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Volumn 51, Issue 2, 1996, Pages 119-125

In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis

Author keywords

Cystic fibrosis; DNA content; RhDNase; Sputum; Theology

Indexed keywords

DEOXYRIBONUCLEASE; DNA; PLACEBO;

EID: 0030027655     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.51.2.119     Document Type: Article
Times cited : (124)

References (32)
  • 2
    • 0027395872 scopus 로고
    • The changing epidemiology of cystic fibrosis
    • FitzSimmons SC. The changing epidemiology of cystic fibrosis. J Pediatr 1993;122:i-9.
    • (1993) J Pediatr , vol.122
    • FitzSimmons, S.C.1
  • 3
    • 0025181636 scopus 로고
    • The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum
    • Lethem MI, James SL, Marriott C, Burke JF. The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum. Eur Respir J 1990;3:19-23.
    • (1990) Eur Respir J , vol.3 , pp. 19-23
    • Lethem, M.I.1    James, S.L.2    Marriott, C.3    Burke, J.F.4
  • 4
    • 0001307488 scopus 로고
    • Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis
    • Chernick WS, Barbero GJ. Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis. Pediatrics 1959;24:739-45.
    • (1959) Pediatrics , vol.24 , pp. 739-745
    • Chernick, W.S.1    Barbero, G.J.2
  • 5
    • 0001513063 scopus 로고
    • Composition of pulmonary secretions from patients with and without cystic fibrosis
    • Potter J, Matthews LW, Lemm J, Spector JS. Composition of pulmonary secretions from patients with and without cystic fibrosis. Am J Dis Child 1960;100:493-5.
    • (1960) Am J Dis Child , vol.100 , pp. 493-495
    • Potter, J.1    Matthews, L.W.2    Lemm, J.3    Spector, J.S.4
  • 6
    • 0024990329 scopus 로고
    • The role of mucous glycoproteins in the rheologic properties of cystic fibrosis sputum
    • Lethem MI, James SL, Marriott C. The role of mucous glycoproteins in the rheologic properties of cystic fibrosis sputum. Am Rev Respir Dis 1990;142:1053-58.
    • (1990) Am Rev Respir Dis , vol.142 , pp. 1053-1058
    • Lethem, M.I.1    James, S.L.2    Marriott, C.3
  • 7
    • 0000592573 scopus 로고
    • Mucus, mucociliary clearance and coughing
    • Bates DV, ed. Philadelphia: Saunders Chapter 3
    • King M. Mucus, mucociliary clearance and coughing. In: Bates DV, ed. Respiratory function in disease. 3rd edn. Philadelphia: Saunders 1989:Chapter 3.
    • (1989) Respiratory Function in Disease. 3rd Edn.
    • King, M.1
  • 8
    • 0026486439 scopus 로고
    • Cystic fibrosis: Respiratory problems and their management
    • Hodson ME, Warner JO. Cystic fibrosis: respiratory problems and their management. Br Med Bull 1992;48:931-48.
    • (1992) Br Med Bull , vol.48 , pp. 931-948
    • Hodson, M.E.1    Warner, J.O.2
  • 9
    • 0023936587 scopus 로고
    • The clinical effect and the effect on the ciliary motility of oral N-acetylcysteine in patients with cystic fibrosis and primary ciliary dyskinesia
    • Stafanger G, Garne S, Howitz P, Morkassel E, Koch C. The clinical effect and the effect on the ciliary motility of oral N-acetylcysteine in patients with cystic fibrosis and primary ciliary dyskinesia. Eur Respir J 1988;1:161-7.
    • (1988) Eur Respir J , vol.1 , pp. 161-167
    • Stafanger, G.1    Garne, S.2    Howitz, P.3    Morkassel, E.4    Koch, C.5
  • 10
    • 0024522584 scopus 로고
    • N-acetylcysteine in cystic fibrosis and Pseudomonas aeruginosa infection: Clinical score, spirometry and ciliary motility
    • Stafanger G, Koch C. N-acetylcysteine in cystic fibrosis and Pseudomonas aeruginosa infection: clinical score, spirometry and ciliary motility. Eur Respir J 1989;2:234-7.
    • (1989) Eur Respir J , vol.2 , pp. 234-237
    • Stafanger, G.1    Koch, C.2
  • 11
    • 0022378715 scopus 로고
    • A double blind placebo controlled trial with oral ambroxol and N-acetylcysteine for mucolytic treatment in cystic fibrosis
