-
1
-
-
60249095813
-
Mucins, mucus, and sputum
-
Voynow, J.A., Rubin, B.K., Mucins, mucus, and sputum. Chest 135:2 (2009), 505–512.
-
(2009)
Chest
, vol.135
, Issue.2
, pp. 505-512
-
-
Voynow, J.A.1
Rubin, B.K.2
-
2
-
-
84865305392
-
A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia
-
Button, B., Cai, L.H., Ehre, C., et al. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science 337:6097 (2012), 937–941.
-
(2012)
Science
, vol.337
, Issue.6097
, pp. 937-941
-
-
Button, B.1
Cai, L.H.2
Ehre, C.3
-
3
-
-
84906089250
-
Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis
-
Hoegger, M.J., Fischer, A.J., McMenimen, J.D., et al. Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science 345:6198 (2014), 818–822.
-
(2014)
Science
, vol.345
, Issue.6198
, pp. 818-822
-
-
Hoegger, M.J.1
Fischer, A.J.2
McMenimen, J.D.3
-
4
-
-
84974623218
-
Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma
-
Bonser, L.R., Zlock, L., Finkbeiner, W., Erle, D.J., Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma. J Clin Invest 126:6 (2016), 2367–2371.
-
(2016)
J Clin Invest
, vol.126
, Issue.6
, pp. 2367-2371
-
-
Bonser, L.R.1
Zlock, L.2
Finkbeiner, W.3
Erle, D.J.4
-
5
-
-
84895871605
-
A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease
-
Hill, D.B., Vasquez, P.A., Mellnik, J., et al. A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease. PLoS One, 9(2), 2014, e87681.
-
(2014)
PLoS One
, vol.9
, Issue.2
-
-
Hill, D.B.1
Vasquez, P.A.2
Mellnik, J.3
-
6
-
-
33750069111
-
Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction
-
Innes, A.L., Woodruff, P.G., Ferrando, R.E., et al. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest 130:4 (2006), 1102–1108.
-
(2006)
Chest
, vol.130
, Issue.4
, pp. 1102-1108
-
-
Innes, A.L.1
Woodruff, P.G.2
Ferrando, R.E.3
-
7
-
-
33644620356
-
Respiratory tract mucin genes and mucin glycoproteins in health and disease
-
Rose, M.C., Voynow, J.A., Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86:1 (2006), 245–278.
-
(2006)
Physiol Rev
, vol.86
, Issue.1
, pp. 245-278
-
-
Rose, M.C.1
Voynow, J.A.2
-
8
-
-
37549051721
-
Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin
-
Itoh, Y., Kamata-Sakurai, M., Denda-Nagai, K., et al. Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. Glycobiology 18:1 (2008), 74–83.
-
(2008)
Glycobiology
, vol.18
, Issue.1
, pp. 74-83
-
-
Itoh, Y.1
Kamata-Sakurai, M.2
Denda-Nagai, K.3
-
9
-
-
78951487586
-
Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis
-
Hijikata, M., Matsushita, I., Tanaka, G., et al. Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis. Hum Genet 129:2 (2011), 117–128.
-
(2011)
Hum Genet
, vol.129
, Issue.2
, pp. 117-128
-
-
Hijikata, M.1
Matsushita, I.2
Tanaka, G.3
-
10
-
-
84921906354
-
Salivary mucin 19 glycoproteins: innate immune functions in Streptococcus mutans-induced caries in mice and evidence for expression in human saliva
-
Culp, D.J., Robinson, B., Cash, M.N., Bhattacharyya, I., Stewart, C., Cuadra-Saenz, G., Salivary mucin 19 glycoproteins: innate immune functions in Streptococcus mutans-induced caries in mice and evidence for expression in human saliva. J Biol Chem 290:5 (2015), 2993–3008.
-
(2015)
J Biol Chem
, vol.290
, Issue.5
, pp. 2993-3008
-
-
Culp, D.J.1
Robinson, B.2
Cash, M.N.3
Bhattacharyya, I.4
Stewart, C.5
Cuadra-Saenz, G.6
-
11
-
-
2442454780
-
Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin
-
Sheehan, J.K., Kirkham, S., Howard, M., et al. Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem 279:15 (2004), 15698–15705.
-
(2004)
J Biol Chem
, vol.279
, Issue.15
, pp. 15698-15705
-
-
Sheehan, J.K.1
Kirkham, S.2
Howard, M.3
-
12
-
-
84984633840
-
Biosynthesis of the polymeric gel-forming mucin MUC5B
-
Ridley, C., Kirkham, S., Williamson, S.J., Davis, C.W., Woodman, P., Thornton, D.J., Biosynthesis of the polymeric gel-forming mucin MUC5B. Am J Physiol Lung Cell Mol Physiol 310:10 (2016), L993–L1002.
-
(2016)
Am J Physiol Lung Cell Mol Physiol
, vol.310
, Issue.10
, pp. L993-L1002
-
-
Ridley, C.1
Kirkham, S.2
Williamson, S.J.3
Davis, C.W.4
Woodman, P.5
Thornton, D.J.6
-
13
-
-
84884281623
-
Normal mucus formation requires cAMP-dependent HCO3- secretion and Ca2+-mediated mucin exocytosis
-
Yang, N., Garcia, M.A., Quinton, P.M., Normal mucus formation requires cAMP-dependent HCO3- secretion and Ca2+-mediated mucin exocytosis. J Physiol 591:18 (2013), 4581–4593.
