-
1
-
-
84884170357
-
An update on the constitutive androstane receptor (CAR)
-
Molnár, F., Küblbeck, J., Jyrkkärinne, J., Prantner, V., Honkakoski, P., An update on the constitutive androstane receptor (CAR). Drug Metab Drug Interact 28 (2013), 79–93.
-
(2013)
Drug Metab Drug Interact
, vol.28
, pp. 79-93
-
-
Molnár, F.1
Küblbeck, J.2
Jyrkkärinne, J.3
Prantner, V.4
Honkakoski, P.5
-
2
-
-
84931045771
-
Small-molecule modulators of the constitutive androstane receptor
-
Cherian, M., Chai, S.C., Chen, T., Small-molecule modulators of the constitutive androstane receptor. Expert Opin Drug Metab Toxicol 11 (2015), 1099–1114.
-
(2015)
Expert Opin Drug Metab Toxicol
, vol.11
, pp. 1099-1114
-
-
Cherian, M.1
Chai, S.C.2
Chen, T.3
-
3
-
-
0031682988
-
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
-
Honkakoski, P., Zelko, I., Sueyoshi, T., Negishi, M., The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18 (1998), 5652–5658.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5652-5658
-
-
Honkakoski, P.1
Zelko, I.2
Sueyoshi, T.3
Negishi, M.4
-
4
-
-
0033525886
-
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
-
Sueyoshi, T., Kawamoto, T., Zelko, I., Honkakoski, P., Negishi, M., The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 274 (1999), 6043–6046.
-
(1999)
J Biol Chem
, vol.274
, pp. 6043-6046
-
-
Sueyoshi, T.1
Kawamoto, T.2
Zelko, I.3
Honkakoski, P.4
Negishi, M.5
-
5
-
-
0035029401
-
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
-
Sugatani, J., Kojima, H., Ueda, A., Kakizaki, S., Yoshinari, K., Gong, Q.H., et al. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33 (2001), 1232–1238.
-
(2001)
Hepatology
, vol.33
, pp. 1232-1238
-
-
Sugatani, J.1
Kojima, H.2
Ueda, A.3
Kakizaki, S.4
Yoshinari, K.5
Gong, Q.H.6
-
6
-
-
0036765751
-
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site
-
Ferguson, S.S., LeCluyse, E.L., Negishi, M., Goldstein, J.A., Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Mol Pharmacol 62 (2002), 737–746.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 737-746
-
-
Ferguson, S.S.1
LeCluyse, E.L.2
Negishi, M.3
Goldstein, J.A.4
-
7
-
-
0036070955
-
Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor
-
Goodwin, B., Hodgson, E., D'Costa, D.J., Robertson, G.R., Liddle, C., Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol Pharmacol 62 (2002), 359–365.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 359-365
-
-
Goodwin, B.1
Hodgson, E.2
D'Costa, D.J.3
Robertson, G.R.4
Liddle, C.5
-
8
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the constitutive androstane receptor
-
Kast, H.R., Goodwin, B., Tarr, P.T., Jones, S.A., Anisfeld, A.M., Stolts, C.M., et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the constitutive androstane receptor. J Biol Chem 277 (2002), 2908–2915.
-
(2002)
J Biol Chem
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stolts, C.M.6
-
9
-
-
84896546382
-
Signaling control of the constitutive androstane receptor (CAR)
-
Yang, H., Wang, H., Signaling control of the constitutive androstane receptor (CAR). Protein Cell 5 (2014), 113–123.
-
(2014)
Protein Cell
, vol.5
, pp. 113-123
-
-
Yang, H.1
Wang, H.2
-
10
-
-
0033652116
-
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene
-
Kawamoto, T., Kakizaki, S., Yoshinari, K., Negishi, M., Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. Mol Endocrinol 14 (2000), 1897–1905.
-
(2000)
Mol Endocrinol
, vol.14
, pp. 1897-1905
-
-
Kawamoto, T.1
Kakizaki, S.2
Yoshinari, K.3
Negishi, M.4
-
11
-
-
77249094026
-
Dietary flavonoids activate the constitutive androstane receptor (CAR)
-
Yao, R., Yasuoka, A., Kamei, A., Kitagawa, Y., Tateishi, N., Tsuruoka, N., et al. Dietary flavonoids activate the constitutive androstane receptor (CAR). J Agric Food Chem 58 (2010), 2168–2173.
