569
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The β-lactamase inhibitor NXL104 does not induce AmpC β-lactamase expression in Enterobacter cloacae
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Miossec C., Claudon M., Patel D., Levasseur P., Hodgson J.E., Black M.T. The β-lactamase inhibitor NXL104 does not induce AmpC β-lactamase expression in Enterobacter cloacae. 46th International Congress of Antimicrobial Agents & Chemotherapy 2006, F-128.
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(2006)
46th International Congress of Antimicrobial Agents & Chemotherapy
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-
Miossec, C.1
Claudon, M.2
Patel, D.3
Levasseur, P.4
Hodgson, J.E.5
Black, M.T.6
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25
-
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78650636489
-
Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae
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Livermore D.M., Mushtaq S., Warner M., Zhang J., Maharjan S., Doumith M., Woodford N. Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae. Antimicrobial Agents & Chemotherapy 2011, 55:390-394.
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(2011)
Antimicrobial Agents & Chemotherapy
, vol.55
, pp. 390-394
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-
Livermore, D.M.1
Mushtaq, S.2
Warner, M.3
Zhang, J.4
Maharjan, S.5
Doumith, M.6
Woodford, N.7
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26
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54549112247
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NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum β-lactamases and carbapenemases
-
Livermore D.M., Mushtaq S., Warner M., Miossec C., Woodford N. NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum β-lactamases and carbapenemases. Journal of Antimicrobial Chemotherapy 2008, 62:1053-1056.
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(2008)
Journal of Antimicrobial Chemotherapy
, vol.62
, pp. 1053-1056
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-
Livermore, D.M.1
Mushtaq, S.2
Warner, M.3
Miossec, C.4
Woodford, N.5
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27
-
-
84857239452
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Activity of NXL104 in combination with β-lactams against genetically characterized class A and class C β-lactamase-producing Escherichia coli and Klebsiella pneumoniae
-
Poster E-807
-
Lagacé-Wiens P.R.S., Tailor F., Simner P., Nichol K., Hoban D., Zhanel G.G. Activity of NXL104 in combination with β-lactams against genetically characterized class A and class C β-lactamase-producing Escherichia coli and Klebsiella pneumoniae. 50th International Congress of Antimicrobial Agents & Chemotherapy 2010, Poster E-807.
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(2010)
50th International Congress of Antimicrobial Agents & Chemotherapy
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-
Lagacé-Wiens, P.R.S.1
Tailor, F.2
Simner, P.3
Nichol, K.4
Hoban, D.5
Zhanel, G.G.6
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28
-
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77957862993
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In vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters
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Mushtaq S., Warner M., Livermore D.M. In vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters. Journal of Antimicrobial Chemotherapy 2010, 65:2376-2381.
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(2010)
Journal of Antimicrobial Chemotherapy
, vol.65
, pp. 2376-2381
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-
Mushtaq, S.1
Warner, M.2
Livermore, D.M.3
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29
-
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79956326529
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In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals: (CANWARD 2009 study)
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Walkty A., DeCorby M., Lagacé-Wiens P.R., Karlowsky J.A., Hoban D.J., Zhanel G.G. In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals: (CANWARD 2009 study). Antimicrobial Agents and Chemotherapy 2011, 55:2992-2994.
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(2011)
Antimicrobial Agents and Chemotherapy
, vol.55
, pp. 2992-2994
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Walkty, A.1
DeCorby, M.2
Lagacé-Wiens, P.R.3
Karlowsky, J.A.4
Hoban, D.J.5
Zhanel, G.G.6
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30
-
-
79959230230
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In vitro activity of ceftazidime-NXL104 against 396 strains of β-lactamase producing anaerobes
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Citron D.M., Tyrrell K.L., Merriam V., Goldstein E.J. In vitro activity of ceftazidime-NXL104 against 396 strains of β-lactamase producing anaerobes. Antimicrobial Agents and Chemotherapy 2011, 55:3616-3620.
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(2011)
Antimicrobial Agents and Chemotherapy
, vol.55
, pp. 3616-3620
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-
Citron, D.M.1
Tyrrell, K.L.2
Merriam, V.3
Goldstein, E.J.4
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31
-
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84877015121
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Safety, single dose pharmacokinetics, and pharmacodynamics of β-lactamase inhibitor NXL104 in healthy young male adults
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Poster #A-809
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Merdjan H., Tarral A., Girard A.M., Levasseur P., Lowther J., Miossec C., Chassard D., Rangaraju M. Safety, single dose pharmacokinetics, and pharmacodynamics of β-lactamase inhibitor NXL104 in healthy young male adults. 47th International Congress of Antimicrobial Agents & Chemotherapy 2007, Poster #A-809.
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(2007)
47th International Congress of Antimicrobial Agents & Chemotherapy
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-
Merdjan, H.1
Tarral, A.2
Girard, A.M.3
Levasseur, P.4
Lowther, J.5
Miossec, C.6
Chassard, D.7
Rangaraju, M.8
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32
-
-
81155161608
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Effect of age and gender on the pharmacokinetics (PK) and safety of NXL104 in healthy subjects (Protocol NXL104/1004)
-
Poster A1-007
-
Tarral A., Lipka J., Gyaw S., Pencheva P., Merdjan H., Heber W., Cheung V., Garner R., Sable C. Effect of age and gender on the pharmacokinetics (PK) and safety of NXL104 in healthy subjects (Protocol NXL104/1004). 49th International Congress of Antimicrobial Agents & Chemotherapy 2009, Poster A1-007.
