Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 44, 2016, Pages E6806-E6812

  Ou, Yang ^a,b   Wang, Shang Jui ^a,b   Li, Dawei ^a,b   Chu, Bo ^a,b   Gu, Wei ^a,b  

^a NewYork Presbyterian Hospital   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Ferroptosis; P53; Polyamine metabolism; SAT1; Tumor suppression

Indexed keywords

ACYLTRANSFERASE; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; DOXORUBICIN; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; POLYAMINE OXIDASE; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RNA; SPERMINE N 1 ACETYLTRANSFERASE; TETRACYCLINE; UNCLASSIFIED DRUG; ALOX15 PROTEIN, HUMAN; DIAMINE N-ACETYLTRANSFERASE; MDM2 PROTEIN, HUMAN; POLYAMINE; PROTEIN MDM2; SPERMIDINE; SPERMINE; STUB1 PROTEIN, HUMAN; TUMOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; BINDING SITE; CANCER INHIBITION; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; GENE ACTIVATION; GENE EXPRESSION; GENE IDENTIFICATION; GROWTH DISORDER; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYAMINE METABOLISM; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; TRANSIENT TRANSFECTION; TUMOR GROWTH; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; CELL CYCLE CHECKPOINT; CELL DEATH; CRISPR CAS SYSTEM; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENE KNOCKDOWN; GENETICS; METABOLISM; NEOPLASM; TUMOR CELL LINE;

ACETYLTRANSFERASES; ANIMALS; APOPTOSIS; ARACHIDONATE 15-LIPOXYGENASE; CARCINOGENESIS; CELL CYCLE CHECKPOINTS; CELL DEATH; CELL LINE, TUMOR; CRISPR-CAS SYSTEMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIPID PEROXIDATION; METABOLIC NETWORKS AND PATHWAYS; MICE; NEOPLASM PROTEINS; NEOPLASMS; OXIDATIVE STRESS; POLYAMINES; PROTO-ONCOGENE PROTEINS C-MDM2; REACTIVE OXYGEN SPECIES; SPERMIDINE; SPERMINE; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84994059408     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1607152113     Document Type: Article

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