-
(2010)
J Agric Food Chem
, vol.58
, pp. 2168-2173
-
-
Yao, R.1
Yasuoka, A.2
Kamei, A.3
Kitagawa, Y.4
Tateishi, N.5
Tsuruoka, N.6
-
12
-
-
84857796387
-
Characterization of human cytochrome P450 induction by pesticides
-
Abass, K., Lämsä, V., Reponen, P., Küblbeck, J., Honkakoski, P., Mattila, S., et al. Characterization of human cytochrome P450 induction by pesticides. Toxicology 294 (2012), 17–26.
-
(2012)
Toxicology
, vol.294
, pp. 17-26
-
-
Abass, K.1
Lämsä, V.2
Reponen, P.3
Küblbeck, J.4
Honkakoski, P.5
Mattila, S.6
-
13
-
-
84883177598
-
Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR)
-
Imai, J., Yamazoe, Y., Yoshinari, K., Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR). Drug Metab Pharmacokinet 28 (2013), 290–298.
-
(2013)
Drug Metab Pharmacokinet
, vol.28
, pp. 290-298
-
-
Imai, J.1
Yamazoe, Y.2
Yoshinari, K.3
-
14
-
-
54049118742
-
Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor
-
Küblbeck, J., Jyrkkärinne, J., Poso, A., Turpeinen, M., Sippl, W., Honkakoski, P., et al. Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor. Biochem Pharmacol 76 (2008), 1288–1297.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 1288-1297
-
-
Küblbeck, J.1
Jyrkkärinne, J.2
Poso, A.3
Turpeinen, M.4
Sippl, W.5
Honkakoski, P.6
-
15
-
-
0028210426
-
A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements
-
Base, M., Gulick, T., Choi, H.S., Martinoli, M.G., Simha, D., Moore, D.D., A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol 14 (1994), 1544–1552.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 1544-1552
-
-
Base, M.1
Gulick, T.2
Choi, H.S.3
Martinoli, M.G.4
Simha, D.5
Moore, D.D.6
-
16
-
-
0037515661
-
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression
-
Wang, H., Faucette, S., Sueyoshi, T., Moore, R., Ferguson, S., Negishi, M., et al. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J Biol Chem 278 (2003), 14146–14152.
-
(2003)
J Biol Chem
, vol.278
, pp. 14146-14152
-
-
Wang, H.1
Faucette, S.2
Sueyoshi, T.3
Moore, R.4
Ferguson, S.5
Negishi, M.6
-
17
-
-
73949102632
-
A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3
-
Chen, T., Tompkins, L.M., Li, L., Li, H., Kim, G., Zheng, Y., et al. A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3. J Pharmacol Exp Ther 332 (2010), 106–115.
-
(2010)
J Pharmacol Exp Ther
, vol.332
, pp. 106-115
-
-
Chen, T.1
Tompkins, L.M.2
Li, L.3
Li, H.4
Kim, G.5
Zheng, Y.6
-
18
-
-
80555149413
-
Use of comprehensive screening methods to detect selective human CAR activators
-
Küblbeck, J., Laitinen, T., Jyrkkärinne, J., Rousu, T., Tolonen, A., Abel, T., et al. Use of comprehensive screening methods to detect selective human CAR activators. Biochem Pharmacol 82 (2011), 1994–2007.
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 1994-2007
-
-
Küblbeck, J.1
Laitinen, T.2
Jyrkkärinne, J.3
Rousu, T.4
Tolonen, A.5
Abel, T.6
-
19
-
-
34249705919
-
Difference in nucleocytoplasmic shuttling sequences of rat and human constitutive active/androstane receptor
-
Kanno, Y., Suzuki, M., Miyazaki, Y., Matsuzaki, M., Nakahama, T., Kurose, K., et al. Difference in nucleocytoplasmic shuttling sequences of rat and human constitutive active/androstane receptor. Biochim Biophys Acta 1773 (2007), 934–944.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 934-944
-
-
Kanno, Y.1
Suzuki, M.2
Miyazaki, Y.3
Matsuzaki, M.4
Nakahama, T.5
Kurose, K.6
-
20
-
-
84930225408
-
Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor
-
Lynch, C., Zhao, J., Huang, R., Xiao, J., Li, L., Heyward, S., et al. Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor. Sci Reports, 5, 2015, 10405.
-
(2015)
Sci Reports
, vol.5
, pp. 10405
-
-
Lynch, C.1
Zhao, J.2
Huang, R.3
Xiao, J.4
Li, L.5
Heyward, S.6
-
21
-
-
84935898135
-
Structure-dependent activity of phthalate esters and phthalate monoesters binding to human constitutive androstane receptor
-
Zhang, H., Zhang, Z., Nakanishi, T., Wan, Y., Hiromori, Y., Nagase, H., et al. Structure-dependent activity of phthalate esters and phthalate monoesters binding to human constitutive androstane receptor. Chem Res Toxcol 28 (2015), 1196–1204.
