메뉴 건너뛰기




Volumn 144, Issue 1, 2015, Pages 79-90

S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-κB pathways

Author keywords

Airway epithelial cells; MUC5AC; S100A12; S100A8; S100A9

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; CALGRANULIN A; CALGRANULIN B; EPIDERMAL GROWTH FACTOR RECEPTOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEDIATOR COMPLEX; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN 5AC; PROTEIN; PROTEIN S 100; RECOMBINANT PROTEIN; RESATORVID; S100 CALCIUM BINDING PROTEIN A12; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; CALGRANULIN C; I KAPPA B KINASE; MUC5AC PROTEIN, HUMAN; S100A12 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

EID: 84918811753     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12352     Document Type: Article
Times cited : (129)

References (54)
  • 2
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, Chu HW. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160:1001-8.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3    Halliday, J.L.4    Trudeau, J.B.5    Gibbs, R.L.6    Chu, H.W.7
  • 3
    • 84879291920 scopus 로고    scopus 로고
    • The neutrophil in chronic obstructive pulmonary disease
    • Hoenderdos K, Condliffe A. The neutrophil in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2013; 48:531-9.
    • (2013) Am J Respir Cell Mol Biol , vol.48 , pp. 531-539
    • Hoenderdos, K.1    Condliffe, A.2
  • 4
    • 0142043977 scopus 로고    scopus 로고
    • Pathophysiology and management of pulmonary infections in cystic fibrosis
    • Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med 2003; 168:918-51.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 918-951
    • Gibson, R.L.1    Burns, J.L.2    Ramsey, B.W.3
  • 5
    • 69949147507 scopus 로고    scopus 로고
    • Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages
    • Armstrong J, Sargent C, Singh D. Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. Clin Exp Immunol 2009; 158:74-83.
    • (2009) Clin Exp Immunol , vol.158 , pp. 74-83
    • Armstrong, J.1    Sargent, C.2    Singh, D.3
  • 7
    • 0032993704 scopus 로고    scopus 로고
    • Role of neutrophil elastase in hypersecretion in asthma
    • Nadel JA, Takeyama K, Agustí C. Role of neutrophil elastase in hypersecretion in asthma. Eur Respir J 1999; 13:190-6.
    • (1999) Eur Respir J , vol.13 , pp. 190-196
    • Nadel, J.A.1    Takeyama, K.2    Agustí, C.3
  • 8
    • 0033045546 scopus 로고    scopus 로고
    • Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells
    • Voynow JA, Young LR, Wang Y, Horger T, Rose MC, Fischer BM. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 1999; 276:L835-43.
    • (1999) Am J Physiol , vol.276 , pp. L835-L843
    • Voynow, J.A.1    Young, L.R.2    Wang, Y.3    Horger, T.4    Rose, M.C.5    Fischer, B.M.6
  • 9
    • 0034129127 scopus 로고    scopus 로고
    • Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways
    • Zuhdi Alimam M, Piazza FM, Selby DM, Letwin N, Huang L, Rose MC. Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol 2000; 22:253-60.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 253-260
    • Zuhdi Alimam, M.1    Piazza, F.M.2    Selby, D.M.3    Letwin, N.4    Huang, L.5    Rose, M.C.6
  • 10
    • 0035132115 scopus 로고    scopus 로고
    • Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    • Ordoñez CL, Khashayar R, Wong HH et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001; 163:517-23.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 517-523
    • Ordoñez, C.L.1    Khashayar, R.2    Wong, H.H.3
  • 12
    • 27744548897 scopus 로고    scopus 로고
    • Tumor necrosis factor-α triggers mucus production in airway epithelium through an IκB kinase β-dependent mechanism
    • Lora JM, Zhang DM, Liao SM et al. Tumor necrosis factor-α triggers mucus production in airway epithelium through an IκB kinase β-dependent mechanism. J Biol Chem 2005; 280:36510-7.