-
(2013)
J Physiol
, vol.591
, Issue.18
, pp. 4581-4593
-
-
Yang, N.1
Garcia, M.A.2
Quinton, P.M.3
-
14
-
-
84864313785
-
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype
-
Gustafsson, J.K., Ermund, A., Ambort, D., et al. Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med 209:7 (2012), 1263–1272.
-
(2012)
J Exp Med
, vol.209
, Issue.7
, pp. 1263-1272
-
-
Gustafsson, J.K.1
Ermund, A.2
Ambort, D.3
-
15
-
-
84874102944
-
Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways
-
Kesimer, M., Ehre, C., Burns, K.A., Davis, C.W., Sheehan, J.K., Pickles, R.J., Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways. Mucosal Immunol 6:2 (2013), 379–392.
-
(2013)
Mucosal Immunol
, vol.6
, Issue.2
, pp. 379-392
-
-
Kesimer, M.1
Ehre, C.2
Burns, K.A.3
Davis, C.W.4
Sheehan, J.K.5
Pickles, R.J.6
-
16
-
-
84879974863
-
Mechanosensitive ATP release maintains proper mucus hydration of airways
-
Button, B., Okada, S.F., Frederick, C.B., Thelin, W.R., Boucher, R.C., Mechanosensitive ATP release maintains proper mucus hydration of airways. Sci Signal, 6(279), 2013, ra46.
-
(2013)
Sci Signal
, vol.6
, Issue.279
, pp. ra46
-
-
Button, B.1
Okada, S.F.2
Frederick, C.B.3
Thelin, W.R.4
Boucher, R.C.5
-
17
-
-
70349096803
-
Chronic intermittent mechanical stress increases MUC5AC protein expression
-
Park, J.A., Tschumperlin, D.J., Chronic intermittent mechanical stress increases MUC5AC protein expression. Am J Respir Cell Mol Biol 41:4 (2009), 459–466.
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, Issue.4
, pp. 459-466
-
-
Park, J.A.1
Tschumperlin, D.J.2
-
18
-
-
84931562241
-
Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells
-
Kanai, K., Koarai, A., Shishikura, Y., et al. Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells. Respir Investig 53:4 (2015), 137–148.
-
(2015)
Respir Investig
, vol.53
, Issue.4
, pp. 137-148
-
-
Kanai, K.1
Koarai, A.2
Shishikura, Y.3
-
19
-
-
68149166400
-
IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells
-
Bautista, M.V., Chen, Y., Ivanova, V.S., Rahimi, M.K., Watson, A.M., Rose, M.C., IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells. J Immunol 183:3 (2009), 2159–2166.
-
(2009)
J Immunol
, vol.183
, Issue.3
, pp. 2159-2166
-
-
Bautista, M.V.1
Chen, Y.2
Ivanova, V.S.3
Rahimi, M.K.4
Watson, A.M.5
Rose, M.C.6
-
20
-
-
34948824382
-
Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells
-
Vincent, A., Perrais, M., Desseyn, J.L., Aubert, J.P., Pigny, P., Van Seuningen, I., Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells. Oncogene 26:45 (2007), 6566–6576.
-
(2007)
Oncogene
, vol.26
, Issue.45
, pp. 6566-6576
-
-
Vincent, A.1
Perrais, M.2
Desseyn, J.L.3
Aubert, J.P.4
Pigny, P.5
Van Seuningen, I.6
-
21
-
-
84874773773
-
Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5
-
Gosalia, N., Leir, S.H., Harris, A., Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5. J Biol Chem 288:9 (2013), 6717–6725.
-
(2013)
J Biol Chem
, vol.288
, Issue.9
, pp. 6717-6725
-
-
Gosalia, N.1
Leir, S.H.2
Harris, A.3
-
22
-
-
0035132115
-
Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
-
Ordonez, C.L., Khashayar, R., Wong, H.H., et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 163:2 (2001), 517–523.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, Issue.2
, pp. 517-523
-
-
Ordonez, C.L.1
Khashayar, R.2
Wong, H.H.3
-
23
-
-
84922375537
-
Chronic bronchitis and current smoking are associated with more goblet cells in moderate to severe COPD and smokers without airflow obstruction
-
Kim, V., Oros, M., Durra, H., et al. Chronic bronchitis and current smoking are associated with more goblet cells in moderate to severe COPD and smokers without airflow obstruction. PLoS One, 10(2), 2015, e0116108.
-
(2015)
PLoS One
, vol.10
, Issue.2
-
-
Kim, V.1
Oros, M.2
Durra, H.3
-
24
-
-
26944447487
-
Basal-like cells constitute the proliferating cell population in cystic fibrosis airways
-
Voynow, J.A., Fischer, B.M., Roberts, B.C., Proia, A.D., Basal-like cells constitute the proliferating cell population in cystic fibrosis airways. Am J Respir Crit Care Med 172:8 (2005), 1013–1018.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, Issue.8
, pp. 1013-1018
-
-
Voynow, J.A.1
Fischer, B.M.2
Roberts, B.C.3
Proia, A.D.4
-
25
-
-
84893632296
-
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity
-
Chen, G., Korfhagen, T.R., Karp, C.L., et al. Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. Am J Respir Crit Care Med 189:3 (2014), 301–313.