-
(2015)
Chem Res Toxcol
, vol.28
, pp. 1196-1204
-
-
Zhang, H.1
Zhang, Z.2
Nakanishi, T.3
Wan, Y.4
Hiromori, Y.5
Nagase, H.6
-
22
-
-
84873433884
-
Identification of novel activation of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches
-
Lynch, C., Pan, Y., Li, L., Ferguson, S.S., Xia, M., Swaan, P.W., et al. Identification of novel activation of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches. Pharm Res 30 (2013), 489–501.
-
(2013)
Pharm Res
, vol.30
, pp. 489-501
-
-
Lynch, C.1
Pan, Y.2
Li, L.3
Ferguson, S.S.4
Xia, M.5
Swaan, P.W.6
-
23
-
-
33746924066
-
Ligand recognition by drug-activated nuclear receptors PXR and CAR structural, site-directed mutagenesis and molecular modeling studies
-
Poso, A., Honkakoski, A., Ligand recognition by drug-activated nuclear receptors PXR and CAR structural, site-directed mutagenesis and molecular modeling studies. Mini-Rev Med Chem 6 (2006), 937–943.
-
(2006)
Mini-Rev Med Chem
, vol.6
, pp. 937-943
-
-
Poso, A.1
Honkakoski, A.2
-
24
-
-
56749177315
-
Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship
-
Jyrkkärinne, J., Windshügel, B., Rönkkö, T., Tervo, A.J., Küblbeck, J., Lahtela-Kakkonen, M., et al. Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship. J Med Chem 51 (2008), 7181–7192.
-
(2008)
J Med Chem
, vol.51
, pp. 7181-7192
-
-
Jyrkkärinne, J.1
Windshügel, B.2
Rönkkö, T.3
Tervo, A.J.4
Küblbeck, J.5
Lahtela-Kakkonen, M.6
-
25
-
-
78149468556
-
Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands
-
Dring, A.M., Anderson, L.E., Qamar, S., Stoner, M.A., Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands. Chem Biol Interact 180 (2010), 512–525.
-
(2010)
Chem Biol Interact
, vol.180
, pp. 512-525
-
-
Dring, A.M.1
Anderson, L.E.2
Qamar, S.3
Stoner, M.A.4
-
26
-
-
19944372389
-
A structural basis for constitutive activity in the human CAR/RXRα heterodimer
-
Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., et al. A structural basis for constitutive activity in the human CAR/RXRα heterodimer. Mol Cell 16 (2004), 919–928.
-
(2004)
Mol Cell
, vol.16
, pp. 919-928
-
-
Xu, R.X.1
Lambert, M.H.2
Wisely, B.B.3
Warren, E.N.4
Weinert, E.E.5
Waitt, G.M.6
-
27
-
-
0042355453
-
Rational selection of training and test sets for the development of validated QSAR models
-
Golbraikh, A., Shen, M., Xiao, Y.D., Lee, K.H., Tropsha, A., Rational selection of training and test sets for the development of validated QSAR models. J Comput Aided Mol Des 17 (2003), 241–253.
-
(2003)
J Comput Aided Mol Des
, vol.17
, pp. 241-253
-
-
Golbraikh, A.1
Shen, M.2
Xiao, Y.D.3
Lee, K.H.4
Tropsha, A.5
-
28
-
-
77956964002
-
Best Practices for QSAR model development, validation, and exploitation
-
Tropsha, A., Best Practices for QSAR model development, validation, and exploitation. Mol Inf 29 (2010), 476–488.
-
(2010)
Mol Inf
, vol.29
, pp. 476-488
-
-
Tropsha, A.1
-
29
-
-
0142026020
-
Quantitative structure-activity relationship methods: perspectives on drug discovery and toxicology
-
Perkins, R., Fang, H., Tong, W., Welsh, W.J., Quantitative structure-activity relationship methods: perspectives on drug discovery and toxicology. Environ Toxicol Chem 22 (2003), 1666–1679.
-
(2003)
Environ Toxicol Chem
, vol.22
, pp. 1666-1679
-
-
Perkins, R.1
Fang, H.2
Tong, W.3
Welsh, W.J.4
-
30
-
-
66149088374
-
Structure-based CoMFA as a predictive model–CYP2C9 inhibitors as a test case
-
Yasuo, K., Yamaotsu, N., Gouda, H., Tsujishita, H., Hirono, S., Structure-based CoMFA as a predictive model–CYP2C9 inhibitors as a test case. J Chem Inf Model 49 (2009), 853–864.