    • (2005) J Biol Chem , vol.280 , pp. 36510-36517
    • Lora, J.M.1    Zhang, D.M.2    Liao, S.M.3
  • 13
    • 5444253271 scopus 로고    scopus 로고
    • Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKβ-IκBα-NF-κB signaling pathways
    • Chen R, Lim JH, Jono H, Gu XX, Kim YS, Basbaum CB, Murphy TF, Li JD. Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKβ-IκBα-NF-κB signaling pathways. Biochem Biophys Res Commun 2004; 324:1087-94.
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 1087-1094
    • Chen, R.1    Lim, J.H.2    Jono, H.3    Gu, X.X.4    Kim, Y.S.5    Basbaum, C.B.6    Murphy, T.F.7    Li, J.D.8
  • 14
    • 0037199957 scopus 로고    scopus 로고
    • Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1
    • Perrais M, Pigny P, Copin MC, Aubert JP, Van Seuningen I. Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. J Biol Chem 2002; 277:32258-67.
    • (2002) J Biol Chem , vol.277 , pp. 32258-32267
    • Perrais, M.1    Pigny, P.2    Copin, M.C.3    Aubert, J.P.4    Van Seuningen, I.5
  • 15
    • 0037593635 scopus 로고    scopus 로고
    • Interleukin-1 β and tumor necrosis factor-α induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells
    • Song KS, Lee WJ, Chung KC, Koo JS, Yang EJ, Choi JY, Yoon JH. Interleukin-1 β and tumor necrosis factor-α induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem 2003; 278:23243-50.
    • (2003) J Biol Chem , vol.278 , pp. 23243-23250
    • Song, K.S.1    Lee, W.J.2    Chung, K.C.3    Koo, J.S.4    Yang, E.J.5    Choi, J.Y.6    Yoon, J.H.7
  • 16
    • 7944225451 scopus 로고    scopus 로고
    • PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-α, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms
    • Hewson CA, Edbrooke MR, Johnston SL. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-α, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. J Mol Biol 2004; 344:683-95.
    • (2004) J Mol Biol , vol.344 , pp. 683-695
    • Hewson, C.A.1    Edbrooke, M.R.2    Johnston, S.L.3
  • 17
    • 0032549673 scopus 로고    scopus 로고
    • Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts
    • Li D, Gallup M, Fan N, Szymkowski DE, Basbaum CB. Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. J Biol Chem 1998; 273:6812-20.
    • (1998) J Biol Chem , vol.273 , pp. 6812-6820
    • Li, D.1    Gallup, M.2    Fan, N.3    Szymkowski, D.E.4    Basbaum, C.B.5
  • 18
    • 33845868493 scopus 로고    scopus 로고
    • S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    • Foell D, Wittkowski H, Vogl T, Roth J. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 2007; 81:28-37.
    • (2007) J Leukoc Biol , vol.81 , pp. 28-37
    • Foell, D.1    Wittkowski, H.2    Vogl, T.3    Roth, J.4
  • 19
    • 0025900907 scopus 로고
    • Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells
    • Edgeworth J, Gorman M, Bennett R, Freemont P, Hogg N. Identification of p8, 14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells. J Biol Chem 1991; 266:7706-13.
    • (1991) J Biol Chem , vol.266 , pp. 7706-7713
    • Edgeworth, J.1    Gorman, M.2    Bennett, R.3    Freemont, P.4    Hogg, N.5
  • 20
    • 34948900275 scopus 로고    scopus 로고
    • Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
    • Vogl T, Tenbrock K, Ludwig S et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 2007; 13:1042-9.
    • (2007) Nat Med , vol.13 , pp. 1042-1049
    • Vogl, T.1    Tenbrock, K.2    Ludwig, S.3
  • 21
    • 0033603241 scopus 로고    scopus 로고
    • RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    • Hofmann MA, Drury S, Fu C et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999; 97:889-901.
    • (1999) Cell , vol.97 , pp. 889-901
    • Hofmann, M.A.1    Drury, S.2    Fu, C.3
  • 22
    • 0034704068 scopus 로고    scopus 로고
    • Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation
    • Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H. Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J Biol Chem 2000; 275:40096-105.
    • (2000) J Biol Chem , vol.275 , pp. 40096-40105
    • Huttunen, H.J.1    Kuja-Panula, J.2    Sorci, G.3    Agneletti, A.L.4    Donato, R.5    Rauvala, H.6
  • 23
    • 67649208478 scopus 로고    scopus 로고
    • The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
    • Ehrchen JM, Sunderkötter C, Foell D, Vogl T, Roth J. The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 2009; 86:557-66.