-
(2014)
Am J Respir Crit Care Med
, vol.189
, Issue.3
, pp. 301-313
-
-
Chen, G.1
Korfhagen, T.R.2
Karp, C.L.3
-
26
-
-
70349664159
-
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
-
Chen, G., Korfhagen, T.R., Xu, Y., et al. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest 119:10 (2009), 2914–2924.
-
(2009)
J Clin Invest
, vol.119
, Issue.10
, pp. 2914-2924
-
-
Chen, G.1
Korfhagen, T.R.2
Xu, Y.3
-
27
-
-
84864559975
-
AGR2 is induced in asthma and promotes allergen-induced mucin overproduction
-
Schroeder, B.W., Verhaeghe, C., Park, S.W., et al. AGR2 is induced in asthma and promotes allergen-induced mucin overproduction. Am J Respir Cell Mol Biol 47:2 (2012), 178–185.
-
(2012)
Am J Respir Cell Mol Biol
, vol.47
, Issue.2
, pp. 178-185
-
-
Schroeder, B.W.1
Verhaeghe, C.2
Park, S.W.3
-
28
-
-
16344374517
-
Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium
-
Harris, J.F., Fischer, M.J., Hotchkiss, J.R., et al. Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium. Am J Respir Crit Care Med 171:7 (2005), 764–772.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, Issue.7
, pp. 764-772
-
-
Harris, J.F.1
Fischer, M.J.2
Hotchkiss, J.R.3
-
29
-
-
78649735324
-
Airway mucus function and dysfunction
-
Fahy, J.V., Dickey, B.F., Airway mucus function and dysfunction. N Engl J Med 363:23 (2010), 2233–2247.
-
(2010)
N Engl J Med
, vol.363
, Issue.23
, pp. 2233-2247
-
-
Fahy, J.V.1
Dickey, B.F.2
-
30
-
-
84955208955
-
Novel therapies to inhibit mucus synthesis and secretion in airway hypersecretory diseases
-
Ha, E.V., Rogers, D.F., Novel therapies to inhibit mucus synthesis and secretion in airway hypersecretory diseases. Pharmacology 97:1-2 (2016), 84–100.
-
(2016)
Pharmacology
, vol.97
, Issue.1-2
, pp. 84-100
-
-
Ha, E.V.1
Rogers, D.F.2
-
31
-
-
84964523667
-
IL13 activates autophagy to regulate secretion in airway epithelial cells
-
Dickinson, J.D., Alevy, Y., Malvin, N.P., et al. IL13 activates autophagy to regulate secretion in airway epithelial cells. Autophagy 12:2 (2016), 397–409.
-
(2016)
Autophagy
, vol.12
, Issue.2
, pp. 397-409
-
-
Dickinson, J.D.1
Alevy, Y.2
Malvin, N.P.3
-
32
-
-
84896691062
-
NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion
-
Wlodarska, M., Thaiss, C.A., Nowarski, R., et al. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156:5 (2014), 1045–1059.
-
(2014)
Cell
, vol.156
, Issue.5
, pp. 1045-1059
-
-
Wlodarska, M.1
Thaiss, C.A.2
Nowarski, R.3
-
33
-
-
84892563951
-
Muc5b is required for airway defence
-
Roy, M.G., Livraghi-Butrico, A., Fletcher, A.A., et al. Muc5b is required for airway defence. Nature 505:7483 (2014), 412–416.
-
(2014)
Nature
, vol.505
, Issue.7483
, pp. 412-416
-
-
Roy, M.G.1
Livraghi-Butrico, A.2
Fletcher, A.A.3
-
34
-
-
79956093663
-
Muc5ac: a critical component mediating the rejection of enteric nematodes
-
Hasnain, S.Z., Evans, C.M., Roy, M., et al. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med 208:5 (2011), 893–900.
-
(2011)
J Exp Med
, vol.208
, Issue.5
, pp. 893-900
-
-
Hasnain, S.Z.1
Evans, C.M.2
Roy, M.3
-
35
-
-
84867345602
-
Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs
-
Ehre, C., Worthington, E.N., Liesman, R.M., et al. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs. Proc Natl Acad Sci U S A 109:41 (2012), 16528–16533.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.41
, pp. 16528-16533
-
-
Ehre, C.1
Worthington, E.N.2
Liesman, R.M.3
-
36
-
-
57349101460
-
MUC1 mucin: a peacemaker in the lung
-
Kim, K.C., Lillehoj, E.P., MUC1 mucin: a peacemaker in the lung. Am J Respir Cell Mol Biol 39:6 (2008), 644–647.