-
(2009)
J Chem Inf Model
, vol.49
, pp. 853-864
-
-
Yasuo, K.1
Yamaotsu, N.2
Gouda, H.3
Tsujishita, H.4
Hirono, S.5
-
31
-
-
84919809202
-
Three-dimensional quantitative structure-activity relationship analysis for human pregnane X receptor for the prediction of CYP3A4 induction in human hepatocytes: structure-based comparative molecular field analysis
-
Handa, K., Nakagome, I., Yamaotsu, N., Gouda, H., Hirono, S., Three-dimensional quantitative structure-activity relationship analysis for human pregnane X receptor for the prediction of CYP3A4 induction in human hepatocytes: structure-based comparative molecular field analysis. J Pharm Sci 104 (2015), 223–232.
-
(2015)
J Pharm Sci
, vol.104
, pp. 223-232
-
-
Handa, K.1
Nakagome, I.2
Yamaotsu, N.3
Gouda, H.4
Hirono, S.5
-
32
-
-
0032189375
-
Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight
-
Camenisch, G., Alsenz, J., van de Waterbeemd, H., Folkers, G., Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight. Eur J Pharm Sci 6 (1998), 313–319.
-
(1998)
Eur J Pharm Sci
, vol.6
, pp. 313-319
-
-
Camenisch, G.1
Alsenz, J.2
van de Waterbeemd, H.3
Folkers, G.4
-
33
-
-
84879800036
-
The use of rule-based and QSPR approaches in ADME profiling: a case study on Caco-2 permeability
-
Pham-The, H., González-Álvarez, I., Bermejo, M., Garrigues, T., Le-Thi-Thu, H., Cabrera-Pérez, M.Á., The use of rule-based and QSPR approaches in ADME profiling: a case study on Caco-2 permeability. Mol Inf 32 (2013), 459–479.
-
(2013)
Mol Inf
, vol.32
, pp. 459-479
-
-
Pham-The, H.1
González-Álvarez, I.2
Bermejo, M.3
Garrigues, T.4
Le-Thi-Thu, H.5
Cabrera-Pérez, M.Á.6
-
34
-
-
3142764845
-
Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin
-
Wang, H., Faucette, S., Moore, R., Sueyoshi, T., Negishi, M., Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem 279 (2004), 29295–29301.
-
(2004)
J Biol Chem
, vol.279
, pp. 29295-29301
-
-
Wang, H.1
Faucette, S.2
Moore, R.3
Sueyoshi, T.4
Negishi, M.5
-
35
-
-
0026777383
-
Enantioselective pharmacokinetics of ethotoin in human following single oral doses of the racemate
-
Hooper, W.D., O'Shea, N.J., Qing, M.S., Enantioselective pharmacokinetics of ethotoin in human following single oral doses of the racemate. Chirality 4 (1992), 142–147.
-
(1992)
Chirality
, vol.4
, pp. 142-147
-
-
Hooper, W.D.1
O'Shea, N.J.2
Qing, M.S.3
-
36
-
-
22344439421
-
Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor
-
Kobayashi, K., Yamanaka, Y., Iwazaki, N., Nakajo, I., Hosokawa, M., Negishi, M., et al. Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos 33 (2005), 924–929.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 924-929
-
-
Kobayashi, K.1
Yamanaka, Y.2
Iwazaki, N.3
Nakajo, I.4
Hosokawa, M.5
Negishi, M.6
-
37
-
-
0030763762
-
Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomers
-
Ducharme, M.P., Bernstein, M.L., Granvil, C.P., Gehrcke, B., Wainer, I.W., Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomers. Cancer Chemother Pharmacol 40 (1997), 531–533.
-
(1997)
Cancer Chemother Pharmacol
, vol.40
, pp. 531-533
-
-
Ducharme, M.P.1
Bernstein, M.L.2
Granvil, C.P.3
Gehrcke, B.4
Wainer, I.W.5
-
38
-
-
0032764608
-
Enantioselective induction of cyclophosphamide metabolism by phenytoin
-
Williams, M.L., Wainer, I.W., Embree, L., Barnett, M., Granvil, C.L., Ducharme, M.P., Enantioselective induction of cyclophosphamide metabolism by phenytoin. Chirality 11 (1999), 569–574.
-
(1999)
Chirality
, vol.11
, pp. 569-574
-
-
Williams, M.L.1
Wainer, I.W.2
Embree, L.3
Barnett, M.4
Granvil, C.L.5
Ducharme, M.P.6
|