    • (2009) J Leukoc Biol , vol.86 , pp. 557-566
    • Ehrchen, J.M.1    Sunderkötter, C.2    Foell, D.3    Vogl, T.4    Roth, J.5
  • 24
    • 38349052450 scopus 로고    scopus 로고
    • S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway
    • Ghavami S, Rashedi I, Dattilo BM et al. S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. J Leukoc Biol 2008; 83:1484-92.
    • (2008) J Leukoc Biol , vol.83 , pp. 1484-1492
    • Ghavami, S.1    Rashedi, I.2    Dattilo, B.M.3
  • 25
    • 28344438623 scopus 로고    scopus 로고
    • S100A8 and S100A9 activate MAP kinase and NF-κB signaling pathways and trigger translocation of RAGE in human prostate cancer cells
    • Hermani A, De Servi B, Medunjanin S, Tessier PA, Mayer D. S100A8 and S100A9 activate MAP kinase and NF-κB signaling pathways and trigger translocation of RAGE in human prostate cancer cells. Exp Cell Res 2006; 312:184-97.
    • (2006) Exp Cell Res , vol.312 , pp. 184-197
    • Hermani, A.1    De Servi, B.2    Medunjanin, S.3    Tessier, P.A.4    Mayer, D.5
  • 26
    • 33845948230 scopus 로고    scopus 로고
    • S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity
    • Yang Z, Yan WX, Cai H et al. S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity. J Allergy Clin Immunol 2007; 119:106-14.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 106-114
    • Yang, Z.1    Yan, W.X.2    Cai, H.3
  • 27
    • 58849125851 scopus 로고    scopus 로고
    • Expression profiling of genes related to asthma exacerbations
    • Aoki T, Matsumoto Y, Hirata K et al. Expression profiling of genes related to asthma exacerbations. Clin Exp Allergy 2009; 39:213-21.
    • (2009) Clin Exp Allergy , vol.39 , pp. 213-221
    • Aoki, T.1    Matsumoto, Y.2    Hirata, K.3
  • 28
    • 84884533825 scopus 로고    scopus 로고
    • Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma
    • Lee TH, Jang AS, Park JS et al. Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma. Ann Allergy Asthma Immunol 2013; 111:268-75.
    • (2013) Ann Allergy Asthma Immunol , vol.111 , pp. 268-275
    • Lee, T.H.1    Jang, A.S.2    Park, J.S.3
  • 29
    • 0041427762 scopus 로고    scopus 로고
    • Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide
    • Vandal K, Rouleau P, Boivin A, Ryckman C, Talbot M, Tessier PA. Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide. J Immunol 2003; 171:2602-9.
    • (2003) J Immunol , vol.171 , pp. 2602-2609
    • Vandal, K.1    Rouleau, P.2    Boivin, A.3    Ryckman, C.4    Talbot, M.5    Tessier, P.A.6
  • 30
    • 79960414820 scopus 로고    scopus 로고
    • MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways
    • Kang JH, Lee EH, Park SW, Chung IY. MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways. J Immunol 2011; 187:222-9.
    • (2011) J Immunol , vol.187 , pp. 222-229
    • Kang, J.H.1    Lee, E.H.2    Park, S.W.3    Chung, I.Y.4
  • 31
    • 33645816115 scopus 로고    scopus 로고
    • Neutrophil elastase causes MUC5AC mucin synthesis via EGF receptor, ERK and NF-κB pathways in A549 cells
    • Song JS, Cho KS, Yoon HK, Moon HS, Park SH. Neutrophil elastase causes MUC5AC mucin synthesis via EGF receptor, ERK and NF-κB pathways in A549 cells. Korean J Intern Med 2005; 20:275-83.
    • (2005) Korean J Intern Med , vol.20 , pp. 275-283
    • Song, J.S.1    Cho, K.S.2    Yoon, H.K.3    Moon, H.S.4    Park, S.H.5
  • 34
    • 70449085204 scopus 로고    scopus 로고
    • S100A8/A9: a mediator of severe asthma pathogenesis and morbidity?