-
(2008)
Am J Respir Cell Mol Biol
, vol.39
, Issue.6
, pp. 644-647
-
-
Kim, K.C.1
Lillehoj, E.P.2
-
37
-
-
84963727355
-
Membrane-tethered MUC1 mucin counter-regulates the phagocytic activity of macrophages
-
Kato, K., Uchino, R., Lillehoj, E.P., Knox, K., Lin, Y., Kim, K.C., Membrane-tethered MUC1 mucin counter-regulates the phagocytic activity of macrophages. Am J Respir Cell Mol Biol 54:4 (2016), 515–523.
-
(2016)
Am J Respir Cell Mol Biol
, vol.54
, Issue.4
, pp. 515-523
-
-
Kato, K.1
Uchino, R.2
Lillehoj, E.P.3
Knox, K.4
Lin, Y.5
Kim, K.C.6
-
38
-
-
85078811298
-
Salivary mucins in host defense and disease prevention
-
Frenkel, E.S., Ribbeck, K., Salivary mucins in host defense and disease prevention. J Oral Microbiol, 7, 2015, 29759.
-
(2015)
J Oral Microbiol
, vol.7
, pp. 29759
-
-
Frenkel, E.S.1
Ribbeck, K.2
-
39
-
-
79952748335
-
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
-
Johansson, M.E.V., Holmén Larsson, J.M., Hansson, G.C., The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci U S A 108:suppl 1 (2011), 4659–4665.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4659-4665
-
-
Johansson, M.E.V.1
Holmén Larsson, J.M.2
Hansson, G.C.3
-
40
-
-
33745746660
-
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
-
Van der Sluis, M., De Koning, B.A., De Bruijn, A.C., et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131:1 (2006), 117–129.
-
(2006)
Gastroenterology
, vol.131
, Issue.1
, pp. 117-129
-
-
Van der Sluis, M.1
De Koning, B.A.2
De Bruijn, A.C.3
-
41
-
-
0036500996
-
Colorectal cancer in mice genetically deficient in the mucin Muc2
-
Velcich, A., Yang, W., Heyer, J., et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295:5560 (2002), 1726–1729.
-
(2002)
Science
, vol.295
, Issue.5560
, pp. 1726-1729
-
-
Velcich, A.1
Yang, W.2
Heyer, J.3
-
42
-
-
84863230541
-
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
-
McDole, J.R., Wheeler, L.W., McDonald, K.G., et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483:7389 (2012), 345–349.
-
(2012)
Nature
, vol.483
, Issue.7389
, pp. 345-349
-
-
McDole, J.R.1
Wheeler, L.W.2
McDonald, K.G.3
-
43
-
-
84922600148
-
Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon
-
Knoop, K.A., McDonald, K.G., McCrate, S., McDole, J.R., Newberry, R.D., Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon. Mucosal Immunol 8:1 (2015), 198–210.
-
(2015)
Mucosal Immunol
, vol.8
, Issue.1
, pp. 198-210
-
-
Knoop, K.A.1
McDonald, K.G.2
McCrate, S.3
McDole, J.R.4
Newberry, R.D.5
-
44
-
-
84976310851
-
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
-
Birchenough, G.M., Nystrom, E.E., Johansson, M.E., Hansson, G.C., A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352:6293 (2016), 1535–1542.
-
(2016)
Science
, vol.352
, Issue.6293
, pp. 1535-1542
-
-
Birchenough, G.M.1
Nystrom, E.E.2
Johansson, M.E.3
Hansson, G.C.4
-
45
-
-
84928997878
-
Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation
-
Rajavelu, P., Chen, G., Xu, Y., Kitzmiller, J.A., Korfhagen, T.R., Whitsett, J.A., Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J Clin Invest 125:5 (2015), 2021–2031.
-
(2015)
J Clin Invest
, vol.125
, Issue.5
, pp. 2021-2031
-
-
Rajavelu, P.1
Chen, G.2
Xu, Y.3
Kitzmiller, J.A.4
Korfhagen, T.R.5
Whitsett, J.A.6
-
46
-
-
84960445960
-
Airway goblet cells secrete pro-inflammatory cytokines, chemokines, and growth factors
-
Tanabe, T., Rubin, B.K., Airway goblet cells secrete pro-inflammatory cytokines, chemokines, and growth factors. Chest 149:3 (2016), 714–720.
-
(2016)
Chest
, vol.149
, Issue.3
, pp. 714-720
-
-
Tanabe, T.1
Rubin, B.K.2
-
47
-
-
34047166052
-
Airway surface dehydration in cystic fibrosis: pathogenesis and therapy
-
Boucher, R.C., Airway surface dehydration in cystic fibrosis: pathogenesis and therapy. Annu Rev Med 58 (2007), 157–170.
-
(2007)
Annu Rev Med
, vol.58
, pp. 157-170
-
-
Boucher, R.C.1
-
48
-
-
0033045546
-
Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells
-
Voynow, J.A., Young, L.R., Wang, Y., Horger, T., Rose, M.C., Fischer, B.M., Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 276:5 (1999), L835–L843.
