CINPA1 binds directly to constitutive androstane receptor and inhibits its activity

Biochemical Pharmacology

Volumn 152, Issue , 2018, Pages 211-223

  Cherian, Milu T ^a   Chai, Sergio C ^a   Wright, William C ^a,b   Singh, Aman ^a,b   Alexandra Casal, Morgan ^a,c   Zheng, Jie ^d   Wu, Jing ^a   Lee, Richard E ^a   Griffin, Patrick R ^d   Chen, Taosheng ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

CAR; Ligand receptor interaction; Transcriptional regulation; Xenobiotic receptor

Indexed keywords

BENZAZEPINE DERIVATIVE; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; ETHYL (5-(DIETHYLGLYCYL)-10,11-DIHYDRO-5H-DIBENZO(B,F)AZEPIN-3-YL)CARBAMATE; PROTEIN BINDING;

AMINO ACID SEQUENCE; HEK293 CELL LINE; HEP-G2 CELL LINE; HUMAN; METABOLISM; MOLECULAR DOCKING; MOLECULAR MODEL; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; BENZAZEPINES; HEK293 CELLS; HEP G2 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 85045121318     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2018.03.029     Document Type: Article

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