    • Halayko AJ, Ghavami S. S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol 2009; 87:743-55.
    • (2009) Can J Physiol Pharmacol , vol.87 , pp. 743-755
    • Halayko, A.J.1    Ghavami, S.2
  • 35
    • 34548036986 scopus 로고    scopus 로고
    • The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor κB and p38 mitogen-activated protein kinase in rheumatoid arthritis
    • Sunahori K, Yamamura M, Yamana J et al. The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor κB and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res Ther 2006; 8:R69.
    • (2006) Arthritis Res Ther , vol.8 , pp. R69
    • Sunahori, K.1    Yamamura, M.2    Yamana, J.3
  • 36
    • 84865786588 scopus 로고    scopus 로고
    • Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent
    • Riva M, Källberg E, Björk P, Hancz D, Vogl T, Roth J, Ivars F, Leanderson T. Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent. Immunology 2012; 137:172-82.
    • (2012) Immunology , vol.137 , pp. 172-182
    • Riva, M.1    Källberg, E.2    Björk, P.3    Hancz, D.4    Vogl, T.5    Roth, J.6    Ivars, F.7    Leanderson, T.8
  • 37
    • 84881527844 scopus 로고    scopus 로고
    • S100A9 promotes human lung fibroblast cells activation through receptor for advanced glycation end-product-mediated extracellular-regulated kinase 1/2, mitogen-activated protein-kinase and nuclear factor-κB-dependent pathways
    • Xu X, Chen H, Zhu X et al. S100A9 promotes human lung fibroblast cells activation through receptor for advanced glycation end-product-mediated extracellular-regulated kinase 1/2, mitogen-activated protein-kinase and nuclear factor-κB-dependent pathways. Clin Exp Immunol 2013; 173:523-35.
    • (2013) Clin Exp Immunol , vol.173 , pp. 523-535
    • Xu, X.1    Chen, H.2    Zhu, X.3
  • 38
    • 77952497546 scopus 로고    scopus 로고
    • Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism
    • Simard JC, Girard D, Tessier PA. Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism. J Leukoc Biol 2010; 87:905-14.
    • (2010) J Leukoc Biol , vol.87 , pp. 905-914
    • Simard, J.C.1    Girard, D.2    Tessier, P.A.3
  • 39
    • 0037443667 scopus 로고    scopus 로고
    • Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion
    • Ryckman C, Vandal K, Rouleau P, Talbot M, Tessier PA. Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion. J Immunol 2003; 170:3233-42.
    • (2003) J Immunol , vol.170 , pp. 3233-3242
    • Ryckman, C.1    Vandal, K.2    Rouleau, P.3    Talbot, M.4    Tessier, P.A.5
  • 40
    • 19944417730 scopus 로고    scopus 로고
    • Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells
    • Viemann D, Strey A, Janning A et al. Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood 2005; 105:2955-62.
    • (2005) Blood , vol.105 , pp. 2955-2962
    • Viemann, D.1    Strey, A.2    Janning, A.3
  • 41
  • 42
    • 1642494708 scopus 로고    scopus 로고
    • Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4
    • Guillot L, Medjane S, Le-Barillec K, Balloy V, Danel C, Chignard M, Si-Tahar M. Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J Biol Chem 2004; 279:2712-8.
    • (2004) J Biol Chem , vol.279 , pp. 2712-2718
    • Guillot, L.1    Medjane, S.2    Le-Barillec, K.3    Balloy, V.4    Danel, C.5    Chignard, M.6    Si-Tahar, M.7
  • 43
    • 27644445147 scopus 로고    scopus 로고
    • Respiratory epithelial cells require Toll-like receptor 4 for induction of human β-defensin 2 by lipopolysaccharide
    • MacRedmond R, Greene C, Taggart CC, McElvaney N, O'Neill S. Respiratory epithelial cells require Toll-like receptor 4 for induction of human β-defensin 2 by lipopolysaccharide. Respir Res 2005; 6:116.