-
(1999)
Am J Physiol
, vol.276
, Issue.5
, pp. L835-L843
-
-
Voynow, J.A.1
Young, L.R.2
Wang, Y.3
Horger, T.4
Rose, M.C.5
Fischer, B.M.6
-
49
-
-
3042709453
-
MUC5AC and MUC5B mucins are decreased in cystic fibrosis airway secretions
-
Henke, M., Renner, A., Huber, R.M., Seeds, M.C., Rubin, B.K., MUC5AC and MUC5B mucins are decreased in cystic fibrosis airway secretions. Am J Respir Cell Mol Biol 31:1 (2004), 86–91.
-
(2004)
Am J Respir Cell Mol Biol
, vol.31
, Issue.1
, pp. 86-91
-
-
Henke, M.1
Renner, A.2
Huber, R.M.3
Seeds, M.C.4
Rubin, B.K.5
-
50
-
-
84903759350
-
Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure
-
Henderson, A.G., Ehre, C., Button, B., et al. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. J Clin Invest 124:7 (2014), 3047–3060.
-
(2014)
J Clin Invest
, vol.124
, Issue.7
, pp. 3047-3060
-
-
Henderson, A.G.1
Ehre, C.2
Button, B.3
-
51
-
-
84989261241
-
Mucus hyperconcentration as a unifying aspect of the chronic bronchitic phenotype
-
Button, B., Anderson, W.H., Boucher, R.C., Mucus hyperconcentration as a unifying aspect of the chronic bronchitic phenotype. Ann Am Thorac Soc 13:suppl 2 (2016), S156–S162.
-
(2016)
Ann Am Thorac Soc
, vol.13
, pp. S156-S162
-
-
Button, B.1
Anderson, W.H.2
Boucher, R.C.3
-
52
-
-
85041171050
-
Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways
-
Abdullah, L.H., Evans, J.R., Wang, T.T., et al. Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways. JCI Insight, 2(6), 2017, e89752.
-
(2017)
JCI Insight
, vol.2
, Issue.6
-
-
Abdullah, L.H.1
Evans, J.R.2
Wang, T.T.3
-
53
-
-
85108851516
-
Microstructural alterations of sputum in cystic fibrosis lung disease
-
Duncan, G.A., Jung, J., Joseph, A., et al. Microstructural alterations of sputum in cystic fibrosis lung disease. JCI Insight, 1(18), 2016, e88198.
-
(2016)
JCI Insight
, vol.1
, Issue.18
-
-
Duncan, G.A.1
Jung, J.2
Joseph, A.3
-
54
-
-
84966293252
-
Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies
-
Shah, V.S., Ernst, S., Tang, X.X., et al. Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies. Proc Natl Acad Sci U S A 113:19 (2016), 5382–5387.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, Issue.19
, pp. 5382-5387
-
-
Shah, V.S.1
Ernst, S.2
Tang, X.X.3
-
55
-
-
70349223856
-
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion
-
Garcia, M.A., Yang, N., Quinton, P.M., Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion. J Clin Invest 119:9 (2009), 2613–2622.
-
(2009)
J Clin Invest
, vol.119
, Issue.9
, pp. 2613-2622
-
-
Garcia, M.A.1
Yang, N.2
Quinton, P.M.3
-
56
-
-
84994037294
-
Goblet cell hyperplasia requires high bicarbonate transport to support mucin release
-
Gorrieri, G., Scudieri, P., Caci, E., et al. Goblet cell hyperplasia requires high bicarbonate transport to support mucin release. Sci Rep, 6, 2016, 36016.
-
(2016)
Sci Rep
, vol.6
, pp. 36016
-
-
Gorrieri, G.1
Scudieri, P.2
Caci, E.3
-
57
-
-
84959908589
-
Acidic pH increases airway surface liquid viscosity in cystic fibrosis
-
Tang, X.X., Ostedgaard, L.S., Hoegger, M.J., et al. Acidic pH increases airway surface liquid viscosity in cystic fibrosis. J Clin Invest 126:3 (2016), 879–891.
-
(2016)
J Clin Invest
, vol.126
, Issue.3
, pp. 879-891
-
-
Tang, X.X.1
Ostedgaard, L.S.2
Hoegger, M.J.3
-
58
-
-
84956707544
-
Airway acidification initiates host defense abnormalities in cystic fibrosis mice
-
Shah, V.S., Meyerholz, D.K., Tang, X.X., et al. Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Science 351:6272 (2016), 503–507.
-
(2016)
Science
, vol.351
, Issue.6272
, pp. 503-507
-
-
Shah, V.S.1
Meyerholz, D.K.2
Tang, X.X.3
-
59
-
-
84923870560
-
Oxidation increases mucin polymer cross-links to stiffen airway mucus gels
-
Yuan, S., Hollinger, M., Lachowicz-Scroggins, M.E., et al. Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Sci Transl Med, 7(276), 2015, 276ra227.
-
(2015)
Sci Transl Med
, vol.7
, Issue.276
, pp. 276ra227
-
-
Yuan, S.1
Hollinger, M.2
Lachowicz-Scroggins, M.E.3
-
60
-
-
43049135102
-
Proteases and cystic fibrosis
-
Voynow, J.A., Fischer, B.M., Zheng, S., Proteases and cystic fibrosis. Int J Biochem Cell Biol 40:6-7 (2008), 1238–1245.
