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Volumn 126, Issue 6, 2016, Pages 2367-2371

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; MUCIN 5AC; MUCIN 5B; GEL; MUC5AC PROTEIN, HUMAN; MUC5B PROTEIN, HUMAN;

EID: 84974623218     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI84910     Document Type: Article
Times cited : (152)

References (24)
  • 1
    • 84934443635 scopus 로고    scopus 로고
    • Epidemiology of asthma: Prevalence and burden of disease
    • Croisant S. Epidemiology of asthma: prevalence and burden of disease. Adv Exp Med Biol. 2014;795:17-29.
    • (2014) Adv Exp Med Biol , vol.795 , pp. 17-29
    • Croisant, S.1
  • 2
    • 0020505359 scopus 로고
    • Impaired tracheobronchial clearance in patients with mild stable asthma
    • Bateman JR, Pavia D, Sheahan NF, Agnew JE, Clarke SW. Impaired tracheobronchial clearance in patients with mild stable asthma. Thorax. 1983;38(6):463-467.
    • (1983) Thorax , vol.38 , Issue.6 , pp. 463-467
    • Bateman, J.R.1    Pavia, D.2    Sheahan, N.F.3    Agnew, J.E.4    Clarke, S.W.5
  • 3
    • 0025847373 scopus 로고
    • Changes in mucociliary clearance during acute exacerbations of asthma
    • Messina MS, O'Riordan TG, Smaldone GC. Changes in mucociliary clearance during acute exacerbations of asthma. Am Rev Respir Dis. 1991;143(5 pt 1):993-997.
    • (1991) Am Rev Respir Dis , vol.143 , Issue.5 , pp. 993-997
    • Messina, M.S.1    O'Riordan, T.G.2    Smaldone, G.C.3
  • 4
    • 0001744937 scopus 로고
    • Causes of death and pathologic findings in 304 cases of bronchial asthma
    • Messer JW, Peters GA, Bennett WA. Causes of death and pathologic findings in 304 cases of bronchial asthma. Dis Chest. 1960;38:616-624.
    • (1960) Dis Chest , vol.38 , pp. 616-624
    • Messer, J.W.1    Peters, G.A.2    Bennett, W.A.3
  • 5
    • 0026503978 scopus 로고
    • Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack
    • Aikawa T, Shimura S, Sasaki H, Ebina M, Takishima T. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest. 1992;101(4):916-921.
    • (1992) Chest , vol.101 , Issue.4 , pp. 916-921
    • Aikawa, T.1    Shimura, S.2    Sasaki, H.3    Ebina, M.4    Takishima, T.5
  • 6
    • 0037812532 scopus 로고    scopus 로고
    • Characterization of airway plugging in fatal asthma
    • Kuyper LM, et al. Characterization of airway plugging in fatal asthma. Am J Med. 2003;115(1):6-11.
    • (2003) Am J Med , vol.115 , Issue.1 , pp. 6-11
    • Kuyper, L.M.1
  • 7
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest. 2002;109(5):571-577.
    • (2002) J Clin Invest , vol.109 , Issue.5 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 8
    • 84865305392 scopus 로고    scopus 로고
    • A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia
    • Button B, et al. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science. 2012;337(6097):937-941.
    • (2012) Science , vol.337 , Issue.6097 , pp. 937-941
    • Button, B.1
  • 9
    • 84906089250 scopus 로고    scopus 로고
    • Cystic fibrosis. Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis
    • Hoegger MJ, et al. Cystic fibrosis. Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science. 2014;345(6198):818-822.
    • (2014) Science , vol.345 , Issue.6198 , pp. 818-822
    • Hoegger, M.J.1
  • 10
    • 43549093774 scopus 로고    scopus 로고
    • Structure and function of the polymeric mucins in airways mucus
    • Thornton DJ, Rousseau K, McGuckin MA. Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol. 2008;70:459-486.
    • (2008) Annu Rev Physiol , vol.70 , pp. 459-486
    • Thornton, D.J.1    Rousseau, K.2    McGuckin, M.A.3
  • 11
    • 0036486435 scopus 로고    scopus 로고
    • Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung
    • Groneberg DA, et al. Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med. 2002;96(2):81-86.
    • (2002) Respir Med , vol.96 , Issue.2 , pp. 81-86
    • Groneberg, D.A.1
  • 12
    • 84892563951 scopus 로고    scopus 로고
    • Muc5b is required for airway defence
    • Roy MG, et al. Muc5b is required for airway defence. Nature. 2013;505(7483):412-416.
    • (2013) Nature , vol.505 , Issue.7483 , pp. 412-416
