Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor

Archives of Toxicology

Volumn 91, Issue 6, 2017, Pages 2375-2390

  Jeske, Judith ^a   Windshügel, Björn ^b   Thasler, Wolfgang E ^c   Schwab, Matthias ^a,d   Burk, Oliver ^a  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

CINPA1; Constitutive androstane receptor; Dibenzazepine carbamate; Molecular docking; Pregnane X receptor; Primary human hepatocytes

Indexed keywords

CARBAMIC ACID; CINPA1 PROTEIN; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 3A4; DIBENZAZEPINE DERIVATIVE; PREGNANE X RECEPTOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; BENZAZEPINE DERIVATIVE; CELL RECEPTOR; ETHYL (5-(DIETHYLGLYCYL)-10,11-DIHYDRO-5H-DIBENZO(B,F)AZEPIN-3-YL)CARBAMATE; LIGAND; PROTEIN BINDING; STEROID RECEPTOR;

ARTICLE; GENE EXPRESSION; GENE SILENCING; HEP-G2 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIGAND BINDING; LIVER CELL; MODULATION; MOLECULAR DOCKING; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPORTER GENE; TRANSACTIVATION; TRANSIENT TRANSFECTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; PRIMARY CELL CULTURE;

BENZAZEPINES; GENE EXPRESSION; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIGANDS; MOLECULAR DOCKING SIMULATION; PRIMARY CELL CULTURE; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID;

EID: 85015091284     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-017-1948-3     Document Type: Article

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