-
(2008)
Int J Biochem Cell Biol
, vol.40
, Issue.6-7
, pp. 1238-1245
-
-
Voynow, J.A.1
Fischer, B.M.2
Zheng, S.3
-
61
-
-
84905652411
-
Secretory hyperresponsiveness and pulmonary mucus hypersecretion
-
Rubin, B.K., Priftis, K.N., Schmidt, H.J., Henke, M.O., Secretory hyperresponsiveness and pulmonary mucus hypersecretion. Chest 146:2 (2014), 496–507.
-
(2014)
Chest
, vol.146
, Issue.2
, pp. 496-507
-
-
Rubin, B.K.1
Priftis, K.N.2
Schmidt, H.J.3
Henke, M.O.4
-
62
-
-
84990886705
-
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation
-
Cho, J.L., Ling, M.F., Adams, D.C., et al. Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci Transl Med, 8(359), 2016, 359ra132.
-
(2016)
Sci Transl Med
, vol.8
, Issue.359
, pp. 359ra132
-
-
Cho, J.L.1
Ling, M.F.2
Adams, D.C.3
-
63
-
-
84923361939
-
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity
-
Evans, C.M., Raclawska, D.S., Ttofali, F., et al. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun, 6, 2015, 6281.
-
(2015)
Nat Commun
, vol.6
, pp. 6281
-
-
Evans, C.M.1
Raclawska, D.S.2
Ttofali, F.3
-
64
-
-
84870520781
-
IL-13-induced airway mucus production is attenuated by MAPK13 inhibition
-
Alevy, Y.G., Patel, A.C., Romero, A.G., et al. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. J Clin Invest 122:12 (2012), 4555–4568.
-
(2012)
J Clin Invest
, vol.122
, Issue.12
, pp. 4555-4568
-
-
Alevy, Y.G.1
Patel, A.C.2
Romero, A.G.3
-
65
-
-
84983409150
-
Inhibition of IL-13-induced periostin in airway epithelium attenuates cellular protein expression of MUC5AC
-
Suzaki, I., Kawano, S., Komiya, K., et al. Inhibition of IL-13-induced periostin in airway epithelium attenuates cellular protein expression of MUC5AC. Respirology 22:1 (2017), 93–100.
-
(2017)
Respirology
, vol.22
, Issue.1
, pp. 93-100
-
-
Suzaki, I.1
Kawano, S.2
Komiya, K.3
-
66
-
-
80555157601
-
Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells
-
Tanabe, T., Kanoh, S., Tsushima, K., Yamazaki, Y., Kubo, K., Rubin, B.K., Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells. Am J Respir Cell Mol Biol 45:5 (2011), 1075–1083.
-
(2011)
Am J Respir Cell Mol Biol
, vol.45
, Issue.5
, pp. 1075-1083
-
-
Tanabe, T.1
Kanoh, S.2
Tsushima, K.3
Yamazaki, Y.4
Kubo, K.5
Rubin, B.K.6
-
67
-
-
82155175243
-
IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells
-
Kanoh, S., Tanabe, T., Rubin, B.K., IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells. Clin Exp Allergy 41:12 (2011), 1747–1756.
-
(2011)
Clin Exp Allergy
, vol.41
, Issue.12
, pp. 1747-1756
-
-
Kanoh, S.1
Tanabe, T.2
Rubin, B.K.3
-
68
-
-
84900555408
-
IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone
-
Chen, Y., Garvin, L.M., Nickola, T.J., Watson, A.M., Colberg-Poley, A.M., Rose, M.C., IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone. Am J Physiol Lung Cell Mol Physiol 306:8 (2014), L797–L807.
-
(2014)
Am J Physiol Lung Cell Mol Physiol
, vol.306
, Issue.8
, pp. L797-L807
-
-
Chen, Y.1
Garvin, L.M.2
Nickola, T.J.3
Watson, A.M.4
Colberg-Poley, A.M.5
Rose, M.C.6
-
69
-
-
0034759886
-
Histopathology of fatal asthma: drowning in mucus
-
Rubin, B.K., Tomkiewicz, R., Fahy, J.V., Green, F.H., Histopathology of fatal asthma: drowning in mucus. Pediatr Pulmonol(suppl 23), 2001, 88–89.
-
(2001)
Pediatr Pulmonol
, pp. 88-89
-
-
Rubin, B.K.1
Tomkiewicz, R.2
Fahy, J.V.3
Green, F.H.4
-
70
-
-
79955146233
-
A common MUC5B promoter polymorphism and pulmonary fibrosis
-
Seibold, M.A., Wise, A.L., Speer, M.C., et al. A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 364:16 (2011), 1503–1512.
-
(2011)
N Engl J Med
, vol.364
, Issue.16
, pp. 1503-1512
-
-
Seibold, M.A.1
Wise, A.L.2
Speer, M.C.3
-
71
-
-
84942924543
-
MUC5B and idiopathic pulmonary fibrosis
-
Yang, I.V., Fingerlin, T.E., Evans, C.M., Schwarz, M.I., Schwartz, D.A., MUC5B and idiopathic pulmonary fibrosis. Ann Am Thorac Soc 12:suppl 2 (2015), S193–S199.