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(2009)
49th International Congress of Antimicrobial Agents & Chemotherapy
-
-
Tarral, A.1
Lipka, J.2
Gyaw, S.3
Pencheva, P.4
Merdjan, H.5
Heber, W.6
Cheung, V.7
Garner, R.8
Sable, C.9
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33
-
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84857237611
-
Efficacy, safety and tolerability of ceftazidime avibactam (ceftazidime/NXL104) versus imipenem cilastatin in the treatment of complicated urinary tract infections in hospitalised adults
-
Poster P1533
-
Vazquez J.A., González-Patzán L.D., Lipka J., Sable C. Efficacy, safety and tolerability of ceftazidime avibactam (ceftazidime/NXL104) versus imipenem cilastatin in the treatment of complicated urinary tract infections in hospitalised adults. 21st European Congress of Clinical Microbiology & Infectious Diseases/27th International Congress of Chemotherapy 2011, Poster P1533.
-
(2011)
21st European Congress of Clinical Microbiology & Infectious Diseases/27th International Congress of Chemotherapy
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-
Vazquez, J.A.1
González-Patzán, L.D.2
Lipka, J.3
Sable, C.4
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34
-
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81155161607
-
Efficacy and safety of ceftazidime avibactam (ceftazidime/NXL104) plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalised adults
-
Poster P1532
-
Lucasti C., Popescu I., Ramesh M., Lipka J., Sable C. Efficacy and safety of ceftazidime avibactam (ceftazidime/NXL104) plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalised adults. 21st European Congress of Clinical Microbiology & Infectious Diseases/27th International Congress of Chemotherapy 2011, Poster P1532.
-
(2011)
21st European Congress of Clinical Microbiology & Infectious Diseases/27th International Congress of Chemotherapy
-
-
Lucasti, C.1
Popescu, I.2
Ramesh, M.3
Lipka, J.4
Sable, C.5
-
37
-
-
79959280244
-
In vivo efficacy of a human-simulated regimen of ceftaroline combined with NXL104 against ESBL- producing and non-ESBL-producing Enterobacteriaceae
-
Wiskirchen D.E., Crandon J.L., Furtado G.H., Williams G., Nicolau D.P. In vivo efficacy of a human-simulated regimen of ceftaroline combined with NXL104 against ESBL- producing and non-ESBL-producing Enterobacteriaceae. Antimicrobial Agents and Chemotherapy 2011, 55:3220-3225.
-
(2011)
Antimicrobial Agents and Chemotherapy
, vol.55
, pp. 3220-3225
-
-
Wiskirchen, D.E.1
Crandon, J.L.2
Furtado, G.H.3
Williams, G.4
Nicolau, D.P.5
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38
-
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84857235535
-
A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of an intravenous β-lactamase inhibitor in healthy male volunteers
-
Slide Presentation F1-1967
-
Butterton J.R., Jumes P., Calder N., Rizk M.L., Nefliu M., Sun P., Schwartz M., Mangini E., Warrington S., Stoch A., Wagner J.A. A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of an intravenous β-lactamase inhibitor in healthy male volunteers. 50th International Congress of Antimicrobial Agents & Chemotherapy 2010, Slide Presentation F1-1967.
-
(2010)
50th International Congress of Antimicrobial Agents & Chemotherapy
-
-
Butterton, J.R.1
Jumes, P.2
Calder, N.3
Rizk, M.L.4
Nefliu, M.5
Sun, P.6
Schwartz, M.7
Mangini, E.8
Warrington, S.9
Stoch, A.10
Wagner, J.A.11
-
39
-
-
81155162231
-
In vitro activity of ceftaroline against 5375 pathogens obtained from patients in Canadian hospitals: CANWARD 2009
-
Poster E-815
-
Karlowski J.A., DeCorby M., Lagace-Wiens P., Adams H., Nichol K., Hoban D.J., Zhanel G.G. In vitro activity of ceftaroline against 5375 pathogens obtained from patients in Canadian hospitals: CANWARD 2009. 50th International Congress of Antimicrobial Agents & Chemotherapy 2010, Poster E-815.
-
(2010)
50th International Congress of Antimicrobial Agents & Chemotherapy
-
-
Karlowski, J.A.1
DeCorby, M.2
Lagace-Wiens, P.3
Adams, H.4
Nichol, K.5
Hoban, D.J.6
Zhanel, G.G.7
-
40
-
-
84857233959
-
Activity of ceftazidime/NXL104 versus CAZ alone and other comparators against 2399 Gram-negative bacilli-results from CANWARD 2009
-
Poster E-806
-
Lagacé-Wiens P., Simner P., Tailor F., DeCorby M., Karlowsky J., Hoban D., Zhanel G.G. Activity of ceftazidime/NXL104 versus CAZ alone and other comparators against 2399 Gram-negative bacilli-results from CANWARD 2009. 50th International Congress of Antimicrobial Agents & Chemotherapy 2010, Poster E-806.
-
(2010)
50th International Congress of Antimicrobial Agents & Chemotherapy
-
-
Lagacé-Wiens, P.1
Simner, P.2
Tailor, F.3
DeCorby, M.4
Karlowsky, J.5
Hoban, D.6
Zhanel, G.G.7
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