    • (2005) Respir Res , vol.6 , pp. 116
    • MacRedmond, R.1    Greene, C.2    Taggart, C.C.3    McElvaney, N.4    O'Neill, S.5
  • 44
    • 33750303583 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease?
    • Morbini P, Villa C, Campo I, Zorzetto M, Inghilleri S, Luisetti M. The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease? Mod Pathol 2006; 19:1437-45.
    • (2006) Mod Pathol , vol.19 , pp. 1437-1445
    • Morbini, P.1    Villa, C.2    Campo, I.3    Zorzetto, M.4    Inghilleri, S.5    Luisetti, M.6
  • 45
    • 62449255580 scopus 로고    scopus 로고
    • Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo
    • van Zoelen MA, Yang H, Florquin S et al. Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo. Shock 2009; 31:280-4.
    • (2009) Shock , vol.31 , pp. 280-284
    • van Zoelen, M.A.1    Yang, H.2    Florquin, S.3
  • 46
    • 84860661046 scopus 로고    scopus 로고
    • High-mobility group box-1 protein induces mucin 8 expression through the activation of the JNK and PI3K/Akt signal pathways in human airway epithelial cells
    • Kim DE, Min KJ, Kim JS, Kwon TK. High-mobility group box-1 protein induces mucin 8 expression through the activation of the JNK and PI3K/Akt signal pathways in human airway epithelial cells. Biochem Biophys Res Commun 2012; 421:436-41.
    • (2012) Biochem Biophys Res Commun , vol.421 , pp. 436-441
    • Kim, D.E.1    Min, K.J.2    Kim, J.S.3    Kwon, T.K.4
  • 47
    • 84872864991 scopus 로고    scopus 로고
    • The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis
    • Petersen B, Wolf M, Austermann J et al. The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. EMBO J 2013; 32:100-11.
    • (2013) EMBO J , vol.32 , pp. 100-111
    • Petersen, B.1    Wolf, M.2    Austermann, J.3
  • 49
    • 77952721659 scopus 로고    scopus 로고
    • Carboxylated N-glycans on RAGE promote S100A12 binding and signaling
    • Srikrishna G, Nayak J, Weigle B et al. Carboxylated N-glycans on RAGE promote S100A12 binding and signaling. J Cell Biochem 2010; 110:645-59.
    • (2010) J Cell Biochem , vol.110 , pp. 645-659
    • Srikrishna, G.1    Nayak, J.2    Weigle, B.3
  • 50
    • 65949111512 scopus 로고    scopus 로고
    • Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides
    • Björk P, Björk A, Vogl T et al. Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides. PLoS Biol 2009; 7:e97.
    • (2009) PLoS Biol , vol.7
    • Björk, P.1    Björk, A.2    Vogl, T.3
  • 51
    • 84879567790 scopus 로고    scopus 로고
    • Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4
    • Foell D, Wittkowski H, Kessel C et al. Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4. Am J Respir Crit Care Med 2013; 187:1324-34.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 1324-1334
    • Foell, D.1    Wittkowski, H.2    Kessel, C.3
  • 52
    • 24744464353 scopus 로고    scopus 로고
    • Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-α-converting enzyme
    • Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-α-converting enzyme. J Immunol 2005; 175:4009-16.
    • (2005) J Immunol , vol.175 , pp. 4009-4016
    • Shao, M.X.1    Nadel, J.A.2
  • 53
    • 84862203625 scopus 로고    scopus 로고
    • Systemic biomarkers of neutrophilic inflammation, tissue injury and repair in COPD patients with differing levels of disease severity
    • Cockayne DA, Cheng DT, Waschki B et al. Systemic biomarkers of neutrophilic inflammation, tissue injury and repair in COPD patients with differing levels of disease severity. PLoS ONE 2012; 7:e38629.
    • (2012) PLoS ONE , vol.7 , pp. e38629
    • Cockayne, D.A.1    Cheng, D.T.2    Waschki, B.3
  • 54
    • 57649136396 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway
    • Bergin DA, Greene CM, Sterchi EE et al. Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. J Biol Chem 2008; 283:31736-44.
    • (2008) J Biol Chem , vol.283 , pp. 31736-31744
    • Bergin, D.A.1    Greene, C.M.2    Sterchi, E.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.