-
(2015)
Ann Am Thorac Soc
, vol.12
, pp. S193-S199
-
-
Yang, I.V.1
Fingerlin, T.E.2
Evans, C.M.3
Schwarz, M.I.4
Schwartz, D.A.5
-
72
-
-
84988664684
-
Idiopathic pulmonary fibrosis: a genetic disease that involves mucociliary dysfunction of the peripheral airways
-
Evans, C.M., Fingerlin, T.E., Schwarz, M.I., et al. Idiopathic pulmonary fibrosis: a genetic disease that involves mucociliary dysfunction of the peripheral airways. Physiol Rev 96:4 (2016), 1567–1591.
-
(2016)
Physiol Rev
, vol.96
, Issue.4
, pp. 1567-1591
-
-
Evans, C.M.1
Fingerlin, T.E.2
Schwarz, M.I.3
-
73
-
-
84878600828
-
Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis
-
Peljto, A.L., Zhang, Y., Fingerlin, T.E., et al. Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA 309:21 (2013), 2232–2239.
-
(2013)
JAMA
, vol.309
, Issue.21
, pp. 2232-2239
-
-
Peljto, A.L.1
Zhang, Y.2
Fingerlin, T.E.3
-
74
-
-
84901418994
-
Severity of cough in idiopathic pulmonary fibrosis is associated with MUC5 B genotype
-
Scholand, M.B., Wolff, R., Crossno, P.F., et al. Severity of cough in idiopathic pulmonary fibrosis is associated with MUC5 B genotype. Cough, 10, 2014, 3.
-
(2014)
Cough
, vol.10
, pp. 3
-
-
Scholand, M.B.1
Wolff, R.2
Crossno, P.F.3
-
75
-
-
84878599042
-
MUC5B promoter polymorphism and interstitial lung abnormalities
-
Hunninghake, G.M., Hatabu, H., Okajima, Y., et al. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med 368:23 (2013), 2192–2200.
-
(2013)
N Engl J Med
, vol.368
, Issue.23
, pp. 2192-2200
-
-
Hunninghake, G.M.1
Hatabu, H.2
Okajima, Y.3
-
76
-
-
85021746464
-
Regulation of MUC5B expression in idiopathic pulmonary fibrosis
-
Helling, B.A., Gerber, A.N., Kadiyala, V., et al. Regulation of MUC5B expression in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 57:1 (2017), 91–99.
-
(2017)
Am J Respir Cell Mol Biol
, vol.57
, Issue.1
, pp. 91-99
-
-
Helling, B.A.1
Gerber, A.N.2
Kadiyala, V.3
-
77
-
-
84883537459
-
Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease
-
Byers, D.E., Alexander-Brett, J., Patel, A.C., et al. Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. J Clin Invest 123:9 (2013), 3967–3982.
-
(2013)
J Clin Invest
, vol.123
, Issue.9
, pp. 3967-3982
-
-
Byers, D.E.1
Alexander-Brett, J.2
Patel, A.C.3
-
78
-
-
84941423127
-
Airway hydration and COPD
-
Ghosh, A., Boucher, R.C., Tarran, R., Airway hydration and COPD. Cell Mol Life Sci 72:19 (2015), 3637–3652.
-
(2015)
Cell Mol Life Sci
, vol.72
, Issue.19
, pp. 3637-3652
-
-
Ghosh, A.1
Boucher, R.C.2
Tarran, R.3
-
79
-
-
0032900458
-
Regulation of human airway mucins by acrolein and inflammatory mediators
-
Borchers, M.T., Carty, M.P., Leikauf, G.D., Regulation of human airway mucins by acrolein and inflammatory mediators. Am J Physiol 276:4 pt 1 (1999), L549–L555.
-
(1999)
Am J Physiol
, vol.276
, Issue.4
, pp. L549-L555
-
-
Borchers, M.T.1
Carty, M.P.2
Leikauf, G.D.3
-
80
-
-
84904292642
-
Nicotine alters mucin rheological properties
-
Chen, E.Y., Sun, A., Chen, C.S., Mintz, A.J., Chin, W.C., Nicotine alters mucin rheological properties. Am J Physiol Lung Cell Mol Physiol 307:2 (2014), L149–L157.
-
(2014)
Am J Physiol Lung Cell Mol Physiol
, vol.307
, Issue.2
, pp. L149-L157
-
-
Chen, E.Y.1
Sun, A.2
Chen, C.S.3
Mintz, A.J.4
Chin, W.C.5
-
81
-
-
0036009464
-
Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species
-
Fischer, B.M., Voynow, J.A., Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am J Respir Cell Mol Biol 26:4 (2002), 447–452.
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, Issue.4
, pp. 447-452
-
-
Fischer, B.M.1
Voynow, J.A.2
-
82
-
-
84918811753
-
S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-κB pathways
-
Kang, J.H., Hwang, S.M., Chung, I.Y., S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-κB pathways. Immunology 144:1 (2015), 79–90.