    • Ratjen F, Wonne R, Posselt HG, Stover B, Hofmann D, Bender SW. A double blind placebo controlled trial with oral ambroxol and N-acetylcysteine for mucolytic treatment in cystic fibrosis. Eur J Pediatr 1985;144:374-8.
    • (1985) Eur J Pediatr , vol.144 , pp. 374-378
    • Ratjen, F.1    Wonne, R.2    Posselt, H.G.3    Stover, B.4    Hofmann, D.5    Bender, S.W.6
  • 13
    • 0026602608 scopus 로고
    • Recombinant human DNase inhalation in normal subjects and patients with cystic fibrosis. A phase I study
    • Aitken ML, Burke W, McDonald G, Shak S, Montgomery AB, Smith A. Recombinant human DNase inhalation in normal subjects and patients with cystic fibrosis. A phase I study. J Am Med Assoc 1992;267:1947-51.
    • (1992) J Am Med Assoc , vol.267 , pp. 1947-1951
    • Aitken, M.L.1    Burke, W.2    McDonald, G.3    Shak, S.4    Montgomery, A.B.5    Smith, A.6
  • 14
    • 0026548151 scopus 로고
    • A preliminary study of aerosolised recombinant human deoxyribonuclease I in the treatment of cystic fibrosis
    • Hubbard RC, McElvaney NG, Birrer P, Shak S, Robinson WW, Jolley C, et al. A preliminary study of aerosolised recombinant human deoxyribonuclease I in the treatment of cystic fibrosis. N Engl J Med 1992;326:812-5.
    • (1992) N Engl J Med , vol.326 , pp. 812-815
    • Hubbard, R.C.1    McElvaney, N.G.2    Birrer, P.3    Shak, S.4    Robinson, W.W.5    Jolley, C.6
  • 15
    • 0027278897 scopus 로고
    • Efficacy and safety of short-term administration of aerosolised recombinant human deoxyribonuclease in patients with cystic fibrosis
    • Ramsey BW, Astley SJ, Aitken ML, Burke W, Colin AA, Dorkin HL, et al. Efficacy and safety of short-term administration of aerosolised recombinant human deoxyribonuclease in patients with cystic fibrosis. Am Rev Respir Dis 1993;148:145-51.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 145-151
    • Ramsey, B.W.1    Astley, S.J.2    Aitken, M.L.3    Burke, W.4    Colin, A.A.5    Dorkin, H.L.6
  • 16
    • 0027181325 scopus 로고
    • Efficacy and safety of short-tern administration of aerosolised recombinant human DNase I in adults with stable stage cystic fibrosis
    • Ranasinha C, Assoufi B, Shak S, Christiansen D, Fuchs H, Empey D, et al. Efficacy and safety of short-tern administration of aerosolised recombinant human DNase I in adults with stable stage cystic fibrosis. Lancet 1993; 342:199-202.
    • (1993) Lancet , vol.342 , pp. 199-202
    • Ranasinha, C.1    Assoufi, B.2    Shak, S.3    Christiansen, D.4    Fuchs, H.5    Empey, D.6
  • 17
    • 0028129568 scopus 로고
    • Effect of aerosolised recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis
    • Fuchs HJ, Borowitz DS, Christiansen DH, Morris EM, Nash ML, Ramsey BW, et al. Effect of aerosolised recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. N Engl J Med 1994;331:637-42.
    • (1994) N Engl J Med , vol.331 , pp. 637-642
    • Fuchs, H.J.1    Borowitz, D.S.2    Christiansen, D.H.3    Morris, E.M.4    Nash, M.L.5    Ramsey, B.W.6
  • 18
    • 9244225677 scopus 로고
    • A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilising pilocarpine by iontophoresis
    • Gibson LE, Cooke RE. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilising pilocarpine by iontophoresis. Pediatrics 1959;23:545-9.
    • (1959) Pediatrics , vol.23 , pp. 545-549
    • Gibson, L.E.1    Cooke, R.E.2
  • 19
    • 0023442646 scopus 로고
    • Standardisation of spirometry - 1987 update
    • American Thoracic Society. Standardisation of spirometry - 1987 update. Am Rev Respir Dis 1987;136:1285-98.
    • (1987) Am Rev Respir Dis , vol.136 , pp. 1285-1298
  • 20
    • 0020585150 scopus 로고
    • Changes in the normal maximal expiratory flow-volume curve with growth and ageing
    • Knudson RJ, Lebowitz MD, Holberg CJ, Burrows B. Changes in the normal maximal expiratory flow-volume curve with growth and ageing. Am Rev Respir Dis 1983; 127:725-34.
    • (1983) Am Rev Respir Dis , vol.127 , pp. 725-734
    • Knudson, R.J.1    Lebowitz, M.D.2    Holberg, C.J.3    Burrows, B.4
  • 21
    • 0022263413 scopus 로고
    • Clearance of mucus by stimulated cough