    • Roy, M.G.1
  • 13
    • 84923361939 scopus 로고    scopus 로고
    • The polymeric mucin Muc5ac is required for allergic airway hyperreactivity
    • Evans CM, et al. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun. 2015;6:6281.
    • (2015) Nat Commun , vol.6 , pp. 6281
    • Evans, C.M.1
  • 14
    • 24744442575 scopus 로고    scopus 로고
    • IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production
    • Kuperman DA, Huang X, Nguyenvu L, Holscher C, Brombacher F, Erle DJ. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol. 2005;175(6):3746-3752.
    • (2005) J Immunol , vol.175 , Issue.6 , pp. 3746-3752
    • Kuperman, D.A.1    Huang, X.2    Nguyenvu, L.3    Holscher, C.4    Brombacher, F.5    Erle, D.J.6
  • 15
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • Kuperman DA, et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002;8(8):885-889.
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 885-889
    • Kuperman, D.A.1
  • 16
    • 69249150516 scopus 로고    scopus 로고
    • T-helper type 2-driven inflammation defines major subphenotypes of asthma
    • Woodruff PG, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009;180(5):388-395.
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.5 , pp. 388-395
    • Woodruff, P.G.1
  • 17
    • 0036471129 scopus 로고    scopus 로고
    • Heterogeneity of airways mucus: Variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B
    • Kirkham S, Sheehan JK, Knight D, Richardson PS, Thornton DJ. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J. 2002;361(pt 3):537-546.
    • (2002) Biochem J , vol.361 , pp. 537-546
    • Kirkham, S.1    Sheehan, J.K.2    Knight, D.3    Richardson, P.S.4    Thornton, D.J.5
  • 18
    • 0029611346 scopus 로고
    • Analysis of respiratory mucus glycoproteins in asthma: A detailed study from a patient who died in status asthmaticus
    • Sheehan JK, Richardson PS, Fung DC, Howard M, Thornton DJ. Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Biol. 1995;13(6):748-756.
    • (1995) Am J Respir Cell Mol Biol , vol.13 , Issue.6 , pp. 748-756
    • Sheehan, J.K.1    Richardson, P.S.2    Fung, D.C.3    Howard, M.4    Thornton, D.J.5
  • 19
    • 45549102949 scopus 로고    scopus 로고
    • -/- baseline secretion defect reveals source of oligomeric mucins in mouse airways
    • -/- baseline secretion defect reveals source of oligomeric mucins in mouse airways. J Physiol. 2008;586(7):1977-1992.
    • (2008) J Physiol , vol.586 , Issue.7 , pp. 1977-1992
    • Zhu, Y.1
  • 20
    • 84895871605 scopus 로고    scopus 로고
    • A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease
    • Hill DB, et al. A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease. PLoS One. 2014;9(2):e87681.
    • (2014) PLoS One , vol.9 , Issue.2
    • Hill, D.B.1
  • 21
    • 84903731146 scopus 로고    scopus 로고
    • Mechanisms of cilia-driven transport in the airways in the absence of mucus
    • Bermbach S, et al. Mechanisms of cilia-driven transport in the airways in the absence of mucus. Am J Respir Cell Mol Biol. 2014;51(1):56-67.
    • (2014) Am J Respir Cell Mol Biol , vol.51 , Issue.1 , pp. 56-67
    • Bermbach, S.1
  • 22
    • 2342523999 scopus 로고    scopus 로고
    • Airway mucus hypersecretion in asthma: An undervalued pathology?
    • Rogers DF. Airway mucus hypersecretion in asthma: an undervalued pathology? Curr Opin Pharmacol. 2004;4(3):241-250.
    • (2004) Curr Opin Pharmacol , vol.4 , Issue.3 , pp. 241-250
    • Rogers, D.F.1
  • 23
    • 0030058496 scopus 로고    scopus 로고
    • Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma
    • Shimura S, Andoh Y, Haraguchi M, Shirato K. Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma. Eur Respir J. 1996;9(7):1395-1401.
    • (1996) Eur Respir J , vol.9 , Issue.7 , pp. 1395-1401
    • Shimura, S.1    Andoh, Y.2    Haraguchi, M.3    Shirato, K.4
  • 24
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • Corren J, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med. 2011;365(12):1088-1098.
    • (2011) N Engl J Med , vol.365 , Issue.12 , pp. 1088-1098
    • Corren, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.