-
(2015)
Immunology
, vol.144
, Issue.1
, pp. 79-90
-
-
Kang, J.H.1
Hwang, S.M.2
Chung, I.Y.3
-
83
-
-
24344454705
-
Macrolides and airway inflammation in children
-
Shinkai, M., Rubin, B.K., Macrolides and airway inflammation in children. Paediatr Respir Rev 6:3 (2005), 227–235.
-
(2005)
Paediatr Respir Rev
, vol.6
, Issue.3
, pp. 227-235
-
-
Shinkai, M.1
Rubin, B.K.2
-
84
-
-
84989214554
-
Hydrator therapies for chronic bronchitis: lessons from cystic fibrosis
-
Bennett, W.D., Henderson, A.G., Donaldson, S.H., Hydrator therapies for chronic bronchitis: lessons from cystic fibrosis. Ann Am Thorac Soc 13:suppl 2 (2016), S186–S190.
-
(2016)
Ann Am Thorac Soc
, vol.13
, pp. S186-S190
-
-
Bennett, W.D.1
Henderson, A.G.2
Donaldson, S.H.3
-
85
-
-
84906952377
-
Clinical mechanism of the cystic fibrosis transmembrane conductance regulator potentiator ivacaftor in G551D-mediated cystic fibrosis
-
Rowe, S.M., Heltshe, S.L., Gonska, T., et al. Clinical mechanism of the cystic fibrosis transmembrane conductance regulator potentiator ivacaftor in G551D-mediated cystic fibrosis. Am J Respir Crit Care Med 190:2 (2014), 175–184.
-
(2014)
Am J Respir Crit Care Med
, vol.190
, Issue.2
, pp. 175-184
-
-
Rowe, S.M.1
Heltshe, S.L.2
Gonska, T.3
-
86
-
-
0030027655
-
In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis
-
Shah, P.L., Scott, S.F., Knight, R.A., Marriott, C., Ranasinha, C., Hodson, M.E., In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis. Thorax 51:2 (1996), 119–125.
-
(1996)
Thorax
, vol.51
, Issue.2
, pp. 119-125
-
-
Shah, P.L.1
Scott, S.F.2
Knight, R.A.3
Marriott, C.4
Ranasinha, C.5
Hodson, M.E.6
-
87
-
-
33751225093
-
Thymosin beta4 sequesters actin in cystic fibrosis sputum and decreases sputum cohesivity in vitro
-
Rubin, B.K., Kater, A.P., Goldstein, A.L., Thymosin beta4 sequesters actin in cystic fibrosis sputum and decreases sputum cohesivity in vitro. Chest 130:5 (2006), 1433–1440.
-
(2006)
Chest
, vol.130
, Issue.5
, pp. 1433-1440
-
-
Rubin, B.K.1
Kater, A.P.2
Goldstein, A.L.3
-
88
-
-
36348952773
-
Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis
-
Broughton-Head, V.J., Shur, J., Carroll, M.P., Smith, J.R., Shute, J.K., Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 293:5 (2007), L1240–L1249.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.293
, Issue.5
, pp. L1240-L1249
-
-
Broughton-Head, V.J.1
Shur, J.2
Carroll, M.P.3
Smith, J.R.4
Shute, J.K.5
-
89
-
-
0030611938
-
Effects of aerosolized surfactant in patients with stable chronic bronchitis: a prospective randomized controlled trial
-
Anzueto, A., Jubran, A., Ohar, J.A., et al. Effects of aerosolized surfactant in patients with stable chronic bronchitis: a prospective randomized controlled trial. JAMA 278:17 (1997), 1426–1431.
-
(1997)
JAMA
, vol.278
, Issue.17
, pp. 1426-1431
-
-
Anzueto, A.1
Jubran, A.2
Ohar, J.A.3
-
90
-
-
80052157895
-
Azithromycin for prevention of exacerbations of COPD
-
Albert, R.K., Connett, J., Bailey, W.C., et al. Azithromycin for prevention of exacerbations of COPD. N Engl J Med 365:8 (2011), 689–698.
-
(2011)
N Engl J Med
, vol.365
, Issue.8
, pp. 689-698
-
-
Albert, R.K.1
Connett, J.2
Bailey, W.C.3
-
91
-
-
84979084506
-
Study protocol, rationale and recruitment in a European multi-centre randomized controlled trial to determine the efficacy and safety of azithromycin maintenance therapy for 6 months in primary ciliary dyskinesia
-
Kobbernagel, H.E., Buchvald, F.F., Haarman, E.G., et al. Study protocol, rationale and recruitment in a European multi-centre randomized controlled trial to determine the efficacy and safety of azithromycin maintenance therapy for 6 months in primary ciliary dyskinesia. BMC Pulm Med, 16(1), 2016, 104.
-
(2016)
BMC Pulm Med
, vol.16
, Issue.1
, pp. 104
-
-
Kobbernagel, H.E.1
Buchvald, F.F.2
Haarman, E.G.3
-
92
-
-
67149133088
-
Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia
-
Ribeiro, C.M., Hurd, H., Wu, Y., et al. Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia. PLoS One, 4(6), 2009, e5806.
-
(2009)
PLoS One
, vol.4
, Issue.6
-
-
Ribeiro, C.M.1
Hurd, H.2
Wu, Y.3
|