    • King M, Brock G, Lundell C. Clearance of mucus by stimulated cough. J Appl Physiol 1985;58:1776-82.
    • (1985) J Appl Physiol , vol.58 , pp. 1776-1782
    • King, M.1    Brock, G.2    Lundell, C.3
  • 22
    • 0023611276 scopus 로고
    • Role of mucus viscoelasticity in cough clearance
    • King M. Role of mucus viscoelasticity in cough clearance. Biorheology 1987;24:589-97.
    • (1987) Biorheology , vol.24 , pp. 589-597
    • King, M.1
  • 23
    • 2442468761 scopus 로고
    • A randomised, placebo controlled trial of the effect of recombinant human DNase I (rhDNase) on the deposition homogeneity and mucociliary clearance of radioaerosol in patients with cystic fibrosis
    • Laube BL, Auci RM, Shields DE, Christiansen D, Fuchs HJ, Rosenstein BJ. A randomised, placebo controlled trial of the effect of recombinant human DNase I (rhDNase) on the deposition homogeneity and mucociliary clearance of radioaerosol in patients with cystic fibrosis. Pediatr Pulmonol 1983;Suppl 9:155-6.
    • (1983) Pediatr Pulmonol , Issue.9 SUPPL. , pp. 155-156
    • Laube, B.L.1    Auci, R.M.2    Shields, D.E.3    Christiansen, D.4    Fuchs, H.J.5    Rosenstein, B.J.6
  • 25
    • 0017406248 scopus 로고
    • Effect of nondialyzable solids concentration and viscoelasticity on ciliary transport of tracheal mucus
    • Shih CK, Litt M, Khan MA, Wolf DP. Effect of nondialyzable solids concentration and viscoelasticity on ciliary transport of tracheal mucus. Am Rev Respir Dis 1977; 115:989-95.
    • (1977) Am Rev Respir Dis , vol.115 , pp. 989-995
    • Shih, C.K.1    Litt, M.2    Khan, M.A.3    Wolf, D.P.4
  • 26
    • 0016311999 scopus 로고
    • On the transport of mucus and its rheologic stimulants in ciliated systems
    • King M, Gilboa A, Meyer FA, Silberberg A. On the transport of mucus and its rheologic stimulants in ciliated systems. Am Rev Respir Dis 1974;110:740-5.
    • (1974) Am Rev Respir Dis , vol.110 , pp. 740-745
    • King, M.1    Gilboa, A.2    Meyer, F.A.3    Silberberg, A.4
  • 27
    • 0016726156 scopus 로고
    • Physical properties of sputum. VII. Rheologie properties and mucociliary transport
    • Dulfano MJ, Adler KB. Physical properties of sputum. VII. Rheologie properties and mucociliary transport. Am Rev Respir Dis 1975;112:341-7.
    • (1975) Am Rev Respir Dis , vol.112 , pp. 341-347
    • Dulfano, M.J.1    Adler, K.B.2
  • 28
    • 85035157397 scopus 로고
    • A comparison of the rheological and inflammatory activity of cystic fibrosis and bronchiectasis sputum
    • abstract
    • Shah PL, Scott SF, Marriott C, Knight RA, Hodson ME. A comparison of the rheological and inflammatory activity of cystic fibrosis and bronchiectasis sputum. Eur Respir J 1994;4(Suppl 18):79s (abstract).
    • (1994) Eur Respir J , vol.4 , Issue.18 SUPPL.
    • Shah, P.L.1    Scott, S.F.2    Marriott, C.3    Knight, R.A.4    Hodson, M.E.5
  • 30
    • 0017124861 scopus 로고
    • Depolymerisation of F-actin by deoxyribonuclease I
    • Hitchcock SE, Carisson L, Lindberg U. Depolymerisation of F-actin by deoxyribonuclease I. Cell 1976;7:531-42.
    • (1976) Cell , vol.7 , pp. 531-542
    • Hitchcock, S.E.1    Carisson, L.2    Lindberg, U.3
  • 31
    • 0016361516 scopus 로고
    • Actin is the naturally occurring inhibitor of deoxyribonuclease I
    • Lazarides E, Lindberg U. Actin is the naturally occurring inhibitor of deoxyribonuclease I. Proc Natl Acad Sci USA 1974;71:4742-6.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 4742-4746
    • Lazarides, E.1    Lindberg, U.2
  • 32
    • 9044224969 scopus 로고
    • The effects of recombinant human DNase I on neutrophil elastase activity and interleukin-8 levels
    • in press
    • Shah PL, Scott SF, Knight RA, Hodson ME. The effects of recombinant human DNase I on neutrophil elastase activity and interleukin-8 levels. Eur Respir J 1995 (in press).
    • (1995) Eur Respir J
    • Shah, P.L.1    Scott, S.F.2    Knight, R.A.3    Hodson, M.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.